5'-Chloro-2'-hydroxyacetophenone | CAS:1450-74-4
5'-Chloro-2'-hydroxyacetophenone
- 名称:2'-羟基-5'-氯苯乙酮 | 5'-Chloro-2'-hydroxyacetophenone
- CAS号:1450-74-4
- 别名:2'-Hydroxy-5'-chloroacetophenone; 1-(5-Chloro-2-hydroxyphenyl)ethanone
- 分子式:C8H7ClO2
- 分子量:170.59
- EINESC号:215-916-8
产品描述
物理化学性质
熔点 | 53 ºC |
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沸点 | 126-128 ºC (28 torr) |
安全数据
危险品标志 | Xi |
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危险类别码 | R36/37/38 |
安全说明书 | S26;S37/39 |
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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?Alex Avdeef et al.Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09)
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.Gustav Ahlin et al.Journal of medicinal chemistry, 51(19), 5932-5942 (2008-09-16)
Formulation and in vivo hypoglycemic effect of glipizide solid dispersion.Gayatri C Patel et al.Current drug delivery, 9(4), 395-404 (2012-05-30)
[The clinical pharmacology of Minidiab (glipizide) (a review of the literature)].A V Shcherbak Likars'ka sprava, (1)(1), 28-33 (1993-01-01)
Lower risk of hypoglycemia with sitagliptin compared to glipizide when either is added to metformin therapy: a pre-specified analysis adjusting for the most recently measured HbA(1c) value.Karl J Krobot et al.Current medical research and opinion, 28(8), 1281-1287 (2012-06-16)
Glipizide: an oral hypoglycemic drug.G Wensing The American journal of the medical sciences, 298(1), 69-71 (1989-07-01)
Identification of CYP3A7 for glyburide metabolism in human fetal livers.Diana L Shuster et al.Biochemical pharmacology, 92(4), 690-700 (2014-12-03)
In vitro characterization of a novel polymeric system for preparation of amorphous solid drug dispersions.Zahra N Mahmoudi et al.The AAPS journal, 16(4), 685-697 (2014-05-03)
Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs.Rajesh Kulkarni et al.Journal of pharmaceutical sciences, 101(11), 4327-4336 (2012-08-18)
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.Gergana Popova et al.Journal of medicinal chemistry, 63(8), 3915-3934 (2020-03-28)
Effect of Piperazine Dithioctate on the Oral Pharmacokinetics of Glimepiride in Rats.Eun-Yeong Kim et al.Biological & pharmaceutical bulletin, 38(8), 1161-1168 (2015-08-04)
Dapagliflozin: a review of its use in type 2 diabetes mellitus.Greg L Plosker Drugs, 72(17), 2289-2312 (2012-11-23)
Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions.Korbinian Löbmann et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(1), 159-169 (2012-02-23)
Glimepiride reduces CD14 expression and cytokine secretion from macrophages.Victoria Ingham et al.Journal of neuroinflammation, 11, 115-115 (2014-06-24)
Dapagliflozin: a review of its use in type 2 diabetes mellitus.Greg L Plosker Drugs, 72(17), 2289-2312 (2012-11-23)
Formulation and in vivo hypoglycemic effect of glipizide solid dispersion.Gayatri C Patel et al.Current drug delivery, 9(4), 395-404 (2012-05-30)
Rapid extraction, identification and quantification of oral hypoglycaemic drugs in serum and hair using LC-MS/MS.Tina M Binz et al.Forensic science international, 223(1-3), 119-124 (2012-09-04)
A rapid and simple UPLC-MS-MS method for determination of glipizide in human plasma and its application to bioequivalence study.Xiangjun Qiu et al.Journal of chromatographic science, 53(1), 85-89 (2014-04-29)
KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinomaGuo Z, et al. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 36(2), 1251-1259 (2015)
Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.S Zini et al.The Journal of pharmacology and experimental therapeutics, 259(2), 566-573 (1991-11-01)
First-principle, structure-based prediction of hepatic metabolic clearance values in human.Haiyan Li et al.European journal of medicinal chemistry, 44(4), 1600-1606 (2008-09-05)
Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10)
Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.Patrick Masson et al.Biochimica et biophysica acta, 1774(1), 16-34 (2006-12-22)
Comparative study of binding of ovine complement factor H with different Borrelia genospecies.Lucia Kišová-Vargová et al.Folia microbiologica, 57(2), 123-128 (2012-03-01)
Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.Daquan Gao et al.Proteins, 62(1), 99-110 (2005-11-17)
Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents.B D Prendergast Clinical pharmacy, 3(5), 473-485 (1984-09-01)
Resolution of insulin-requiring diabetes in a liver transplant recipient after treatment of a pheochromocytoma: case report and review of literature.E J Gallagher et al.Minerva endocrinologica, 36(4), 341-345 (2012-02-11)
