
3-Bromobenzoic acid | CAS:585-76-2
3-Bromobenzoic acid
- 名称:3-溴苯甲酸; 间溴苯甲酸 | 3-Bromobenzoic acid
- CAS号:585-76-2
- 别名:
- 分子式:C7H5BrO2
- 分子量:201.02
- EINESC号:209-562-3
产品描述
物理化学性质
熔点 | 154-158 ºC |
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水溶性 | 0.54 g/L (32 ºC) |
安全数据
危险品标志 | Xi |
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危险类别码 | R36/37/38 |
安全说明书 | S26;S36 |
产品合成路线
名称 | CAS号 |
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Screening active anti-breast cancer compounds from Cortex Magnolia officinalis by 2D LC-MS.Xiaofang Hou et al.Journal of separation science, 36(4), 706-712 (2013-02-13)
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model.Divya Teja Vavilala et al.Biochemical and biophysical research communications, 438(4), 697-702 (2013-08-08)
[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].Qing-qing Shan et al.Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 43(3), 362-366 (2012-07-21)
Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.Hyo-Kyung Han et al.Anticancer research, 32(10), 4445-4452 (2012-10-13)
Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes.Min Suk Seo et al.Journal of ethnopharmacology, 157, 140-148 (2014-09-28)
Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.Shing Hwa Liu et al.PloS one, 7(8), e43711-e43711 (2012-09-01)
Intravenous administration of Honokiol provides neuroprotection and improves functional recovery after traumatic brain injury through cell cycle inhibition.Haiquan Wang et al.Neuropharmacology, 86, 9-21 (2014-06-29)
Supermolecular evodiamine loaded water-in-oil nanoemulsions: enhanced physicochemical and biological characteristics.Jiangbo Hu et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 556-564 (2014-06-26)
Potent anti-inflammatory effects of honokiol in human fetal membranes and myometrium.Yasaswi Kaumadha Wijesuriya et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 49, 11-22 (2018-09-16)
Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells.Peng Zhang et al.Neuroscience letters, 534, 123-127 (2012-12-25)
Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling.Hsiu-Jen Wang et al.Journal of biomedical science, 20, 11-11 (2013-02-26)
Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo.Seiya Kitamura et al.PloS one, 10(2), e0117438-e0117438 (2015-02-07)
Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells.Yao Wang et al.Biochemical and biophysical research communications, 430(3), 876-882 (2012-12-25)
Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis inductionHahm ER, et al. Clinical Cancer Research, 14(4), 1248-1257 (2008)
Modulating testosterone pathway: a new strategy to tackle male skin aging?Philippe Bernard et al.Clinical interventions in aging, 7, 351-361 (2012-10-11)
[The relationship between the quality and the leaf shape of Magnolia officinalis produced in Hubei enshi].Hong-Bing Yang et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(7), 1036-1039 (2012-12-21)
Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.Han-Lin Gong et al.Chinese journal of integrative medicine, 18(9), 708-713 (2012-09-01)
Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells.Gaurav Kaushik et al.American journal of surgery, 204(6), 868-873 (2012-12-13)
Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis.Yukio Murakami et al.In vivo (Athens, Greece), 26(6), 941-950 (2012-11-20)
Honokiol inhibits androgen receptor activity in prostate cancer cells.Eun-Ryeong Hahm et al.The Prostate, 74(4), 408-420 (2013-12-18)
Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction.Zhenyu Hu et al.Brain research, 1491, 204-212 (2012-11-15)
The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells.Wei-Zhe Liang et al.Chemico-biological interactions, 221, 13-23 (2014-08-12)
Honokiol downregulates Kruppel-like factor 4 expression, attenuates inflammation, and reduces histopathology after spinal cord injury in rats.Jia Liu et al.Spine, 40(6), 363-368 (2015-03-17)
Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus.Su Young Kim et al.BioMed research international, 2015, 283630-283630 (2015-09-12)
SIRT3 elicited an anti-Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis.Lei Xu et al.Cancer medicine, 8(5), 2380-2391 (2019-04-18)
Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.Jui-Lung Shen et al.Molecules (Basel, Switzerland), 15(9), 6452-6465 (2010-09-30)
Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.Roland Baur et al.Biochimica et biophysica acta, 1840(10), 3017-3021 (2014-06-29)
Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling.Shujie Cheng et al.International journal of oncology, 46(6), 2293-2298 (2015-04-08)
Characterization, pharmacokinetics, tissue distribution and antitumor activity of honokiol submicron lipid emulsions in tumor-burdened mice.Jiaxin Zheng et al.Die Pharmazie, 68(1), 41-46 (2013-03-01)
Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells.Ying-Jiun Lai et al.Journal of cellular biochemistry, 115(11), 1888-1899 (2014-06-07)
Honokiol: a novel natural agent for cancer prevention and therapy.S Arora et al.Current molecular medicine, 12(10), 1244-1252 (2012-07-28)
