熔点	93-95 ºC
水溶性	0.094 g/L (15 ºC)
沸点	270 ºC
闪点	175 ºC

危险品标志	T;N
危险类别码	R23/24/25;R33;R50/53
安全说明书	S28A;S36/37;S45;S60;S61

来源	SDS样本
Alfa-Aesar	浏览或下载
Sigma-Aldrich	浏览或下载
TCI	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Inhibition of human glioblastoma cell adhesion and invasion by 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3'-bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154).R K Narla et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 4(10), 2463-2471 (1998-10-31) Properties and functions of KATP during mouse perinatal development.Li Nie et al.Biochemical and biophysical research communications, 418(1), 74-80 (2012-01-19) Evidence against a systemic arterial defect in patients with inflammatory bowel disease.Luke A Neill et al.The Journal of surgical research, 191(2), 318-322 (2014-05-14) Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.Qunhua Bai et al.Oncology reports, 28(4), 1376-1384 (2012-08-17) [The influence of activation of the ATP-sensitive potassium channels by flocalin on the function of the cardiovascular system].R B Strutyns'kyĭ et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 11-16 (2013-05-30) Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy.Won Sun Park et al.American journal of physiology. Cell physiology, 303(2), C170-C178 (2012-05-11) Kensuke Kataoka et al.Frontiers in cell and developmental biology, 8, 307-307 (2020-07-17)Tendons and ligaments are pivotal connective tissues that tightly connect muscle and bone. In this study, we developed a novel approach to generate tendon/ligament-like tissues with a hierarchical structure, by introducing the tendon/ligament-specific transcription factor Mohawk (MKX) into the mesenchymal... Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channelsBodiga S, et al. Journal of Molecular and Cellular Cardiology, 46(6), 978-988 (2009) [The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].R B Strutyns'kyĭ et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58(1), 13-26 (2012-05-17) Protective effects of pinacidil hyperpolarizing cardioplegia on myocardial ischemia reperfusion injury by mitochondrial KATP channels.Tian Yu et al.Chinese medical journal, 124(24), 4205-4210 (2012-02-22) Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts.Najate Benamer et al.American journal of physiology. Heart and circulatory physiology, 304(9), H1231-H1239 (2013-02-26) WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells.Hui Zhang et al.Cancer science, 105(8), 1071-1078 (2014-06-07) JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.Outi Sareila et al.Mediators of inflammation, 2006(2), 16161-16161 (2006-08-03) The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells.G R Richards et al.Journal of neurochemistry, 97(1), 201-210 (2006-03-07) ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.Ioannis Eleftherianos et al.Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12024-12029 (2011-07-02) 4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride.S Ghosh et al.Acta crystallographica. Section C, Crystal structure communications, 57(Pt 1), 76-78 (2001-02-15) 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.R K Narla et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 4(6), 1405-1414 (1998-06-17) Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death.Shefalee K Bhavsar et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27(5), 547-556 (2011-06-22) Pleiotrophin (PTN) is expressed in vascularized human atherosclerotic plaques: IFN-{gamma}/JAK/STAT1 signaling is critical for the expression of PTN in macrophages.Fuqiang Li et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(3), 810-822 (2009-11-18) Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A₂-IIA in microvascular endothelial cells of the injured brain.Guansong Wang et al.Journal of neuroinflammation, 9, 170-170 (2012-07-14) Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.J H Cho-Vega et al.Leukemia, 18(11), 1872-1878 (2004-09-24) Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.Yi-Wei Wang et al.Neoplasia (New York, N.Y.), 13(8), 704-715 (2011-08-19) IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta.Eric L Deszo et al.Cellular signalling, 16(2), 271-280 (2003-11-26) Oncostatin M Promotes Osteoblastic Differentiation of Human Vascular Smooth Muscle Cells Through JAK3-STAT3 Pathway.Yoshinori Kakutani et al.Journal of cellular biochemistry, 116(7), 1325-1333 (2015-03-05) Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase.Kyung-Ae Ji et al.Glia, 48(2), 102-111 (2004-09-21) The Role of Janus Kinase 3 in the Regulation of Na⁺/K⁺ ATPase under Energy Depletion.Zohreh Hosseinzadeh et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(2), 727-740 (2015-05-30) Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.E A Sudbeck et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 