熔点	-92 ºC
水溶性	6 g/L (20 ºC)
沸点	94-95 ºC
闪点	6 ºC
密度	0.805
折射率	1.387-1.389

危险品标志	F
危险类别码	R11
安全说明书	S16;S33;S9

来源	SDS样本
Alfa-Aesar	浏览或下载
Sigma-Aldrich	浏览或下载
TCI	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.Lian Chen et al.Journal of medicinal chemistry, 55(12), 5965-5981 (2012-06-21) Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans.Prem K Gupta et al.Drug metabolism and disposition: the biological fate of chemicals, 43(4), 534-552 (2015-01-23) Acceleration of reaction in charged microdroplets.Jae Kyoo Lee et al.Quarterly reviews of biophysics, 48(4), 437-444 (2015-11-06) Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.Abdol R Hajipour et al.Bioorganic & medicinal chemistry, 19(24), 7435-7440 (2011-11-08) Secondhand smoke in waterpipe tobacco venues in Istanbul, Moscow, and Cairo.Katherine A Moon et al.Environmental research, 142, 568-574 (2015-08-25) Steady state and time-resolved fluorescence study of isoquinoline: reinvestigation of excited state proton transfer.Neeraj Kumar Joshi et al.The journal of physical chemistry. A, 116(27), 7272-7278 (2012-06-14) Cascade Synthesis of Functionalized 2H-Imidazo [5, 1-a] isoquinolinium Chlorides from Isoquinoline, Chloroformamidines (= Carbamimidoyl Chlorides), and IsocyanidesYavari I, et al. Helvetica Chimica Acta, 93(1), 72-76 (2010) Electrochemical direct detection of DNA deamination catalyzed by APOBEC3G.Junya Chiba et al.Chemical communications (Cambridge, England), 48(99), 12115-12117 (2012-11-13) In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.Giorgio Ottaviani et al.Journal of medicinal chemistry, 50(4), 742-748 (2007-02-16) Iodine-catalyzed oxidative multiple C-H bond functionalization of isoquinolines with methylarenes: an efficient synthesis of isoquinoline-1, 3, 4 (2 H)-trionesZhu D, et al. Organic & Biomolecular Chemistry, 15(34), 7112-7116 (2017) The π-acceptor effect in the substitution reactions of tridentate N-donor ligand complexes of platinum(II): a detailed kinetic and mechanistic study.Peter Ongoma et al.Dalton transactions (Cambridge, England : 2003), 41(35), 10724-10730 (2012-08-01) Toward prediction of alkane/water partition coefficients.Anita Toulmin et al.Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19) Induction of G₂/M Arrest by Berberine via Activation of PI3K/Akt and p38 in Human Chondrosarcoma Cell Line.Seong-Hui Eo et al.Oncology research, 22(3), 147-157 (2015-07-15) Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors.Takashi Sugane et al.Bioorganic & medicinal chemistry, 20(1), 34-41 (2011-12-20) One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation.Hong Hou et al.Chemical communications (Cambridge, England), 48(37), 4492-4494 (2012-03-30) Intrinsically microporous poly (imide) s: structure- porosity relationship studied by gas sorption and X-ray scatteringRitter N, et al. Macromolecules, 44(7), 2025-2033 (2011) An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1.Yu Lei et al.Food chemistry, 136(3-4), 1117-1121 (2012-12-01) Synthesis of the 1-phenethyltetrahydroisoquinoline alkaloids (+)-dysoxyline, (+)-colchiethanamine, and (+)-colchiethine.Raju Jannapu Reddy et al.The Journal of organic chemistry, 77(24), 11101-11108 (2012-11-28) Construction of indole- and isoquinoline-fused nitrogen-containing heterocycles through copper-catalyzed multi-component reaction.Yusuke Ohta Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130(7), 925-936 (2010-07-08) Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).Giulia Caron et al.Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29) Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA.Junfen Li et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 80-85 (2012-05-23) Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.Gerda Brunhofer et al.Bioorganic & medicinal chemistry, 20(22), 6669-6679 (2012-10-16) Identification of a gene involved in the synthesis of a dipeptidyl peptidase IV inhibitor in Aspergillus oryzae.Kazuhiko Imamura et al.Applied and environmental microbiology, 78(19), 6996-7002 (2012-07-31) Deconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors.Katy N Olafson et al.Chemistry (Weinheim an der Bergstrasse, Germany), 23(55), 13638-13647 (2017-08-24) Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research.Fumihiko Sato et al.Proceedings of the Japan Academy. Series B, Physical and