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Tranilast and hypertensive heart disease: further insights into mechanisms of an anti-inflammatory and anti-fibrotic drug.Thiemo Pfab et al.Journal of hypertension, 22(5), 883-886 (2004-04-21) Tranilast inhibits the function of cancer-associated fibroblasts responsible for the induction of immune suppressor cell types.Y Ohshio et al.Scandinavian journal of immunology, 80(6), 408-416 (2014-09-17) Prolonged Distribution of Tranilast in the Eyes after Topical Application onto Eyelid Skin.Gerard Lee See et al.Chemical & pharmaceutical bulletin, 68(8), 779-783 (2020-08-04) Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.P Thapak et al.Neurochemistry international, 139, 104783-104783 (2020-07-12) Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice.Eman Said et al.Inflammopharmacology, 20(2), 77-87 (2012-01-27) Less contribution of mast cells to the progression of renal fibrosis in Rat kidneys with chronic renal failure.Asuka Baba et al.Nephrology (Carlton, Vic.), 22(2), 159-167 (2016-02-04) The Histone Deacetylase Inhibitor Valproic Acid Sensitizes Gemcitabine-Induced Cytotoxicity in Gemcitabine-Resistant Pancreatic Cancer Cells Possibly Through Inhibition of the DNA Repair Protein Gamma-H2AX.Yufeng Wang et al.Targeted oncology, 10(4), 575-581 (2015-05-06) Mast cell involvement in the progression of peritoneal fibrosis in rats with chronic renal failure.Itsuro Kazama et al.Nephrology (Carlton, Vic.), 20(9), 609-616 (2015-04-18) Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine.Yasuhiko Ohshio et al.Cancer science, 106(2), 134-142 (2014-12-09) MAPK signaling pathways in eye wounds: Multifunction and cooperation.Boyuan Yao et al.Experimental cell research, 359(1), 10-16 (2017-07-04) Production of TRPV2-targeting functional antibody ameliorating dilated cardiomyopathy and muscular dystrophy in animal models.Yuko Iwata et al.Laboratory investigation; a journal of technical methods and pathology, 100(2), 324-337 (2020-01-04) A pilot study of scheduled endoscopic balloon dilation with oral agent tranilast to improve the efficacy of stricture dilation after endoscopic submucosal dissection of the esophagus.Kaname Uno et al.Journal of clinical gastroenterology, 46(9), e76-e82 (2012-09-08) Inhibition of interleukin-1β-induced matrix metalloproteinase expression in human corneal fibroblasts by tranilast.Ye Liu et al.Current eye research, 39(9), 885-893 (2014-03-05) Novel action of 3,4-DAA ameliorating acute liver allograft injury.Qing-Feng Sun et al.Cell biochemistry and function, 29(8), 673-678 (2011-09-21) Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cellsHarigai R, et al. Scientific reports, 8(1), 6069-6069 (2018) Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.Noriaki Minami et al.Cancer medicine, 6(11), 2635-2645 (2017-10-06) Biomarkers for the identification of cardiac fibroblast and myofibroblast cells.Emiri Tarbit et al.Heart failure reviews, 24(1), 1-15 (2018-07-11) Biocompatibility and antifibrotic effect of UV-cross-linked hyaluronate as a release-system for tranilast after trabeculectomy in a rabbit model--a pilot study.Martin S Spitzer et al.Current eye research, 37(6), 463-470 (2012-05-15) Tranilast inhibits the cell growth of normal human keratinocytes in vitro.Miyoko Kubo et al.Archives of dermatological research, 304(9), 745-753 (2012-10-12) Inhibitory Effect of Tranilast on Transforming Growth Factor-Beta-Induced Protein in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts.Tae-Im Kim et al.Cornea, 34(8), 950-958 (2015-05-29) Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells.Colleen S Curran et al.Environmental toxicology and pharmacology, 39(1), 114-124 (2014-12-08) Tranilast inhibits TGF-β-induced collagen gel contraction mediated by human corneal fibroblasts.Ye Liu et al.International journal of ophthalmology, 11(8), 1247-1252 (2018-08-25) Inhibitory Effects of