5(6), 1569-1582 (1999-07-02) CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.Dovenia S Ponnoth et al.American journal of physiology. Regulatory, integrative and comparative physiology, 303(10), R1003-R1010 (2012-09-29) Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.Jing Xu et al.Journal of cardiovascular pharmacology, 59(6), 514-522 (2012-02-22) Inhibition of Cyclic GMP Export by Multidrug Resistance Protein 4: A New Strategy to Treat Erectile Dysfunction?Charlotte Boydens et al.The journal of sexual medicine, 14(4), 502-509 (2017-03-05) Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.Yung-Kuo Lin et al.Clinical science (London, England : 1979), 122(3), 121-132 (2011-09-02) Pinacidil enhances survival of cryopreserved human embryonic stem cells.Ivana Barbaric et al.Cryobiology, 63(3), 298-305 (2011-10-27) Effects of regular exercise on ventricular myocyte biomechanics and KATP channel function.Xinrui Wang et al.American journal of physiology. Heart and circulatory physiology, 315(4), H885-H896 (2018-08-04) Calcitonin gene-related peptide hyperpolarizes mouse pulmonary artery endothelial tubes through KATP channel activation.Charles E Norton et al.American journal of physiology. Lung cellular and molecular physiology, 315(2), L212-L226 (2018-03-16) NMR and fluorescence studies of drug binding to the first nucleotide binding domain of SUR2A.Jorge P López-Alonso et al.Biochemistry, 51(45), 9211-9222 (2012-10-20) Effects of fluorine-containing opener of ATP-sensitive potassium channels, pinacidil-derivative flocalin, on cardiac voltage-gated sodium and calcium channels.Oleg I Voitychuk et al.Naunyn-Schmiedeberg's archives of pharmacology, 385(11), 1095-1102 (2012-09-11) Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.Li Jiang et al.Die Pharmazie, 67(6), 547-552 (2012-07-25) [Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].Norbert Lovász et al.Acta pharmaceutica Hungarica, 81(3), 101-107 (2011-12-15) Potassium ion channels and allergic asthma.M Kocmalova et al.Advances in experimental medicine and biology, 838, 35-45 (2014-10-16) Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytesWatanabe Y, et al. Journal of Pharmacological Sciences, 135(1), 37-43 (2017) Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies.Jennifer Baumbach et al.American journal of obstetrics and gynecology, 206(3), 254-254 (2012-01-17) Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.Luciano Amarelle et al.American journal of physiology. Lung cellular and molecular physiology, 316(6), L1094-L1106 (2019-03-21) Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.Adebowale Adebiyi et al.American journal of physiology. Heart and circulatory physiology, 301(4), H1360-H1368 (2011-07-26) Kcnh2 and Kcnj8 interactively regulate skin wound healing and regeneration.Wengeng Zhang et al.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 797-806 (2015-07-30) Dispersion of repolarization and arrhythmogenesisCoronel R, et al. Heart Rhythm : the Official Journal of the Heart Rhythm Society, 6(4), 537-543 (2009) Effects of pinacidil and calcium on isolated rat heart mitochondria.S M Korotkov et al.Doklady. Biochemistry and biophysics, 443, 113-117 (2012-05-09) Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats.Asami Mori et al.European journal of pharmacology, 669(1-3), 94-99 (2011-08-30) Lectin from Erythrina cristagalli supports undifferentiated growth and differentiation of human pluripotent stem cells.Milla Mikkola et al.Stem cells and development, 22(5), 707-716 (2012-10-31) Efficient Cardiac Differentiation of Human Amniotic Fluid-Derived Stem Cells into Induced Pluripotent Stem Cells and Their Potential Immune Privilege.Yi-Hsien Fang et al.International journal of molecular sciences, 21(7) (2020-04-03) Potassium-channel openers KMUP-1 and pinacidil prevent subarachnoid hemorrhage-induced vasospasm by restoring the BKCa-channel activity.Jun-Yih Chen et al.Shock (Augusta, Ga.), 38(2), 203-212 (2012-05-12) K+ channels regulate ENaC expression via changes in promoter activity and control fluid clearance in alveolar epithelial cells.Olivier Bardou et al.Biochimica et biophysica acta, 1818(7), 1682-1690 (2012-03-13) Differential effects of pinacidil and levcromakalim on the contractions elicited electrically or by noradrenaline in the portal vein of the rabbit.L Gojković-Bukarica et al.Fundamental & clinical pharmacology, 13(5), 527-534 (1999-10-16) [Influence of flocalin on development of apoptosis and necrosis at anoxia-reoxygenation of culture rats neonatal cardiomyocytes].R B Strutyns'kyĭ et al.Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 3-9 (2013-08-21) Up-regulated ATP-sensitive potassium channels play a role in increased inflammation and plaque vulnerability in macrophages.Ming-Ying Ling et al.Atherosclerosis, 226(2), 348-355 (2012-12-12)

备注