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3-Bromo-4-fluoroaniline | CAS:656-64-4
3-Bromo-4-fluoroaniline
  • 名称:3-溴-4-氟苯胺 | 3-Bromo-4-fluoroaniline
  • CAS号:656-64-4
  • 别名:3-Bromo-4-fluorobenzenamine
  • 分子式:C6H5BrFN
  • 分子量:190.01
  • EINESC号:

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Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH.T Nishiyama et al.Molecular pharmacology, 57(5), 899-905 (2000-04-25) In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.H Machida et al.Antimicrobial agents and chemotherapy, 36(1), 214-216 (1992-01-01) Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases.Cheng YC, et al. Antimicrobial Agents and Chemotherapy, 20(3), 420-423 (1981) Lethal drug interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.H Okuda et al.Drug metabolism and disposition: the biological fate of chemicals, 25(2), 270-273 (1997-02-01) Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.H Marquardt et al.Carcinogenesis, 6(8), 1207-1209 (1985-08-01) Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.E De Clercq et al.Journal of medicinal chemistry, 29(2), 213-217 (1986-02-01) Suicidal inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil derived from the antiviral, sorivudine.K Ogura et al.Cancer letters, 122(1-2), 107-113 (1998-02-17) Simultaneous high-performance liquid chromatographic assay for 5-(2-bromo-E-ethenyl)-2'-deoxyuridine and its metabolite, 5-(2-bromo-E-ethenyl)uracil, in plasma.Y Robinson et al.Journal of chromatography, 338(1), 219-224 (1985-02-27) Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.H Nakayama et al.Pharmacogenetics, 7(1), 35-43 (1997-02-01) Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging.G Brix et al.Magnetic resonance in medicine, 42(5), 936-943 (1999-11-05) Manual and automated determination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil and its metabolite (E)-5-(2-bromovinyl)uracil in urine.D B Whigan et al.Journal of chromatography. B, Biomedical applications, 664(2), 357-363 (1995-02-17) [Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].Tadashi Watabe et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 122(8), 527-535 (2002-08-22) A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.H Okuda et al.The Journal of pharmacology and experimental therapeutics, 287(2), 791-799 (1998-11-10) The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster.J Yan et al.Clinical pharmacology and therapeutics, 61(5), 563-573 (1997-05-01) Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.A S Jones et al.Journal of medicinal chemistry, 24(6), 759-760 (1981-06-01) Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.S I Kanamitsu et al.Drug metabolism and disposition: the biological fate of chemicals, 28(4), 467-474 (2000-03-22) Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.Jan Balzarini et al.Molecular pharmacology, 61(5), 1140-1145 (2002-04-19) Potential of bromovinyldeoxyuridine in anticancer chemotherapy.E De Clercq Anticancer research, 6(4), 549-556 (1986-07-01) Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine.C Desgranges et al.Biochemical pharmacology, 35(10), 1647-1653 (1986-05-15) Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.C Desgranges et al.Cancer research, 46(3), 1094-1101 (1986-03-01) Relationships among plasma [2-(13)C]uracil concentrations, breath (13)CO(2) expiration, and dihydropyrimidine dehydrogenase (DPD) activity in the liver in normal and dpd-deficient dogs.Makoto Inada et al.Drug metabolism and disposition: the biological fate of chemicals, 33(3), 381-387 (2004-12-24)
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