没有数据	没有数据

没有数据	没有数据

来源	SDS样本
Sigma-Aldrich	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages.Etimad A Huwait et al.Journal of cellular biochemistry, 116(9), 2032-2038 (2015-03-11) Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.Congcong Shen et al.EBioMedicine, 16, 238-250 (2017-02-06) Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.Cynthia Hong et al.Journal of lipid research, 52(3), 531-539 (2010-12-29) Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.Kosuke Dodo et al.Bioorganic & medicinal chemistry, 16(8), 4272-4285 (2008-03-18) Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.I L M H Aye et al.Placenta, 32(2), 183-191 (2011-01-07) Induction of DKK1 by ox-LDL negatively regulates intracellular lipid accumulation in macrophages.Yu Zhang et al.FEBS letters, 589(1), 52-58 (2014-12-02) A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.Houssein S Abdou et al.Molecular and cellular biology, 34(23), 4257-4271 (2014-09-17) Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.Chih-Pin Chuu et al.Anticancer research, 30(9), 3643-3648 (2010-10-15) Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.Hitoshi Kotani et al.Journal of natural products, 73(8), 1332-1336 (2010-08-11) Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.Tatsuhiko Adachi et al.Molecular pharmaceutics, 6(6), 1678-1688 (2009-07-11) Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.Ikuya Sagimori et al.Bioorganic & medicinal chemistry, 28(3), 115298-115298 (2020-01-07) Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.Jing-Min Wang et al.Molecular and cellular biochemistry, 399(1-2), 7-15 (2014-10-05) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.WenChieh Chen et al.Experimental dermatology, 19(5), 470-472 (2010-03-27) Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.Suticha Kittayaruksakul et al.American journal of physiology. Renal physiology, 302(5), F552-F560 (2011-12-16) Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol.Shiro Hiramitsu et al.Frontiers in endocrinology, 9, 470-470 (2018-09-08) Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells.Sunhapas Soodvilai et al.American journal of physiology. Renal physiology, 303(12), F1610-F1616 (2012-10-19) Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.Hiranthi Jayasuriya et al.Journal of natural products, 68(8), 1247-1252 (2005-08-30) Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes.Lourdes Cruz-Garcia et al.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 160(2), 125-136 (2011-06-04) Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.Patricia Pereiro et al.Antiviral research, 145, 146-159 (2017-08-10) A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.Lawrence O Olala et al.Molecular and cellular endocrinology, 366(1), 31-37 (2012-11-28) 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide.Zhi-Xing Yao et al.Journal of neurochemistry, 83(5), 1110-1119 (2002-11-20) Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.V Papadopoulos et al.Journal of neuroendocrinology, 24(1), 93-101 (2011-06-01) Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet.Jingsong Ou et al.Circulation research, 97(11), 1190-1197 (2005-10-15) Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo.Ravinder Kumar et al.Experimental dermatology, 21(11), 853-858 (2012-11-21) Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.Hirohisa Minagawa et al.Journal of neuroscience research, 87(11), 2498-2508 (2009-03-28) Endocrine activity of extraembryonic membranes extends beyond placental amniotes.Lori C Albergotti et al.PloS one, 4(5), e5452-e5452 (2009-05-09) Regulation of adrenal and ovarian steroidogenesis by miR-132.Zhigang Hu et al.Journal of molecular endocrinology, 59(3), 269-283 (2017-07-22) Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.Jaspreet Sandhu et al.Cell, 175(2), 514-529 (2018-09-18) Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.Hiroaki Fukumoto et al.The Journal of biological chemistry, 277(50), 48508-48513 (2002-10-18) Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.Diego Crespo et al.Biology of reproduction, 86(1), 1-12 (2011-09-02) COMarko Tarvainen et al.Journal of agricultural and food chemistry, 64(51), 9653-9662 (2016-12-16) 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder.Jing-Min Wang et al.Biochemical and biophysical research communications, 447(1), 152-157 (2014-04-08) Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.Emmanuelle Sarzi et al.Human molecular genetics, 