
(R)-3-Hydroxybutyric acid | CAS:625-72-9
(R)-3-Hydroxybutyric acid
- 名称:(R)-3-羟基丁酸 | (R)-3-Hydroxybutyric acid
- CAS号:625-72-9
- 别名:
- 分子式:C4H8O3
- 分子量:104.10
- EINESC号:210-909-6
产品描述
物理化学性质
熔点 | 49-50 ºC |
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比旋光度 | -25 º (c=6% in H2O) |
闪点 | 112 ºC |
安全数据
危险品标志 | Xi |
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危险类别码 | R36/37/38 |
安全说明书 | S26;S36 |
产品合成路线
名称 | CAS号 |
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Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.Yao Ye et al.Endocrine connections, 7(5), 749-761 (2018-04-28)
Uterine rupture after induction of labour for intrauterine death using the prostaglandin E2 analogue sulprostone.R N Prasad et al.The Australian & New Zealand journal of obstetrics & gynaecology, 32(3), 282-283 (1992-08-01)
The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood.Lisa J Schober et al.Thrombosis and haemostasis, 103(6), 1268-1269 (2010-05-01)
Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4.Fredika M Robertson et al.Cancer, 116(11 Suppl), 2806-2814 (2010-06-22)
Efficacy of pelvic artery embolisation for severe postpartum hemorrhage.Annette Spreu et al.Archives of gynecology and obstetrics, 296(6), 1117-1124 (2017-10-11)
Pharmacologic and Molecular Characterization of Underactive Bladder Induced by Lumbar Canal Stenosis.Hung-Jen Wang et al.Urology, 85(6), 1284-1290 (2015-03-17)
PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.Kamal M Kassem et al.Prostaglandins & other lipid mediators, 113-115, 62-68 (2014-09-30)
Prostaglandin EAli Mirsaidi et al.Scientific reports, 7(1), 2243-2243 (2017-05-24)
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.Catherine Olesch et al.Oncotarget, 6(12), 10284-10296 (2015-04-15)
Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.Hakima Mechiche et al.PloS one, 7(9), e45273-e45273 (2012-09-18)
Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.Huifeng Hao et al.Arteriosclerosis, thrombosis, and vascular biology, 38(5), 1115-1124 (2018-03-31)
EP3 activation facilitates bladder excitability via HCN channels on ICCs.Chao Wu et al.Biochemical and biophysical research communications, 485(2), 535-541 (2017-01-31)
The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes.Pei-Pei Guan et al.Signal transduction and targeted therapy, 3, 27-27 (2018-12-05)
Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney.Carlos P Vio et al.American journal of physiology. Renal physiology, 303(3), F449-F457 (2012-05-25)
Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue.Hu Xu et al.Journal of molecular cell biology, 8(6), 518-529 (2016-07-21)
Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.Anna Bonanno et al.Prostaglandins, leukotrienes, and essential fatty acids, 106, 11-18 (2016-03-02)
Signalling transduction events involved in agonist-induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons.W Ma et al.European journal of pain (London, England), 22(5), 845-861 (2018-01-18)
Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.Clifford W Mason et al.Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2077-2086 (2014-09-28)
Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.Ioannis D Gallos et al.The Cochrane database of systematic reviews, 4, CD011689-CD011689 (2018-04-26)
[Intracerebral haemorrhage and postpartum cerebral angiopathy associated with the administration of sulprostone and norepinephrine].Y Ruzic et al.Annales francaises d'anesthesie et de reanimation, 31(1), 78-81 (2011-12-14)
Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner.Morag K Mansley et al.The Journal of general physiology, 152(8) (2020-05-23)
Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct.R L Hébert Prostaglandins, leukotrienes, and essential fatty acids, 51(3), 147-155 (1994-09-01)
EP2 receptor signaling pathways regulate classical activation of microglia.Yi Quan et al.The Journal of biological chemistry, 288(13), 9293-9302 (2013-02-14)
Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis.Xin Li et al.Arthritis and rheumatism, 60(2), 513-523 (2009-01-31)
Nanosuspensions of a new compound, ER-β005, for enhanced oral bioavailability and improved analgesic efficacy.Ling Ye et al.International journal of pharmaceutics, 531(1), 246-256 (2017-08-30)
Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression.Tingting Fang et al.Cell biology and toxicology, 32(6), 499-511 (2016-08-01)
Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.Koen Van Crombruggen et al.Naunyn-Schmiedeberg's archives of pharmacology, 383(6), 613-626 (2011-04-28)
The EP3 receptor regulates water excretion in response to high salt intake.Shoujin Hao et al.American journal of physiology. Renal physiology, 311(4), F822-F829 (2016-07-29)
Distribution and Function of Prostaglandin E2 Receptors in Mouse Uterus: Translational Value for Human Reproduction.Deborah P Fischer et al.The Journal of pharmacology and experimental therapeutics, 373(3), 381-390 (2020-03-25)
