
Ethylmalonic acid | CAS:601-75-2
Ethylmalonic acid
- 名称:乙基丙二酸 | Ethylmalonic acid
- CAS号:601-75-2
- 别名:
- 分子式:C5H8O4
- 分子量:132.11
- EINESC号:210-007-2
产品描述
物理化学性质
熔点 | 109-114 ºC |
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安全数据
危险品标志 | Xi |
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危险类别码 | R36/37/38 |
安全说明书 | S26;S36 |
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Effects of Long-Term Antiglaucoma Eye Drops on Conjunctival Structures: An In Vivo Confocal Microscopy Study.Wenqing Zhu et al.Journal of ophthalmology, 2015, 165475-165475 (2015-07-15)
Preservative-free versus preserved brimonidine %0.15 preparations in the treatment of glaucoma and ocular hypertension: short term evaluation of efficacy, safety, and potential advantages.Zeynep Duru et al.Cutaneous and ocular toxicology, 39(1), 21-24 (2019-10-17)
Interactions of full and partial agonists with HT29 cell alpha 2-adrenoceptor: comparative study of [3H]UK-14,304 and [3H]clonidine binding.H Paris et al.Molecular pharmacology, 35(3), 345-354 (1989-03-01)
Association between the Frequency of Optic Disk Hemorrhage and Progression of NTG Related with the Initial Location of RNFL Defect.Hyun-Kyung Cho et al.Ophthalmic research, 60(3), 152-160 (2018-06-13)
Comparison of different combinations of maximum medical therapy for lowering intraocular pressure in primary open angle glaucoma: 12-month retrospective consecutive case series.Hee Jung Joh et al.Japanese journal of ophthalmology, 63(4), 322-327 (2019-05-23)
Influence of timolol, benzalkonium-preserved timolol, and benzalkonium-preserved brimonidine on oxidative stress biomarkers in the tear film.Lech Sedlak et al.Cutaneous and ocular toxicology, 39(3), 260-268 (2020-07-01)
Characterization of α(2B)-adrenoceptor ligand binding in the presence of muscarinic toxin α and delineation of structural features of receptor binding selectivity.Katja Näreoja et al.European journal of pharmacology, 683(1-3), 63-70 (2012-04-03)
Interactions of full and partial agonists with HT29 cell alpha 2-adrenoceptor: comparative study of [3H]UK-14,304 and [3H]clonidine binding.H Paris et al.Molecular pharmacology, 35(3), 345-354 (1989-03-01)
α2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity.J Cai et al.Neuroscience, 228, 23-35 (2012-10-17)
Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA.Carlos A Jiménez-Rivera et al.The European journal of neuroscience, 35(9), 1406-1415 (2012-05-09)
Intraocular Pressure After Cataract Surgery Combined With Ab Interno Trabeculectomy Versus Trabecular Micro-bypass Stent: An Intrasubject Same-surgeon Comparison.Adam J Weiner et al.Journal of glaucoma, 29(9), 773-782 (2020-05-15)
α2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity.J Cai et al.Neuroscience, 228, 23-35 (2012-10-17)
[Phase III clinical trial of brimonidine in patients with primary open-angle glaucoma and ocular hypertension--comparison of the effects of brimonidine monotherapy versus timolol monotherapy, or combination brimonidine/prostaglandins therapy versus combination placebo/prostaglandins therapy].Makoto Araie et al.Nippon Ganka Gakkai zasshi, 116(10), 955-966 (2013-01-05)
Alpha2-adrenoceptors couple to inhibition of R-type calcium currents in myenteric neurons.X Bian et al.Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 19(10), 845-855 (2007-09-22)
A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study.Nathan G Congdon et al.Ophthalmic epidemiology, 19(3), 149-158 (2012-05-10)
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.Tadashi Saigusa et al.European journal of pharmacology, 688(1-3), 35-41 (2012-05-24)
Alpha 2-adrenergic receptors in the human cell line, HT29. Characterization with the full agonist radioligand [3H]UK-14,304 and inhibition of adenylate cyclase.J T Turner et al.Molecular pharmacology, 28(5), 422-430 (1985-11-01)
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.Nadja Zeltner et al.Nature medicine, 22(12), 1421-1427 (2016-11-15)
Visual and structural prognosis of the untreated fellow eyes of unilateral normal tension glaucoma patients.Hyun-Kyung Cho et al.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(9), 1547-1555 (2015-07-02)
Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%.Quang H Nguyen et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(3), 290-297 (2013-02-22)
Brimonidine allergy presenting as vernal-like keratoconjunctivitis.Aparna A Shah et al.Journal of glaucoma, 24(1), 89-91 (2013-05-02)
Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.Xi Han et al.Experimental eye research, 170, 20-28 (2018-02-17)
The inhibitory role of purinergic P2Y receptor on Mg2+ transport across intestinal epithelium-like Caco-2 monolayer.Narongrit Thongon et al.The journal of physiological sciences : JPS, 69(1), 129-141 (2018-07-23)
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia.Zan Li et al.Redox biology, 26, 101297-101297 (2019-08-24)
Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum.C Dorner et al.The Journal of biological chemistry, 273(32), 20267-20275 (1998-08-01)
Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity.Anne Riemann et al.Oncology research, 26(2), 191-200 (2017-06-21)
