熔点	115-116 ºC (isooctane )***
闪点	111.7±25.9 ºC, 计算值*
密度	1.6 g/cm3 (60 ºC)**

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来源	SDS样本
没有数据	没有数据

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Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers.Arik Dahan et al.Molecular pharmaceutics, 11(12), 4385-4394 (2014-11-05) Effect of melphalan and hyperthermia on p34cdc2 kinase activity in human melanoma cells.L Orlandi et al.British journal of cancer, 74(12), 1924-1928 (1996-12-01) Consensus guidelines for the optimal management of adverse events in newly diagnosed, transplant-ineligible patients receiving melphalan and prednisone in combination with thalidomide (MPT) for the treatment of multiple myeloma.A Palumbo et al.Annals of hematology, 89(8), 803-811 (2010-03-17) Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer.X Song et al.Cell death & disease, 5, e1504-e1504 (2014-10-31) Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2.Cindy Gallerne et al.Biochimica et biophysica acta, 1833(6), 1356-1366 (2013-03-15) Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study.Jasmine H Francis et al.Ophthalmology, 121(9), 1810-1817 (2014-05-14) Renal response after high-dose melphalan and stem cell transplantation is a favorable marker in patients with primary systemic amyloidosis.Nelson Leung et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 46(2), 270-277 (2005-08-23) Systemic immunoglobulin light-chain amyloidosis (AL) in Mexico: a single institution, 30-year experience.Jesús Hernández-Reyes et al.Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 64(6 Pt 2), 604-608 (2013-04-19) Evaluation of patients with cardiac amyloidosis using echocardiography, ECG and right heart catheterization.Sven-Olof Granstam et al.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 20(1), 27-33 (2013-01-24) A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.Ryosuke Saijo et al.Chemical & pharmaceutical bulletin, 65(4), 365-372 (2017-04-07) Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.R Timothy Bentley et al.World neurosurgery, 116, e534-e542 (2018-05-19) Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.Eliana Mc Tacconi et al.EMBO molecular medicine, 11(7), e9982-e9982 (2019-07-06) Electrosprayed nanoparticles of poly(p-dioxanone-co-melphalan) macromolecular prodrugs for treatment of xenograft ovarian carcinoma.Aiping Wen et al.Materials science & engineering. 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Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma.Tasnim Ara et al.Cancer research, 73(13), 3852-3864 (2013-05-02) Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study.Jasmine H Francis et al.Ophthalmology, 121(9), 1810-1817 (2014-05-14) Renal response after high-dose melphalan and stem cell transplantation is a favorable marker in patients with primary systemic amyloidosis.Nelson Leung et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 46(2), 270-277 (2005-08-23) Disulfide-Linked Dinitroxides for Monitoring Cellular Thiol Redox Status through Electron Paramagnetic Resonance Spectroscopy.Eric A Legenzov et al.Biochemistry, 54(47), 6973-6982 (2015-11-03) Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.R Timothy Bentley et al.World 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cytotoxins.Umashankar Das et al.Journal of medicinal chemistry, 54(9), 3445-3449 (2011-04-01) Bortezomib induced a phrenic palsy in a multiple myeloma patient.Vitalie Nizeica et al.Annals of hematology, 92(8), 1135-1136 (2013-02-02) DexaBEAM versus ICE salvage regimen prior to autologous transplantation for relapsed or refractory aggressive peripheral T cell lymphoma: a retrospective evaluation of parallel patient cohorts of one center.Jan-Henrik Mikesch et al.Annals of hematology, 92(8), 1041-1048 (2013-03-28) Melphalan: old and new uses of a still master drug for multiple myeloma.Pellegrino Musto et al.Expert opinion on investigational drugs, 16(9), 1467-1487 (2007-08-24) DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan.Ji Cao et al.Cancer letters, 383(1), 115-124 (2016-10-30) Oncological outcome of primary non-metastatic soft tissue sarcoma treated by neoadjuvant isolated limb perfusion and 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medicinal chemistry, 42(1), 71-80 (2006-09-26) Overexpression of Yin