沸点	116 ºC (20 Torr)**
闪点	103.8±25.9 ºC, 计算值*
密度	1.591±0.06 g/cm3 (20 º

没有数据	没有数据

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Tolfenamic acid and leukotriene synthesis inhibition.E Moilanen et al.Pharmacology & toxicology, 75 Suppl 2, 60-63 (1994-01-01) Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.Eun-Sun Choi et al.Cancer science, 102(4), 742-748 (2011-01-19) Interplay between molecular conformation and intermolecular interactions in conformational polymorphism: a molecular perspective from electronic calculations of tolfenamic acid.Alessandra Mattei et al.International journal of pharmaceutics, 418(2), 179-186 (2011-05-17) Combined treatment of pancreatic cancer with mithramycin a and tolfenamic Acid promotes sp1 degradation and synergistic antitumor activity--letter.Ting-Chao Chou Cancer research, 71(7), 2793-2793 (2011-03-31) Tolfenamic acid inhibits ovarian cancer cell growth and decreases the expression of c-Met and survivin through suppressing specificity protein transcription factors.Riyaz Basha et al.Gynecologic oncology, 122(1), 163-170 (2011-04-19) Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.K-H Choi et al.Oral diseases, 17(5), 469-475 (2011-04-19) Tolfenamic acid suppresses cytochrome P450 2E1 expression in mouse liver.Mohammed I Shukoor et al.Integrative biology : quantitative biosciences from nano to macro, 4(9), 1122-1129 (2012-07-27) Tolfenamic acid, metoclopramide, caffeine and their combinations in the treatment of migraine attacks.R A Tokola et al.Cephalalgia : an international journal of headache, 4(4), 253-263 (1984-12-01) Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: a novel therapeutic agent for neuroblastoma.Don Eslin et al.Molecular carcinogenesis, 52(5), 377-386 (2012-01-04) Polymer-induced heteronucleation of tolfenamic acid: structural investigation of a pentamorph.Vilmalí López-Mejías et al.Journal of the American Chemical Society, 131(13), 4554-4555 (2009-04-02) Evaluating the effects of 14-day oral vedaprofen and tolfenamic acid treatment on renal function, hematological and biochemical profiles in healthy cats.V Khwanjai et al.Journal of veterinary pharmacology and therapeutics, 35(1), 13-18 (2011-03-12) Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding modeHamiaux C, et al. The Biochemical Journal, 476(12), 1843-1856 (2019) Cobalt(II) complexes with non-steroidal anti-inflammatory drug tolfenamic acid: Structure and biological evaluation.Sofia Tsiliou et al.European journal of medicinal chemistry, 48, 132-142 (2011-12-31) Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.Hywel D Williams et al.Journal of pharmaceutical sciences, 103(8), 2441-2455 (2014-07-06) Polymorph formation and nucleation mechanism of tolfenamic acid in solution: an investigation of pre-nucleation solute association.Alessandra Mattei et al.Pharmaceutical research, 29(2), 460-470 (2011-09-01) Tolfenamic acid and migraine--aspects on prostaglandins and leukotrienes.H Vapaatalo Pharmacology & toxicology, 75 Suppl 2, 76-80 (1994-01-01) The overall safety of tolfenamic acid.J Hendel Pharmacology & toxicology, 75 Suppl 2, 53-55 (1994-01-01) Tolfenamic acid in acute and prophylactic treatment of migraine: a review.P E Hansen Pharmacology & toxicology, 75 Suppl 2, 81-82 (1994-01-01) Poorly soluble marketed drugs display solvation limited solubility.Christel A S Bergström et al.Journal of medicinal chemistry, 50(23), 5858-5862 (2007-10-13) Biopharmaceutical aspects of tolfenamic acid.S B Pedersen Pharmacology & toxicology, 75 Suppl 2, 22-32 (1994-01-01) Gastrointestinal tolerance studies on tolfenamic acid in humans and animals.O Eskerod Pharmacology & toxicology, 75 Suppl 2, 44-48 (1994-01-01) Polymer-induced heteronucleation of tolfenamic acid: structural investigation of a pentamorphLopez M V, et al. Journal of the American Chemical Society, 131(13), 4554-4555 (2009) Raman and IR spectroscopic studies of fenamates--conformational differences in polymorphs of flufenamic acid, mefenamic acid and tolfenamic acid.Saima Jabeen et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 972-985 (2012-09-08) Identification and characterization of mefloquine efficacy against JC virus in vitro.Margot Brickelmaier et al.Antimicrobial agents and chemotherapy, 53(5), 1840-1849 (2009-03-05) Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.Harini Venkataraman et al.Bioorganic & medicinal chemistry, 22(20), 5613-5620 (2014-07-08) Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode.Cyril Hamiaux et al.The Biochemical journal, 476(12), 1843-1856 (2019-06-13) Tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer: involvement of NAG-1 expression.Sung