熔点	230 ºC

安全说明书	S24/25

来源	SDS样本
Alfa-Aesar	浏览或下载
Sigma-Aldrich	浏览或下载
TCI	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Targeting Cellular Metabolism in Acute Myeloid Leukemia and The Role of Patient Heterogeneity.Ida Sofie Grønningsæter et al.Cells, 9(5) (2020-05-13) HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer.Holly Brunton et al.Cell reports, 31(6), 107625-107625 (2020-05-14) Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia.John M Floberg et al.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 61(3), 427-432 (2019-10-06) Metabolic vulnerability of cisplatin-resistant cancers.Florine Obrist et al.The EMBO journal, 37(14) (2018-06-08) Dehydroepiandrosterone inhibits glucose flux through the pentose phosphate pathway in human and mouse endometrial stromal cells, preventing decidualization and implantation.Antonina I Frolova et al.Molecular endocrinology (Baltimore, Md.), 25(8), 1444-1455 (2011-06-18) Metallothionein I + II expression and roles during neuropathology in the CNS.Milena Penkowa Danish medical bulletin, 53(2), 105-121 (2006-11-08) Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis.Fangtao Chi et al.Developmental cell, 53(1), 9-26 (2020-03-21) Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway.Yan Chen et al.Scientific reports, 5, 9925-9925 (2015-04-22) Inhibition of glycogen catabolism induces intrinsic apoptosis and augments multikinase inhibitors in hepatocellular carcinoma cells.Shrikant Barot et al.Experimental cell research, 381(2), 288-300 (2019-05-28) HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress.Brandt A Nichols et al.Cancer research, 78(21), 6196-6208 (2018-09-07) Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling.Debadrita Bhattacharya et al.Developmental cell, 53(2), 199-211 (2020-04-04) Effects of small molecules on chaperone-mediated autophagy.Patrick F Finn et al.Autophagy, 1(3), 141-145 (2006-07-29) Glucose-6-phosphate dehydrogenase (G6PD) activity can modulate macrophage response to Leishmania major infection.Shahrzad Zamani et al.International immunopharmacology, 69, 178-183 (2019-02-05) Glucose-6-phosphate dehydrogenase is critical for suppression of cardiac hypertrophy by H2S.Aastha Chhabra et al.Cell death discovery, 4, 6-6 (2018-03-14) Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.Sachin A Gupte et al.Pulmonary pharmacology & therapeutics, 19(4), 303-309 (2005-10-06) Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy.Wenming Li et al.Nature communications, 8(1), 1763-1763 (2017-11-28) A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction.Richa Bhardwaj et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 32(5), 951-964 (2011-06-11) A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells.Richa Bhardwaj et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 33(4), 1021-1030 (2012-02-14) Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma.Giuseppe Lucarelli et al.Oncotarget, 6(15), 13371-13386 (2015-05-07) A borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water.Hikawa H, et al. Green Chemistry, 20(13), 3044-3049 (2018) Metabolic interaction of hydrogen peroxide and hypoxia in zebrafish fibroblasts.Valentina Dikova et al.Free radical biology & medicine, 152, 469-481 (2019-11-20) Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.Robert P Erickson The Journal of craniofacial surgery, 21(5), 1384-1387 (2010-09-08) Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations.Frank Rolfs et al.Cancer research, 75(22), 4817-4829 (2015-11-05) The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration.Dezhen Tu et al.Journal of neuroinflammation, 16(1), 255-255 (2019-12-07) A bioenergetic shift is required for spermatogonial differentiation.Wei Chen et al.Cell discovery, 6, 56-56 (2020-08-31) The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.Christopher L Hamblett et al.Bioorganic & medicinal chemistry letters, 17(19), 5300-5309 (2007-09-01) Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second.Laurent M Paardekooper et al.Frontiers in immunology, 10, 1216-1216 (2019-06-14) Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes.Jenny Lund et al.Cells, 8(9) (2019-09-22) Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function.Dhwajbahadur K Rawat et al.PloS one, 7(10), e45365-e45365 (2012-10-17) Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.Saif Zaman et al.Molecular cancer therapeutics, 18(8), 1355-1365 (2019-06-15) Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture.Ramazan Kurt et al.PloS one, 10(5), e0125962-e0125962 (2015-05-12) Electrocatalytic synthesis of 6-aminonicotinic acid at silver cathodes under mild conditions.Gennaro A, et al. Electrochemical Communications, 6(7), 627-631 (2004) Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.Rakhee S Gupte et al.Free radical biology & medicine, 47(3), 219-228 (2009-02-24) Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.Eduardo Balsa et al.Nature communications, 11(1), 2714-2714 (2020-06-03) Degradation