Yang 1 in bone marrow-derived human multiple myeloma and its clinical significance.Sara Huerta-Yepez et al.International journal of oncology, 45(3), 1184-1192 (2014-06-28) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.Anne J Lombardi et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 21(8), 1962-1972 (2015-01-23) Proposed strategy for the use of high-dose chemotherapy with stem cell rescue and intrathecal topotecan without whole-brain irradiation for infantile classic medulloblastoma.Ai Yamada et al.Pediatric blood & cancer, 61(12), 2316-2318 (2014-09-02) Blue toe syndrome as a 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B, Biointerfaces, 166, 45-53 (2018-03-14) Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogeneic hematopoietic cell transplantation.Ji Hyun Kim et al.International journal of radiation oncology, biology, physics, 89(1), 75-81 (2014-04-15) Synthesis, characterization and structure-activity relationship of novel N-phosphorylated E,E-3,5-bis(thienylidene)piperid-4-ones.Michael V Makarov et al.European journal of medicinal chemistry, 45(3), 992-1000 (2009-12-09) Cerebral vasoconstriction triggered by sympathomimetic drugs during intra-atrerial chemotherapy.Todd Abruzzo et al.Pediatric neurology, 48(2), 139-142 (2013-01-23) The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.Hari N Pati et al.European journal of medicinal chemistry, 44(1), 54-62 (2008-05-13) Isolated limb perfusion with melphalan and TNF-alpha in the treatment of extremity sarcoma.Cornelis Verhoef et al.Current treatment options in oncology, 8(6), 417-427 (2007-12-11) Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.Bhavin Marvania et al.Bioorganic & medicinal chemistry, 19(6), 1987-1998 (2011-03-02) Characteristics of graft-versus-host disease occurring after alemtuzumab-containing allogeneic stem cell transplants: incidence, organ involvement, risk factors and survival.Maria C Finazzi et al.British journal of haematology, 188(4), 550-559 (2019-11-13) The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells.Ping Chen et al.Cellular oncology (Dordrecht), 39(6), 511-522 (2016-07-31) The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors.Maria Pia Abruzzese et al.Cell death & disease, 10(4), 324-324 (2019-04-13) Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Stephen D Dertinger et al.Environmental and molecular mutagenesis, 55(4), 299-308 (2014-01-23) The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma.A Tagde et al.Blood cancer journal, 4, e229-e229 (2014-07-19) Fludarabine, cytarabine, granulocyte colony-stimulating factor and melphalan (FALG with L-PAM) as a reduced toxicity conditioning regimen in children with acute leukemia.Koji Kato et al.Pediatric blood & cancer, 61(4), 712-716 (2014-01-01) Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma.Hayyam Kiratli et al.European journal of ophthalmology, 27(4), 423-427 (2017-01-21) Physicochemical determinants of human renal clearance.Manthena V S Varma et al.Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19) Cancer chemotherapy and cardiac arrhythmias: a review.Juan Tamargo et al.Drug safety, 38(2), 129-152 (2015-01-13) Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma.Arne Kolstad et al.Blood, 123(19), 2953-2959 (2014-03-22) Contribution of involved-field radiotherapy to survival in patients with relapsed or refractory Hodgkin lymphoma undergoing autologous stem cell transplantation.Celalettin Eroglu et al.American journal of clinical oncology, 38(1), 68-73 (2013-04-09) Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells.Claire Gourzones et al.Cancers, 11(4) (2019-03-31) Optimizing oncolytic virotherapy in cancer treatment.Kevin Harrington et al.Nature reviews. Drug discovery, 18(9), 689-706 (2019-07-12) Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.Xiaoyun Lu et al.Journal of immunology (Baltimore, Md. : 1950), 194(4), 2011-2021 (2015-01-07) Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.Bhavin Marvania et al.Bioorganic & medicinal chemistry, 19(6), 1987-1998 (2011-03-02) Characteristics of graft-versus-host disease occurring after alemtuzumab-containing allogeneic stem cell transplants: incidence, organ involvement, risk factors and survival.Maria C Finazzi et al.British journal of haematology, 188(4), 550-559 (2019-11-13) The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors.Maria Pia Abruzzese et al.Cell death & disease, 10(4), 324-324 (2019-04-13) Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Stephen D Dertinger et al.Environmental and molecular mutagenesis, 55(4), 299-308 (2014-01-23) The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma.A Tagde et al.Blood cancer journal, 4, e229-e229 (2014-07-19) Autologous transplantation and maintenance therapy in multiple myeloma.Antonio Palumbo et al.The New England journal of medicine, 371(10), 895-905 (2014-09-04) Melphalan and dexamethasone with or without bortezomib in newly diagnosed AL amyloidosis: a matched case-control study on 174 patients.G Palladini et al.Leukemia, 28(12), 2311-2316 (2014-07-26) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Melphalan in regional chemotherapy for locally recurrent metastatic melanoma.C L Defty et al.Current topics in medicinal chemistry, 12(1), 53-60 (2011-12-27) In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia.Sara Strese et al.Oncotarget, 8(4), 6341-6352 (2016-12-16) [Autopsy case of light chain deposition disease presented by nephrotic syndrome].Soh Suzuki et al.Nihon Jinzo Gakkai shi, 55(1), 63-70 (2013-03-07) Isolated limb infusion with melphalan and actinomycin D for melanoma: a systematic review.Hidde M Kroon et al.Journal of surgical oncology, 109(4), 348-351 (2014-02-14) Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation.Lothar Bohm Radiation oncology (London, England), 1, 12-12 (2006-05-26) Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.Michael L Mohler et al.Journal of medicinal chemistry, 49(19), 5845-5848 (2006-09-15) Chemosaturation with percutaneous hepatic perfusions of melphalan for hepatic metastases: experience from two European centers.T J Vogl et al.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 186(10), 937-944 (2014-04-15) Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide.J H Burton et al.Veterinary and comparative oncology, 15(4), 1558-1563 (2017-01-26) Isolated limb infusion with melphalan and actinomycin D in melanoma patients: factors predictive of acute regional toxicity.Peter C A Kam et al.Expert opinion on drug metabolism & toxicology, 6(9), 1039-1045 (2010-07-08) Effect of photobiomodulation therapy on reducing the chemo-induced oral mucositis severity and on salivary levels of CXCL8/interleukin 8, nitrite, and myeloperoxidase in patients undergoing hematopoietic stem cell transplantation: a randomized clinical trial.Daniella Ribeiro Naves Salvador et al.Lasers in medical science, 32(8), 1801-1810 (2017-07-01) Intravitreal injection of melphalan for intraocular retinoblastoma.Shigenobu Suzuki et al.Japanese journal of ophthalmology, 59(3), 164-172 (2015-03-27) Characterization of a novel mouse model of multiple myeloma and its use in preclinical therapeutic assessment.Rosemary A Fryer et al.PloS one, 8(2), e57641-e57641 (2013-02-26) ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer.Arun Kanakkanthara et al.Nature communications, 10(1), 4632-4632 (2019-10-13) Factors associated with response, survival, and limb salvage in patients undergoing isolated limb infusion.Jonathan Steinman et al.Journal of surgical oncology, 109(5), 405-409 (2013-12-10) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Lourdes Santana et al.Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07) Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma.Lotfi Benboubker et al.The New England journal of medicine, 371(10), 906-917 (2014-09-04) Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines.Hajime Asada et al.The Journal of veterinary medical science, 77(6), 677-684 (2015-02-27) Microwave supported synthesis of some novel 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities.Seref Demirayak et al.European journal of medicinal chemistry, 46(1), 411-416 (2010-12-03) Bivalent bendamustine and melphalan derivatives as anticancer agents.Ana Maria Scutaru et al.European journal of medicinal chemistry, 46(5), 1604-1615 (2011-03-05) Role of Fanconi anemia/BRCA pathway genes in hepatocellular carcinoma chemoresistance.Sana Ferroudj et al.Hepatology research : the official journal of the Japan Society of Hepatology, 46(12), 1264-1274 (2016-02-18) Nucleotide excision repair is a potential therapeutic target in multiple