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4-(Diphenylamino)benzyl alcohol | CAS:25069-40-3
4-(Diphenylamino)benzyl alcohol
  • 名称:4-(二苯基氨基)苄醇 | 4-(Diphenylamino)benzyl alcohol
  • CAS号:25069-40-3
  • 别名:4-(Hydroxymethyl)triphenylamine; p-(Diphenylamino)benzyl alcohol
  • 分子式:C19H17NO
  • 分子量:275.34
  • EINESC号:

产品描述

物理化学性质

熔点 106-107 ºC (dichloromethane
密度 1.174±0.06 g/cm3 (20 º

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来源 SDS样本
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Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with type 2 diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography.Peifeng Dai et al.Experimental and therapeutic medicine, 10(3), 869-876 (2015-12-02) Influence of polymer blends on the characterization of gliclazide--encapsulated into poly (ε-caprolactone) microparticles.Nahla S Barakat et al.Drug development and industrial pharmacy, 39(2), 352-362 (2012-05-01) [Medication of the month. Gliclazide modified release (Uni Diamicron)].A J Scheen Revue medicale de Liege, 58(10), 641-645 (2003-12-18) Vascular benefits of gliclazide beyond glycemic control.P E Jennings Metabolism: clinical and experimental, 49(10 Suppl 2), 17-20 (2000-11-15) Protective effects of beta glucan and gliclazide on brain tissue and sciatic nerve of diabetic rats induced by streptozosin.Harun Alp et al.Experimental diabetes research, 2012, 230342-230342 (2012-02-01) Current status of non-insulin-dependent diabetes mellitus (type II): management with gliclazide.H Rifkin The American journal of medicine, 90(6A), 3S-7S (1991-06-24) [The use of gliclazide in individualized sulfonylurea therapy].Gábor Winkler Orvosi hetilap, 155(14), 541-548 (2014-04-01) Treating diabetes today with gliclazide MR: a matter of numbers.A Avogaro Diabetes, obesity & metabolism, 14 Suppl 1, 14-19 (2011-12-14) Modulation of trichloroethylene in vitro metabolism by different drugs in rats.Mouna Cheikh Rouhou et al.Toxicology in vitro : an international journal published in association with BIBRA, 27(1), 34-43 (2012-10-24) Multi-residue analytical method for human pharmaceuticals and synthetic hormones in river water and sewage effluents by solid-phase extraction and liquid chromatography-tandem mass spectrometry.Najat Ahmed Al-Odaini et al.Journal of chromatography. A, 1217(44), 6791-6806 (2010-09-21) Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.Rachel E Jarrard et al.Molecular pharmacology, 83(1), 191-205 (2012-10-17) The effect of glycation on bovine serum albumin conformation and ligand binding properties with regard to gliclazide.Ewa Żurawska-Płaksej et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 189, 625-633 (2017-09-10) Association of KCNJ11 E23K gene polymorphism with hypoglycemia in sulfonylurea-treated type 2 diabetic patients.Georgia Ragia et al.Diabetes research and clinical practice, 98(1), 119-124 (2012-05-18) [Gliclazide: review of metabolic and vascular action].K G Alberti Diabete & metabolisme, 20(3 Pt 2), 341-348 (1994-11-01) Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives.Ebtehal S Al-Abdullah et al.Molecules (Basel, Switzerland), 20(5), 8125-8143 (2015-05-09) Pathophysiology of vascular disease in diabetes: effects of gliclazide.J A Colwell The American journal of medicine, 90(6A), 50S-54S (1991-06-24) Analysis of free drug fractions by ultrafast affinity extraction: interactions of sulfonylurea drugs with normal or glycated human serum albumin.Xiwei Zheng et al.Journal of chromatography. A, 1371, 82-89 (2014-12-03) Development and validation of a new analytical HPLC method for simultaneous determination of the antidiabetic drugs, metformin and gliclazideGedawy GA, et al. Journal of food and drug analysis, 27(1), 315-322 (2019) Predicting the effects of blood pressure-lowering treatment on major cardiovascular events for individual patients with type 2 diabetes mellitus: results from Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation.Joep van der Leeuw et al.Hypertension (Dallas, Tex. : 1979), 65(1), 115-121 (2014-10-15) [The effects of insulin and gliclazide therapy on endoplasmic reticulum stress and insulin sensitivity in liver of type 2 diabetic rats].Wei-ping