In vitro and in vivo antimicrobial efficacy of natural plant-derived compounds against Vibrio cholerae of O1 El Tor Inaba serotype.Hyung-Ip Kim et al.Bioscience, biotechnology, and biochemistry, 79(3), 475-483 (2014-12-18)
SIRT3 elicited an anti-Warburg effect through HIF1alpha/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesisXu L, et al. Cancer Medicine, 8(5) (2019)
Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor.Tripti Singh et al.Oncotarget, 6(25), 21268-21282 (2015-05-29)
Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic ratsZheng J, et al. Frontiers in Neuroscience, 12, 526376-526376 (2018)
Time and dose-response effects of honokiol on UVB-induced skin cancer development.Ruth F Guillermo et al.Drug discoveries & therapeutics, 6(3), 140-146 (2012-08-15)
The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney diseaseLiu Y, et al. PLoS ONE, 8(8), e73173-e73173 (2013)
Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.Ankit Kumar et al.Future medicinal chemistry, 5(7), 809-829 (2013-05-09)
Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations.Shucai Li et al.Journal of chromatography. A, 1344, 51-58 (2014-04-29)
Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.Gaurav Kaushik et al.American journal of surgery, 208(6), 995-1002 (2014-12-03)
Effect of honokiol on erythrocytes.Mohanad Zbidah et al.Toxicology in vitro : an international journal published in association with BIBRA, 27(6), 1737-1745 (2013-05-16)
Nutritional Assessment, 2507-2514 (2017)
Honokiol, a multifunctional tumor cell death inducer.Wei Tian et al.Die Pharmazie, 67(10), 811-816 (2012-11-10)
Neuro-modulating effects of honokiol: a reviewWoodbury A, et al. Frontiers in Neurology, 4, 130-130 (2013)
Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model.Hung-Chuan Pan et al.Carcinogenesis, 34(11), 2568-2579 (2013-07-06)
Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation.Chwan-Fwu Lin et al.International journal of pharmaceutics, 445(1-2), 153-162 (2013-02-06)
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in ObesityTimper K, et al. Testing, 25(2), 383-397 (2018)
Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?Jürg Gertsch et al.Journal of neuroinflammation, 9, 135-135 (2012-06-22)
Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein.Na Li et al.Journal of neuroinflammation, 17(1), 272-272 (2020-09-19)
Surface enhancement of WO3 nanowires toward the oxidation and electrochemical detection of honokiol in traditional Chinese medicine.Wanyun Qu et al.Colloids and surfaces. B, Biointerfaces, 100, 103-106 (2012-07-07)
Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo.Tripti Singh et al.Epigenetics, 8(1), 54-65 (2012-12-12)
The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptorsAlexeev M, et al. Neuropharmacology, 62(8), 2507-2514 (2012)
Honokiol: a non-adipogenic PPARγ agonist from nature.Atanas G Atanasov et al.Biochimica et biophysica acta, 1830(10), 4813-4819 (2013-07-03)
Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein.Tomohiro Nabekura et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 140-145 (2015-03-18)
Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection.Jamie Royle et al.Viruses, 12(5) (2020-05-14)
Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.Chunhua Yu et al.American journal of physiology. Gastrointestinal and liver physiology, 303(5), G561-G569 (2012-06-30)
Honokiol, a multifunctional antiangiogenic and antitumor agent.Levi E Fried et al.Antioxidants & redox signaling, 11(5), 1139-1148 (2009-02-11)
Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway.Ju-Hee Lee et al.Experimental biology and medicine (Maywood, N.J.), 240(4), 508-518 (2014-08-16)
Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.Sun-Sil Choi et al.BioFactors (Oxford, England), 38(5), 372-377 (2012-06-08)
Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release controlRamirez S, et al. Cell Metabolism, 25(6), 1390-1399 (2017)
Honokiol induces cell cycle arrest and apoptosis via p53 activation in H4 human neuroglioma cells.Yun-Bao Guo et al.International journal of clinical and experimental medicine, 8(5), 7168-7175 (2015-07-30)
Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes.Ying Ju Chen et al.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(4), 573-580 (2014-01-01)
In vitro genotoxicity tests point to an unexpected and harmful effect of a Magnolia and Aristolochia association.Amandine Nachtergael et al.Journal of ethnopharmacology, 174, 178-186 (2015-08-19)
Honokiol inhibits HIF pathway and hypoxia-induced expression of histone lysine demethylases.Divya Teja Vavilala et al.Biochemical and biophysical research communications, 422(3), 369-374 (2012-05-15)
Honokiol inhibits vascular vessel formation of mouse embryonic stem cell-derived endothelial cells via the suppression of PECAM and MAPK/mTOR signaling pathway.Gi Dae Kim et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 758-770 (2012-08-15)
Honokiol induces cell cycle arrest and apoptosis via inhibiting class I histone deacetylases in acute myeloid leukemia.Hai-Ying Li et al.Journal of cellular biochemistry, 116(2), 287-298 (2014-09-05)
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Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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