myeloma.R Szalat et al.Leukemia, 32(1), 111-119 (2017-06-08) Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7.Jiro Kikuchi et al.Leukemia, 34(1), 180-195 (2019-07-31) The lymphoma-like polychemotherapy regimen "Dexa-BEAM" in advanced and extramedullary multiple myeloma.Leo Rasche et al.Annals of hematology, 93(7), 1207-1214 (2014-02-15) The Transfer of Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma.Sylvia Faict et al.Cancers, 11(12) (2019-11-24) Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.Christine Lam et al.Haematologica, 103(7), 1218-1228 (2018-04-07) Sporadic late-onset nemaline myopathy with MGUS: long-term follow-up after melphalan and SCT.Nicol C Voermans et al.Neurology, 83(23), 2133-2139 (2014-11-08) Isolated limb perfusion for in-transit melanoma metastases: melphalan or TNF-melphalan perfusion?Harald J Hoekstra et al.Journal of surgical oncology, 109(4), 338-347 (2014-01-10) An overview of high-dose melphalan and stem cell transplantation in the treatment of AL amyloidosis.Vaishali Sanchorawala et al.Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 14(4), 261-269 (2007-10-31) Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization.Piman Pocasap et al.Biomolecules & therapeutics, 27(6), 540-552 (2019-08-14) Treatment of ovarian cancer at the crossroads: 50 years after single-agent melphalan chemotherapy.M Steven Piver Oncology (Williston Park, N.Y.), 20(10), 1156-1156 (2006-10-10) Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases.Mateusz J Swierz et al.The Cochrane database of systematic reviews, 3, CD009498-CD009498 (2020-03-13) Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study.John P Campbell et al.The Lancet. Haematology, 4(12), e584-e594 (2017-11-18) Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy.Indu R Ramachandran et al.Cancer letters, 371(1), 117-124 (2015-12-08) Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier.Amit Sagi et al.Bioorganic & medicinal chemistry, 15(11), 3720-3727 (2007-04-10) Natural killer cell recognition ofFabrizio Antonangeli et al.Oncoimmunology, 5(10), e1218105-e1218105 (2016-11-18) Calculating regional tissue volume for hyperthermic isolated limb perfusion: Four methods compared.D Cecchin et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 42(12), 1898-1905 (2016-03-24) In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs.Michael J Reese et al.PloS one, 13(9), e0203517-e0203517 (2018-09-08) Lymphocytic leukemia in a captive dhole (Cuon alpinus).Christopher Scala et al.Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 44(1), 204-207 (2013-03-20) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08) A case of γ1-heavy chain deposition disease successfully treated with melphalan and prednisolone therapy.Yuji Oe et al.Internal medicine (Tokyo, Japan), 49(14), 1411-1415 (2010-07-22) Isolated lung perfusion with melphalan for the treatment of metastatic pulmonary sarcoma.S Nawata et al.The Journal of thoracic and cardiovascular surgery, 112(6), 1542-1547 (1996-12-01) Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin.Aleksandra M Dudek-Perić et al.Cancer research, 75(8), 1603-1614 (2015-03-13) An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.Mirta M L Sousa et al.PloS one, 8(2), e55493-e55493 (2013-02-14) Clinical features, outcome, and prognostic factors for survival and evolution to multiple myeloma of solitary plasmacytomas: a report of the Greek myeloma study group in 97 patients.Eirini Katodritou et al.American journal of hematology, 89(8), 803-808 (2014-04-24) Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI.James C Padussis et al.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 24(3), 239-249 (2008-04-09) Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage.Naval Kapuriya et al.Bioorganic & medicinal chemistry, 16(10), 5413-5423 (2008-05-03) Melphalan and its role in the management of patients with multiple myeloma.Patrizia Falco et al.Expert review of anticancer therapy, 7(7), 945-957 (2007-07-14) Histopathological tumor response following neoadjuvant hyperthermic isolated limb perfusion in extremity soft tissue sarcomas: Evaluation of the EORTC-STBSG response score.Marc G Stevenson et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 44(9), 1406-1411 (2018-06-03) Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myeloma.Shang-Yi