Un Kang et al.PloS one, 7(4), e34988-e34988 (2012-04-27) Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.Jason L Liggett et al.Cancer letters, 346(2), 217-224 (2014-02-04) Caffeine as an analgesic adjuvant for acute pain in adults.Christopher J Derry et al.The Cochrane database of systematic reviews, 12(12), CD009281-CD009281 (2014-12-17) Postoperative analgesic efficacy of meloxicam compared to tolfenamic acid in cats undergoing orthopaedic surgery.P J Murison et al.The Journal of small animal practice, 51(10), 526-532 (2010-09-16) Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.Gayathri Chadalapaka et al.International journal of cancer, 132(4), 795-806 (2012-07-21) Anticancer activity of tolfenamic acid in medulloblastoma: a preclinical study.Don Eslin et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(5), 2781-2789 (2013-05-21) Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.JeongWoo Kang et al.Food additives & contaminants. Part B, Surveillance, 8(2), 106-112 (2014-12-30) A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-κB activation.Jin Boo Jeong et al.Carcinogenesis, 34(10), 2350-2360 (2013-06-21) The ability of tolfenamic acid to penetrate the brain: a model for testing the brain disposition of candidate Alzheimer's drugs using multiple platforms.Gehad M Subaiea et al.Current Alzheimer research, 8(8), 860-867 (2011-05-25) Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid.Riyaz Basha et al.Frontiers in bioscience (Scholar edition), 3, 797-805 (2011-01-05) Cholesterol lowering effect in the gall bladder of dogs by a standardized infusion of Herniaria hirsuta L.Ines van Dooren et al.Journal of ethnopharmacology, 169, 69-75 (2015-04-12) Anti-leukemic response of a NSAID, tolfenamic acid.Robert M Sutphin et al.Targeted oncology, 9(2), 135-144 (2013-04-24) High confidence predictions of drug-drug interactions: predicting affinities for cytochrome P450 2C9 with multiple computational methods.Matthew G Hudelson et al.Journal of medicinal chemistry, 51(3), 648-654 (2008-01-24) Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome.T Matsunaga et al.Free radical research, 48(11), 1371-1385 (2014-08-27) Effect of pH, polymer concentration and molecular weight on the physical state properties of tolfenamic acid.Muhammad Ali Sheraz et al.Pharmaceutical development and technology, 20(3), 352-360 (2014-01-15) Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats.Pius Maliakal et al.Investigational new drugs, 30(3), 853-861 (2011-01-05) Simultaneous determination of mefenamic and tolfenamic acids in real samples by terbium-sensitized luminescence.J A Murillo Pulgarín et al.Journal of fluorescence, 22(6), 1483-1492 (2012-07-04) Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1.Jung-Hyun Shim et al.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 20(2), 102-111 (2010-12-07) Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway.L I Adwan et al.Current Alzheimer research, 8(4), 385-392 (2011-05-12) Multiresidue determination of ten nonsteroidal anti-inflammatory drugs in bovine, porcine, and chicken liver tissues by HPLC-MS/MS.JeongWoo Kang et al.Applied biochemistry and biotechnology, 174(1), 1-5 (2014-07-30) Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.Umesh T Sankpal et al.The Prostate, 72(15), 1648-1658 (2012-04-05) Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves.P K Sidhu et al.Journal of veterinary pharmacology and therapeutics, 34(4), 376-387 (2010-11-26) Tolfenamic acid, metoclopramide, caffeine and their combinations in the treatment of migraine attacksTokola R A, et al. Cephalalgia, 4(4), 253-263 (1984) Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells.Jin Boo Jeong et al.Archives of biochemistry and biophysics, 537(2), 168-175 (2013-07-31) Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells.H Wilson et al.Journal of veterinary internal medicine, 26(4), 977-986 (2012-04-28) Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand.Alketa Tarushi et al.Dalton transactions (Cambridge, England : 2003), 41(23), 7082-7091 (2012-05-05) A surface on the androgen receptor that allosterically regulates coactivator binding.Eva Estébanez-Perpiñá et al.Proceedings of the National Academy of Sciences of the United States of America, 104(41), 16074-16079 (2007-10-04) 9,10-phenanthrenequinone induces monocytic differentiation of U937 cells through regulating expression of aldo-keto reductase 1C3.Toshiyuki Matsunaga et al.Biological & pharmaceutical bulletin, 35(9), 1598-1602 (2012-09-15) Tolfenamic acid: clinical experience in rheumatic diseases.H Isomäki Pharmacology & toxicology, 75 Suppl 2, 64-65 (1994-01-01)

备注