Sun et al.Zhonghua nei ke za zhi, 51(8), 638-641 (2012-11-20) Gliclazide modified release: its place in the therapeutic armamentarium.G Crepaldi et al.Metabolism: clinical and experimental, 49(10 Suppl 2), 21-25 (2000-11-15) [Non-insulin dependent diabetes. Role of gliclazide (diamicron)].B Lesobre Journees annuelles de diabetologie de l'Hotel-Dieu, 313-322 (1995-01-01) Antimicrobial and hypoglycemic activities of novel N-Mannich bases derived from 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thiones.Ebtehal S Al-Abdullah et al.International journal of molecular sciences, 15(12), 22995-23010 (2014-12-17) Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats.Ganapathy Saravanan et al.Journal of diabetes and its complications, 26(4), 280-285 (2012-05-01) Gliclazide modified release: A critical review of pharmacodynamic, metabolic, and vasoprotective effects.Guntram Schernthaner Metabolism: clinical and experimental, 52(8 Suppl 1), 29-34 (2003-08-27) Benefits of gliclazide in the atherosclerotic process: decrease in monocyte adhesion to endothelial cells.Geneviève Renier et al.Metabolism: clinical and experimental, 52(8 Suppl 1), 13-18 (2003-08-27) Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: in vitro-in vivo evaluation.Dilipkumar Pal et al.Drug delivery, 19(3), 123-131 (2012-02-23) A stewardship intervention program for safe medication management and use of antidiabetic drugs.Rui-yi Zhao et al.Clinical interventions in aging, 10, 1201-1212 (2015-08-01) Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial.John Chalmers et al.Hypertension (Dallas, Tex. : 1979), 63(2), 259-264 (2013-12-11) Evidence-based triple antihypertensive therapy yields lower mortality in older patients with diabetes mellitus.Hala Yamout et al.Hypertension (Dallas, Tex. : 1979), 63(2), 220-221 (2013-12-11) In vitro evaluation and in vivo performance of lyophilized gliclazide.Heba F Mansour et al.Drug development and industrial pharmacy, 41(4), 650-657 (2014-02-27) Development of novel gastroretentive floating particulate drug delivery system of gliclazide.Rajendra Awasthi et al.Current drug delivery, 9(5), 437-451 (2012-08-28) Comparative evaluation of the anti-diabetic activity of Pterocarpus marsupium Roxb. heartwood in alloxan induced diabetic rats using extracts obtained by optimized conventional and non conventional extraction methods.Manish Devgan et al.Pakistan journal of pharmaceutical sciences, 26(5), 973-976 (2013-09-17) From hemobiology to vascular disease: a review of the potential of gliclazide to influence the pathogenesis of diabetic vascular disease.P E Jennings Journal of diabetes and its complications, 8(4), 226-230 (1994-10-01) Metabolic approach to atherosclerosis: effect of gliclazide.D N Brindley Metabolism: clinical and experimental, 41(5 Suppl 1), 20-24 (1992-05-01) Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.Fouad F Al-Qaim et al.Journal of chromatography. A, 1345, 139-153 (2014-04-29) Development and validation of a new analytical HPLC method for simultaneous determination of the antidiabetic drugs, metformin and gliclazide.Ahmed Gedawy et al.Journal of food and drug analysis, 27(1), 315-322 (2019-01-17) Blockers of sulfonylureas receptor 1 subunits may lead to cardiac protection against isoprenaline-induced injury in obese rats.Yige Bao et al.European journal of pharmacology, 690(1-3), 142-148 (2012-07-07) Gliclazide modified release: from once-daily administration to 24-hour blood glucose control.A Harrower Metabolism: clinical and experimental, 49(10 Suppl 2), 7-11 (2000-11-15) Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.Peter Proks et al.Diabetes, 62(11), 3909-3919 (2013-07-10) Physicochemical investigations and stability studies of amorphous gliclazide.Shital Jondhale et al.AAPS PharmSciTech, 13(2), 448-459 (2012-03-03) Glycaemic control and cost analysis when changing from gliclazide co-administered with metformin to pre-combined glibenclamide-metformin tablets in type 2 diabetes mellitus.P C Lim et al.The Medical journal of Malaysia, 67(1), 21-24 (2012-05-16) [Glycogen synthetase and non-insulin-dependent diabetes: role of gliclazide].B Lesobre Journees annuelles de diabetologie de