2-Bromofluorene | CAS:1133-80-8
2-Bromofluorene
- 名称:2-溴芴 | 2-Bromofluorene
- CAS号:1133-80-8
- 别名:2-Bromo-9H-fluorene
- 分子式:C13H9Br
- 分子量:245.12
- EINESC号:214-480-6
产品描述
物理化学性质
熔点 | 110-115 ºC |
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沸点 | 185 ºC (135 mmHg) |
安全数据
危险品标志 | Xi |
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危险类别码 | R36/37/38 |
安全说明书 | S26;S37/39 |
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Storage effect on the analysis of pharmaceuticals and personal care products in wastewater.Ganna Fedorova et al.Chemosphere, 111, 55-60 (2014-07-07)
HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.V L Yip et al.Clinical pharmacology and therapeutics, 92(6), 757-765 (2012-11-08)
Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.Fouad F Al-Qaim et al.Journal of chromatography. A, 1345, 139-153 (2014-04-29)
Inhibition of cytochrome P450 by ethambutol in human liver microsomes.Sang Yoon Lee et al.Toxicology letters, 229(1), 33-40 (2014-06-10)
Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.Zhican Wang et al.Endocrinology, 155(6), 2052-2063 (2014-03-20)
The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: an in vitro study.Jacek Wójcikowski et al.Pharmacological reports : PR, 66(6), 1122-1126 (2014-12-03)
Determination of species-difference in microsomal metabolism of amitriptyline using a predictive MRM-IDA-EPI method.Ji-Yoon Lee et al.Chemico-biological interactions, 229, 109-118 (2015-01-28)
Evaluation of analytical performance and reliability of direct nanoLC-nanoESI-high resolution mass spectrometry for profiling the (xeno)metabolome.Andrew J Chetwynd et al.Journal of mass spectrometry : JMS, 49(10), 1063-1069 (2014-10-11)
Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: potential application to quantitative analysis.Clara Boix et al.Food chemistry, 160, 313-320 (2014-05-07)
Riverbank filtration potential of pharmaceuticals in a wastewater-impacted stream.Paul M Bradley et al.Environmental pollution (Barking, Essex : 1987), 193, 173-180 (2014-07-20)
Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.Yasuhiro Horita et al.Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)
Vigabatrin versus carbamazepine monotherapy for epilepsy.Yousheng Xiao et al.The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20)
Question 2 Should phenytoin and carbamazepine be avoided in Asian populations with the HLA-B*1502 positive genetic variant?Subramanian Ganesan et al.Archives of disease in childhood, 96(1), 104-106 (2010-12-21)
Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells.Chen-Hsu Wang et al.Pharmaceutical biology, 52(11), 1451-1459 (2014-07-16)
Treatment of selected pharmaceuticals by ferrate(VI): performance, kinetic studies and identification of oxidation products.Zhengwei Zhou et al.Journal of pharmaceutical and biomedical analysis, 106, 37-45 (2014-07-27)
Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsy.Tae Hwan Kim et al.Epilepsia, 56(1), e6-e9 (2014-12-10)
Hybrid bioreactor (HBR) of hollow fiber microfilter membrane and cross-linked laccase aggregates eliminate aromatic pharmaceuticals in wastewaters.Sidy Ba et al.Journal of hazardous materials, 280, 662-670 (2014-09-15)
UPLC-MS/MS determination of voriconazole in human plasma and its application to a pharmacokinetic study.Zhe Wang et al.Biomedical chromatography : BMC, 29(2), 188-193 (2014-06-14)
The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome.R Barrons et al.Journal of clinical pharmacy and therapeutics, 35(2), 153-167 (2010-05-12)
A rapid and simple UPLC-MS-MS method for determination of glipizide in human plasma and its application to bioequivalence study.Xiangjun Qiu et al.Journal of chromatographic science, 53(1), 85-89 (2014-04-29)
Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting.Julia Martín et al.The Science of the total environment, 503-504, 97-104 (2014-06-10)
Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures.Marcus W Koch et al.The Cochrane database of systematic reviews, (4)(4), CD006453-CD006453 (2009-10-13)
Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus.Kuan Ming Chiu et al.Biological & pharmaceutical bulletin, 38(4), 522-530 (2015-04-04)
Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China.Mei-Quan Cai et al.Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.Robert J Hatch et al.Epilepsia, 55(4), 601-608 (2014-03-13)
A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.Sylwia Magiera et al.Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.M Muz et al.Environmental technology, 35(9-12), 1055-1063 (2014-04-08)