Tranilast on Cytokine, Chemokine, Adhesion Molecule, and Matrix Metalloproteinase Expression in Human Corneal Fibroblasts Exposed to Poly(I:C).Ye Liu et al.Current eye research, 41(11), 1400-1407 (2016-04-27) Tranilast treatment decreases cell growth, migration and inhibits colony formation of human breast cancer cells.Venkateswaran Subramaniam et al.Experimental and molecular pathology, 90(1), 116-122 (2010-11-03) Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.Asuka Baba et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38(1), 15-27 (2016-01-08) Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging.Yukiko Miyazaki et al.Molecular neurobiology, 56(1), 367-377 (2018-04-29) Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis.Suwen Chen et al.Journal of the American Heart Association, 9(12), e015513-e015513 (2020-06-02) Junya Kawai et al.Bioscience, biotechnology, and biochemistry, 83(12), 2280-2287 (2019-08-16)The increasing number of patients suffering from allergic diseases is a global health problem. Grifola frondosa is an edible mushroom consumed as a health food in Asia, and has recently been reported to have anti-allergic effects. We previously reported that... Tranilast induces MiR-200c expression through blockade of RelA/p65 activity in leiomyoma smooth muscle cells.Tsai-Der Chuang et al.Fertility and sterility, 113(6), 1308-1318 (2020-03-23) Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation.Yelena Glinka et al.Biochemical and biophysical research communications, 425(4), 775-780 (2012-08-14) Mechanisms and interventions in peritoneal fibrosis.Yasuhiko Tomino Clinical and experimental nephrology, 16(1), 109-114 (2011-09-22) TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells.Toshiaki Sawatani et al.American journal of physiology. Cell physiology, 316(3), C434-C443 (2019-01-17) Lysozyme as the anti-proliferative agent to block the interaction between S100A6 and the RAGE V domain.Md Imran Khan et al.PloS one, 14(5), e0216427-e0216427 (2019-05-10) Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid.Ken Fukuda et al.Cornea, 30(12), 1491-1494 (2011-11-10) TRPC5 regulates axonal outgrowth in developing retinal ganglion cells.Mai Oda et al.Laboratory investigation; a journal of technical methods and pathology, 100(2), 297-310 (2019-12-18) Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action.Lewis A Quayle et al.Oncotarget, 8(51), 88670-88688 (2017-11-29) Tranilast inhibits interleukin-33 production by macrophages.Sachiko Hiraide et al.European journal of pharmacology, 818, 235-240 (2017-11-07) Exploring the interaction between the antiallergic drug, tranilast and human serum albumin: Insights from calorimetric, spectroscopic and modeling studies.Saad Tayyab et al.International journal of pharmaceutics, 491(1-2), 352-358 (2015-07-05) Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function.Md Soriful Islam et al.The Journal of clinical endocrinology and metabolism, 99(5), E775-E785 (2014-03-13) Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1.Chateen Krueger et al.PloS one, 5(11), e15511-e15511 (2010-12-15) Suppression of the allogeneic response by the anti-allergy drug N-(3,4-dimethoxycinnamonyl) anthranilic acid results from T-cell cycle arrest.Sarah S Zaher et al.Immunology, 138(2), 157-164 (2012-11-06) Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.Natsuko Kageyama-Yahara et al.FEBS letters, 584(1), 111-118 (2009-11-12) Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain.Shiori Sugawara et al.International journal of molecular sciences, 20(24) (2019-12-22) Case in which tranilast ophthalmic solution was thought to be effective for the prevention of symblepharon and recurrence after pterygium surgery.Akira Tsuji et al.The Tokai journal of experimental and clinical medicine, 36(4), 120-123 (2011-12-15) Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells.Longfei Gao et al.Scientific reports, 9(1), 