水溶性	不溶
沸点	284 ºC
闪点	110 ºC
密度	1.18
折射率	1.577-1.58

安全说明书	S24/25

来源	SDS样本
Sigma-Aldrich	浏览或下载
Acros-Organics	浏览或下载
Strem	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Henrik Sahlin Pettersen et al.Nucleic acids research, 39(19), 8430-8444 (2011-07-13) Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.Rita Humeniuk et al.Molecular cancer therapeutics, 8(5), 1045-1054 (2009-04-23) UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Henrik Sahlin Pettersen et al.Nucleic acids research, 39(19), 8430-8444 (2011-07-13) UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.Akos Gyenis et al.PLoS genetics, 10(7), e1004483-e1004483 (2014-07-25) Diverse gene expression pattern during 5-fluorouridine-induced apoptosis.Thomas D Schmittgen et al.International journal of oncology, 27(2), 297-306 (2005-07-13) A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.Davendra Sohal et al.American journal of cancer research, 10(9), 3047-3060 (2020-10-13) Bisphosphonate derivatives of nucleoside antimetabolites: hydrolytic stability and hydroxyapatite adsorption of 5'-beta,gamma-methylene and 5'-beta,gamma-(1-hydroxyethylidene) triphosphates of 5-fluorouridine and ara-cytidine.Mikko Ora et al.The Journal of organic chemistry, 73(11), 4123-4130 (2008-05-14) Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.Rita Humeniuk et al.Molecular cancer therapeutics, 8(5), 1037-1044 (2009-04-23) Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5'-fluorouridine into nascent RNA.I Casafont et al.Neuroscience, 140(2), 453-462 (2006-03-28) Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.Rita Humeniuk et al.Molecular cancer therapeutics, 8(5), 1045-1054 (2009-04-23) Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.Mingjie Chen et al.The Plant cell, 23(8), 2991-3006 (2011-08-11) Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.M Barberi-Heyob et al.Cancer chemotherapy and pharmacology, 37(1-2), 110-116 (1995-01-01) Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.Delphine Carli et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 2937-2944 (2009-07-22) The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.Björn Titz et al.FEMS microbiology letters, 270(1), 49-57 (2007-02-09) Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.Angelica M Bello et al.Journal of medicinal chemistry, 52(6), 1648-1658 (2009-03-06) The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation.Ales Obrdlik et al.Nucleus (Austin, Tex.), 2(1), 72-79 (2011-06-08) Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos.Yun Fei Diao et al.PloS one, 9(6), e100205-e100205 (2014-06-14) Gemcitabine treatment of rat soft tissue sarcoma with phosphatidyldiglycerol-based thermosensitive liposomes.Simone Limmer et al.Pharmaceutical research, 31(9), 2276-2286 (2014-03-07) Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs.Stephen Hanessian et al.Bioorganic & medicinal chemistry, 16(6), 2921-2931 (2008-01-30) A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.Alexander J Webb et al.Journal of bacteriology, 188(23), 8005-8012 (2006-09-26) Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.Olaf H Temmink et al.The international journal of biochemistry & cell biology, 39(3), 565-575 (2006-11-14) Halogenated nucleotide labeling of nascent RNAs reveals dynamic transcription in growing pig oocytes.Reza K Oqani et al.Developmental dynamics : an official publication of the American Association of Anatomists, 242(1), 16-22 (2012-11-20) Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro.Kara L Vine et al.Bioorganic & medicinal chemistry letters, 20(9), 2908-2911 (2010-04-07) Fluctuations of pol I and fibrillarin contents of the nucleoli.M Hornáček et al.Nucleus (Austin, Tex.), 8(4), 421-432 (2017-06-18) RP-LC determination of 5-fluorouridine in nanoparticulate formulations.P Arbós et al.Journal of pharmaceutical and biomedical analysis, 28(5), 857-866 (2002-06-01) Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.Niki Tzioumaki et al.European journal of medicinal chemistry, 46(4), 993-1005 (2011-02-19) TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.Iñigo Casafont et al.Journal of structural biology, 167(3), 235-241 (2009-06-23) Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.Iñigo Casafont et al.Neurotoxicity research, 17(2), 167-178 (2009-07-18) Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta.P M Ellery et al.Placenta, 30(4), 329-334 (2009-02-14) Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.P V Sahasrabudhe et al.Nucleic acids research, 23(19), 3916-3921 (1995-10-11) Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.Ellen J B Derissen et al.Journal of pharmaceutical and biomedical analysis, 110, 58-66 (2015-03-26) Inhibition of RNA synthesis by 5-fluorouridine accounts for its cyto toxicity on colorectal cancer cells in vitroSubbarayan PR, et al. Cancer Research, 65(9) (2005) Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films.Alvaro A A de Queiroz et al.Acta biomaterialia, 2(6), 641-650 (2006-08-01) Life time of some RNA products of rDNA intergenic spacer in HeLa cells.T Vacík et al.Histochemistry and cell biology, 152(4), 271-280 (2019-07-28) Inhibition of RNA synthesis by 5-fluorouridine accounts for its cyto toxicity on colorectal cancer cells in vitroSubbarayan PR, et al. Cancer research, 65(9) (2005) Novel and highly regioselective route for synthesis of 5-fluorouridine lipophilic ester derivatives by lipozyme TL IM.Huai Wang et al.Journal of biotechnology, 129(4), 689-695 (2007-03-21) The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA.Marguerite K McDonald et al.Biochemistry, 50(3), 426-436 (2010-12-15) Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.Karita Peltonen et al.Molecular cancer therapeutics, 13(11), 2537-2546 (2014-10-04) The fluorouridine insensitive 1 (fur1) mutant is defective in equilibrative nucleoside transporter 3 (ENT3), and thus represents an important pyrimidine nucleoside uptake system in Arabidopsis thaliana.Michaela Traub et al.The Plant journal : for cell and molecular biology, 49(5), 855-864 (2007-01-27) The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another.Edward J Miracco et al.Journal of the American Chemical Society, 133(31), 11826-11829 (2011-07-13) Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli.Terezie Imrichova et al.Aging, 11(17), 7206-7235 (2019-09-08) Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.Nikolaos Tsesmetzis et al.Cancers, 10(7) (2018-07-26) Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy.Erik Schleicher et al.The FEBS journal, 272(8), 1855-1866 (2005-04-12) Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine.Christopher S Hamilton et al.Biochemistry, 45(39), 12029-12038 (2006-09-28) Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.Mingjie Chen et al.The Plant cell, 23(8), 2991-3006 (2011-08-11)

备注