Twice-daily brinzolamide/brimonidine fixed combination versus brinzolamide or brimonidine in open-angle glaucoma or ocular hypertension.Tin Aung et al.Ophthalmology, 121(12), 2348-2355 (2014-07-30)
Fixed-combination brimonidine-timolol versus latanoprost in glaucoma and ocular hypertension: a 12-week, randomized, comparison study.L Jay Katz et al.Current medical research and opinion, 28(5), 781-788 (2012-03-31)
Effect of brimonidine on retinal vascular autoregulation and short-term visual function in normal tension glaucoma.Gilbert T Feke et al.American journal of ophthalmology, 158(1), 105-112 (2014-04-09)
Comparative pharmacodynamic analysis of imidazoline compounds using rat model of ocular mydriasis with a test of quantitative structure-activity relationships.Joanna Raczak-Gutknecht et al.Journal of pharmaceutical and biomedical analysis, 144, 122-128 (2017-04-20)
Fixed combination brimonidine-timolol versus brimonidine for treatment of intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy.Veysi Öner et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(6), 576-580 (2012-07-20)
A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.Magdalena Dudek et al.PloS one, 10(10), e0141327-e0141327 (2015-10-28)
Comparative pharmacokinetics and bioavailability of brimonidine following ocular and dermal administration of brimonidine tartrate ophthalmic solution and gel in patients with moderate-to-severe facial erythema associated with rosacea.K Benkali et al.The British journal of dermatology, 171(1), 162-169 (2014-02-11)
[Current trend of glaucoma medication with various eye drops].Takeo Fukuchi Nippon Ganka Gakkai zasshi, 117(10), 781-783 (2013-12-21)
Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon's fibroblasts.Samin Hong et al.BMC ophthalmology, 15, 54-54 (2015-05-29)
Chronic fluoxetine reverses the effects of chronic corticosterone treatment on α2-adrenoceptors in the rat frontal cortex but not locus coeruleus.Igor Horrillo et al.Neuropharmacology, 158, 107731-107731 (2019-08-04)
Neuroprotection for treatment of glaucoma in adults.Dayse F Sena et al.The Cochrane database of systematic reviews, 2(2), CD006539-CD006539 (2013-03-02)
Comparative In Vitro Study of Various α2-Adrenoreceptor Agonist Drugs for Ticagrelor Reversal.Guillaume Porta Bonete et al.Journal of clinical medicine, 9(3) (2020-03-20)
Concurrent injection of dexamethasone intravitreal implant and anti-angiogenic agent in patients with macular edema: A retrospective cohort study.Hung-Yu Lin et al.Medicine, 96(47), e8868-e8868 (2018-02-01)
Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study.Rafael L Furlanetto et al.American journal of ophthalmology, 157(5), 945-952 (2014-02-12)
Visual and structural prognosis of the untreated fellow eyes of unilateral normal tension glaucoma patients.Hyun-Kyung Cho et al.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(9), 1547-1555 (2015-07-02)
Ability of Bottle Cap Color to Facilitate Accurate Patient-Physician Communication Regarding Medication Identity in Patients with Glaucoma.Pujan Dave et al.Ophthalmology, 122(12), 2373-2379 (2015-08-12)
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.Marcin Maziarz et al.Cell, 182(3), 770-785 (2020-07-08)
Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%.Quang H Nguyen et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(3), 290-297 (2013-02-22)
Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.Theodore A Pasquali et al.Journal of refractive surgery (Thorofare, N.J. : 1995), 29(7), 469-475 (2013-07-04)
28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres.Morgan V Fedorchak et al.Experimental eye research, 125, 210-216 (2014-07-02)
A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension.Anton Hommer et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(6), 569-575 (2012-07-11)
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.Shih MF and Taberner PV Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)
Investigation and prediction of retention characteristics of imidazoline and serotonin receptor ligands and their related compounds on mixed-mode stationary phase.Darija Obradović et al.Journal of chromatography. A, 1585, 92-104 (2018-12-17)
Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial.Kenric Rui-Pin Fan et al.Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)
A Comparative Study of Chromatographic Behavior and Lipophilicity of Selected Imidazoline Derivatives.Slavica Filipic et al.Journal of chromatographic science, 54(7), 1137-1145 (2016-07-14)
The comparison of retention behaviour of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction chromatography and supercritical fluid chromatography.Darija Obradović et al.Journal of chromatography. A, 1603, 371-379 (2019-05-08)
Cost-Utility Analysis of Glaucoma Medication Adherence.Paula Anne Newman-Casey et al.Ophthalmology, 127(5), 589-598 (2019-11-27)
Rosacea: update on management and emerging therapies.Robyn S Fallen et al.Skin therapy letter, 17(10), 1-4 (2012-12-12)
Heterodimerization of alpha 2A- and beta 1-adrenergic receptors.Jianguo Xu et al.The Journal of biological chemistry, 278(12), 10770-10777 (2003-01-17)
Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist.Magdalena Kotańska et al.Journal of endocrinological investigation, 41(5), 609-619 (2017-11-08)