l'Hotel-Dieu, 315-321 (1991-01-01) Development of modified release gliclazide biological macromolecules using natural biodegradable polymers.Vipulkumar D Prajapati et al.International journal of biological macromolecules, 55, 6-14 (2013-01-12) [Diabetes mellitus and chronic kideny disease: modern diagnostics and treatment].M V Shestakova Vestnik Rossiiskoi akademii meditsinskikh nauk, (1)(1), 45-49 (2012-05-04) In vitro and in vivo evaluation of gliclazide push-pull osmotic pump coated with aqueous colloidal polymer dispersions.Xin Tang et al.Drug development and industrial pharmacy, 39(1), 67-76 (2012-02-22) Role of K(ATP) channels in β-cell resistance to oxidative stress.G Drews et al.Diabetes, obesity & metabolism, 14 Suppl 3, 120-128 (2012-09-07) Adverse cardiovascular events during treatment with glyburide (glibenclamide) or gliclazide in a high-risk population.D N Juurlink et al.Diabetic medicine : a journal of the British Diabetic Association, 29(12), 1524-1528 (2012-08-24) Gene networks modified by sulphonylureas in beta cells: a pathway-based analysis of insulin secretion and cell death.Nils E Magnusson et al.Basic & clinical pharmacology & toxicology, 111(4), 254-261 (2012-05-31) Refraction paradox in diabetics: an extreme case of transient hyperopia.Mehmet Ali Sekeroglu et al.Journal of diabetes, 5(3), 325-326 (2013-02-21) Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats.Hanan Naeim Attia et al.Behavioural pharmacology, 23(2), 153-161 (2012-03-14) Increased fibrinolytic potential induced by gliclazide in type I and type II diabetic patients.J Gram et al.Metabolism: clinical and experimental, 41(5 Suppl 1), 25-29 (1992-05-01) Gliclazide modified release.Jane K McGavin et al.Drugs, 62(9), 1357-1364 (2002-06-22) Rapid extraction, identification and quantification of oral hypoglycaemic drugs in serum and hair using LC-MS/MS.Tina M Binz et al.Forensic science international, 223(1-3), 119-124 (2012-09-04) Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients.Simona Bo et al.European journal of endocrinology, 169(1), 117-126 (2013-05-11) Gliclazide. An update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus.K J Palmer et al.Drugs, 46(1), 92-125 (1993-07-01) Gliclazide: metabolic and vascular effects--a perspective.K G Alberti et al.Metabolism: clinical and experimental, 41(5 Suppl 1), 40-45 (1992-05-01) In vitro permeability, pharmacokinetics and brain uptake of WAY-100635 and FCWAY in rats using liquid chromatography electrospray ionization tandem mass spectrometry.Zhi Zheng et al.Archives of pharmacal research, 38(6), 1072-1079 (2014-05-20) Protective effect of gliclazide on diabetic peripheral neuropathy through Drp-1 mediated-oxidative stress and apoptosis.Yuan-bo Wu et al.Neuroscience letters, 523(1), 45-49 (2012-06-27) KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.Martin Javorsky et al.European journal of internal medicine, 23(3), 245-249 (2012-03-06) Mechanistic Evidence of Viscum schimperi (Viscaceae) Antihyperglycemic Activity: From a Bioactivity-guided Approach to Comprehensive Metabolite Profiling.Hossam M Abdallah et al.Phytotherapy research : PTR, 29(11), 1737-1743 (2015-08-04) Gliclazide does not fully prevent 2-deoxy-D-ribose-induced oxidative damage because it does not restore glutathione content in a pancreatic β-cell line.Gwanpyo Koh et al.Oxidative medicine and cellular longevity, 2012, 390678-390678 (2012-02-09) Hemobiological properties of gliclazide.O Ziegler et al.Journal of diabetes and its complications, 8(4), 235-239 (1994-10-01) Serum concentrations and hypoglycemic effect of gliclazide: crosspovidone solid dispersion on streptozotocin induced diabetic rats.K Adibkia et al.Drug research, 63(2), 94-97 (2013-02-22) Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats.Hanan Naeim Attia et al.Behavioural pharmacology, 23(2), 153-161 (2012-03-14) ATP and sulfonylurea linkage in the K(ATP) channel solves a diabetes puzzler.Peter Drain Diabetes, 62(11), 3666-3668 (2013-10-26) Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.Sophia Zoungas et al.The New England journal of medicine, 371(15), 1392-1406 (2014-09-23)
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