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Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.Han-Ming Wang et al.Canadian journal of physiology and pharmacology, 90(11), 1506-1515 (2012-11-28) Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo.Chin-Chang Cheng et al.International journal of molecular sciences, 20(6) (2019-03-27) Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension.Amal Houssaini et al.American journal of respiratory cell and molecular biology, 48(5), 568-577 (2013-03-09) Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition.Silvia Cantoni et al.The FEBS journal, 280(9), 2042-2055 (2013-03-08) Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.Satoshi Matsuo et al.The Journal of thoracic and cardiovascular surgery, 149(3), 902-909 (2014-12-03) Plasma biomarkers of pulmonary hypertension identified by Fourier transform infrared spectroscopy and principal component analysis.Emilia Staniszewska-Slezak et al.The Analyst, 140(7), 2273-2279 (2015-01-21) Regorafenib suppresses sinusoidal obstruction syndrome in rats.Masayuki Okuno et al.The Journal of surgical research, 193(2), 693-703 (2014-10-01) Mechanisms and pathology of monocrotaline pulmonary toxicity.D W Wilson et al.Critical reviews in toxicology, 22(5-6), 307-325 (1992-01-01) Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat.Edward A Pankey et al.American journal of physiology. Heart and circulatory physiology, 305(9), H1288-H1296 (2013-09-03) Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.Yongguang Xiao et al.Arteriosclerosis, thrombosis, and vascular biology, 33(12), 2733-2739 (2013-09-28) Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension.Emily A Gray et al.Journal of synchrotron radiation, 20(Pt 5), 756-764 (2013-08-21) Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil.Stephan Schroll et al.Respiratory physiology & neurobiology, 186(1), 61-64 (2012-12-19) Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits.Lei Zhou et al.Circulation, 128(9), 982-994 (2013-07-12) Iptakalim ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.Junshan Li et al.Journal of cardiovascular pharmacology and therapeutics, 18(1), 60-69 (2012-09-06) [Inhibitory effect of nitric oxide-induced total ginsenosides on right ventricular hypertrophy in rats].Na Qin et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3353-3357 (2014-01-16) Additive effect of tadalafil and simvastatin on monocrotaline-induced pulmonary hypertension rats.Wei-Hua Zhang et al.Scandinavian cardiovascular journal : SCJ, 46(6), 374-380 (2012-09-14) Sildenafil improves long-term effect of endothelial progenitor cell-based treatment for monocrotaline-induced rat pulmonary arterial hypertension.Chia-Hung Yen et al.Cytotherapy, 15(2), 209-223 (2013-01-17) Sulfur conjugates as putative pneumotoxic metabolites of the pyrrolizidine alkaloid, monocrotaline.R J Huxtable et al.Advances in experimental medicine and biology, 283, 605-612 (1991-01-01) Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys.C R M Pessoa et al.Toxicon : official journal of the International Society on Toxinology, 71, 113-120 (2013-06-04) Right ventricular electrical remodeling and arrhythmogenic substrate in rat pulmonary hypertension.Yoshihiro Tanaka et al.American journal of respiratory cell and molecular biology, 49(3), 426-436 (2013-04-23) Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite.R A Roth et al.Advances in experimental medicine and biology, 283, 477-487 (1991-01-01) The Japanese toxicogenomics project: application of toxicogenomics.Takeki Uehara et al.Molecular nutrition & food research, 54(2), 218-227 (2009-12-31) Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.Jolyane Meloche et al.Journal of the American Heart Association, 2(1), e005157-e005157 (2013-03-26) [Protective effects of rosiglitazone intervention on monocrotaline-induced pulmonary arterial hypertension in rats and related inflammatory mechanisms].Xiao-fang Wang et al.Zhonghua yi xue za zhi, 92(30), 2144-2147 (2012-11-20) [Monocrotaline-induced pulmonary hypertension in animals].Y Tanino Nihon rinsho. Japanese journal of clinical medicine, 59(6), 1076-1080 (2001-06-20) Anti-Endothelin Receptor Type A Autoantibodies in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension.Li Guo et al.Arthritis & rheumatology (Hoboken, N.J.), 67(9), 2394-2402 (2015-05-29) Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.Jun Yang et al.Arteriosclerosis, thrombosis, and vascular biology, 33(1), 34-42 (2012-11-10) Effect of small hairpin RNA targeting endothelin-converting enzyme-1 in monocrotaline-induced pulmonary hypertensive rats.Jae Sung Son et al.Journal of Korean medical science, 27(12), 1507-1516 (2012-12-21) Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.Jongmin Kim et al.Circulation, 131(2), 190-199 (2014-10-23) The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerineGunaydin S, et al. Cardiovascular Surgery (London, England), 10(2), 138-145 (2002) New aspect of plant-rhizobia interaction: alkaloid biosynthesis in Crotalaria depends on nodulation.Simon Irmer et al.Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4164-4169 (2015-03-17) Endothelial cell global positioning system for pulmonary arterial hypertension: homing in on vascular repair.Natasha M Rogers et al.Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1336-1338 (2014-06-22) Arginase inhibition protects against hypoxia‑induced pulmonary arterial hypertension.Wenjin Jiang et al.Molecular medicine reports, 12(3), 4743-4749 (2015-07-02) Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension.Rachel Stones et al.Journal of molecular and cellular cardiology, 56, 91-96 (2012-12-25) Cervical ganglion block attenuates the progression of pulmonary hypertension via nitric oxide and arginase pathways.Sungwon Na et al.Hypertension (Dallas, Tex. : 1979), 63(2), 309-315 (2013-12-11) Blockade of frontocortical-brain stem pathway prevents ventricular fibrillation of ischemic heartSkinner JE and Reed JC American Journal of Physiology. Heart and Circulatory Physiology, 240(2), H156-H163 (1981) Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor.Yahan Liu et al.Hypertension (Dallas, Tex. : 1979), 60(6), 1471-1478 (2012-10-31) Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.Emmy Manders et al.American journal of physiology. Lung cellular and molecular physiology, 303(12), L1070-L1078 (2012-09-11) Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension.Takeshi Ogo et al.American journal of respiratory cell and molecular biology, 48(6), 733-741 (2013-02-19) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.Irina Enache et al.Molecular and cellular biochemistry, 373(1-2), 161-170 (2012-10-27) NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling.Scott A Barman et al.Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1704-1715 (2014-06-21) Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.Abigail S Forrest et al.American journal of physiology. Cell physiology, 303(12), C1229-C1243 (2012-10-05) Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments.Lan Zhao et al.Circulation, 128(11), 1214-1224 (2013-08-01) A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats.R Conotte et al.Toxicology and applied pharmacology, 276(2), 147-156 (2014-03-04) Chymase inhibition attenuates monocrotaline-induced sinusoidal obstruction syndrome in hamsters.S Masubuchi et al.Current medicinal chemistry, 20(21), 2723-2729 (2013-03-26) Mitochondrial hyperpolarization in pulmonary vascular remodeling. 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Part B, Critical reviews, 1(4), 271-346 (1998-10-20) Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells.Aya Yamamura et al.Circulation research, 112(4), 640-650 (2013-01-10) [Study on determination method for components in monocrotalinum liposomes and their entrapment efficiency].Yang Xiong et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(20), 3489-3492 (2014-02-05) Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.Valentina Biasin et al.The international journal of biochemistry & cell biology, 54, 137-148 (2014-07-13) Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.Basar Sirmagul et al.Clinical and experimental hypertension (New York, N.Y. : 1993), 35(3), 220-227 (2012-09-13) Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats.Yoshiro Naito et al.Biochemical and biophysical research communications, 436(2), 145-151 (2013-05-28) Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model.Magdalena Strobl et al.American journal of physiology. Lung cellular and molecular physiology, 305(7), L485-L490 (2013-07-31) Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.Bin He et al.Molecular biology reports, 40(9), 5513-5521 (2013-08-21) Nodular lesions and mesangiolysis in diabetic nephropathy.Takashi Wada et al.Clinical and experimental nephrology, 17(1), 3-9 (2012-10-27) Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.Alexander H Nave et al.Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1446-1458 (2014-05-17) 3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation.Jie Liu et al.Chinese medical journal, 133(1), 49-60 (2020-01-11) The monocrotaline model of pulmonary hypertension in perspective.Jose G Gomez-Arroyo et al.American journal of physiology. Lung cellular and molecular physiology, 302(4), L363-L369 (2011-10-04)

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