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Irigenin | CAS:548-76-5
Irigenin
  • 名称:野鸢尾黄素 | Irigenin
  • CAS号:548-76-5
  • 别名:5,7-Dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
  • 分子式:C18H16O8
  • 分子量:360.32
  • EINESC号:208-958-3

产品描述

物理化学性质

熔点 189-192 ºC**
密度 1.461±0.06 g/cm3 (20 º

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A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules.Katsuko Shiraya et al.The Journal of biological chemistry, 285(29), 22141-22151 (2010-05-08) Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation.Chao Fang et al.Blood, 121(15), 3023-3032 (2013-02-07) [Bone marrow edema syndrome (BMES)].B S Craiovan et al.Der Orthopade, 42(3), 191-204 (2013-03-06) miR-221/222 compensates for Skp2-mediated p27 degradation and is a primary target of cell cycle regulation by prostacyclin and cAMP.Paola Castagnino et al.PloS one, 8(2), e56140-e56140 (2013-02-15) Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.Noritada Yoshikawa et al.PloS one, 7(12), e52522-e52522 (2013-01-10) Estradiol-17β and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites selectively stimulate production of prostacyclin in uterine artery endothelial cells: role of estrogen receptor-α versus estrogen receptor-β.Sheikh O Jobe et al.Hypertension (Dallas, Tex. : 1979), 61(2), 509-518 (2013-01-16) Testosterone alters maternal vascular adaptations: role of the endothelial NO system.Vijayakumar Chinnathambi et al.Hypertension (Dallas, Tex. : 1979), 61(3), 647-654 (2013-01-23) Regulation of cyclooxygenase enzymes by nitric oxide.D Salvemini Cellular and molecular life sciences : CMLS, 53(7), 576-582 (1997-07-01) Successful management of an acute subdural hematoma in a patient dependent on continuous treprostinil infusion therapy.Mina Safain et al.Journal of neurosurgery, 118(4), 753-756 (2013-02-05) Relationship between prostacyclin and nitric oxide in the thrombotic process.S Moncada et al.Thrombosis research. Supplement, 11, 3-13 (1990-01-01) Prostacyclin among prostanoids.Ryszard J Gryglewski Pharmacological reports : PR, 60(1), 3-11 (2008-02-16) PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells.Shinji Toki et al.Journal of leukocyte biology, 94(1), 77-88 (2013-04-30) Treatment satisfaction is associated with improved quality of life in patients treated with inhaled treprostinil for pulmonary arterial hypertension.Hubert Chen et al.Health and quality of life outcomes, 11, 31-31 (2013-03-19) Targeted delivery of carbaprostacyclin to ischemic hindlimbs enhances adaptive remodeling of the microvascular network.Xiaobing Liu et al.Hypertension (Dallas, Tex. : 1979), 61(5), 1036-1043 (2013-03-27) Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.Simon Stritt et al.Nature communications, 7, 11097-11097 (2016-03-30) Involvement of prostacyclin and potassium channels in the diabetes-induced hyporeactivity of the rabbit carotid artery to B-type natriuretic peptide.José M Centeno et al.European journal of pharmacology, 701(1-3), 159-167 (2013-01-24) Reply to Ricciotti et al.: Evidence for vascular COX isoforms.Jane A Mitchell et al.Proceedings of the National Academy of Sciences of the United States of America, 110(3), E184-E184 (2013-02-26) Prostacyclin withdrawal in pulmonary hypertension #264.Christi Bartlett et al.Journal of palliative medicine, 16(2), 204-205 (2013-01-23) Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.Markus Bender et al.Nature communications, 5, 4746-4746 (2014-09-05) Referral of patients with pulmonary hypertension diagnoses to tertiary pulmonary hypertension centers: the multicenter RePHerral study.Roderick C Deaño et al.JAMA internal medicine, 173(10), 887-893 (2013-04-10) Measurement of kinetic parameters of human platelet DNA polymerase gamma.Jan-Willem Taanman et al.Methods (San Diego, Calif.), 51(4), 374-378 (2010-03-17) Inhibition of transforming growth factor-beta1 and UV light-induced apoptosis by prostanoids in primary cultures of rat hepatocytes.B Kroll et al.Toxicology and