熔点	-97 ºC
水溶性	不溶
沸点	145 ºC (10 mmHg)
闪点	107 ºC
密度	1.057
折射率	1.4725-1.4745

危险品标志	T;N
危险类别码	R21;R25;R36/38;R48/23;R50/53
安全说明书	S35;S36/37/39;S45;S60;S61

来源	SDS样本
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Disdier et al.Particle and fibre toxicology, 12, 27-27 (2015-09-05) Neural computational prediction of oral drug absorption based on CODES 2D descriptors.A Guerra et al.European journal of medicinal chemistry, 45(3), 930-940 (2009-12-22) Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.Gustav Ahlin et al.Journal of medicinal chemistry, 51(19), 5932-5942 (2008-09-16) 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.David A Ellis et al.Bioorganic & medicinal chemistry letters, 18(16), 4628-4632 (2008-07-30) Enantioselective quantification of atenolol in mouse plasma by high performance liquid chromatography using a chiral Stationary phase: application to a pharmacokinetic study.Mohammed M Hefnawy et al.Journal of AOAC International, 96(5), 976-980 (2013-11-29) Long-term treatment of clonidine, atenolol, amlodipine and dihydrochlorothiazide, but not 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A, 1368, 82-88 (2014-10-15) How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?Alex Avdeef et al.Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09) Clinical pharmacology of drugs acting on imidazoline and adrenergic receptors. Studies with clonidine, moxonidine, rilmenidine, and atenolol.J L Reid et al.Annals of the New York Academy of Sciences, 763, 673-678 (1995-07-12) Physicochemical determinants of human renal clearance.Manthena V S Varma et al.Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19) Atenolol developmental toxicity: animal-to-human comparisons.Sonia Tabacova et al.Birth defects research. 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A, 1409, 79-88 (2015-07-29) Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol).James J DiNicolantonio et al.The American journal of cardiology, 111(5), 765-769 (2013-01-08) Treatment of infantile haemangiomas with atenolol: comparison with a historical propranolol group.M de Graaf et al.Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 66(12), 1732-1740 (2013-09-10) Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.José Marco-Contelles et al.Journal of medicinal chemistry, 52(9), 2724-2732 (2009-04-21) Development of an enzyme-linked immunosorbent assay and a beta-1 adrenergic receptor-based assay for monitoring the drug atenolol.A Sapir et al.Environmental toxicology and chemistry, 32(3), 585-593 (2012-11-28) Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.Shigeo Hayashi et al.Bioorganic & medicinal chemistry, 18(21), 7675-7699 (2010-09-30) Hydrophilic interaction liquid chromatographic tandem mass spectrometric determination of atenolol in human plasma.Wenkui Li et al.Biomedical chromatography : BMC, 19(5), 385-393 (2005-01-15) Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives: their cytoprotection effect from rotenone toxicity and preliminary DMPK properties.Yuefen Zhou et al.Bioorganic & medicinal chemistry letters, 19(21), 6114-6118 (2009-09-30) Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.Frank Ruebsam et al.Bioorganic & medicinal chemistry letters, 18(12), 3616-3621 (2008-05-20) Ask the Doctor. 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A, 1358, 208-216 (2014-07-23) A prospective, randomized, open-label, active-controlled, clinical trial to assess central haemodynamic effects of bisoprolol and atenolol in hypertensive patients.Sungha Park et al.Journal of hypertension, 31(4), 813-819 (2013-02-07) Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of basic drugs and metabolites.Ludmila Mut et al.Biomedical chromatography : BMC, 29(6), 935-952 (2014-11-18) Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes.Bing-Xing Huo et al.NeuroImage, 118, 301-312 (2015-06-10) Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat.Ana I Loureiro et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(9), 828-839 (2015-04-29) Mechanism considerations for photocatalytic oxidation, ozonation and photocatalytic ozonation of some pharmaceutical compounds in water.Eva M Rodríguez et al.Journal of environmental management, 127, 114-124 (2013-05-21) Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.Lourdes Santana et al.Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07) Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms.Luigi Villa et al.The Journal of pathology, 229(5), 672-684 (2012-11-30) An integrated ceramic, micro-fluidic device for the LC/MS/MS analysis of pharmaceuticals in plasma.Paul D Rainville et al.The Analyst, 140(16), 5546-5556 (2015-07-07) Acupuncture Prevents the Impairment of Hippocampal LTP Through β1-AR in Vascular Dementia Rats.Ling-Yong Xiao et al.Molecular neurobiology, 55(10), 7677-7690 (2018-02-13) Crushed tablets: does the administration of food vehicles and thickened fluids to aid medication swallowing alter drug release?Yady J Manrique et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(2), 207-219 (2014-06-18) Mechanisms of butylidenephthalide for twitch facilitation in electrically stimulated mouse vas deferens.Chung-Hung Shih et al.Pharmaceutical biology, 56(1), 378-384 (2018-08-21) Design, synthesis and pharmacological screening of novel antihypertensive agents using hybrid approach.Shashikant V Bhandari et al.Bioorganic & medicinal chemistry, 17(1), 390-400 (2008-11-28) Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.Maria V Sergeeva et al.Bioorganic & medicinal chemistry letters, 18(11), 3421-3426 (2008-04-30) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.Huaqing Liu et al.Journal of medicinal chemistry, 51(22), 7094-7098 (2008-11-06) Kidney function and population-based outcomes of initiating oral atenolol versus metoprolol tartrate in older adults.Jamie L Fleet et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 64(6), 883-891 (2014-07-20) Activated cranial cervical cord neurons affect left ventricular infarct size and the potential for sudden cardiac death.E Marie Southerland et al.Autonomic neuroscience : basic & clinical, 169(1), 34-42 (2012-04-17) Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.Bruno Bard et al.Journal of medicinal chemistry, 52(10), 3416-3419 (2009-04-29) Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.Markus Fridén et al.Journal of medicinal chemistry, 52(20), 6233-6243 (2009-09-22) Human pharmaceuticals in wastewaters from urbanized areas of Argentina.Yanina Elorriaga et al.Bulletin of environmental contamination and toxicology, 90(4), 397-400 (2012-12-12) Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.Manthena V S Varma et al.Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15) In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.Giorgio Ottaviani et al.Journal of medicinal chemistry, 50(4), 742-748 (2007-02-16) Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability.Ruiqian Wan et al.Journal of neurochemistry, 129(4), 573-580 (2014-01-31) Characterization of the drug binding specificity of rat liver fatty acid binding protein.Sara Chuang et al.Journal of medicinal chemistry, 51(13), 3755-3764 (2008-06-07) Nebivolol induces distinct changes in profibrosis microRNA expression compared with atenolol, in salt-sensitive hypertensive rats.Hongmei Ye et al.Hypertension (Dallas, Tex. : 1979), 61(5), 1008-1013 (2013-03-06) Solar photocatalytic ozonation of a mixture of pharmaceutical compounds in water.Gracia Márquez et al.Chemosphere, 113, 71-78 (2014-07-30) Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.Milena Marsoni et al.Ecotoxicology and environmental safety, 108, 52-57 (2014-07-22) Guide to Receptors and Channels (GRAC), 4th Edition. British journal of pharmacology, 158 Suppl 1, S1-254 (2009-11-04) Nanocarriers and the delivered drug: effect interference due to intravenous administration.Maria A Vlasova et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 96-102 (2014-06-26) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.Cheryl A Grice et al.Journal of medicinal chemistry, 51(14), 4150-4169 (2008-07-01) Photodegradation kinetics and transformation products of ketoprofen, diclofenac and atenolol in pure water and treated wastewater.R Salgado et al.Journal of hazardous materials, 244-245, 516-527 (2012-11-28) Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors.Moira L Bode et al.Bioorganic & medicinal chemistry, 19(14), 4227-4237 (2011-06-28) Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.Michael H Abraham et al.European journal of medicinal chemistry, 43(3), 478-485 (2007-06-05) Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.Matthew G Baron et al.PloS one, 12(1), e0168837-e0168837 (2017-01-04) Atenolol depresses post-ischaemic recovery in the isolated rat heart.S Allibardi et al.Pharmacological research, 39(6), 431-435 (1999-06-22) Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.Xiaofan Sui et al.European journal of