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Baclofen | CAS:1134-47-0
Baclofen
  • 名称:巴氯芬; 4-氨基-3-(4-氯苯基)-丁酸 | Baclofen
  • CAS号:1134-47-0
  • 别名:beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; Lioresal
  • 分子式:C10H12ClNO2
  • 分子量:213.66
  • EINESC号:214-486-9

产品描述

物理化学性质

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安全数据

危险品标志 T
危险类别码 R61;R25;R36/37/38;R42/43
安全说明书 S52;S22;S36/37/39;S45

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来源 SDS样本
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Bead layering as a process to stabilize nanosuspensions: influence of drug hydrophobicity on nanocrystal reagglomeration following in-vitro release from sugar beads.Pieterjan Kayaert et al.The Journal of pharmacy and pharmacology, 63(11), 1446-1453 (2011-10-13) Formulation and in vitro evaluation of self-emulsifying formulations of Cinnarizine.Shyam Vithlani et al.Drug development and industrial pharmacy, 38(10), 1188-1194 (2011-12-27) [Vertigo in elderly patients. Early therapy chronification]. MMW Fortschritte der Medizin, 153(46), 52-53 (2011-12-08) Comparison of cinnarizine/dimenhydrinate fixed combination with the respective monotherapies for vertigo of various origins: a randomized, double-blind, active-controlled, multicentre study.Ales Hahn et al.Clinical drug investigation, 31(6), 371-383 (2011-03-16) Inhibition of steroid sex hormones release in rats by two Ca2+ channel blockers.F Morad et al.Pharmacological research, 35(3), 177-180 (1997-03-01) Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.Arne-Wulf Scholtz et al.Clinical drug investigation, 32(6), 387-399 (2012-04-18) Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.David Cadagan et al.Anticancer research, 33(10), 4381-4387 (2013-10-15) Improving the prognosis ways of central genesis and management option in infertile women.N Halilova Georgian medical news, (212)(212), 19-23 (2012-12-12) Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).Berit Packert Jensen et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(9-10), 605-609 (2011-02-22) Palladium-catalyzed vinylation of aminals with simple alkenes: a new strategy to construct allylamines.Yinjun Xie et al.Journal of the American Chemical Society, 134(51), 20613-20616 (2012-12-14) Lipid-based formulations solidified via adsorption onto the mesoporous carrier Neusilin® US2: effect of drug type and formulation composition on in vitro pharmaceutical performance.Hywel D Williams et al.Journal of pharmaceutical sciences, 103(6), 1734-1746 (2014-04-18) Novel self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of cinnarizine: design, optimization, and in-vitro assessment.Ahmad Abdul-Wahhab Shahba et al.AAPS PharmSciTech, 13(3), 967-977 (2012-07-05) No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters.Robby Vanspauwen et al.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(3), 497-503 (2011-02-11) Flunarizine-and cinnarizine-induced extrapyramidal reactionsMicheli F, et al. Neurology, 37(5), 881-881 (1987) Simultaneous determination of a novel diphenylpiperazine calcium channel blocker and its four metabolites in rat liver microsomes by liquid chromatography tandem mass spectrometry.Wei Guo et al.Pharmacology, 89(3-4), 201-210 (2012-04-05) Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspensionJorgensen S, et al. Acta Pharmaceutica Sinica. B, 9(1), 194-201 (2019) A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.John S Morrison et al.Journal of pharmaceutical sciences, 103(10), 3022-3032 (2014-07-30) In vitro efficacy of cinnarizine against lymphoma and multiple myeloma.Leonard Christopher Schmeel et al.Anticancer research, 35(2), 835-841 (2015-02-11) [Vertigo. Evidence based therapy of dizziness]. MMW Fortschritte der Medizin, 152(47), 52-53 (2011-01-14) Zebrafish (Danio rerio) embryos as a model for testing proteratogens.Stefan Weigt et al.Toxicology, 281(1-3), 25-36 (2011-01-18) Efficacy and safety of cinnarizine in the prophylaxis of migraine headaches in children: an open, randomized comparative trial with propranolol.Mansoureh Togha et al.Acta neurologica Belgica, 112(1), 51-55 (2012-03-20) Betahistine or Cinnarizine for treatment of Meniere's disease.Jasminka Djelilovic-Vranic et al.Medical archives (Sarajevo, Bosnia and Herzegovina), 66(6), 396-398 (2013-02-16) The effect of pressure on potassium currents in the inner hair cells isolated from guinea-pig cochleaKimitsuki T Acta Neurobiologiae Experimentalis, 73, 521-528 (2013) Colon cancer cell-derived 12 (S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca 2+ signallingStadler S, et al. Cellular and Molecular Life Sciences, 