Preparation and in vitro characterization of a non-effervescent floating drug delivery system for poorly soluble drug, glipizide.Venkata Srikanth Meka et al.Acta poloniae pharmaceutica, 72(1), 193-204 (2015-04-09)
Glipizide. A review of the pharmacoeconomic implications of the extended-release formulation in type 2 diabetes mellitus.R H Foster et al.PharmacoEconomics, 18(3), 289-306 (2001-01-09)
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.Fabien Vincent et al.Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24)
Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers.Guiying Cui et al.Pflugers Archiv : European journal of physiology, 463(3), 405-418 (2011-12-14)
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus.Geoffrey A Walford et al.Metabolism: clinical and experimental, 62(12), 1772-1778 (2013-08-21)
Physicochemical determinants of human renal clearance.Manthena V S Varma et al.Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19)
The second generation oral sulfonylureas: glyburide and glipizide.T Kuhn American pharmacy, NS28(10), 55-61 (1988-10-01)
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?Alex Avdeef et al.Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09)
Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions.Korbinian Löbmann et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(1), 159-169 (2012-02-23)
Glimepiride reduces CD14 expression and cytokine secretion from macrophages.Victoria Ingham et al.Journal of neuroinflammation, 11, 115-115 (2014-06-24)
QSAR-based solubility model for drug-like compounds.Rafael Gozalbes et al.Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine.D Raeburn et al.The Journal of pharmacology and experimental therapeutics, 256(2), 480-485 (1991-02-01)
The risk of overall mortality in patients with Type 2 diabetes receiving different combinations of sulfonylureas and metformin: a retrospective analysis.K M Pantalone et al.Diabetic medicine : a journal of the British Diabetic Association, 29(8), 1029-1035 (2012-01-18)
Effect of Piperazine Dithioctate on the Oral Pharmacokinetics of Glimepiride in Rats.Eun-Yeong Kim et al.Biological & pharmaceutical bulletin, 38(8), 1161-1168 (2015-08-04)
Glycemic control was unchanged in Veterans Health Administration patients converted from glyburide to glipizide.Sherrie L Aspinall et al.Journal of managed care pharmacy : JMCP, 18(1), 73-73 (2012-01-13)
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with (99m)Tc-DTPA-glipizide.Chang-Sok Oh et al.Annals of nuclear medicine, 26(3), 253-261 (2012-01-13)
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.Manthena V S Varma et al.Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15)
Combination exenatide-sitagliptin therapy used with glipizide in a patient with type 2 diabetes mellitus.Manav B Patel et al.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 69(12), 1044-1048 (2012-05-31)
Osmotic pellet system comprising osmotic core and in-process amorphized drug in polymer-surfactant layer for controlled delivery of poorly water-soluble drug.Nilesh Saindane et al.Journal of pharmaceutical sciences, 101(9), 3169-3179 (2012-03-16)
[Glipizide a new oral antidiabetic agent (comprehensive review)].E Brunová Vnitrni lekarstvi, 22(6), 595-599 (1976-06-01)
Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.Xing Zhang et al.Biomedical chromatography : BMC, 29(4), 560-569 (2014-08-29)
[The role of glipizide in the treatment of non-insulin dependent diabetes].M Małecki Przeglad lekarski, 53(9), 663-665 (1996-01-01)
Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate.Sanjay Singh et al.Pharmaceutical biology, 52(6), 750-755 (2014-03-13)
Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis.K M Pantalone et al.Diabetes, obesity & metabolism, 14(9), 803-809 (2012-04-11)
Coadministration of co-trimoxazole with sulfonylureas: hypoglycemia events and pattern of use.Alai Tan et al.The journals of gerontology. Series A, Biological sciences and medical sciences, 70(2), 247-254 (2014-05-27)
Glipizide suppresses embryonic vasculogenesis and angiogenesis through targeting natriuretic peptide receptor A.Quliang Gu et al.Experimental cell research, 333(2), 261-272 (2015-04-01)
Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.Diana L Shuster et al.The Journal of pharmacology and experimental therapeutics, 350(2), 425-434 (2014-06-06)
Analysis of glipizide binding to normal and glycated human serum albumin by high-performance affinity chromatography.Ryan Matsuda et al.Analytical and bioanalytical chemistry, 407(18), 5309-5321 (2015-04-29)