3462-3462 (2019-03-07) Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction.Yosuke Nakatani et al.Journal of the American College of Cardiology, 61(5), 582-588 (2013-01-01) TRPV2 channel inhibitors attenuate fibroblast differentiation and contraction mediated by keratinocyte-derived TGF-β1 in an in vitro wound healing model of rats.Taro Ishii et al.Journal of dermatological science, 90(3), 332-342 (2018-04-04) Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation.Kodappully S Siveen et al.Scientific reports, 9(1), 1554-1554 (2019-02-09) Tranilast could has potential therapeutic value in the treatment of psoriasis.Kamran Mansouri et al.Medical hypotheses, 76(2), 217-219 (2010-10-30) Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System.Kinga Fanni Tóth et al.Molecules (Basel, Switzerland), 24(5) (2019-03-09) Atypical clinical appearance of eosinophilic pustular folliculitis of seborrheic areas of the face.Yumi Matsumura et al.European journal of dermatology : EJD, 22(5), 658-662 (2012-09-04) Tranilast inhibits cardiac allograft vasculopathy in association with p21waf1/cip1 expression on neointimal cells in murine cardiac transplantation modelIzawa A, et al. Arteriosclerosis, Thrombosis, and Vascular Biology, 21(7), 1172-1178 (2001) Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin.Koichi Ogura et al.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 17(2), 194-198 (2011-05-12) Lupus miliaris disseminatus faciei successfully treated with tranilast: report of two cases.Yumi Koike et al.The Journal of dermatology, 38(6), 588-592 (2011-06-01) Safer approaches to therapeutic modulation of TGF-β signaling for respiratory disease.Philippe Lachapelle et al.Pharmacology & therapeutics, 187, 98-113 (2018-02-21) Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.Ritsuko Harigai et al.Scientific reports, 8(1), 6069-6069 (2018-04-19) Tranilast Inhibits Genes Functionally Involved in Cell Proliferation, Fibrosis, and Epigenetic Regulation and Epigenetically Induces miR-29c Expression in Leiomyoma Cells.Tsai-Der Chuang et al.Reproductive sciences (Thousand Oaks, Calif.), 24(9), 1253-1263 (2017-01-25) Tranilast: a pharmaceutical candidate for reduction of adhesions using a novel approach.Janel Petrilli et al.Seminars in reproductive medicine, 26(4), 341-348 (2008-08-30) Effect of TJN-331 on anti-Thy1 nephritis in rats via inhibition of transforming growth factor-β1 production.Yayoi Saegusa et al.Biological & pharmaceutical bulletin, 33(10), 1710-1715 (2010-10-12) Tranilast binds to aβ monomers and promotes aβ fibrillation.Christopher R Connors et al.Biochemistry, 52(23), 3995-4002 (2013-05-18) Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders.Moshe Rogosnitzky et al.Anticancer research, 32(7), 2471-2478 (2012-07-04) Tranilast enhances the anti-tumor effects of tamoxifen on human breast cancer cells in vitro.Sara Darakhshan et al.Journal of biomedical science, 20, 76-76 (2013-10-23) Olopatadine ophthalmic solution suppresses substance P 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creates interstitial cystitis-like symptoms with increased vascular permeability.Saori Nishijima et al.Life sciences, 93(23), 897-903 (2013-10-26) Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist.Gérald J Prud'homme et al.PloS one, 5(11), e13831-e13831 (2010-11-13) Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men.Henrik Brovold et al.Scientific reports, 9(1), 10513-10513 (2019-07-22) Tranilast enhances the effect of anticancer agents in osteosarcoma.Takayuki Nakashima et al.Oncology reports, 42(1), 176-188 (2019-05-07) Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.Shin Mukai et al.PloS one, 13(10), e0203742-e0203742 (2018-10-12) Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage.Charlotte Lorin et al.Cardiovascular research, 106(1), 153-162 (2015-01-27) Stable dry powder inhaler 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