Huang et al.Annals of hematology, 93(8), 1371-1380 (2014-04-02) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) Lenalidomide and metronomic melphalan for CMML and higher risk MDS: a phase 2 clinical study with biomarkers of angiogenesis.Rena Buckstein et al.Leukemia research, 38(7), 756-763 (2014-05-14) Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells.Benigno C Valdez et al.Experimental hematology, 81, 32-41 (2020-01-19) 3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy.Umashankar Das et al.Bioorganic & medicinal chemistry letters, 20(3), 912-917 (2010-01-13) Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.Romeo Romagnoli et al.Bioorganic & medicinal chemistry letters, 20(9), 2733-2739 (2010-04-10) Intravitreal chemotherapy provides control for massive vitreous seeding from retinoblastoma.Brendan M Lawson et al.Journal of pediatric ophthalmology and strabismus, 51 Online, e92-e94 (2014-12-10) Hologram QSAR model for the prediction of human oral bioavailability.Tiago L Moda et al.Bioorganic & medicinal chemistry, 15(24), 7738-7745 (2007-09-18) Design, cytotoxic and fluorescent properties of novel N-phosphorylalkyl substituted E,E-3,5-bis(arylidene)piperid-4-ones.Michael V Makarov et al.European journal of medicinal chemistry, 44(5), 2135-2144 (2008-12-03) Long-Term Results of High-Dose Therapy and Autologous Stem Cell Transplantation for Mantle Cell Lymphoma: Effectiveness of Maintenance Rituximab.Matthew G Mei et al.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 23(11), 1861-1869 (2017-07-25) Cytotoxic 2-benzylidene-6-(nitrobenzylidene)cyclohexanones which display substantially greater toxicity for neoplasms than non-malignant cells.Umashankar Das et al.Bioorganic & medicinal chemistry, 18(6), 2219-2224 (2010-03-02) Addressing the questions of tomorrow: melphalan and new combinations as conditioning regimens before autologous hematopoietic progenitor cell transplantation in multiple myeloma.Massimo Martino et al.Expert opinion on investigational drugs, 22(5), 619-634 (2013-04-05) Current treatment for multiple myeloma.David Avigan et al.The New England journal of medicine, 371(10), 961-962 (2014-09-04) BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.Mateusz Rytelewski et al.Molecular oncology, 8(8), 1429-1440 (2014-06-30) Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators.Yogesh Yadav et al.European journal of medicinal chemistry, 46(9), 3858-3866 (2011-06-18) Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.Martin Krug et al.Bioorganic & medicinal chemistry letters, 20(23), 6915-6919 (2010-11-03) Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells.Mitsuki Tabata et al.Clinical and experimental medicine, 20(1), 63-71 (2019-10-28) Long-term results of the combination of the N7 induction chemotherapy and the busulfan-melphalan high dose chemotherapy.Dominique Valteau-Couanet et al.Pediatric blood & cancer, 61(6), 977-981 (2013-08-24) Targeted Cancer Therapy Using Fusion Protein of TNFα and Tumor-Associated Fibronectin-Specific Aptide.Hyungsu Jeon et al.Molecular pharmaceutics, 14(11), 3772-3779 (2017-10-04) Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment.Morie A Gertz American journal of hematology, 89(12), 1132-1140 (2014-11-20) Comparative Study of Antitumor Efficiency of Intraperitoneal and Intravenous Cytostatics in Experimental Rats with Disseminated Ovarian Cancer.V G Bespalov et al.Bulletin of experimental biology and medicine, 162(3), 383-386 (2017-01-17) Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker.Rajesh Kakadiya et al.Bioorganic & medicinal chemistry, 18(6), 2285-2299 (2010-02-26) Bone marrow osteoblast vulnerability to chemotherapy.Marieta Gencheva et al.European journal of haematology, 90(6), 469-478 (2013-04-05) 1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells.Hari N Pati et al.Bioorganic & medicinal chemistry, 16(10), 5747-5753 (2008-04-10) 3-(3,4,5-Trimethoxyphenyl)-1-oxo-2-propene: a novel pharmacophore displaying potent multidrug resistance reversal and selective cytotoxicity.Umashankar Das et al.Bioorganic & medicinal chemistry, 15(10), 3373-3380 (2007-03-27) Selection and characterization of a human ovarian cancer cell line resistant to auranofin.Ida Landini et al.Oncotarget, 8(56), 96062-96078 (2017-12-10) Efficiency