询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
5-Methylbenzimidazole | CAS:614-97-1
5-Methylbenzimidazole
  • 名称:5-甲基苯并咪唑 | 5-Methylbenzimidazole
  • CAS号:614-97-1
  • 别名:5-Methyl-1H-benzimidazole
  • 分子式:C8H8N2
  • 分子量:132.16
  • EINESC号:210-401-4

产品描述

物理化学性质

熔点 110-114 ºC
沸点 169-172 ºC (1 mmHg)

安全数据

危险品标志 Xn
危险类别码 R22

SDS

来源 SDS样本
Alfa-Aesar 浏览或下载
Sigma-Aldrich 浏览或下载
TCI 浏览或下载
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Acitretin affects bioenergetics of liver mitochondria and promotes mitochondrial permeability transition: potential mechanisms of hepatotoxicity.Filomena S G Silva et al.Toxicology, 306, 93-100 (2013-02-07) Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous squamous cell carcinoma cell line SCL-1.Xiu-Ying Lin et al.Journal of cellular and molecular medicine, 13(9A), 2888-2898 (2008-07-16) Systemic retinoids in the management of ichthyoses and related skin types.John J Digiovanna et al.Dermatologic therapy, 26(1), 26-38 (2013-02-07) Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis.Howa Yeung et al.Journal of the American Academy of Dermatology, 68(1), 64-72 (2012-08-01) A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.Byong Hoon Yoo et al.Journal of biomolecular screening, 17(9), 1211-1220 (2012-07-04) Consensus conference: acitretin in combination with UVB or PUVA in the treatment of psoriasis.M Lebwohl et al.Journal of the American Academy of Dermatology, 45(4), 544-553 (2001-09-25) Two nested developmental waves demarcate a compartment boundary in the mouse lung.Denise Martinez Alanis et al.Nature communications, 5, 3923-3923 (2014-06-01) British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatology.A D Ormerod et al.The British journal of dermatology, 162(5), 952-963 (2010-04-29) The effects of alcohol on the metabolism and toxicology of anti-psoriasis drugs.Gino A Vena et al.Expert opinion on drug metabolism & toxicology, 8(8), 959-972 (2012-05-19) An overlooked cause of back pain and stiffness.Roberta Gualtierotti et al.Rheumatology (Oxford, England), 52(6), 985-985 (2013-01-25) A novel therapeutic combination approach for treating multiple vemurafenib-induced keratoacanthomas: systemic acitretin and intralesional fluorouracil.Lindsay LaPresto et al.JAMA dermatology, 149(3), 279-281 (2013-04-05) A review of acitretin for the treatment of psoriasis.Chai Sue Lee et al.Expert opinion on drug safety, 8(6), 769-779 (2009-12-10) A review of acitretin, a systemic retinoid for the treatment of psoriasis.Chai Sue Lee et al.Expert opinion on pharmacotherapy, 6(10), 1725-1734 (2005-08-10) Low-dose acitretin in treatment of plaque-type psoriasis: descriptive study of efficacy and safety.Alessandro Borghi et al.Acta dermato-venereologica, 95(3), 332-336 (2014-07-01) Keratoacanthomas arising in association with prurigo nodules in pruritic, actinically damaged skin.Timothy P Wu et al.Journal of the American Academy of Dermatology, 69(3), 426-430 (2013-05-15) Acitretin for treatment of familial porokeratosis palmaris et plantaris disseminate.Nevena Skroza et al.European journal of dermatology : EJD, 22(5), 699-700 (2012-09-18) Agranulocytosis and total scalp alopecia following acitretin.T A Chave et al.The British journal of dermatology, 148(5), 1063-1064 (2003-06-06) Success treatment of post-irradiation morphoea with acitretin and narrowband UVB.Kate Newland et al.The Australasian journal of dermatology, 53(2), 136-138 (2012-05-11) Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.Justin D Lutz et al.Biochemical pharmacology, 77(2), 258-268 (2008-11-11) Combined imiquimod and acitretin for non-surgical treatment of basal cell carcinoma.Christoffer Ingves et al.Scandinavian journal of plastic and reconstructive surgery and hand surgery, 37(5), 293-295 (2003-12-03) Generalized linear porokeratosis: a rare entity with excellent response to acitretin.Taru Garg et al.Dermatology online journal, 17(5), 3-3 (2011-06-04) Acitretin in dermatology: a review.Lauren K Dunn et al.Journal of drugs in dermatology : JDD, 10(7), 772-782 (2011-07-02) Napsi.Ana Maria Tchornobay Anais brasileiros de dermatologia, 87(5), 805-805 (2012-10-10) Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.Shijin Yin et al.The Journal of clinical investigation, 123(9), 3941-3951 (2013-08-09) Sustained clinical resolution of acquired epidermodysplasia verruciformis in an immunocompromised patient after discontinuation of oral acitretin with topical imiquimod.Rajiv I Nijhawan et al.Journal of drugs in dermatology : JDD, 12(3), 348-349 (2013-04-03) Treatment of severe nail psoriasis with acitretin: an impressive therapeutic result.F Ricceri et al.Dermatologic therapy, 26(1), 77-78 (2013-02-07) [Patient with lichen ruber planus. How should it be treated?].H S Füessl et al.MMW Fortschritte der Medizin, 155(2), 26-26 (2013-04-12) Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris.Emiliano Antiga et al.Journal of clinical immunology, 32(6), 1221-1232 (2012-06-16) [Erythrokeratodermia variabilis].P Bilan et al.Annales de dermatologie et de venereologie, 140(2), 129-133 (2013-02-12) A case of Ferguson-Smith type multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum: response to oral acitretin.F Aydin et al.Clinical and experimental dermatology, 32(6), 683-686 (2007-08-24) Widespread biphasic amyloidosis: response to acitretin.A Hernández-Núñez et al.Clinical and experimental dermatology, 26(3), 256-259 (2001-06-26) Acitretin in dermatology.Rashmi Sarkar et al.Indian journal of dermatology, venereology and leprology, 79(6), 759-771 (2013-11-02) Pseudoainhum in acute psoriasis.Muhammad Irfan Anwar et al.Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 22(12), 786-788 (2012-12-12) Acitretin: no pregnancy during treatment and, as a precaution, for 3 years after discontinuation. Prescrire international, 22(141), 213-213 (2013-10-31) From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies.Jeremy Hugh et al.Journal of the American Academy of Dermatology, 70(1), 168-177 (2013-11-05) Retinoids in the chemoprevention of non-melanoma skin cancers: why, when and how.Vincenzo Bettoli et al.The Journal of dermatological treatment, 24(3), 235-237 (2012-11-15) Genitogluteal porokeratosis: an unusual clinical presentation.Sanjeev Srinivas Kumar et al.The Australasian journal of dermatology, 53(2), e36-e39 (2012-05-11) Evidence based or theoretical concern? Pseudotumor cerebri and depression as acitretin side effects.John Starling et al.Journal of drugs in dermatology : JDD, 4(6), 690-696 (2005-11-24) Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle.Maria Lapteva et al.Nanoscale, 7(44), 18651-18662 (2015-10-27) Successful treatment of giant condyloma acuminatum with combination retinoid and interferon-γ therapy.Y P Tian et al.International journal of STD & AIDS, 23(6), 445-447 (2012-07-19) Comparative effectiveness of less commonly used systemic monotherapies and common combination therapies for moderate to severe psoriasis in the clinical setting.Junko Takeshita et al.Journal of the American Academy of Dermatology, 71(6), 1167-1175 (2014-09-28) Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen-ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients.F S G Silva et al.Mutation research, 753(1), 42-47 (2013-03-12) Complete and rapid regression of primary cutaneous follicular lymphoma with repeated oral administration of acitretin for palmoplantar psoriasis.Mohamed Khashoggi et al.Journal of the American Academy of Dermatology, 69(4), e176-e177 (2013-09-17) Rapid downregulation of innate immune cells, interleukin-12 and interleukin-23 in generalized pustular psoriasis