询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
1-Octyne | CAS:629-05-0
1-Octyne
  • 名称:1-辛炔 | 1-Octyne
  • CAS号:629-05-0
  • 别名:
  • 分子式:C8H14
  • 分子量:110.20
  • EINESC号:211-069-3

产品描述

物理化学性质

熔点 -80 ºC
沸点 127-128 ºC
闪点 17 ºC
密度 0.74
折射率 1.415-1.417

安全数据

危险品标志 F;Xn
危险类别码 R11;R65
安全说明书 S16;S62

SDS

来源 SDS样本
Alfa-Aesar 浏览或下载
Sigma-Aldrich 浏览或下载
TCI 浏览或下载
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Genetic modifiers of HbF and response to hydroxyurea in sickle cell disease.Nancy S Green et al.Pediatric blood & cancer, 56(2), 177-181 (2010-09-11) Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management.Ayalew Tefferi et al.American journal of hematology, 90(2), 162-173 (2015-01-23) Prophylaxis and management of venous thromboembolism in patients with myeloproliferative neoplasms: consensus statement of the Haemostasis Working Party of the German Society of Hematology and Oncology (DGHO), the Austrian Society of Hematology and Oncology (ÖGHO) and Society of Thrombosis and Haemostasis Research (GTH e.V.).Stephan Kreher et al.Annals of hematology, 93(12), 1953-1963 (2014-10-14) Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression.Benjamin D Landry et al.The EMBO journal, 33(9), 1044-1060 (2014-04-10) HbSD-Punjab: clinical and hematological profile of a rare hemoglobinopathy.Sapna Oberoi et al.Journal of pediatric hematology/oncology, 36(3), e140-e144 (2013-11-28) Hydroxyurea-induced leg ulceration in a patient with a homozygous MTHFR polymorphism misdiagnosed as pyoderma gangrenosum.Sunita C Crittenden et al.JAMA dermatology, 150(7), 780-781 (2014-03-07) Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway.Jana Peremartí et al.Toxicological sciences : an official journal of the Society of Toxicology, 142(1), 93-104 (2014-08-06) CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop.Zhao Wei et al.Free radical biology & medicine, 79, 1-13 (2014-12-03) Increased antioxidant defense mechanism in human adventitia-derived progenitor cells is associated with therapeutic benefit in ischemia.Dominga Iacobazzi et al.Antioxidants & redox signaling, 21(11), 1591-1604 (2014-02-12) Evidence review of hydroxyurea for the prevention of sickle cell complications in low-income countries.Mercy Mulaku et al.Archives of disease in childhood, 98(11), 908-914 (2013-09-03) H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.Chia-Yeh Lin et al.PLoS genetics, 10(10), e1004667-e1004667 (2014-10-03) Human RECQL1 participates in telomere maintenance.Venkateswarlu Popuri et al.Nucleic acids research, 42(9), 5671-5688 (2014-03-14) Hydroxycarbamide: clinical aspects.Russell E Ware Comptes rendus biologies, 336(3), 177-182 (2013-05-07) Methyl-hydroxylamine as an efficacious antibacterial agent that targets the ribonucleotide reductase enzyme.Esther Julián et al.PloS one, 10(3), e0122049-e0122049 (2015-03-18) Management of patients with sickle cell disease.Simeon Pollack JAMA, 313(1), 90-91 (2015-01-07) The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.Richard O Adeyemi et al.Journal of virology, 88(17), 10189-10199 (2014-06-27) BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.Jianqiu Zou et al.Cell cycle (Georgetown, Tex.), 13(23), 3685-3697 (2014-12-09) Busulfan in patients with polycythemia vera or essential thrombocythemia refractory or intolerant to hydroxyurea.Alberto Alvarez-Larrán et al.Annals of hematology, 93(12), 2037-2043 (2014-07-02) Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania.Siana Nkya Mtatiro et al.American journal of hematology, 90(1), E1-E4 (2014-09-30) Fanconi anemia gene editing by the CRISPR/Cas9 system.Mark J Osborn et al.Human gene therapy, 26(2), 114-126 (2014-12-30) MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes.Jiangbin Wu et al.Cell communication and signaling : CCS, 12, 66-66 (2014-10-12) Complex karyotype in a polycythemia vera patient with a novel SETD1B/GTF2H3 fusion gene.Clelia Tiziana Storlazzi et al.American journal of hematology, 89(4), 438-442 (2014-01-03) Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children.John J Strouse et al.Pediatric blood & cancer, 59(2), 365-371 (2012-04-21) Hydroxyurea-induced hematological response in transfusion-independent beta-thalassemia intermedia: case series and review of literature.Mohammad Ali Ehsani et al.Pediatric hematology and oncology, 26(8), 560-565 (2009-12-04) Hydroxyurea and hydroxamic acid derivatives as antitumor drugs.Nina Saban et al.Cancer chemotherapy