74(10), 1907-1921 (2017) Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: generation of solvent-free drug-polymer solid dispersions.Caiqin Yang et al.Chemical & pharmaceutical bulletin, 60(7), 837-845 (2012-07-14) Bead layering as a process to stabilize nanosuspensions: influence of drug hydrophobicity on nanocrystal reagglomeration following in-vitro release from sugar beads.Pieterjan Kayaert et al.The Journal of pharmacy and pharmacology, 63(11), 1446-1453 (2011-10-13) Improving the prognosis ways of central genesis and management option in infertile women.N Halilova Georgian medical news, (212)(212), 19-23 (2012-12-12) Palladium-catalyzed vinylation of aminals with simple alkenes: a new strategy to construct allylamines.Yinjun Xie et al.Journal of the American Chemical Society, 134(51), 20613-20616 (2012-12-14) Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).Berit Packert Jensen et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(9-10), 605-609 (2011-02-22) Lipid-based formulations solidified via adsorption onto the mesoporous carrier Neusilin® US2: effect of drug type and formulation composition on in vitro pharmaceutical performance.Hywel D Williams et al.Journal of pharmaceutical sciences, 103(6), 1734-1746 (2014-04-18) Novel self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of cinnarizine: design, optimization, and in-vitro assessment.Ahmad Abdul-Wahhab Shahba et al.AAPS PharmSciTech, 13(3), 967-977 (2012-07-05) Is the amorphous fraction of a dried nanosuspension caused by milling or by drying? A case study with Naproxen and Cinnarizine.Pieterjan Kayaert et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(3), 650-656 (2012-05-15) Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems.Mette D Mosgaard et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 493-500 (2015-07-15) Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomachRaghuvanshi S and Pathak K Journal of Drug Delivery, 201 (2014) RS-WebPredictor: a server for predicting CYP-mediated sites of metabolism on drug-like molecules.Jed Zaretzki et al.Bioinformatics (Oxford, England), 29(4), 497-498 (2012-12-18) Simultaneous determination of a novel diphenylpiperazine calcium channel blocker and its four metabolites in rat liver microsomes by liquid chromatography tandem mass spectrometry.Wei Guo et al.Pharmacology, 89(3-4), 201-210 (2012-04-05) No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters.Robby Vanspauwen et al.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(3), 497-503 (2011-02-11) [Vertigo. Evidence based therapy of dizziness]. MMW Fortschritte der Medizin, 152(47), 52-53 (2011-01-14) Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.David Cadagan et al.Anticancer research, 33(10), 4381-4387 (2013-10-15) Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.Arne-Wulf Scholtz et al.Clinical drug investigation, 32(6), 387-399 (2012-04-18) Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspensionJorgensen S, et al. Acta Pharmaceutica Sinica. B, 9(1), 194-201 (2019) A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.John S Morrison et al.Journal of pharmaceutical sciences, 103(10), 3022-3032 (2014-07-30) In vitro efficacy of cinnarizine against lymphoma and multiple myeloma.Leonard Christopher Schmeel et al.Anticancer research, 35(2), 835-841 (2015-02-11) Colon cancer cell-derived 12 (S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca 2+ signallingStadler S, et al. Cellular and Molecular Life Sciences, 74(10), 1907-1921 (2017) Efficacy and safety of cinnarizine in the prophylaxis of migraine headaches in children: an open, randomized comparative trial with propranolol.Mansoureh Togha et al.Acta neurologica Belgica, 112(1), 51-55 (2012-03-20) Zebrafish (Danio rerio) embryos as a model for testing proteratogens.Stefan Weigt et al.Toxicology, 281(1-3), 25-36 (2011-01-18) The effect of pressure on potassium currents in the inner hair cells isolated from guinea-pig cochleaKimitsuki T Acta Neurobiologiae Experimentalis, 73, 521-528 (2013) Betahistine or Cinnarizine for treatment of Meniere's disease.Jasminka Djelilovic-Vranic et al.Medical archives (Sarajevo, Bosnia and Herzegovina), 66(6), 396-398 (2013-02-16) Use of the co-grinding method to enhance the dissolution behavior of a poorly water-soluble drug: generation of solvent-free drug-polymer solid dispersions.Caiqin Yang et al.Chemical & pharmaceutical bulletin, 60(7), 837-845 (2012-07-14) Aggravation of Parkinson's disease by cinnarizine.Masso JFM, et al. Journal of Neurology, Neurosurgery, and Psychiatry, 50(6), 804-805 (1987)
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