25(12), 2539-2551 (2016-06-05) The human placenta expresses CYP17 and generates androgens de novo.J C Escobar et al.The Journal of clinical endocrinology and metabolism, 96(5), 1385-1392 (2011-02-11) Dysregulation of SREBP2 induces BACE1 expression.Raffaella Mastrocola et al.Neurobiology of disease, 44(1), 116-124 (2011-07-06) Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human.Nina Hallmark et al.Environmental health perspectives, 115(3), 390-396 (2007-04-14) LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.Cynthia Hong et al.Journal of lipid research, 53(6), 1126-1133 (2012-03-29) A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo.Laurent Lecanu et al.Steroids, 77(3), 224-232 (2011-12-06) A Dioxygenase Catalyzes Steroid 16α-Hydroxylation in Steroidal Glycoalkaloid Biosynthesis.Masaru Nakayasu et al.Plant physiology, 175(1), 120-133 (2017-07-30) Oxysterol-induced soluble endoglin release and its involvement in hypertension.Ana C Valbuena-Diez et al.Circulation, 126(22), 2612-2624 (2012-11-01) Nuclear receptors and lipid physiology: opening the X-files.A Chawla et al.Science (New York, N.Y.), 294(5548), 1866-1870 (2001-12-01) Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.Marianne Demerjian et al.Experimental dermatology, 18(7), 643-649 (2009-02-25) LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.Ali El Roz et al.Anticancer research, 32(7), 3007-3013 (2012-07-04) Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages.Stephanie Schaffer et al.Biochemical pharmacology, 86(2), 279-285 (2013-05-15) Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.Louise Ménégaut et al.Cell reports, 31(7), 107665-107665 (2020-05-21) Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol.Eili Tranheim Kase et al.Lipids, 47(5), 483-493 (2012-03-20) Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes.Yan Weng et al.International immunopharmacology, 55, 28-37 (2017-12-09) Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.Kazutaka Nanba et al.Endocrinology, 156(5), 1750-1756 (2015-02-14) Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.Natalia Mast et al.The Journal of biological chemistry, 286(7), 5607-5613 (2010-12-17) Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.Lawrence O Olala et al.Molecular and cellular endocrinology, 392(1-2), 173-181 (2014-05-27) The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism.Nina Pettersen Hessvik et al.The Journal of steroid biochemistry and molecular biology, 128(3-5), 154-164 (2011-11-05) Conversion of exogenous cholesterol into glycoalkaloids in potato shoots, using two methods for sterol solubilisation.Erik V Petersson et al.PloS one, 8(12), e82955-e82955 (2013-12-19) Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.Sheo B Singh et al.Bioorganic & medicinal chemistry letters, 15(11), 2824-2828 (2005-05-25) Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.Julie Dufour et al.PloS one, 8(3), e58876-e58876 (2013-04-05) HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.Svetlana Fa et al.Toxicology and applied pharmacology, 282(1), 20-29 (2014-12-03) Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1).Xiumei Han et al.Toxicology in vitro : an international journal published in association with BIBRA, 60, 383-388 (2019-05-28) Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR.Linara Gabitova et al.Cell reports, 12(11), 1927-1938 (2015-09-08) LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.Fulvio Morello et al.Atherosclerosis, 207(1), 38-44 (2009-05-12) Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.Elaine M Quinet et al.Journal of lipid research, 45(10), 1929-1942 (2004-08-05) Effects of mancozeb, metalaxyl and tebuconazole on steroid production by bovine luteal cells in vitro.Nurgul Atmaca et al.Environmental toxicology and pharmacology, 59, 114-118 (2018-03-21) Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.Kenichi Matsushita et al.The Journal of biological chemistry, 285(16), 11974-11982 (2010-02-02) Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.Cinzia Casella et al.Gynecologic oncology, 135(2), 333-341 (2014-08-20) Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.Mercedes Mori Sequeiros García et al.Chemico-biological interactions, 199(3), 185-191 (2012-09-04) BDE-47 Decreases Progesterone Levels in BeWo Cells by Interfering with Mitochondrial Functions and Genes Related to Cholesterol Transport.Anqi Shan et al.Chemical research in toxicology, 32(4), 621-628 (2019-02-05)

备注