and pharmacology, 64(2), 213-221 (2009-04-08) Mutations and thrombosis in essential thrombocythemia: prognostic interaction with age and thrombosis history.Naseema Gangat et al.European journal of haematology, 94(1), 31-36 (2014-06-04) Hydroxyurea: a key player in cancer chemotherapy.Kapish Madaan et al.Expert review of anticancer therapy, 12(1), 19-29 (2011-12-14) HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.Min Zhu et al.Nucleic acids research, 42(21), 13074-13081 (2014-10-19) Bullet 'manicure': does lead prevent hydroxyurea-induced cutaneous toxicity?Lorenzo Falchi et al.Japanese journal of clinical oncology, 44(5), 512-512 (2014-05-02) Advances in the use of hydroxyurea.Russell E Ware et al.Hematology. American Society of Hematology. Education Program, 62-69 (2009-12-17) Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?Mehdi Banan Annals of hematology, 92(3), 289-299 (2013-01-16) How I use hydroxyurea to treat young patients with sickle cell anemia.Russell E Ware Blood, 115(26), 5300-5311 (2010-03-13) Hydroxyurea in the management of thalassemia intermedia.Mehran Karimi Hemoglobin, 33 Suppl 1, S177-S182 (2009-12-17) Behavioral and circuit basis of sucrose rejection by Drosophila females in a simple decision-making task.Chung-Hui Yang et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(4), 1396-1410 (2015-01-30) Fixing the price of the orphan drug Siklos: the Council of State takes over the decision.Susana Murteira et al.European journal of health law, 21(5), 505-515 (2014-12-10) A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle-cell disease.Susan E Creary et al.Pediatric blood & cancer, 61(6), 1068-1073 (2014-01-18) [Hydroxyurea (hydroxycarbamide)-induced hepatic dysfunction confirmed by drug-induced lymphocyte stimulation test].Takayuki Shimizu et al.[Rinsho ketsueki] The Japanese journal of clinical hematology, 55(1), 125-129 (2014-02-05) Update on the use of hydroxyurea therapy in sickle cell disease.Trisha E Wong et al.Blood, 124(26), 3850-3857 (2014-10-08) A rare disorder in an orphan disease: Kikuchi-Fujimoto disease in a young-adult patient with sickle cell anemia.Elisa Vencato et al.American journal of hematology, 89(12), 1151-1152 (2014-06-26) Intensive chemotherapy, azacitidine, or supportive care in older acute myeloid leukemia patients: an analysis from a regional healthcare network.Pierre Bories et al.American journal of hematology, 89(12), E244-E252 (2014-09-10) Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer.J Kowshik et al.PloS one, 9(10), e109114-e109114 (2014-10-09) Management of patients with sickle cell disease.Elizabeth S Klings et al.JAMA, 313(1), 91-91 (2015-01-07) Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells.Ryohei Sugahara et al.FEBS letters, 588(21), 3959-3963 (2014-09-23) The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.Junho Choe et al.Nucleic acids research, 42(14), 9334-9349 (2014-07-14) [Ulcers following therapy with hydroxyurea. Three case reports and review of the literature].S Boneberger et al.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 61(7), 598-602 (2009-09-19) Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.Ruei-Yue Liang et al.Journal of molecular biology, 426(24), 4049-4060 (2014-10-15) Clinical reasoning: a 69-year-old man with leukocytosis and hemorrhagic brain lesions.Kristin M Scott et al.Neurology, 83(1), e1-e5 (2014-07-02) Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders.Jerry L Spivak et al.Expert review of anticancer therapy, 11(3), 403-414 (2011-03-23) Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.Anne Olazabal-Herrero et al.Molecular cancer, 14, 33-33 (2015-03-10) Characterization of microtubule-binding and dimerization activity of Giardia lamblia end-binding 1 protein.Juri Kim et al.PloS one, 9(5), e97850-e97850 (2014-05-16) Hydroxyurea induced dermatomyositis-like eruption.Tania M Zappala et al.The Australasian journal of dermatology, 53(3), e58-e60 (2012-08-14) A retrospective study to assess the utility of frequent laboratory monitoring of pediatric patients with sickle cell disease on hydroxyurea.John Nevin et al.Journal of pediatric hematology/oncology, 36(3), e180-e184 (2013-09-28) Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.Luisa Ronzoni et al.British journal of haematology, 165(5), 714-721 (2014-03-13) Cutaneous involvement by post-polycythemia vera myelofibrosis.Alessandro Pecci et al.American journal of hematology, 89(4), 