PGE2-induced colon cancer growth is mediated by mTORC1.Marc Dufour et al.Biochemical and biophysical research communications, 451(4), 587-591 (2014-08-17)
Targeted delivery of antiglaucoma drugs to the supraciliary space using microneedles.Yoo C Kim et al.Investigative ophthalmology & visual science, 55(11), 7387-7397 (2014-09-13)
Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage.Jennifer A Salati et al.The Cochrane database of systematic reviews, 4, CD001808-CD001808 (2019-04-30)
Angiogenesis in the primate ovulatory follicle is stimulated by luteinizing hormone via prostaglandin E2.Heidi A Trau et al.Biology of reproduction, 92(1), 15-15 (2014-11-08)
Prostaglandin EHui Li et al.Immunology letters, 191, 63-72 (2017-10-01)
Regulation of calcium channels and exocytosis in mouse adrenal chromaffin cells by prostaglandin EP3 receptors.Mark L Jewell et al.Molecular pharmacology, 79(6), 987-996 (2011-03-09)
PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells.Lorenzo Bazzani et al.Oncotarget, 8(19), 31270-31287 (2017-04-19)
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.Grazia Tamma et al.Journal of cell science, 116(Pt 16), 3285-3294 (2003-06-28)
EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation.Zhi-Hua Zhang et al.American journal of physiology. Heart and circulatory physiology, 301(4), H1559-H1569 (2011-08-02)
Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery.Keith Morrison et al.The Journal of pharmacology and experimental therapeutics, 365(3), 727-733 (2018-03-29)
Activation of prostanoid EP receptors by prostacyclin analogues in rabbit iliac artery: implications for anti-restenotic potential.Christopher McCormick et al.European journal of pharmacology, 641(2-3), 160-167 (2010-05-11)
The Endocannabinoid Metabolite Prostaglandin ECaroline Turcotte et al.Journal of immunology (Baltimore, Md. : 1950), 198(8), 3255-3263 (2017-03-05)
Opposing effects of prostaglandin EBethany A Carboneau et al.Molecular metabolism, 6(6), 548-559 (2017-06-06)
Effects of LPA2R, LPA3R, or EP4R agonists on luteal or endometrial function in vivo or in vitro and sirtuin or EP1R, EP2R, EP3R or EP4R agonists on endometrial secretion of PGE and PGFMagen E LaPorte et al.Theriogenology, 95, 8-17 (2017-05-04)
Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.Zhongbin Deng et al.Nature communications, 6, 6956-6956 (2015-04-25)
Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.Chenggang Li et al.Molecular cancer research : MCR, 15(10), 1318-1330 (2017-07-16)
Bioanalysis of sulprostone, a prostaglandin E2 analogue and selective EP3 agonist, in monkey plasma by liquid chromatography-tandem mass spectrometry.Yifan Shi et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1092, 51-57 (2018-06-09)
[Lessons and impact of two audits on postpartum hemorrhages in 24 maternity hospitals of the network "Sécurité Naissance - Naître Ensemble" in "Pays-de-la-Loire" area].B Branger et al.Journal de gynecologie, obstetrique et biologie de la reproduction, 40(7), 657-667 (2011-09-24)
Prostaglandin E2 and vascular endothelial growth factor A mediate angiogenesis of human ovarian follicular endothelial cells.Heidi A Trau et al.Human reproduction (Oxford, England), 31(2), 436-444 (2016-01-08)
Cardiac arrest during sulprostone administration--a case report.L Lampati et al.Acta anaesthesiologica Scandinavica, 57(3), 395-397 (2012-11-29)
[Severe hyperthermia and neurological disorders following prostaglandin treatment for uterine atonia after caesarean section].Q Cellier et al.Annales francaises d'anesthesie et de reanimation, 31(3), 243-245 (2012-03-01)
Postpartum hemorrhage: use of hemostatic combat gauze.Bernd C Schmid et al.American journal of obstetrics and gynecology, 206(1), e12-e13 (2011-10-21)
Skewing effect of sulprostone on dendritic cell maturation compared with dinoprostone.Jenny Bulgarelli et al.Cytotherapy, 20(6), 851-860 (2018-05-15)
Cervical preparation for first trimester surgical abortion.Nathalie Kapp et al.The Cochrane database of systematic reviews, (2)(2), CD007207-CD007207 (2010-02-19)
Prostaglandin E2 analogue sulprostone for treatment of atonic postpartum hemorrhage.Thomas Schmitz et al.Obstetrics and gynecology, 118(2 Pt 1), 257-265 (2011-07-22)
Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34.Hiroshi Nango et al.Journal of pharmacological sciences, 135(2), 64-71 (2017-10-03)
Prostaglandin E2 as a Regulator of Immunity to Pathogens.Giovanny J Martínez-Colón et al.Pharmacology & therapeutics, 185, 135-146 (2017-12-25)
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.Vinay Kondeti et al.The Journal of allergy and clinical immunology, 137(1), 289-298 (2015-08-10)
Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings.Tzu-Yu Lin et al.The Journal of pharmacology and experimental therapeutics, 351(1), 134-145 (2014-07-23)
Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis.Ryo Iwasaki et al.Scientific reports, 9(1), 7650-7650 (2019-05-23)
Role of prostanoid EPKelvin K W Kan et al.European journal of pharmacology, 803, 112-117 (2017-03-23)
Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat.Takahiro Shimizu et al.Neuropharmacology, 82, 19-27 (2014-03-25)
Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats.Keiko Ishida et al.Pflugers Archiv : European journal of physiology, 463(4), 593-602 (2012-03-01)
Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery.Nabil Foudi et al.European journal of pharmacology, 804, 31-37 (2017-04-05)
Prostaglandin E1 Inhibits GLI2 Amplification-Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth.Fujia Wu et al.Cancer research, 80(13), 2818-2832 (2020-05-07)
Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis.Hu Xu et al.JCI insight, 5(13) (2020-07-10)
Prostaglandin E2 sequentially activates E-prostanoid receptor-3 and thromboxane prostanoid receptor to evoke contraction and increase in resistance of the mouse renal vasculature.Bin Liu et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2568-2578 (2020-01-08)
Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf.Kirsten Mary Hooper et al.PloS one, 12(6), e0179184-e0179184 (2017-06-13)
Effect of PGELu Yang et al.Oncotarget, 8(54), 92004-92017 (2017-12-02)
An observational study of the fresh frozen plasma: red blood cell ratio in postpartum hemorrhage.Pierre Pasquier et al.Anesthesia and analgesia, 116(1), 155-161 (2012-12-12)
[Cardiac arrest associated with sulprostone use during cesarean section].Asma Jnifen et al.La Tunisie medicale, 89(1), 82-82 (2011-01-27)
Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.Fengyin Li et al.Cell stem cell, 21(3), 359-373 (2017-08-29)
Intravenous sulprostone infusion in the treatment of retained placenta.Vedran Stefanovic et al.Acta obstetricia et gynecologica Scandinavica, 92(4), 426-432 (2012-08-07)
Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1β-related lung injury.G J Martínez-Colón et al.Mucosal immunology, 11(2), 319-332 (2017-06-08)
Quantitative phosphoproteomic analysis of signaling downstream of the prostaglandin e2/g-protein coupled receptor in human synovial fibroblasts: potential antifibrotic networks.Casimiro Gerarduzzi et al.Journal of proteome research, 13(11), 5262-5280 (2014-09-17)
Is a cause of postpartum hemorrhage of using of tocolytic agents in preterm delivery?Soo Ran Choi et al.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 30(22), 2711-2715 (2016-11-16)
Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.Hye Sun Kuehn et al.Immunology letters, 141(1), 45-54 (2011-07-30)
[RU 486 and sulprostone in pregnancy termination in the 2nd and 3rd trimesters].H Werner et al.Journal de gynecologie, obstetrique et biologie de la reproduction, 23(6), 701-705 (1994-01-01)
Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins.Toni N Welsh et al.PloS one, 9(8), e105253-e105253 (2014-08-27)
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.Philippa Dale et al.Cell calcium, 71, 53-64 (2018-04-02)
Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.Juan Ma et al.International journal of oncology, 42(3), 1093-1104 (2013-01-23)
KMN-159, a novel EP4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow.Thomas A Owen et al.Gene, 748, 144668-144668 (2020-04-26)
EP₃ receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats.Hanna Kozłowska et al.Pharmacological reports : PR, 64(6), 1526-1536 (2013-02-15)
Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.Keith Morrison et al.The Journal of pharmacology and experimental therapeutics, 335(1), 249-255 (2010-07-28)
Differential reactivity of human mammary artery and saphenous vein to prostaglandin E(2) : implication for cardiovascular grafts.N Foudi et al.British journal of pharmacology, 163(4), 826-834 (2011-02-18)
Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells.Sara Scutera et al.Frontiers in immunology, 9, 1207-1207 (2018-06-19)
The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP(4) receptor activation and platelet function in whole blood.Lisa J Schober et al.Journal of thrombosis and thrombolysis, 32(2), 158-166 (2011-03-23)
[Interaction of PGE2 and a specific analog: sulprostone with intracellular second messengers in the kidney].R L Hébert Nephrologie, 16(2), 209-214 (1995-01-01)
Up-regulation of EPGeorgina Flórez-Grau et al.Journal of leukocyte biology, 102(3), 881-895 (2017-06-21)
Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.Junyan Zhu et al.Oncotarget, 9(1), 982-994 (2018-02-09)
Interleukin 1β and Prostaglandin E2 affect expression of DNA methylating and demethylating enzymes in human gingival fibroblasts.Sara Seutter et al.International immunopharmacology, 78, 105920-105920 (2019-12-08)
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