熔点	57-63 ºC
水溶性	0.1 g/mL
沸点	140-142 ºC (45 mmHg)
闪点	65 ºC
密度	1.48

危险品标志	F;C
危险类别码	R11;R34
安全说明书	S26;S36/37/39;S45

来源	SDS样本
Alfa-Aesar	浏览或下载
Sigma-Aldrich	浏览或下载
TCI	浏览或下载

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Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.Sadaf Naeem et al.Bioorganic & medicinal chemistry, 20(3), 1251-1258 (2012-01-21) Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.Li Liu et al.Bioorganic & medicinal chemistry letters, 22(1), 154-163 (2011-12-06) Bioprocess design for the microbial production of natural phenolic compounds by Debaryomyces hansenii.Belén Max et al.Applied biochemistry and biotechnology, 168(8), 2268-2284 (2012-10-19) Synthesis, HPLC measurement and bioavailability of the phenolic amide amkamide.Jae B Park Journal of chromatographic science, 52(5), 436-441 (2013-05-29) [Chemical constituents from stems of Dysoxylum laxiracemosum].Ting Tang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(9), 1237-1240 (2012-07-19) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites.Andreas R Rechner et al.Free radical research, 36(11), 1229-1241 (2003-02-21) Surfactant-coated graphitized multiwalled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids.Wan Cao et al.Electrophoresis, 36(7-8), 1055-1063 (2015-02-03) Evaluation of vanillic acid as inhibitor of carbonic anhydrase isozyme III by using a modified Hummel-Dreyer method: approach for drug discovery.Muhammed Alzweiri et al.Biomedical chromatography : BMC, 27(9), 1157-1161 (2013-04-23) The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells.Woo-Suk Choi et al.Cellular immunology, 280(2), 164-170 (2013-02-13) High-performance liquid chromatography method for determination of hydrogen peroxide in aqueous solution and application to simulated Martian soil and related materials.Spencer M Steinberg Environmental monitoring and assessment, 185(5), 3749-3757 (2012-08-15) 3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.Chao-Bin Xue et al.Bioorganic & medicinal chemistry, 15(5), 2006-2015 (2007-01-30) A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.Wai Mun Loke et al.The Journal of nutrition, 139(12), 2309-2314 (2009-10-09) Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.Shuang Song et al.Journal of natural products, 73(2), 177-184 (2010-01-23) Effect of commonly used organic solvents on aldehyde oxidase-mediated vanillin, phthalazine and methotrexate oxidation in human, rat and mouse liver subcellular fractions.Dayanidhi Behera et al.Xenobiotica; the fate of foreign compounds in biological systems, 44(8), 722-733 (2014-02-19) Phenolic Compounds Inhibit 3T3-L1 Adipogenesis Depending on the Stage of Differentiation and Their Binding Affinity to PPARγ.Paula Aranaz et al.Molecules (Basel, Switzerland), 24(6) (2019-03-20) Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats.Mireia Urpi-Sarda et al.Analytical and bioanalytical chemistry, 394(6), 1545-1556 (2009-04-01) Heterogeneous reactions of particulate methoxyphenols with NO₃ radicals: kinetics, products, and mechanisms.Changgeng Liu et al.Environmental science & technology, 46(24), 13262-13269 (2012-11-23) Production of an anthocyanin-rich food colourant from Thymus moroderi and its application in foods.Miriam Cristina Díaz-García et al.Journal of the science of food and agriculture, 95(6), 1283-1293 (2014-07-22) Isolation, structural assignment, and total synthesis of barmumycin.Lorente A, et al. The Journal of Organic Chemistry, 75(24), 8508-8515 (2010) Urinary excretion of conjugated homovanillic acid, 3,4-dihydroxyphenylacetic acid, p-hydroxyphenylacetic acid, and vanillic acid by persons on their usual diet and patients with neuroblastoma.F A Muskiet et al.Clinical chemistry, 25(7), 1281-1284 (1979-07-01) An LC-MS-based metabolomics approach for exploring urinary metabolome modifications after cocoa consumption.Rafael Llorach et al.Journal of proteome research, 8(11), 5060-5068 (2009-09-17) Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.Meng Wu et al.PloS one, 8(2), e56475-e56475 (2013-02-19) The antibiofilm activity of lingonberry flavonoids against oral pathogens is a case connected to residual complexity.Kaisu R Riihinen et al.Fitoterapia, 97, 78-86 (2014-06-01) A Picrorhiza kurroa derivative, picroliv, attenuates the development of dextran-sulfate-sodium-induced colitis in mice.De-Kui Zhang et al.Mediators of inflammation, 2012, 751629-751629 (2012-11-06) [Chemical constituents from Imperata cylindrica].Xuan Liu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(15), 2296-2300 (2012-11-30) Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: a biochemical and molecular study.Ganapathy Sindhu et al.Environmental toxicology and pharmacology, 39(1), 392-404 (2015-01-07) Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids.Wendy R Russell et al.Bioorganic & medicinal chemistry, 16(8), 4589-4593 (2008-03-04) Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis.Jih-Jung Chen et al.Journal of natural products, 70(2), 202-205 (2007-02-24) Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans.Mireia Urpi-Sarda et al.Journal of agricultural and food chemistry, 58(8), 4706-4711 (2010-03-13) Aromatic thermotropic polyesters based on 2, 5-furandicarboxylic acid and vanillic acid.Wilsens C H, et al. Polymer, 55(10), 2432-2439 (2014) Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects.Laurent Y Rios et al.The American journal of clinical nutrition, 77(4), 912-918 (2003-03-29) Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.Delphine Lamoral-Theys et al.Bioorganic & medicinal chemistry, 18(11), 3823-3833 (2010-05-15) Removal Ability and Resistance to Cinnamic and Vanillic Acids by Fungi.Barbara Speranza et al.Microorganisms, 8(6) (2020-06-25) Phytosteryl sinapates and vanillates: chemoenzymatic synthesis and antioxidant capacity assessment.Zhuliang Tan et al.Food chemistry, 138(2-3), 1438-1447 (2013-02-16) Antagonistic control of a dual-input mammalian gene switch by food additives.Mingqi Xie et al.Nucleic acids research, 42(14), e116-e116 (2014-07-18) Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.Peter J McNamara et al.Antimicrobial agents and chemotherapy, 53(5), 1898-1906 (2009-02-19) Escherichia coli "Marionette" strains with 12 highly optimized small-molecule sensors.Adam J Meyer et al.Nature chemical biology, 15(2), 196-204 (2018-11-28) Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.Xiao-Liang Wang et al.European journal of medicinal chemistry, 57, 373-382 (2012-11-06) Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation.Tae Hoon Kim et al.Bioorganic & medicinal chemistry letters, 21(5), 1512-1514 (2011-02-02) Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Raw and Fermented Tomato Pomace and Their Correlations with Aglycate-Polyphenols.Parisa Abbasi-Parizad et al.Antioxidants (Basel, Switzerland), 9(2) (2020-02-27)

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