448-448 (2013-07-24) Hyperfiltration is associated with the development of microalbuminuria in patients with sickle cell anemia.Benjamin Vazquez et al.American journal of hematology, 89(12), 1156-1157 (2014-08-19) Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.Lucia Morgado-Palacin et al.Carcinogenesis, 35(12), 2822-2830 (2014-10-27) Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression.Li-Na Zhang et al.Biochimica et biophysica acta, 1853(2), 522-534 (2014-12-17) PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.R M Kershaw et al.Oncogene, 33(49), 5592-5600 (2013-11-19) Reproductive issues in sickle cell disease.Kim Smith-Whitley Blood, 124(24), 3538-3543 (2014-12-05) Complement factor I promotes progression of cutaneous squamous cell carcinoma.Pilvi Riihilä et al.The Journal of investigative dermatology, 135(2), 579-588 (2014-09-04) TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy.Jacopo C DiFrancesco et al.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 36(2), 323-330 (2014-09-13) Clofarabine in combination with a standard remission induction regimen (cytosine arabinoside and idarubicin) in patients with previously untreated intermediate and bad-risk acute myelogenous leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS): phase I results of an ongoing phase I/II study of the leukemia groups of EORTC and GIMEMA (EORTC GIMEMA 06061/AML-14A trial).R Willemze et al.Annals of hematology, 93(6), 965-975 (2014-04-01) Polycythemia vera disease burden: contributing factors, impact on quality of life, and emerging treatment options.Brady L Stein et al.Annals of hematology, 93(12), 1965-1976 (2014-10-02) Response to hydroxycarbamide in pediatric β-thalassemia intermedia: 8 years' follow-up in Egypt.Amal El-Beshlawy et al.Annals of hematology, 93(12), 2045-2050 (2014-07-27) A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus process.Giovanni Barosi et al.British journal of haematology, 148(6), 961-963 (2009-11-26) Calreticulin mutations and long-term survival in essential thrombocythemia.A Tefferi et al.Leukemia, 28(12), 2300-2303 (2014-05-06) Hydroxyurea for children with sickle cell disease: are we starting too late?Brigitta U Mueller Pediatric blood & cancer, 56(1), 3-4 (2010-11-09) Activation of endogenous anti-inflammatory mediator cyclic AMP attenuates acute pyelonephritis in mice induced by uropathogenic Escherichia coli.Yang Wei et al.The American journal of pathology, 185(2), 472-484 (2014-12-06) Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.Kimiko Ishiguro et al.Biochemical pharmacology, 91(3), 312-322 (2014-08-19) Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children.John J Strouse et al.Pediatrics, 122(6), 1332-1342 (2008-12-03) Effect of brain-derived neurotrophic factor on mesenchymal stem cell-seeded electrospinning biomaterial for treating ischemic diabetic ulcers via milieu-dependent differentiation mechanism.Siyi He et al.Tissue engineering. Part A, 21(5-6), 928-938 (2014-10-16) SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.Murilo T D Bueno et al.Epigenetics, 8(11), 1162-1175 (2013-08-24) From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia.Jane S Hankins et al.Medicine, 93(28), e215-e215 (2014-12-20) Essential differences in clinical and bone marrow features in BCR/ABL-positive thrombocythemia compared to thrombocythemia in the BCR/ABL-negative myeloproliferative neoplasms essential thrombocythemia and polycythemia vera.Jan Jacques Michiels et al.Acta haematologica, 133(1), 52-55 (2014-08-15) Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication.Takayuki Sekimoto et al.Molecular and cellular biology, 35(4), 699-715 (2014-12-10) CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.Takahisa Hirokawa et al.Cancer research, 74(14), 3880-3889 (2014-05-31) Medication adherence among pediatric patients with sickle cell disease: a systematic review.Kathleen E Walsh et al.Pediatrics, 134(6), 1175-1183 (2014-11-19) Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.Ana Ramos-Amaya et al.Journal of immunology (Baltimore, Md. : 1950), 194(3), 1031-1038 (2014-12-31) Re-evaluation of cytostatic therapies for meningiomas in vitro.Annette Wilisch-Neumann et al.Journal of cancer research and clinical oncology, 140(8), 1343-1352 (2014-05-13) A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.Scott C Smith et al.Nucleic acids research, 42(18), 11517-11527 (2014-09-14) Practice patterns of stroke screening