medicinal chemistry, 44(11), 4455-4460 (2009-07-10) Atenolol and ischaemic heart disease: an overview.J M Cruickshank et al.Current medical research and opinion, 12(8), 485-496 (1991-01-01) Differential effects of sympathetic nervous system and hypothalamic-pituitary-adrenal axis on systemic immune cells after severe experimental stroke.Eva Mracsko et al.Brain, behavior, and immunity, 41, 200-209 (2014-06-03) Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.Sun Hee Kim et al.Bioorganic & medicinal chemistry letters, 18(14), 4181-4185 (2008-06-17) Cardiogenic shock triggered by verapamil and atenolol: a case report of therapeutic experience with intravenous calcium.H Sakurai et al.Japanese circulation journal, 64(11), 893-896 (2000-12-08) Atenolol versus Losartan in Marfan's Syndrome.Bulat A Ziganshin et al.The New England journal of medicine, 372(10), 977-978 (2015-03-05) Impact of Luminal Fluid Volume on the Drug Absorption After Oral Administration: Analysis Based on In Vivo Drug Concentration-Time Profile in the Gastrointestinal Tract.Yusuke Tanaka et al.Journal of pharmaceutical sciences, 104(9), 3120-3127 (2015-03-31) Implementation of gradients of organic solvent in micellar liquid chromatography using DryLab(®): separation of basic compounds in urine samples.J Rodenas-Montano et al.Journal of chromatography. A, 1344, 31-41 (2014-04-29) Effect of contrasted sodium diets on the pharmacokinetics and pharmacodynamic effects of renin-angiotensin system blockers.Michel Azizi et al.Hypertension (Dallas, Tex. : 1979), 61(6), 1239-1245 (2013-04-24) [Atenolol/nifedipine combination: efficacy and tolerability of low dose synergistic bitherapy in the treatment of arterial hypertension].A Krivitzky et al.Drugs, 56 Suppl 2, 31-43 (1998-11-14) Role of wetland organic matters as photosensitizer for degradation of micropollutants and metabolites.Eunkyung Lee et al.Journal of hazardous materials, 276, 1-9 (2014-05-28) Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.R Scott Obach et al.Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23) Air-assisted liquid-liquid microextraction using floating organic droplet solidification for simultaneous extraction and spectrophotometric determination of some drugs in biological samples through chemometrics methods.Farnaz Farahmand et al.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 188, 72-79 (2017-07-12) Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.Alicja J Copik et al.PloS one, 10(1), e0115701-e0115701 (2015-01-22) Hexafluoroisopropanol-modified cetyltrimethylammonium bromide/sodium dodecyl sulfate vesicles as a pseudostationary phase in electrokinetic chromatography.Yu Tian et al.Journal of chromatography. A, 1404, 131-140 (2015-06-06) Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials.Sripal Bangalore et al.The American journal of medicine, 127(10), 939-953 (2014-06-15) Evaluation of skin permeation of β-blockers for topical drug delivery.Doungdaw Chantasart et al.Pharmaceutical research, 30(3), 866-877 (2012-12-05) QSAR-based permeability model for drug-like compounds.Rafael Gozalbes et al.Bioorganic & medicinal chemistry, 19(8), 2615-2624 (2011-04-05) The possible role of medial prefrontal cortex beta-1-adrenoceptors in morphine-induced amnesia.Anahita Torkaman-Boutorabi et al.Pharmacology, 93(5-6), 272-277 (2014-08-07) Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability.Jef Stappaerts et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 178-186 (2014-07-27) [A possibility to interchange heart rate-slowing therapy with ivabradine and atenolol in patients with stable angina pectoris].A A Shavarov et al.Terapevticheskii arkhiv, 85(4), 77-83 (2013-07-03) Property based optimization of δ-lactam HDAC inhibitors for metabolic stability.Hong Chul Yoon et al.Bioorganic & medicinal chemistry letters, 20(22), 6808-6811 (2010-09-21) Evaluation of an electrochemical biosensor for uric acid measurement in human whole blood samples.Li-Ting Liao et al.Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13) Direct doping analysis of beta-blocker drugs from urinary samples by on-line molecularly imprinted solid-phase extraction coupled to liquid chromatography/mass spectrometry.Mariane Gonçalves Santos et al.The Analyst, 140(8), 2696-2703 (2015-02-14) Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.Marieke Voets et al.Journal of medicinal chemistry, 49(7), 2222-2231 (2006-03-31) Perioperative metoprolol and risk of stroke after noncardiac surgery.George A Mashour et al.Anesthesiology, 119(6), 1340-1346 (2013-04-25) Influence of cholesterol on liposome stability and on in vitro drug release.Maria-Lucia Briuglia et al.Drug delivery and translational research, 5(3), 231-242 (2015-03-20) Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).Giulia Caron et al.Journal of medicinal chemistry, 48(9), 3269-3279 (2005-04-29) Influence of pH and organic modifiers on the dissociation constants of selected drugs using reversed-phase thin-layer chromatography: Comparison with other techniques and computational tools.Nejal M Bhatt et al.Biomedical chromatography : BMC, 33(11), e4666-e4666 (2019-07-30) [Atenolol in treatment of patients with airway obstruction].R Chazan Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 1(6), 428-430 (1996-12-01) Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy.Ronald V Lacro et al.American heart journal, 165(5), 828-835 (2013-04-30) The traditional herbal medicine, Ge-Gen-Tang, inhibits pacemaker potentials by nitric oxide/cGMP dependent ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from mouse small intestine.Soojin Lee et al.Journal of ethnopharmacology, 170, 201-209 (2015-05-25) Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.Lei Du-Cuny et al.Bioorganic & medicinal chemistry, 17(19), 6983-6992 (2009-09-08) Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.Thomas H Miller et al.The Science of the total environment, 511, 153-160 (2014-12-30) Long-term antihypertensive treatment fails to improve E/e' despite regression of left ventricular mass: an Anglo-Scandinavian cardiac outcomes trial substudy.Anthony J Barron et al.Hypertension (Dallas, Tex. : 1979), 63(2), 252-258 (2013-11-13) Unusual problems in the management of hyperthyroid Graves' disease.Devin W Steenkamp et al.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 19(1), 162-165 (2013-02-26) Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier.Mike De Vrieze et al.Analytical and bioanalytical chemistry, 406(25), 6179-6188 (2014-08-16) Prediction of drug intestinal absorption by new linear and non-linear QSPR.Alan Talevi et al.European journal of medicinal chemistry, 46(1), 218-228 (2010-11-30) Assessing Medicare Part D claim completeness using medication self-reports: the role of veteran status and Generic Drug Discount Programs.Lei Zhou et al.Medical care, 53(5), 463-470 (2015-03-21) Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.Marija Petruševska et al.Journal of pharmaceutical sciences, 104(9), 2676-2687 (2015-02-11) In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.Isabel Lozoya-Agullo et al.Journal of pharmaceutical sciences, 104(9), 3136-3145 (2015-04-22) Beta-blocker selectivity at cloned human beta 1- and beta 2-adrenergic receptors.C Smith et al.Cardiovascular drugs and therapy, 13(2), 123-126 (1999-06-18) Further data on beta-blockers and cancer risk: observational study and meta-analysis of randomized clinical trials.Matteo Monami et al.Current medical research and opinion, 29(4), 369-378 (2013-02-02) Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial.Simon Thom et al.JAMA, 310(9), 918-929 (2013-09-05) Ionic matrices pre-spotted matrix-assisted laser desorption/ionization plates for patient maker following in course of treatment, drug titration, and MALDI mass spectrometry imaging.David Bonnel et al.Analytical biochemistry, 434(1), 187-198 (2012-11-13) Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.Ganesha Rai et al.Journal of medicinal chemistry, 52(20), 6474-6483 (2009-09-19) The combination of slow-release nifedipine and atenolol for stable angina.D G Waller et al.Cardiovascular drugs and therapy, 4 Suppl 5, 899-904 (1990-08-01) Tonic modulatory role of mouse cerebellar α- and β-adrenergic receptors in the expression of ethanol-induced ataxia: role of AC-cAMP.M Saeed Dar et al.Behavioural brain research, 241, 154-160 (2012-12-19) Noradrenergic modulation of the parallel fiber-Purkinje cell synapse in mouse cerebellum.Pellegrino Lippiello et al.Neuropharmacology, 89, 33-42 (2014-09-15) Proteomic analysis of vascular smooth muscle cells with S- and R-enantiomers of atenolol by iTRAQ and LC-MS/MS.Jianhua Zhang et al.Methods in molecular biology (Clifton, N.J.), 1000, 45-52 (2013-04-16) Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer.Shuai Wu et al.Molecules (Basel, Switzerland), 20(10), 18704-18716 (2015-10-27)

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