Effect of myricetin on cytochrome P450 isoforms CYP1A2, CYP2C9 and CYP3A4 in rats.Yu-Jin Guo et al.Die Pharmazie, 69(4), 306-310 (2014-05-06)
Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study.Janneke Jentink et al.BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.Claudia Kasserra et al.Journal of clinical pharmacology, 55(2), 168-178 (2014-08-28)
Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.Yasuhiro Horita et al.Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)
Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults.Mona Darwish et al.Clinical therapeutics, 37(2), 325-337 (2014-12-03)
Obtaining process mass balances of pharmaceuticals and triclosan to determine their fate during wastewater treatment.Bruce Petrie et al.The Science of the total environment, 497-498, 553-560 (2014-08-29)
Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting.Julia Martín et al.The Science of the total environment, 503-504, 97-104 (2014-06-10)
Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures.Marcus W Koch et al.The Cochrane database of systematic reviews, (4)(4), CD006453-CD006453 (2009-10-13)
Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus.Kuan Ming Chiu et al.Biological & pharmaceutical bulletin, 38(4), 522-530 (2015-04-04)
Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China.Mei-Quan Cai et al.Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.Giuseppe Gangarossa et al.Hippocampus, 24(12), 1466-1481 (2014-07-22)
Effects of Polygonum multiflorum on the activity of cytochrome P450 isoforms in rats.Yuan Zhang et al.Die Pharmazie, 70(1), 47-54 (2015-05-16)
Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.Robert J Hatch et al.Epilepsia, 55(4), 601-608 (2014-03-13)
Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.Seda Salar et al.Epilepsia, 55(8), 1255-1263 (2014-07-06)
Co-metabolic oxidation of pharmaceutical compounds by a nitrifying bacterial enrichment.Anwar Dawas-Massalha et al.Bioresource technology, 167, 336-342 (2014-07-06)
Polymorph characterization of active pharmaceutical ingredients (APIs) using low-frequency Raman spectroscopy.Peter J Larkin et al.Applied spectroscopy, 68(7), 758-776 (2014-07-12)
HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.Sandeep Grover et al.Pharmacogenetics and genomics, 24(2), 94-112 (2013-12-18)
Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats.Xin-shuai Wang et al.Phytotherapy research : PTR, 29(3), 366-372 (2014-12-03)
Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes.Sang Yoon Lee et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 131-138 (2014-08-26)
Aggravation of symptomatic occipital epilepsy of childhood by carbamazepine.Fadil E Skrijelj et al.Vojnosanitetski pregled, 71(4), 404-407 (2014-05-03)
Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy.Graham Powell et al.The Cochrane database of systematic reviews, 12(12), CD007124-CD007124 (2014-12-04)
Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry.Clara Boix et al.Talanta, 131, 719-727 (2014-10-05)
The antidepressant drug carbamazepine induces differential transcriptome expression in the brain of Atlantic salmon, Salmo salar.M Hampel et al.Aquatic toxicology (Amsterdam, Netherlands), 151, 114-123 (2014-01-21)
Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.Ursula Amstutz et al.Epilepsia, 55(4), 496-506 (2014-03-07)
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.Ramesh Boinpally et al.Clinical therapeutics, 36(11), 1638-1649 (2014-09-23)
Archimedes. Question 3. Should carbamazepine be administered to manage agitation and aggressive behaviour following paediatric acquired brain injury?Emma Waters et al.Archives of disease in childhood, 95(11), 950-952 (2010-10-29)
Effect of binder liquid type on spherical crystallization.Maryam Maghsoodi et al.Drug development and industrial pharmacy, 40(11), 1468-1475 (2013-08-14)
Extracorporeal treatment for carbamazepine poisoning: systematic review and recommendations from the EXTRIP workgroup.Marc Ghannoum et al.Clinical toxicology (Philadelphia, Pa.), 52(10), 993-1004 (2014-10-31)
Reducing PEC uncertainty in coastal zones: a case study on carbamazepine, oxcarbazepine and their metabolites.Hélène Fenet et al.Environment international, 68, 177-184 (2014-04-20)
Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy.Graham Powell et al.The Cochrane database of systematic reviews, (1)(1), CD007124-CD007124 (2010-01-22)
In vitro metabolism of the alkaloid piplartine by rat liver microsomes.Lucas Maciel Mauriz Marques et al.Journal of pharmaceutical and biomedical analysis, 95, 113-120 (2014-03-29)