and Tolerability of Induction and Consolidation Therapy with Arsenic Trioxide/Bortezomib/Ascorbic Acid/Dexamethasone (ABCD) Regimen Compared to Bortezomib/Dexamethasone (BD) Regimen in Newly Diagnosed Myeloma Patients.Wensi Qian et al.Cancer management and research, 12, 431-441 (2020-02-06) Longitudinal Evaluation of Immune Reconstitution and B-cell Function After Hematopoietic Cell Transplantation for Primary Immunodeficiency.Alessia Scarselli et al.Journal of clinical immunology, 35(4), 373-383 (2015-04-16) Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma.Carol L Shields et al.Ophthalmology, 121(7), 1453-1460 (2014-03-25) Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.R Scott Obach et al.Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23) RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells.Keiji Mashimo et al.Clinical and experimental medicine, 19(1), 133-141 (2018-10-07) Hydrolyzable tannins of tamaricaceous plants. V. Structures of monomeric-trimeric tannins and cytotoxicity of macrocyclic-type tannins isolated from Tamarix nilotica (1).Mohamed A A Orabi et al.Journal of natural products, 76(5), 947-956 (2013-05-17) Fifty years of melphalan use in hematopoietic stem cell transplantation.Ulas D Bayraktar et al.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 344-356 (2012-08-28) Melphalan in the Treatment of MyelomatosisDorothy E. Speed British Medical Journal, 1(5399), 1664-1669 (1964) Use of the comet assay technique for quick and reliable prediction of in vitro response to chemotherapeutics in breast and colon cancerApostolou P Journal of biological research (Thessalonike?, Greece), 21(1)14 (2014) Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.Jyothi Matharu et al.Bioorganic & medicinal chemistry letters, 20(12), 3688-3691 (2010-05-15) 2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.Umashankar Das et al.Bioorganic & medicinal chemistry, 17(11), 3909-3915 (2009-05-12) Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma.Simon Rule et al.British journal of haematology, 184(6), 999-1005 (2018-12-19) Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.A Bhangu et al.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 39(4), 311-319 (2013-01-29) A patient with persistent renal AL amyloid deposition after clinical remission by HDM/SCT therapy.Hiroshi Okuyama et al.Clinical nephrology, 79(3), 233-236 (2013-02-27) A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications.Jana Jakubikova et al.Oncotarget, 7(47), 77326-77341 (2016-10-21) Real-life multidisciplinary treatment for unresectable colorectal cancer liver metastases including hepatic artery infusion with chemo-filtration and liquid biopsy precision oncotherapy: observational cohort study.Stefano Guadagni et al.Journal of cancer research and clinical oncology, 146(5), 1273-1290 (2020-02-24) Clinical significance of granule-containing myeloma cells in patients with newly diagnosed multiple myeloma.Kazuhito Suzuki et al.Cancer medicine, 5(11), 3051-3058 (2016-10-14) Bendamustine and melphalan kill myeloma cells similarly through reactive oxygen species production and activation of the p53 pathway and do not overcome resistance to each other.Sylvanie Surget et al.Leukemia & lymphoma, 55(9), 2165-2173 (2013-12-07) Sixteenth biannual report of the Cochrane Haematological Malignancies Group: focus on Non-Hodgkin's lymphoma.Michaela Rancea et al.Journal of the National Cancer Institute, 106(8), doi:10-doi:10 (2014-07-18) PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.Ting Xiong et al.International journal of oncology, 46(1), 223-232 (2014-10-30) New advances in the diagnosis and treatment of POEMS syndrome.Jian Li et al.British journal of haematology, 161(3), 303-315 (2013-02-13) Synthesis, computational study and cytotoxic activity of new 4-hydroxycoumarin derivatives.Stancho Stanchev et al.European journal of medicinal chemistry, 43(4), 694-706 (2007-07-07) P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade.Li-Fang Lin et al.Oncotarget, 8(28), 45072-45087 (2017-02-09) Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells.Alessia Ongaro et al.Anti-cancer drugs, 26(3), 284-292 (2014-12-17) Evaluation of melphalan, oxaliplatin, and paclitaxel in colon, liver, and gastric cancer cell lines in a short-term exposure model of chemosaturation