
Ioxynil | CAS:1689-83-4
Ioxynil
- 名称:碘苯腈; 3,5-二碘-4-羟基苯甲腈 | Ioxynil
- CAS号:1689-83-4
- 别名:3,5-Diiodo-4-hydroxybenzonitrile; 4-Hydroxy-3,5-diiodobenzonitrile
- 分子式:C7H3I2NO
- 分子量:370.91
- EINESC号:216-881-1
产品描述
物理化学性质
熔点 | 200 ºC |
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水溶性 | 不溶 |
安全数据
危险品标志 | T;N |
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危险类别码 | R21;R23/25;R36;R48/22;R50/53;R63 |
安全说明书 | S36/37;S45;S60;S61 |
产品合成路线
名称 | CAS号 |
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OAT1 and OAT3: targets of drug-drug interaction between entecavir and JBP485.Qinghan Xu et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 650-657 (2013-01-15)
Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells.Hiroshi Arakawa et al.Journal of pharmaceutical sciences, 108(8), 2798-2804 (2019-04-09)
Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption.Jinling Wang et al.International journal of nanomedicine, 13, 7997-8012 (2018-12-13)
Enantiomeric separation of glycyl dipeptides by capillary electrophoresis with cyclodextrins as chiral selectors.C E Sänger-van de Griend Electrophoresis, 20(17), 3417-3424 (1999-12-23)
Fast chiral separation by ligand-exchange HPLC using a dynamically coated monolithic column.Martin G Schmid et al.Journal of separation science, 29(10), 1470-1475 (2006-08-10)
Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice.Ke Ma et al.Pharmaceutical research, 29(2), 535-545 (2011-09-10)
Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.Claire Colas et al.Molecular pharmaceutics, 14(12), 4685-4693 (2017-11-08)
In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1.Y Anne Pak et al.Drug metabolism and disposition: the biological fate of chemicals, 45(2), 137-144 (2016-11-30)
Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.Ina Hubatsch et al.Journal of medicinal chemistry, 50(21), 5238-5242 (2007-09-25)
Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system.Benjamin Clémençon et al.Journal of pharmacological and toxicological methods, 92, 67-76 (2018-03-28)
Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines.Zhiying Wang et al.International journal of pharmaceutics, 441(1-2), 40-49 (2012-12-25)
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.Yongjun Hu et al.Drug metabolism and disposition: the biological fate of chemicals, 40(7), 1328-1335 (2012-04-12)
Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone.Xiaoyue Xu et al.Carbohydrate polymers, 227, 115356-115356 (2019-10-09)
Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.Yeamin Huh et al.Pharmaceutical research, 30(5), 1423-1434 (2013-02-02)
Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.Junji Miyabe et al.Journal of pharmacological sciences, 139(3), 215-222 (2019-03-06)
Functionalized PLA-PEG nanoparticles targeting intestinal transporter PepT1 for oral delivery of acyclovir.Betty Gourdon et al.International journal of pharmaceutics, 529(1-2), 357-370 (2017-07-15)
Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.Steven D Coon et al.American journal of physiology. Gastrointestinal and liver physiology, 308(1), G56-G62 (2014-11-08)
Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.Kanae Kawai et al.Molecular therapy. Methods & clinical development, 17, 49-57 (2020-01-01)
Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.Janet E Simpson et al.American journal of physiology. Gastrointestinal and liver physiology, 298(5), G683-G691 (2010-02-13)
Effects of JBP485 on the expression and function of PEPT1 in indomethacin-induced intestinal injury in rats and damage in Caco-2 cells.Wei Wang et al.Peptides, 32(5), 946-955 (2011-02-12)
Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.Yufeng Zhang et al.Journal of ethnopharmacology, 243, 112097-112097 (2019-07-22)
Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice.David E Smith et al.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 31(1), 250-261 (2010-06-24)
Transport Characteristics of 5-Aminosalicylic Acid Derivatives Conjugated with Amino Acids via Human H+-Coupled Oligopeptide Transporter PEPT1.Tatsushi Yuri et al.Biological & pharmaceutical bulletin, 43(4), 697-706 (2020-04-03)
Role of PEPT1in the transport of cinnabar in Caco-2 cells.Qing Wu et al.Toxicology in vitro : an international journal published in association with BIBRA, 63, 104747-104747 (2019-12-16)
Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.Michiko Kudo et al.Biochemical and biophysical research communications, 522(1), 151-156 (2019-11-24)
Gene ablation for PEPT1 in mice abolishes the effects of dipeptides on small intestinal fluid absorption, short-circuit current, and intracellular pH.Mingmin Chen et al.American journal of physiology. Gastrointestinal and liver physiology, 299(1), G265-G274 (2010-05-01)
Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy.Yanxia Gong et al.Oncotarget, 8(25), 40454-40468 (2017-05-04)
Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats.Jian Cang et al.Drug metabolism and pharmacokinetics, 25(5), 500-507 (2010-09-30)
The Soy Peptide Phe-Leu-Val Reduces TNFα-Induced Inflammatory Response and Insulin Resistance in Adipocytes.Su-Jin Kwak et al.Journal of medicinal food, 19(7), 678-685 (2016-06-21)
Identification and characterization of the Atlantic salmon peptide transporter 1a.Ana S Gomes et al.American journal of physiology. Cell physiology, 318(1), C191-C204 (2019-10-31)
Prevention of Zinc Precipitation with Calcium Phosphate by Casein Hydrolysate Improves Zinc Absorption in Mouse Small Intestine ex Vivo via a Nanoparticle-Mediated Mechanism.Yinong Feng et al.Journal of agricultural and food chemistry, 68(2), 652-659 (2019-12-24)
Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen.Diana Højmark Omkvist et al.British journal of pharmacology, 161(8), 1793-1805 (2010-08-24)
Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods.Jeffrey S Scow et al.The Journal of surgical research, 170(1), 17-23 (2011-05-03)
Exploring the role of different drug transport routes in permeability screening.Pär Matsson et al.Journal of medicinal chemistry, 48(2), 604-613 (2005-01-22)
Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells.Mikihisa Takano et al.Life sciences, 229, 173-179 (2019-05-20)
Effect of N-glycosylation on the transport activity of the peptide transporter PEPT1.Tamara Stelzl et al.American journal of physiology. Gastrointestinal and liver physiology, 310(2), G128-G141 (2015-11-21)
Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2.Shuping Li et al.Frontiers in pharmacology, 8, 541-541 (2017-09-06)
Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.Kailas S Khomane et al.Molecular pharmaceutics, 9(9), 2458-2468 (2012-07-12)
Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats.Asdghig H Der-Boghossian et al.Canadian journal of physiology and pharmacology, 88(7), 753-759 (2010-07-24)
Synthesis and characterization of a new Peptide prodrug of glucosamine with enhanced gut permeability.Hamed Gilzad Kohan et al.PloS one, 10(5), e0126786-e0126786 (2015-05-16)
Chiral separation of amino acids and glycyl dipeptides by chiral ligand-exchange capillary electrophoresis comparing Cu(II), Co(II), Ni(II) and Zn(II) complexes of three different sugar acids.Heike Hödl et al.Journal of chromatography. A, 1204(2), 210-218 (2008-06-24)
Enantioseparation of dipeptides and tripeptides by micro-HPLC comparing teicoplanin and teicoplanin aglycone as chiral selectors.Martin G Schmid et al.Journal of biochemical and biophysical methods, 61(1-2), 1-10 (2004-11-25)
The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.Stefanie Geissler et al.The FEBS journal, 277(3), 790-795 (2010-01-14)
Ontogeny of dipeptide uptake and peptide transporter 1 (PepT1) expression along the gastrointestinal tract in the neonatal Yucatan miniature pig.Matthew G Nosworthy et al.The British journal of nutrition, 110(2), 275-281 (2012-12-14)
The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.S Frølund et al.British journal of pharmacology, 161(3), 589-600 (2010-10-01)
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.Griet Van Zeebroeck et al.Nature chemical biology, 5(1), 45-52 (2008-12-09)
Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design.Saba Ghassemi et al.Molecular therapy. Methods & clinical development, 18, 595-606 (2020-08-11)
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.Balvinder S Vig et al.Journal of medicinal chemistry, 49(12), 3636-3644 (2006-06-09)
Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.Dilara Jappar et al.Drug metabolism and disposition: the biological fate of chemicals, 39(12), 2250-2257 (2011-09-02)
Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.Hovhannes J Gukasyan et al.Pharmaceutical research, 34(12), 2488-2497 (2017-08-24)
Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice.Katherine Ma et al.Journal of pharmaceutical sciences, 100(2), 767-774 (2010-09-24)
Influence of PLA-PEG nanoparticles manufacturing process on intestinal transporter PepT1 targeting and oxytocin transport.Betty Gourdon et al.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 129, 122-133 (2018-05-29)
Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides.Sidsel Frølund et al.Molecular pharmaceutics, 9(9), 2761-2769 (2012-08-03)
Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.Chenlin Shen et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 78, 214-224 (2015-08-02)
QSAR-based permeability model for drug-like compounds.Rafael Gozalbes et al.Bioorganic & medicinal chemistry, 19(8), 2615-2624 (2011-04-05)
Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice.Dilara Jappar et al.Drug metabolism and disposition: the biological fate of chemicals, 38(10), 1740-1746 (2010-07-28)
Construction, identification and application of HeLa cells stably transfected with human PEPT1 and PEPT2.Xinjin Guo et al.Peptides, 34(2), 395-403 (2012-03-01)
Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice.Daniel Epling et al.Biochemical pharmacology, 155, 1-7 (2018-06-24)
Membrane transporters in drug development.Kathleen M Giacomini et al.Nature reviews. Drug discovery, 9(3), 215-236 (2010-03-02)
Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier.Yaxian Zheng et al.Biomaterials, 262, 120323-120323 (2020-09-09)
Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP).Christina Gatschelhofer et al.Journal of biochemical and biophysical methods, 69(1-2), 67-77 (2006-03-25)
Anti-inflammatory Effect and Cellular Uptake Mechanism of Peptides from Common Bean (Phaseolus vulga L.) Milk and Yogurts in Caco-2 Mono- and Caco-2/EA.hy926 Co-culture Models.Yuhuan Chen et al.Journal of agricultural and food chemistry, 67(30), 8370-8381 (2019-07-05)
Mitochondrial localization of P-glycoprotein and peptide transporters in corneal epithelial cells--novel strategies for intracellular drug targeting.Megha Barot et al.Experimental eye research, 106, 47-54 (2012-11-03)
Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation.Hisham G Qandeel et al.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 15(9), 1537-1547 (2011-06-08)
Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.Bei Yang et al.Drug metabolism and disposition: the biological fate of chemicals, 41(3), 608-614 (2012-12-25)
Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses.Mitsuru Tanaka et al.Molecular nutrition & food research, 59(8), 1541-1549 (2015-03-27)
Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy.Christopher M Leavitt et al.Journal of the American Society for Mass Spectrometry, 22(11), 1941-1952 (2011-09-29)
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Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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