Brimonidine gel (Mirvaso) for rosacea. The Medical letter on drugs and therapeutics, 55(1427), 82-83 (2013-10-17)
Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection.Shereen Nizari et al.Cell death & disease, 7(12), e2514-e2514 (2016-12-09)
A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.Jiesi Feng et al.Neuron, 102(4), 745-761 (2019-03-30)
Combining the isoabsorptive point in the ratio spectrum and the smart ratio difference methods for a single step determination of compounds with overlapped spectra.Eman S Elzanfaly et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 95, 188-192 (2012-05-29)
Effect of Brimonidine on the B Cells, T Cells, and Cytokines of the Ocular Surface and Aqueous Humor in Rat Eyes.Hye-Young Shin et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(10), 623-626 (2015-09-25)
Brimonidine effective but may lead to significant rebound erythema.Dan Ilkovitch et al.Journal of the American Academy of Dermatology, 70(5), e109-e110 (2014-04-20)
Mildly Cross-Linked Dendrimer Hydrogel Prepared via Aza-Michael Addition Reaction for Topical Brimonidine Delivery.Juan Wang et al.Journal of biomedical nanotechnology, 13(9), 1089-1096 (2018-02-27)
Three-month randomized trial of fixed-combination brinzolamide, 1%, and brimonidine, 0.2%.Gregory Katz et al.JAMA ophthalmology, 131(6), 724-730 (2013-04-13)
Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.Qiang Yang et al.Investigative ophthalmology & visual science, 53(7), 3733-3741 (2012-05-19)
Management of facial erythema of rosacea: what is the role of topical α-adrenergic receptor agonist therapy?James Q Del Rosso Journal of the American Academy of Dermatology, 69(6 Suppl 1), S44-S56 (2013-11-28)
[Effect of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular functions].Makoto Araie et al.Nippon Ganka Gakkai zasshi, 116(7), 623-634 (2012-08-01)
Reduction in ultraviolet B light-induced erythema by oxymetazoline and brimonidine is mediated by different α-adrenoceptors.Edward Hsia et al.Experimental dermatology, 27(7), 763-768 (2018-04-11)
Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor.Kaweh Mansouri et al.Clinical & experimental ophthalmology, 43(9), 787-795 (2015-07-15)
Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.Yunpeng Du et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2194-2204 (2015-02-11)
Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP.A C Andorn et al.Life sciences, 43(22), 1805-1812 (1988-01-01)
Brinzolamide/brimonidine (Simbrinza) for glaucoma. The Medical letter on drugs and therapeutics, 55(1421), 57-58 (2013-07-19)
Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma: A Single-center Randomized Trial.Yu Yokoyama et al.Journal of glaucoma, 28(7), 575-583 (2019-06-13)
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.Jensen BC, et al. Naunyn-Schmiedeberg'S Archives of Pharmacology, 382(5-6), 475-482 (2010)
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?Z Lehner et al.Diabetologia, 55(11), 3071-3082 (2012-08-18)
[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections].H El Chehab et al.Journal francais d'ophtalmologie, 35(8), 614-621 (2012-07-27)
Pharmacological evidence that metformin blocks the vasopressor responses mediated by stimulation of αSaúl Huerta de la Cruz et al.European journal of pharmacology, 820, 130-137 (2017-12-19)
Predictors of success in selective laser trabeculoplasty for normal tension glaucoma.Jacky W Y Lee et al.Medicine, 93(28), e236-e236 (2014-12-20)
The activity of lowering intraocular pressure of cassiae seed extract in a DBA/2J mouse glaucoma model.Chi-Ting Horng et al.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 29(1), 48-54 (2012-10-09)
Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.Yanjun Chen et al.Investigative ophthalmology & visual science, 54(4), 2951-2958 (2013-03-21)
Alpha2 -adrenoceptor agonists inhibit form-deprivation myopia in the chick.Brittany J Carr et al.Clinical & experimental optometry, 102(4), 418-425 (2019-01-31)
Outflow facility efficacy of five drugs in enucleated porcine eyes by a method of constant-pressure perfusion.Ning Li et al.International journal of clinical and experimental medicine, 8(5), 7184-7191 (2015-07-30)
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.Francis H, et al. American Journal of Physiology. Cell Physiology, 293(4), C1252-C1262 (2007)
Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury.Dongwook Lee et al.PloS one, 7(10), e47098-e47098 (2012-10-12)
Topical cyclosporine to control ocular surface disease in patients with chronic glaucoma after long-term usage of topical ocular hypotensive medications.M Saini et al.Eye (London, England), 29(6), 808-814 (2015-04-11)
Comparison of the progression rates of the superior, inferior, and both hemifield defects in normal-tension glaucoma patients.Hyun-Kyung Cho et al.American journal of ophthalmology, 154(6), 958-968 (2012-09-11)
Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transductionZhao-Hui Feng et al.International journal of ophthalmology, 10(12), 1805-1811 (2017-12-21)
Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes.Sunil P Deokule et al.Acta ophthalmologica, 90(5), e344-e348 (2012-06-09)
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