with infliximab in combination with acitretin.M M Tang et al.Dermatology (Basel, Switzerland), 225(4), 338-343 (2013-01-25) Acitretin revisited in the era of biologics.Mariëlle Te Booij et al.The Journal of dermatological treatment, 22(2), 86-89 (2010-08-03) Repigmentation and curling of hair after acitretin therapy.Dilek Seckin et al.The Australasian journal of dermatology, 50(3), 214-216 (2009-08-08) Guidelines for the use of acitretin in psoriasis. Psoriasis Group of the Spanish Academy of Dermatology and Venereology.G Carretero et al.Actas dermo-sifiliograficas, 104(7), 598-616 (2013-07-31) Depression and acitretin: a true association or a class labeling?Jennifer Hayes et al.Journal of drugs in dermatology : JDD, 10(4), 409-412 (2011-04-02) A human induced pluripotent stem cell-based in vitro assay predicts developmental toxicity through a retinoic acid receptor-mediated pathway for a series of related retinoid analogues.Jessica A Palmer et al.Reproductive toxicology (Elmsford, N.Y.), 73, 350-361 (2017-07-27) Combination of adalimumab with traditional systemic antipsoriatic drugs - a report of 39 cases.Sandra Philipp et al.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 10(11), 821-837 (2012-09-01) IgA pemphigus: case series with emphasis on therapeutic response.Ana Carulina L Moreno et al.Journal of the American Academy of Dermatology, 70(1), 200-201 (2013-12-21) Acitretin, an enhancer of alpha-secretase expression, crosses the blood-brain barrier and is not eliminated by P-glycoprotein.David Holthoewer et al.Neuro-degenerative diseases, 10(1-4), 224-228 (2012-02-04) Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin.Frank Tippmann et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1643-1654 (2009-01-16) Acitretin for the treatment of cutaneous T-cell lymphoma.Justin Cheeley et al.Journal of the American Academy of Dermatology, 68(2), 247-254 (2012-08-25) Systemic retinoid therapy for chemoprevention of nonmelanoma skin cancer in a patient treated with vemurafenib.Rachael Anforth et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(19), e165-e167 (2012-06-06) Pityriasis rubra pilaris with polyarthritis treated with adalimumab.Hsien-Yi Chiu et al.Journal of the American Academy of Dermatology, 68(1), 187-188 (2012-12-19) Therapeutic combination of radiofrequency surgical dissection and oral acitretin in the management of perianal Buschke-Lowenstein tumour: a case report.P Mavrogianni et al.International journal of STD & AIDS, 23(5), 362-364 (2012-06-01) Acitretin suppression of squamous cell carcinoma: case report and literature review.M Lebwohl et al.The Journal of dermatological treatment, 14 Suppl 2, 3-6 (2003-10-28) The retinoic acid receptor (RAR) α-specific agonist Am80 (tamibarotene) and other RAR agonists potently inhibit hepatitis B virus transcription from cccDNA.Shirin Nkongolo et al.Antiviral research, 168, 146-155 (2019-04-25) An updated review of acitretin--a systemic retinoid for the treatment of psoriasis.Mei-Lin Pang et al.Expert opinion on drug metabolism & toxicology, 4(7), 953-964 (2008-07-16) Retinoid resistance and multifaceted impairment of retinoic acid synthesis in glioblastoma.Benito Campos et al.Glia, 63(10), 1850-1859 (2015-05-07) Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.Katharina Seidensaal et al.Molecular cancer, 14, 204-204 (2015-12-05) Successful treatment of harlequin ichthyosis with acitretin.S Singh et al.International journal of dermatology, 40(7), 472-473 (2001-10-27) Hypertrophic and ulcerated discoid lupus erythematosus.Peter J Green et al.Journal of cutaneous medicine and surgery, 16(6), 453-457 (2012-11-15) Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.Ming-Lian Yu et al.Die Pharmazie, 68(6), 449-452 (2013-07-24)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交