询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
5-Bromo-2-(trifluoromethyl)benzoic acid | CAS:654-97-7
5-Bromo-2-(trifluoromethyl)benzoic acid
  • 名称:5-溴-2-(三氟甲基)苯甲酸 | 5-Bromo-2-(trifluoromethyl)benzoic acid
  • CAS号:654-97-7
  • 别名:
  • 分子式:C8H4BrF3O2
  • 分子量:269.02
  • EINESC号:

产品描述

物理化学性质

熔点 86-87 ºC**
密度 1.773±0.06 g/cm3 (20 º

安全数据

没有数据没有数据

SDS

来源 SDS样本
没有数据没有数据
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Synthesis and antitumor activity of nitrogen-based thiocolchicine derivatives.Bin Wang et al.Yao xue xue bao = Acta pharmaceutica Sinica, 41(11), 1057-1063 (2007-02-01) Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.L Sun et al.Journal of medicinal chemistry, 36(5), 544-551 (1993-03-05) Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain.A Banerjee et al.Biochemical and biophysical research communications, 254(2), 334-337 (1999-01-27) [TENS + mesotherapy association in the therapy of cervico-brachialgia: preliminary data].S Palermo et al.Minerva anestesiologica, 57(10), 1084-1085 (1991-10-01) Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis.Q Shi et al.Bioorganic & medicinal chemistry, 5(12), 2277-2282 (1998-02-12) Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors.Giuseppina Raspaglio et al.Biochemical pharmacology, 69(1), 113-121 (2004-12-14) Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents.Q Shi et al.Journal of medicinal chemistry, 40(6), 961-966 (1997-03-14) Colchicine analogues: effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes.B Wolach et al.European journal of clinical investigation, 22(9), 630-634 (1992-09-01) New synthetic thiocolchicine derivatives as lowtoxic anticancer agents.Sun-Hee Lee et al.Archiv der Pharmazie, 338(12), 582-589 (2005-12-15) Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers.E Perucca et al.European journal of drug metabolism and pharmacokinetics, 20(4), 301-305 (1995-10-01) Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.Daniele Passarella et al.European journal of medicinal chemistry, 45(1), 219-226 (2009-11-03) Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids.Bruno Danieli et al.Chemistry & biodiversity, 1(2), 327-345 (2006-12-29) Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines.R De Vincenzo et al.Anti-cancer drug design, 13(1), 19-33 (1998-02-25) Conformation of thiocolchicine and two B-ring-modified analogues bound to tubulin studied with optical spectroscopy.P Lincoln et al.Biochemistry, 30(5), 1179-1187 (1991-02-05) Recent progress in structure-activity relationship studies on the anticancer drug colchicine and its analogues.Xian-dao Pan et al.Yao xue xue bao = Acta pharmaceutica Sinica, 37(10), 821-827 (2003-02-06) Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.L Sun et al.Journal of medicinal chemistry, 36(10), 1474-1479 (1993-05-14) Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly.R Brecht et al.Bioorganic & medicinal chemistry, 8(3), 557-562 (2000-03-25) Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.A Muzaffar et al.Journal of medicinal chemistry, 33(2), 567-571 (1990-02-01) Biological evaluation on different human cancer cell lines of novel colchicine analogs.R De Vincenzo et al.Oncology research, 11(3), 145-152 (1999-10-20) Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.Bruno Danieli et al.The Journal of organic chemistry, 71(7), 2848-2853 (2006-03-25) Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.Daniele Passarella et al.Bioorganic & medicinal chemistry, 16(11), 6269-6285 (2008-05-13) Association of thiocolchicine with tubulin.R M Chabin et al.Biochemical and biophysical research communications, 161(2), 544-550 (1989-06-15) Derivatives of thiocolchicine and its applications to CEM cells treatment using 19F magnetic resonance ex vivo.Dorota Bartusik et al.Bioorganic chemistry, 38(1), 1-6 (2009-12-01)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交