therapy by percutaneous hepatic perfusion.Rajneesh P Uzgare et al.Anticancer research, 33(5), 1989-2000 (2013-05-07) Soft Tissue Cancer Management: Isolated Limb Infusion for Sarcoma.Jyri Teras et al.Visceral medicine, 35(6), 373-379 (2020-01-15) Predicting disease progression after regional therapy for in-transit melanoma.Michael E Lidsky et al.JAMA surgery, 148(6), 493-498 (2013-04-06) Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore.Amitabh Jha et al.Bioorganic & medicinal chemistry letters, 20(5), 1510-1515 (2010-02-13) Effectiveness of regional chemotherapy with TNF-alpha/melphalan in advanced soft tissue sarcoma of the extremities.G Taeger et al.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 24(3), 193-203 (2008-04-09) Precision oncotherapy based on liquid biopsies in multidisciplinary treatment of unresectable recurrent rectal cancer: a retrospective cohort study.Stefano Guadagni et al.Journal of cancer research and clinical oncology, 146(1), 205-219 (2019-10-18) Synthesis and in vitro evaluation of a hyaluronic acid-quantum dots-melphalan conjugate.Haixing Xu et al.Carbohydrate polymers, 121, 132-139 (2015-02-11) Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.Seyed Nasrollah Tabatabaei et al.Journal of controlled release : official journal of the Controlled Release Society, 298, 177-185 (2019-02-19) Structure-cytotoxicity relationship in a series of N-phosphorus substituted E,E-3,5-bis(3-pyridinylmethylene)- and E,E-3,5-bis(4-pyridinylmethylene)piperid-4-ones.Evgeniya S Leonova et al.European journal of medicinal chemistry, 45(12), 5926-5934 (2010-11-03) Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma.Elizabeta A Rojas et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 23(21), 6602-6615 (2017-08-10) Pilomatrixoma in a patient with bilateral retinoblastoma.Ian R Gorovoy et al.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 17(1), 103-104 (2013-01-15) Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma.Jian-Jun Zhao et al.Cancer research, 75(20), 4384-4397 (2015-08-08) Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.Kamila Anna Zub et al.PloS one, 10(3), e0119857-e0119857 (2015-03-15) Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.Kana Nishihara et al.Mutagenesis, 31(1), 69-81 (2015-08-06) Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.Jasper Boschmans et al.Rapid communications in mass spectrometry : RCM, 27(7), 835-841 (2013-03-16) Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents.Dani Youssef et al.Bioorganic & medicinal chemistry letters, 19(22), 6364-6367 (2009-10-13) Isolated limb perfusion with melphalan in the treatment of malignant melanoma of the extremities: a systematic review of randomised controlled trials.Marko B Lens et al.The Lancet. Oncology, 4(6), 359-364 (2003-06-06) QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.Andrey A Toropov et al.European journal of medicinal chemistry, 45(4), 1639-1647 (2010-01-29) Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents.Franciszek Saczewski et al.European journal of medicinal chemistry, 43(9), 1847-1857 (2008-01-12) Long-Term Follow-Up Evaluation of 68 Patients with Uveal Melanoma Liver Metastases Treated with Isolated Hepatic Perfusion.Ilan Ben-Shabat et al.Annals of surgical oncology, 23(4), 1327-1334 (2015-12-03) Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis.D L M van Broekhoven et al.The British journal of surgery, 101(13), 1674-1680 (2014-10-10) Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.Ryan S Turley et al.Annals of surgery, 261(2), 368-377 (2014-03-22) Impact of graft-versus-lymphoma effect on outcomes after reduced intensity conditioned-alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies.Charlotte K Brierley et al.British journal of haematology, 184(4), 547-557 (2018-11-24) Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.Hari N Pati et al.European journal of medicinal chemistry, 43(1), 1-7 (2007-05-15) Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.Na Li et al.Clinical cancer research : an official journal of the American Association for Cancer Research, 25(1), 369-377 (2018-09-13) Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.Michelle A Lawson et al.Nature communications, 6, 8983-8983 (2015-12-04)

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