biological sciences, 89(5), 165-182 (2013-05-15) Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.Peter Ray et al.Bioorganic & medicinal chemistry letters, 21(1), 97-101 (2010-12-15) Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.John I Trujillo et al.Bioorganic & medicinal chemistry letters, 22(11), 3795-3799 (2012-05-02) Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle.Thanh Thao Nguyen et al.Die Pharmazie, 70(3), 183-192 (2015-05-20) Asymmetric synthesis of isoquinoline alkaloids.Maria Chrzanowska et al.Chemical reviews, 104(7), 3341-3370 (2004-07-15) Alkaloids produced by endophytic fungi: a review.Yanyan Zhang et al.Natural product communications, 7(7), 963-968 (2012-08-23) Simple Determination of Gaseous and Particulate Compounds Generated from Heated Tobacco Products.Shigehisa Uchiyama et al.Chemical research in toxicology, 31(7), 585-593 (2018-06-05) Electrochemical oxidation of nitrogen-heterocyclic compounds at boron-doped diamond electrode.Xuan Xing et al.Chemosphere, 86(4), 368-375 (2011-11-11) A proposal for an extended dual descriptor: a possible solution when Frontier Molecular Orbital Theory fails.Vincent Tognetti et al.Physical chemistry chemical physics : PCCP, 15(34), 14465-14475 (2013-07-31) Catalytic enantioselective cross-couplings of secondary alkyl electrophiles with secondary alkylmetal nucleophiles: Negishi reactions of racemic benzylic bromides with achiral alkylzinc reagents.Jörg T Binder et al.Journal of the American Chemical Society, 134(41), 17003-17006 (2012-10-09) Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.Ben S Pilgrim et al.Organic letters, 15(24), 6190-6193 (2013-11-21) Beta-phenylethylamines and the isoquinoline alkaloids.K W Bentley Natural product reports, 18(2), 148-170 (2001-05-05) cIEF for rapid pKa determination of small molecules: a proof of concept.Stéphanie Romand et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 14-21 (2014-07-06) 2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.Dahui Zhou et al.Journal of medicinal chemistry, 55(5), 2452-2468 (2012-02-09) Microwave-assisted extraction in combination with capillary electrophoresis for rapid determination of isoquinoline alkaloids in Chelidonium majus L.Qiuhong Zhou et al.Talanta, 99, 932-938 (2012-09-13) The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase.Philip J Burke et al.Bioorganic & medicinal chemistry letters, 21(24), 7447-7450 (2011-11-15) Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.Bram Baert et al.Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11) Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.Oleg V Larionov et al.Organic letters, 16(3), 864-867 (2014-01-15) Binding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interaction.Giordano Mancini et al.PloS one, 7(12), e51354-e51354 (2012-12-14) Silver triflate-copper(II) acetate cooperative catalysis in a cascade reaction for concise synthesis of 2-carbonyl H-pyrazolo[5,1-a]isoquinolines.Zhiyuan Chen et al.Chemical communications (Cambridge, England), 48(33), 3975-3977 (2012-03-17) Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine.Eduardo Sobarzo-Sánchez et al.Molecules (Basel, Switzerland), 17(9), 10958-10970 (2012-09-14) Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.Giorgio Ottaviani et al.Journal of medicinal chemistry, 49(13), 3948-3954 (2006-06-23) Isoquinoline alkaloids and their binding with DNA: calorimetry and thermal analysis applications.Kakali Bhadra et al.Mini reviews in medicinal chemistry, 10(13), 1235-1247 (2010-08-19) A ligand-free Pd-catalyzed cascade reaction: an access to the highly diverse isoquinolin-1(2H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursors.Vikas Tyagi et al.Organic letters, 14(12), 3126-3129 (2012-05-26) A structure-activity analysis of biased agonism at the dopamine D2 receptor.Jeremy Shonberg et al.Journal of medicinal chemistry, 56(22), 9199-9221 (2013-10-22) Electronic spectra of gas-phase polycyclic aromatic nitrogen heterocycle cations: isoquinoline+ and quinoline+.Viktoras Dryza et al.The journal of physical chemistry. A, 116(17), 4323-4329 (2012-04-14) RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem.Yuli Li et al.PloS one, 10(5), e0125722-e0125722 (2015-05-06) Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.Thomas D Pfister et al.PloS one, 7(12), e50494-e50494 (2013-01-04)

备注