The biopharmaceutics of successful controlled release drug product: Segmental-dependent permeability of glipizide vs. metoprolol throughout the intestinal tract.Moran Zur et al.International journal of pharmaceutics, 489(1-2), 304-310 (2015-05-11)
Liquid chromatography - tandem mass spectrometry for the simultaneous quantitation of glipizide, cilostazol and its active metabolite 3, 4-dehydro-cilostazol in rat plasma: application for a pharmacokinetic study.T R S Satheeshmanikandan et al.Arzneimittel-Forschung, 62(9), 425-432 (2012-07-24)
Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacology, pharmacokinetics and clinical use.H E Lebovitz Pharmacotherapy, 5(2), 63-77 (1985-03-01)
Microwave-induced solid dispersion technology to improve bioavailability of glipizide.Jinu Isaac et al.The Journal of pharmacy and pharmacology, 65(2), 219-229 (2013-01-03)
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.Kunal Roy et al.European journal of medicinal chemistry, 44(7), 2913-2922 (2009-01-09)
Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling.Alfredo Juárez-Saldivar et al.International journal of molecular sciences, 21(12) (2020-06-21)
Cost effectiveness of saxagliptin and metformin versus sulfonylurea and metformin in the treatment of type 2 diabetes mellitus in Germany: a Cardiff diabetes model analysis.Wilma Erhardt et al.Clinical drug investigation, 32(3), 189-202 (2012-02-02)
[Glycosuria with SGLT-2 inhibitors--a new treatment approach for type 2 diabetes mellitus].C Rosak et al.MMW Fortschritte der Medizin, 154 Suppl 4, 95-101 (2013-01-19)
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.Mark C Wenlock et al.Bioorganic & medicinal chemistry letters, 21(12), 3550-3556 (2011-05-24)
Severe hypertriglyceridemia and hypercholesterolemia accelerating renal injury: a novel model of type 1 diabetic hamsters induced by short-term high-fat / high-cholesterol diet and low-dose streptozotocin.Liang He et al.BMC nephrology, 16, 51-51 (2015-04-18)
Molecular characteristics for solid-state limited solubility.Carola M Wassvik et al.Journal of medicinal chemistry, 51(10), 3035-3039 (2008-04-10)
Influence of the traditional Brazilian drink Ilex paraguariensis tea on glucose homeostasis.D F Pereira et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(10), 868-877 (2012-07-17)
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).Jenny M Pedersen et al.Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07)
Hypoglycemia in hospitalized patients treated with sulfonylureas.Christina M Deusenberry et al.Pharmacotherapy, 32(7), 613-617 (2012-05-10)
Stimulatory effect of apigenin-6-C-beta-L-fucopyranoside on insulin secretion and glycogen synthesis.Luisa Helena Cazarolli et al.European journal of medicinal chemistry, 44(11), 4668-4673 (2009-07-25)
Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: in vitro and in vivo evaluation.Haiqin Huang et al.International journal of pharmaceutics, 446(1-2), 211-218 (2013-02-02)
Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis.Cuiling Qi et al.Oncotarget, 5(20), 9966-9979 (2014-10-09)
Microwave-generated bionanocomposites for solubility and dissolution enhancement of poorly water-soluble drug glipizide: in-vitro and in-vivo studies.Sachin Shivaji Kushare et al.The Journal of pharmacy and pharmacology, 65(1), 79-93 (2012-12-12)
Bioequivalence Comparison of Two Formulations of Fixed-Dose Combination Glimepiride/Metformin (2/500 mg)Tablets in Healthy Volunteers.Sang-Hoon Jung et al.Iranian journal of pharmaceutical research : IJPR, 13(2), 365-371 (2014-09-23)
Glipizide: a review of its pharmacological properties and therapeutic use.R N Brogden et al.Drugs, 18(5), 329-353 (1979-11-01)
Split calibration curve: an approach to avoid repeat analysis of the samples exceeding ULOQ.Sudipta Basu et al.Bioanalysis, 4(19), 2375-2389 (2012-10-24)
NIDDM in the cat: treatment with the oral hypoglycemic medication, glipizide.S L Ford The Veterinary clinics of North America. Small animal practice, 25(3), 599-615 (1995-05-01)
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.R Scott Obach et al.Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23)
A stewardship intervention program for safe medication management and use of antidiabetic drugs.Rui-yi Zhao et al.Clinical interventions in aging, 10, 1201-1212 (2015-08-01)
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.Xiaofan Sui et al.European journal of medicinal chemistry, 44(11), 4455-4460 (2009-07-10)
Hologram QSAR model for the prediction of human oral bioavailability.Tiago L Moda et al.Bioorganic & medicinal chemistry, 15(24), 7738-7745 (2007-09-18)
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