and hydroxyurea use in children with sickle cell disease: a survey of health care providers.Nicholas A Madden et al.Journal of pediatric hematology/oncology, 36(6), e382-e386 (2014-04-10) What is the evidence that hydroxyurea improves health-related quality of life in patients with sickle cell disease?Deepika S Darbari et al.Hematology. American Society of Hematology. Education Program, 2012, 290-291 (2012-12-13) What is the evidence for using hydroxyurea for secondary stroke prevention?Jeffrey D Lebensburger et al.Hematology. American Society of Hematology. Education Program, 2011, 440-442 (2011-12-14) Second malignancies in philadelphia-negative myeloproliferative neoplasms-single-center experience.Jarmila Kissova et al.Anticancer research, 34(5), 2489-2496 (2014-04-30) Mast cell activation syndrome as a significant comorbidity in sickle cell disease.Lawrence B Afrin The American journal of the medical sciences, 348(6), 460-464 (2014-08-30) Hydroxyurea for children with sickle cell disease.Matthew M Heeney et al.Hematology/oncology clinics of North America, 24(1), 199-214 (2010-02-02) Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?Patrick T McGann et al.Current opinion in hematology, 18(3), 158-165 (2011-03-05) The effect of hydroxyurea on compound heterozygotes for sickle cell-hemoglobin D-Punjab--a single centre experience in eastern India.Siris Patel et al.Pediatric blood & cancer, 61(8), 1341-1346 (2014-03-13) Interferon α-2b gains high sustained response therapy for advanced essential thrombocythemia and polycythemia vera with JAK2V617F positive mutation.Bin-Tao Huang et al.Leukemia research, 38(10), 1177-1183 (2014-07-30) National trends in hospitalizations for sickle cell disease in the United States following the FDA approval of hydroxyurea, 1998-2008.Maureen M Okam et al.Medical care, 52(7), 612-618 (2014-06-14) ATM-p53 pathway causes G2/M arrest, but represses apoptosis in pseudolaric acid B-treated HeLa cells.Guodong Yao et al.Archives of biochemistry and biophysics, 558, 51-60 (2014-06-15) EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.Tijana Mitić et al.Molecular therapy : the journal of the American Society of Gene Therapy, 23(1), 32-42 (2014-09-06) Chlamydia pneumoniae infection induces vascular smooth muscle cell migration via Rac1 activation.Junxia Zhang et al.Journal of medical microbiology, 63(Pt 2), 155-161 (2013-11-20) A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex.Ola Orgil et al.PLoS genetics, 11(3), e1005036-e1005036 (2015-03-10) Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation.Vicky Chaar et al.The Journal of biological chemistry, 289(16), 11512-11521 (2014-03-13) Characterization of DNA repair deficient strains of Chlamydomonas reinhardtii generated by insertional mutagenesis.Andrea Plecenikova et al.PloS one, 9(8), e105482-e105482 (2014-08-22) Participation of signaling cascades in the regulation of erythropoiesis under conditions of cytostatic treatment.A M Dygai et al.Bulletin of experimental biology and medicine, 158(3), 304-307 (2015-01-13) Ruxolitinib versus standard therapy for the treatment of polycythemia vera.Alessandro M Vannucchi et al.The New England journal of medicine, 372(5), 426-435 (2015-01-30) 3,6-Epidioxy-1,10-bisaboladiene inhibits G1 -specific transcription through Swi4/Swi6 and Mbp1/Swi6 via the Hog1 stress pathway in yeast.Yuko Imamura et al.The FEBS journal, 281(20), 4612-4621 (2014-08-13) PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.Giuditta Illuzzi et al.Nucleic acids research, 42(12), 7776-7792 (2014-06-08) Hydroxycarbamide treatment in sickle cell disease: estimates of possible leukaemia risk and of hospitalization survival benefit.Oswaldo Castro et al.British journal of haematology, 167(5), 687-691 (2014-08-26) Hydroxycarbamide modulates components involved in the regulation of adenosine levels in blood cells from sickle-cell anemia patients.Ana C Silva-Pinto et al.Annals of hematology, 93(9), 1457-1465 (2014-04-04) Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association.Prabha Sarangi et al.Nucleic acids research, 42(10), 6393-6404 (2014-04-23) Treatment options for hydroxyurea-refractory disease complications in myeloproliferative neoplasms: JAK2 inhibitors, radiotherapy, splenectomy and transjugular intrahepatic portosystemic shunt.Elena Mishchenko et al.European journal of haematology, 85(3), 192-199 (2010-06-10)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交