3H-Imidazo[1,2-a]pyrrolo[2,3-e]pyrazine, 8-[(3R,4S)-4-ethyl-3-pyrrolidinyl]-, hydrochloride (1:2) | CAS:2050038-84-9
3H-Imidazo[1,2-a]pyrrolo[2,3-e]pyrazine, 8-[(3R,4S)-4-ethyl-3-pyrrolidinyl]-, hydrochloride (1:2)
- 名称：乌帕替尼N-1 | 3H-Imidazo[1,2-a]pyrrolo[2,3-e]pyrazine, 8-[(3R,4S)-4-ethyl-3-pyrrolidinyl]-, hydrochloride (1:2)
- CAS号：2050038-84-9
- 别名：
- 分子式：C14H18ClN5
- 分子量：291.78
- EINESC号：
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Description for route of synthesis:
Dissolve the intermediate N-2 of Upatinib in ethanol, add a palladium carbon catalyst, and perform a catalytic hydrogenolysis reaction in a hydrogen atmosphere to remove the benzyloxycarbonyl protecting group; After the reaction is complete, the palladium carbon is removed by filtration, and concentrated hydrochloric acid is added to the filtrate to form a salt. After concentration, cooling crystallization, filtration and drying, the target product, intermediate N-1 hydrochloride of Upatinib, is obtained.
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