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Ebselen alters mitochondrial physiology and reduces viability of rat hippocampal astrocytes.Patricia Santofimia-Castaño et al.DNA and cell biology, 32(4), 147-155 (2013-03-19) Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction.Mayumi Sasaki et al.Diabetes, 62(6), 1996-2003 (2013-01-26) The early research and development of ebselen.Michael J Parnham et al.Biochemical pharmacology, 86(9), 1248-1253 (2013-09-10) Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant implication for inflammation-associated carcinogenesisNakamura Y, et al. The Journal of Biological Chemistry, 277(4), 2687-2694 (2002) Synergistic therapeutic efficacy of ebselen and silver ions against multidrug-resistant Acinetobacter baumannii-induced urinary tract infections.Chuanjiang Dong et al.Metallomics : integrated biometal science, 12(6), 860-867 (2020-05-27) The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.Andrew C Terentis et al.Biochemistry, 49(3), 591-600 (2009-12-17) Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production.Lili Zou et al.Scientific reports, 8(1), 11131-11131 (2018-07-26) Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals.N Noguchi et al.Biochimica et biophysica acta, 1213(2), 176-182 (1994-07-14) The glutathione mimic ebselen inhibits oxidative stress but not endoplasmic reticulum stress in endothelial cells.Salma Makhoul Ahwach et al.Life sciences, 134, 9-15 (2015-05-27) Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats.Jana Mahadevan et al.Diabetes, 62(10), 3582-3588 (2013-06-27) Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats.Hager Tarek H Ismail Biological trace element research, 187(2), 452-463 (2018-06-03) Ebselen: a glutathione peroxidase mimic.H Sies Methods in enzymology, 234, 476-482 (1994-01-01) Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle.Marie E Sandström et al.The Journal of physiology, 575(Pt 1), 251-262 (2006-06-17) Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione.Jun Lu et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(4), 1394-1403 (2012-12-19) Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.Claudio Kupfahl et al.Molecular immunology, 49(4), 621-627 (2011-11-29) Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen.Jade B Aitken et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17(4), 589-598 (2012-02-14) A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy.Wenyi Zheng et al.Scientific reports, 10(1), 1274-1274 (2020-01-29) Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.Yatao Du et al.The Journal of biological chemistry, 287(45), 38210-38219 (2012-09-15) Ebselen could be used as anti-inflammatory Nox inhibitor. Future medicinal chemistry, 4(12), 1533-1535 (2012-08-25) Synergistic effect of Ebselen and gamma radiation on breast cancer cells.Noura M Thabet et al.International journal of radiation biology, 93(8), 784-792 (2017-05-04) Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscleSandstrom ME, et al. The Journal of Physiology, 575(1), 251-262 (2006) Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis.Sandrine Verpoorten et al.Acta physiologica (Oxford, England), 228(3), e13395-e13395 (2019-10-11) Military aircrew and noise-induced hearing loss: prevention and management.Renu Rajguru Aviation, space, and environmental medicine, 84(12), 1268-1276 (2014-01-28) Interaction of ebselen with glutathione S-transferase and papain in vitro.T Nikawa et al.Biochemical pharmacology, 47(6), 1007-1012 (1994-03-15) Low Po₂ conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers.Li Zuo et al.American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R1009-R1016 (2013-04-12) Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione.C Schewe et al.Biochemical pharmacology, 48(1), 65-74 (1994-07-05) Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in Neonatal Cochlear ExplantsLiang Q, et al. Frontiers in Neuroscience, 13, 1073-1073 (2019) Ebselen.H Sies Methods in enzymology, 252, 341-342 (1995-01-01) Selenite and ebselen supplementation attenuates D-galactose-induced oxidative stress and increases expression of SELR and SEP15 in rat lens.Jie Dai et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 21(8), 1037-1046 (2016-10-19) Ebselen reduces hyperglycemia temporarily-induced by diazinon: a compound with insulin-mimetic properties.Michael D Costa et al.Chemico-biological interactions, 197(2-3), 80-86 (2012-04-10) The pharmacology of ebselen.M J Parnham et al.Agents and actions, 32(1-2), 4-9 (1991-01-01) Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.Lili Zou et al.EMBO molecular medicine, 9(8), 1165-1178 (2017-06-14) Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.Sourav Mukherjee et al.ACS chemical biology, 9(10), 2393-2403 (2014-08-16) Biological activities and clinical potential of Ebselen.M J Parnham Advances in experimental medicine and biology, 264, 193-197 (1990-01-01) Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.Vidya Chandrasekaran et al.Molecular and cellular neurosciences, 67, 116-125 (2015-06-17) Ebselen: prospective therapy for cerebral ischaemia.M Parnham et al.Expert opinion on investigational drugs, 9(3), 607-619 (2000-11-04) Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling.Rajendra Karki et al.Free radical biology & medicine, 71, 256-269 (2014-03-19) Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs.Yuren Wang et al.Drug design, development and therapy, 11, 1369-1382 (2017-05-13) Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation.Selcuk Yatmaz et al.American journal of respiratory cell and molecular biology, 48(1), 17-26 (2012-09-25) A hydrogen peroxide electrode assay to measure thiol peroxidase activity for organoselenium and organotellurium drugs.Niroshini M Giles et al.Analytical biochemistry, 429(2), 103-107 (2012-07-21) Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.H Sies et al.Advances in pharmacology (San Diego, Calif.), 38, 229-246 (1997-01-01) Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells.Victor O Okoh et al.PloS one, 8(2), e54206-e54206 (2013-02-26) Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation.Yongliang Liang et al.Clinica chimica acta; international journal of clinical chemistry, 414, 1-6 (2012-06-13) Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries.Christophe Morisseau et al.Analytical biochemistry, 434(1), 105-111 (2012-12-12) The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice.Juan Carlos Ledesma et al.Drug and alcohol dependence, 124(1-2), 42-49 (2012-01-21) Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase.Chuanjiang Dong et al.Frontiers in microbiology, 10, 3016-3016 (2020-02-06) T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.Sirinart Kumfu et al.European journal of haematology, 88(6), 535-548 (2012-03-13) Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury.Diana Islam et al.American journal of respiratory and critical care medicine, 199(10), 1214-1224 (2018-12-07) The protective effect of ebselen on radiocontrast-induced nephrotoxicity.Tumay Ozgur et al.Renal failure, 34(8), 991-997 (2012-08-14) Molecular actions of ebselen--an antiinflammatory antioxidant.T Schewe General pharmacology, 26(6), 1153-1169 (1995-10-01) Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.Jun Chen et al.The American journal of pathology, 180(3), 973-983 (2012-01-12) Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.A P Marreilha Dos Santos et al.Toxicology and applied pharmacology, 258(3), 394-402 (2011-12-20) In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology.I J Kade et al.Chemico-biological interactions, 206(1), 27-36 (2013-08-13) Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent.Alkystis Phinikaridou et al.Journal of the American Heart Association, 2(5), e000402-e000402 (2013-09-28) A safe lithium mimetic for bipolar disorder.Nisha Singh et al.Nature communications, 4, 1332-1332 (2013-01-10) Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.Zonghua Luo et al.Journal of medicinal chemistry, 56(22), 9089-9099 (2013-10-29) Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.Yogy Simanjuntak et al.PLoS pathogens, 16(5), e1008521-e1008521 (2020-05-12) Helicobacter pylori-induced IL-1β secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.Raphaela P Semper et al.Journal of immunology (Baltimore, Md. : 1950), 193(7), 3566-3576 (2014-08-31) Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.Kai Takaya et al.Free radical biology & medicine, 53(4), 817-827 (2012-06-27) Effects of ebselen on ischemia/reperfusion injury in rat brain.M Aras et al.The International journal of neuroscience, 124(10), 771-776 (2014-01-11) Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction.Jianguo Fang et al.Toxicology and applied pharmacology, 207(2 Suppl), 103-109 (2005-06-28) Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth.Qi Feng et al.Cancer management and research, 12, 6921-6934 (2020-08-18) Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut.Alexandra Vaccaro et al.Cell, 181(6), 1307-1328 (2020-06-06) Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats.Filiz Ozyigit et al.Bosnian journal of basic medical sciences, 15(4), 36-43 (2015-11-29) The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains.Cristiane L Dalla Corte et al.Brain research, 1430, 101-111 (2011-12-03) Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake.Ling Xie et al.Neurochemistry international, 61(3), 334-340 (2012-05-29) A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities.Desirée Bartolini et al.PloS one, 14(4), e0205626-e0205626 (2019-04-30) Repurposing ebselen for treatment of multidrug-resistant staphylococcal infectionsThangamani S, et al. Scientific reports, 5, 11596-11596 (2015) T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.Mai Matsushita et al.The Journal of experimental medicine, 212(4), 555-568 (2015-04-01) Glutathione S-transferase P influences the Nrf2-dependent response of cellular thiols to seleno-compounds.Desirée Bartolini et al.Cell biology and toxicology, 36(4), 379-386 (2020-02-20) Protective effects of ebselen on sodium-selenite-induced experimental cataract in rats.Orhan Aydemir et al.Journal of cataract and refractive surgery, 38(12), 2160-2166 (2012-09-25) Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screeningUrban DJ, et al. Combinatorial Chemistry & High Throughput Screening, 11(10), 817-824 (2008) Mathematical modeling of pathogenicity of Cryptococcus neoformans.Jacqueline Garcia et al.Molecular systems biology, 4, 183-183 (2008-04-17) Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.Il-Ho Park et al.International archives of allergy and immunology, 159(3), 278-286 (2012-06-23) A new long-wavelength fluorescent probe for tracking peroxynitrite in live cells and inflammatory sites of zebrafish.Guanyang Wang et al.The Analyst, 145(3), 828-835 (2019-12-13) Ebselen, a selenoorganic compound as glutathione peroxidase mimic.H Sies Free radical biology & medicine, 14(3), 313-323 (1993-03-01) Investigation into the intracellular fates, speciation and mode of action of selenium-containing neuroprotective agents using XAS and XFM.Jason L Wedding et al.Biochimica et biophysica acta. 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