UPLC-MS/MS method for determination of avicularin in rat plasma and its application to a pharmacokinetic study.Wei-Min Zhang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 107-111 (2014-07-11)
Sorption affinities of sulfamethoxazole and carbamazepine to two sorbents under co-sorption systems.Chi Wang et al.Environmental pollution (Barking, Essex : 1987), 194, 203-209 (2014-08-26)
Determination of the solubility of crystalline low molar mass compounds in polymers by differential scanning calorimetry.Timo Rager Journal of pharmaceutical sciences, 103(6), 1673-1679 (2014-04-12)
Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.Sébastien Anthérieu et al.Toxicology and applied pharmacology, 276(1), 63-72 (2014-02-15)
Multiresidue method for the determination of pharmacologically active substances in egg and honey using a continuous solid-phase extraction system and gas chromatography-mass spectrometry.Abdelmonaim Azzouz et al.Food chemistry, 178, 63-69 (2015-02-24)
Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release?Yady J Manrique et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(2), 207-219 (2014-06-18)
Carbamazepine for acute and chronic pain in adults.Nerys Brick Clinical journal of oncology nursing, 15(3), 335-336 (2011-06-01)
In vivo induction of CYP in mice by carbamazepine is independent on PXR.Aiming Liu et al.Pharmacological reports : PR, 67(2), 299-304 (2015-02-26)
A dispersive liquid-liquid micellar microextraction for the determination of pharmaceutical compounds in wastewaters using ultra-high-performace liquid chromatography with DAD detection.Sarah Montesdeoca-Esponda et al.Biomedical chromatography : BMC, 29(3), 353-356 (2014-07-25)
Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders.Robert M Post et al.CNS neuroscience & therapeutics, 17(6), 649-660 (2010-12-17)
Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge.Bokun Lin et al.Journal of hazardous materials, 282, 158-164 (2014-07-30)
Hot-melt extruded drug-loaded rods: evaluation of the mechanical properties for individual dosing via the Solid Dosage Pen.Eva Julia Laukamp et al.International journal of pharmaceutics, 475(1-2), 344-350 (2014-09-10)
[Challenge in genome-wide association study for establishment of personalized medicine: focusing on the pharmacogenomics of warfarin and carbamazepine].Taisei Mushiroda Rinsho byori. The Japanese journal of clinical pathology, 61(5), 422-427 (2013-08-21)
T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.Tai-Ming Ko et al.Expert review of clinical immunology, 8(5), 467-477 (2012-08-14)
Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.Roger Lille-Langøy et al.Toxicology and applied pharmacology, 284(1), 54-64 (2015-02-15)
Depression and anxiety in women with epilepsy during pregnancy and after delivery: a prospective population-based cohort study on frequency, risk factors, medication, and prognosis.Marte Helene Bjørk et al.Epilepsia, 56(1), 28-39 (2014-12-20)
Is the full potential of the biopharmaceutics classification system reached?Christel A S Bergström et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 224-231 (2013-10-01)
Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review.Nynke G L Jager et al.Bioanalysis, 6(18), 2481-2514 (2014-11-12)
Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.Milena Marsoni et al.Ecotoxicology and environmental safety, 108, 52-57 (2014-07-22)
Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis.Qiang-Ping Wang et al.CNS drugs, 25(10), 847-857 (2011-09-23)
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.Sabine Klein et al.Neuropharmacology, 90, 53-62 (2014-12-03)
The roles of variants in human multidrug resistance (MDR1) gene and their haplotypes on antiepileptic drugs response: a meta-analysis of 57 studies.Hui Li et al.PloS one, 10(3), e0122043-e0122043 (2015-03-31)
Identification of prometon, deisopropylprometon, and hydroxyprometon in groundwater by high resolution liquid chromatography/mass spectrometry.C Fernández-Ramos et al.The Science of the total environment, 497-498, 459-466 (2014-08-26)
Analysis of trace organic pollutants in wastewater to assess biodegradation using wrong-way-round ionization in liquid chromatography/tandem mass spectrometry.Lijuan Su et al.Rapid communications in mass spectrometry : RCM, 28(11), 1265-1272 (2014-04-25)
A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy.Konrad J Werhahn et al.Epilepsia, 56(3), 450-459 (2015-02-17)
Characterization of a novel CYP2C9 mutation (1009C>A) detected in a warfarin-sensitive patient.Shun-Bin Luo et al.Journal of pharmacological sciences, 125(2), 150-156 (2014-07-31)