applied pharmacology, 152(1), 240-250 (1998-10-17) Platelets mediate oxidized low-density lipoprotein-induced monocyte extravasation and foam cell formation.Sigrun Badrnya et al.Arteriosclerosis, thrombosis, and vascular biology, 34(3), 571-580 (2013-12-29) Effects of ethanol on aggregation, serotonin release, and amyloid precursor protein processing in rat and human plateletsEhrlich D and Humpel C Platelets, 25(1), 16-22 (2014) The PRAISE study: a prospective, multi-center, randomized, double blinded, placebo-controlled study for the evaluation of iloprost in the early postoperative period after liver transplantation (ISRCTN12622749).Erik Bärthel et al.BMC surgery, 13, 1-1 (2013-01-30) Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury.Y Numaguchi et al.Arteriosclerosis, thrombosis, and vascular biology, 19(3), 727-733 (1999-03-12) An Assay of Measuring Platelet Reactivity Using Monoclonal Antibody against Activated Platelet Glycoprotein IIb/IIIa in Patients Taking Clopidogrel.Seung-Jae Joo et al.Korean circulation journal, 45(5), 378-385 (2015-09-29) Development of an ex vivo xenogeneic bone environment producing human platelet-like cells.Shingo Fujiyama et al.PloS one, 15(4), e0230507-e0230507 (2020-04-08) Gingival pain: an unusual side effect of ziprasidone.Ashwati Raghunath BMJ case reports, 2013, doi:10-doi:10 (2013-01-04) Cyclic guanosine monophosphate modulates accumulation of phosphodiesterase 5 inhibitors in human platelets.Gzona Bajraktari et al.Biochemical pharmacology, 145, 54-63 (2017-10-02) Pharmacodynamic profile of prostacyclin.J R Vane et al.The American journal of cardiology, 75(3), 3A-10A (1995-01-19) Pulmonary arterial hypertension. Recognition is the first essential step.Virginia Nider Advance for NPs & PAs, 4(5), 33-37 (2013-06-04) Nitric oxide in atherosclerosis: vascular protector or villain?G J Dusting et al.Clinical and experimental pharmacology & physiology. Supplement, 25, S34-S41 (1998-11-11) Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts.Anna-Karin Larsson-Callerfelt et al.Respiratory research, 14, 21-21 (2013-02-15) Prostacyclin: a potential new target for endothelial progenitor cell-mediated angiogenesis.Yuji Shiba et al.Circulation journal : official journal of the Japanese Circulation Society, 77(4), 906-907 (2013-02-16) Effective treatment of malignant atrophic papulosis (Köhlmeier-Degos disease) with treprostinil--early experience.Lee S Shapiro et al.Orphanet journal of rare diseases, 8, 52-52 (2013-04-06) Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.Paola Vitale et al.Journal of medicinal chemistry, 56(11), 4277-4299 (2013-05-09) Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension.Takeshi Ogo et al.American journal of respiratory cell and molecular biology, 48(6), 733-741 (2013-02-19) Human follicular dendritic cells promote germinal center B cell survival by providing prostaglandins.Jini Kim et al.Molecular immunology, 55(3-4), 418-423 (2013-04-16) Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers.Sophie Blaise et al.Journal of clinical pharmacology, 53(1), 58-66 (2013-02-13) Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets.Wenchun Chen 陈温纯 et al.Arteriosclerosis, thrombosis, and vascular biology, 39(10), 2028-2037 (2019-07-19) Cyclooxygenase-1 and prostacyclin production by endothelial cells in the presence of mild oxidative stress.Alice Toniolo et al.PloS one, 8(2), e56683-e56683 (2013-02-27) When to initiate intravenous therapy and/or refer.Hunter C Champion The American journal of cardiology, 111(8 Suppl), 21C-24C (2013-04-12) Improving care for patients with pulmonary hypertension: comment on "Referral of patients with pulmonary hypertension diagnoses to tertiary pulmonary hypertension centers: the multicenter RePHerral study".Rita F Redberg JAMA internal medicine, 173(10), 893-893 (2013-04-10) Preparation of washed platelet suspensions from human and rodent blood Platelets and megakaryocytes, 13-28 (2004)
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