of AF1Q by chaperone-mediated autophagy.Peng Li et al.Experimental cell research, 327(1), 48-56 (2014-06-01) Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.Jorge Domínguez-Andrés et al.PLoS pathogens, 13(9), e1006632-e1006632 (2017-09-19) Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control.Harish Muniyappa et al.The Journal of biological chemistry, 284(25), 17069-17081 (2009-04-17) LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.Manoj Arra et al.Nature communications, 11(1), 3427-3427 (2020-07-11) Cisplatin Toxicity in Dorsal Root Ganglion Neurons Is Relieved by Meclizine via Diminution of Mitochondrial Compromise and Improved Clearance of DNA Damage.Murat F Gorgun et al.Molecular neurobiology, 54(10), 7883-7895 (2016-11-20) CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells.Patrycja Kaczara et al.The FEBS journal, 285(7), 1346-1358 (2018-02-22) JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells.Evan Noch et al.PloS one, 7(4), e35054-e35054 (2012-04-13) NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.Magali Balteau et al.Cardiovascular research, 92(2), 237-246 (2011-08-24) Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress.Ayan K Ghosh et al.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2081-2098 (2015-02-19) The effect of glucose on the progression of the nuclear maturation of pig oocytes.H Sato et al.Animal reproduction science, 99(3-4), 299-305 (2006-06-21) Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function.Nathan P Ward et al.The Journal of experimental medicine, 217(6) (2020-03-21) Acetylation of translationally controlled tumor protein promotes its degradation through chaperone-mediated autophagy.Anne Bonhoure et al.European journal of cell biology, 96(2), 83-98 (2017-01-24) 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense.Pradeep Kumar Sharma et al.Free radical research, 46(12), 1446-1457 (2012-09-06) Glucose regulated protein 78 prompts scavenger receptor A-mediated secretion of tumor necrosis factor-α by RAW 264.7 cells.Song Gao et al.Clinical and experimental pharmacology & physiology, 36(9), 940-944 (2009-05-29) Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.Rikke Illum Høgh et al.Journal of immunology (Baltimore, Md. : 1950), 204(7), 1746-1759 (2020-03-08) High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells.L Poulain et al.Leukemia, 31(11), 2326-2335 (2017-03-11) Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization.Mayuko Osada-Oka et al.FEBS letters, 584(14), 3073-3079 (2010-07-14) Protection by 6-aminonicotinamide against oxidative stress in cardiac cells.Johannes P Hofgaard et al.Pharmacological research, 54(4), 303-310 (2006-08-02) Survival Mechanisms and Xenobiotic Susceptibility of Keratinocytes Exposed to Metal-Derived Nanoparticles.Veronica Montesinos-Cruz et al.Chemical research in toxicology, 33(2), 536-552 (2020-01-14) Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes.Pradeep K Sharma et al.Cancer letters, 295(2), 154-166 (2010-04-07) 6-Substituted imidazo [1, 2-a] pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2.Dahan-Farkas N, et al. European Journal of Medicinal Chemistry, 46(9), 4573-4583 (2011) Neural stem/progenitor cells display a low requirement for oxidative metabolism independent of hypoxia inducible factor-1alpha expression.Kate M Candelario et al.Journal of neurochemistry, 125(3), 420-429 (2013-02-16) ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.Yunjie Xu et al.International journal of oncology, 53(3), 1055-1068 (2018-07-18) A new strategy to improve the efficiency and sustainability of Candida parapsilosis catalyzing deracemization of (R,S)-1-phenyl-1,2-ethanediol under non-growing conditions: increase of NADPH availability.Yao Nie et al.Journal of microbiology and biotechnology, 19(1), 65-71 (2009-02-05) Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts.Robert P Erickson et al.Molecular reproduction and development, 75(6), 1071-1076 (2007-12-29) NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC.Qiao Zhang et al.Cancer cell international, 20, 483-483 (2020-10-13) Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.Yuting Sun et al.Cell reports, 26(2), 469-482 (2019-01-10) Controlled release of 6-aminonicotinamide from aligned, electrospun fibers alters astrocyte metabolism and dorsal root ganglia neurite outgrowth.Nicholas J Schaub et al.Journal of neural engineering, 8(4), 046026-046026 (2011-07-07) Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase.Neha Sharma et al.Cancer & metabolism, 8, 19-19 (2020-09-26) ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.Yunjie Xu et al.International journal of oncology, 53(3), 1055-1068 (2018-07-18) Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.Sachin A Gupte et al.Journal of molecular and cellular cardiology, 41(2), 340-349 (2006-07-11) Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells.Pradeep Kumar Sharma et al.Free radical biology & medicine, 53(7), 1500-1513 (2012-07-25)

备注