The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.Karsten Nödler et al.International journal of environmental research and public health, 11(10), 10390-10405 (2014-10-14)
Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.Jang Su Jeon et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 76, 94-102 (2014-12-24)
The generation of neutrophils in the bone marrow is controlled by autophagy.S Rožman et al.Cell death and differentiation, 22(3), 445-456 (2014-10-18)
Determination of acacetin in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.Li-hua Fan et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 18-22 (2015-02-24)
Carbamazepine for acute and chronic pain in adults.Philip J Wiffen et al.The Cochrane database of systematic reviews, (1)(1), CD005451-CD005451 (2011-01-21)
Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.Simon Hebeisen et al.Neuropharmacology, 89, 122-135 (2014-09-23)
Simultaneous determination of polar pharmaceuticals and personal care products in biological organs and tissues.Rumi Tanoue et al.Journal of chromatography. A, 1355, 193-205 (2014-06-25)
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.Jean-François Desaphy et al.Experimental neurology, 255, 96-102 (2014-03-13)
Role of wetland organic matters as photosensitizer for degradation of micropollutants and metabolites.Eunkyung Lee et al.Journal of hazardous materials, 276, 1-9 (2014-05-28)
Fetal malformations associated with the use of methylphenobarbital and carbamazepine during pregnancy. Two case reports and review of the literature.Alenka Aksamija et al.Fetal diagnosis and therapy, 25(1), 79-82 (2009-02-17)
Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature.Murugesan Ram Prabahar et al.Hemodialysis international. International Symposium on Home Hemodialysis, 15(3), 407-411 (2011-06-01)
Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.Yoko Nagaya et al.Drug metabolism and pharmacokinetics, 29(5), 419-426 (2014-05-09)
Occurrence of carbamazepine and five metabolites in an urban aquifer.Anna Jurado et al.Chemosphere, 115, 47-53 (2014-02-25)
Interaction of famotidine, an H2 histamine receptor antagonist, with conventional antiepileptic drugs in mice.Mariusz J Świąder et al.Pharmacological reports : PR, 66(3), 485-491 (2014-06-07)
Dissipation of triclosan, triclocarban, carbamazepine and naproxen in agricultural soil following surface or sub-surface application of dewatered municipal biosolids.Abdul Jabbar Al-Rajab et al.The Science of the total environment, 512-513, 480-488 (2015-02-04)
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.Kinga K Borowicz et al.Pharmacological reports : PR, 66(3), 430-435 (2014-06-07)
Pharmacogenetic screening of carbamazepine-induced severe cutaneous allergic reactions.Chaichon Locharernkul et al.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 18(10), 1289-1294 (2011-08-02)
Carbamazepine potentiates the effectiveness of morphine in a rodent model of neuropathic pain.Michael R Due et al.PloS one, 9(9), e107399-e107399 (2014-09-16)
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.Leonie Pothmann et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9720-9735 (2014-07-18)
Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.Thomas H Miller et al.The Science of the total environment, 511, 153-160 (2014-12-30)
Effects of chronic, parental pharmaceutical exposure on zebrafish (Danio rerio) offspring.Michal Galus et al.Aquatic toxicology (Amsterdam, Netherlands), 151, 124-134 (2014-02-15)
Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.Mike De Vrieze et al.Analytical and bioanalytical chemistry, 406(25), 6179-6188 (2014-08-16)
Population pharmacokinetics of oxcarbazepine active metabolite in Chinese children with epilepsy.Jing Peng et al.International journal of clinical pharmacology and therapeutics, 52(8), 684-692 (2014-06-03)
Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.Niraj S Trasi et al.The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys.Mikiko Tsukimoto et al.Biopharmaceutics & drug disposition, 36(1), 15-33 (2014-09-30)
Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis.Wimonchat Tangamornsuksan et al.JAMA dermatology, 149(9), 1025-1032 (2013-07-26)
Effects of Alismatis rhizome on rat cytochrome P450 enzymes.Yi Huang et al.Pharmaceutical biology, 52(6), 681-687 (2014-05-16)
Photocatalytic degradation of carbamazepine in wastewater by using a new class of whey-stabilized nanocrystalline TiO2 and ZnO.D P Mohapatra et al.The Science of the total environment, 485-486, 263-269 (2014-04-15)
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