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Dimethyl suberate | CAS:1732-09-8
Dimethyl suberate
  • 名称:辛二酸二甲酯 | Dimethyl suberate
  • CAS号:1732-09-8
  • 别名:Octanedioic acid dimethyl ester
  • 分子式:C10H18O4
  • 分子量:202.25
  • EINESC号:217-059-5

产品描述

物理化学性质

沸点 268 ºC
闪点 113 ºC
密度 1.01
折射率 1.4325-1.4345

安全数据

安全说明书 S22;S24/25

SDS

来源 SDS样本
Alfa-Aesar 浏览或下载
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Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver.N Fukuda et al.Journal of lipid research, 25(8), 831-842 (1984-08-01) Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.Tian Du et al.Breast cancer research : BCR, 20(1), 106-106 (2018-09-06) Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.Heike Zitzer et al.Endocrinology, 147(8), 3898-3905 (2006-04-29) Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells.Srikanth Elesela et al.PLoS pathogens, 16(2), e1008319-e1008319 (2020-02-28) Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection.Samad A Ibitokou et al.Journal of immunology (Baltimore, Md. : 1950), 200(2), 643-656 (2017-12-15) Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells.Benjamin J Hershey et al.Journal of clinical medicine, 9(1) (2020-01-08) Metformin Decouples Phospholipid Metabolism in Breast Cancer Cells.Tim A D Smith et al.PloS one, 11(3), e0151179-e0151179 (2016-03-10) De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection.Matthew D Greseth et al.PLoS pathogens, 10(3), e1004021-e1004021 (2014-03-22) Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells.Luciano Galdieri et al.The Journal of biological chemistry, 291(48), 25154-25166 (2016-10-14) Reciprocal effects of 5-(tetradecyloxy)-2-furoic acid on fatty acid oxidation.D A Otto et al.Archives of biochemistry and biophysics, 242(1), 23-31 (1985-10-01) Nonesterified fatty acid accumulation and release during heart muscle-cell (myocyte) injury: modulation by extracellular "acceptor".D R Janero et al.Journal of cellular physiology, 140(1), 150-160 (1989-07-01) Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors.J C Tsai et al.Journal of pharmaceutical sciences, 85(6), 643-648 (1996-06-01) Global metabolic profiling of infection by an oncogenic virus: KSHV induces and requires lipogenesis for survival of latent infection.Tracie Delgado et al.PLoS pathogens, 8(8), e1002866-e1002866 (2012-08-24) Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil.David W Hunt et al.The Journal of investigative dermatology, 137(7), 1415-1423 (2017-03-06) Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.Yue Zong et al.Cell research, 29(6), 460-473 (2019-04-06) Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.J N Thupari et al.Biochemical and biophysical research communications, 285(2), 217-223 (2001-07-11) The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth.Arvin M Gouw et al.Cell metabolism, 30(3), 556-572 (2019-08-27) Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.Walied A Kamel et al.Molecular cancer therapeutics, 16(1), 182-192 (2016-11-02) SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids.Paul Mason et al.PloS one, 7(3), e33823-e33823 (2012-03-30) Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth.Marta Palomo-Guerrero et al.eLife, 8 (2019-12-24) Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster.C M Arbeeny et al.Journal of lipid research, 33(6), 843-851 (1992-06-01) MicroRNA‑212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells.Zhi Chen et al.Molecular medicine reports, 20(4), 3633-3641 (2019-09-06) Nutritional status influences socially regulated foraging ontogeny in honey bees.Amy L Toth et al.The Journal of experimental biology, 208(Pt 24), 4641-4649 (2005-12-06) Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.E S Pizer et al.Cancer research, 60(2), 213-218 (2000-02-10) Simvastatin induced neurite outgrowth unveils role of cell surface cholesterol and acetyl CoA carboxylase in SH-SY5Y cells.Varshiesh Raina et al.PloS one, 8(9), e74547-e74547 (2013-09-17) AMPK β1 reduces tumor progression and improves survival in p53 null mice.Vanessa P Houde et al.Molecular oncology, 11(9), 1143-1155 (2017-05-26) Energy-stress-mediated AMPK activation inhibits ferroptosis.Hyemin Lee et al.Nature cell biology, 22(2), 225-234 (2020-02-08) Targeting de novo lipogenesis as a novel approach in anti-cancer therapy.Katharina Stoiber et al.British journal of cancer, 118(1), 43-51 (2017-11-08) A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs.Alexander Karlas et al.Nature communications, 7, 11320-11320 (2016-05-14) Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis.Chun Wang et al.Biochemical and biophysical research communications, 385(3), 302-306 (2009-05-20) Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBPRomani P, et al. Nature Cell Biology, 21(3), 338-338 (2019) Role of the mitochondrial metabolism of pyruvate on the regulation of ketogenesis in rat hepatocytes.F Demaugre et al.Metabolism: clinical and experimental, 32(1), 40-48 (1983-01-01) Leptin receptor-deficient obese Zucker rats reduce their food intake in response to a systemic supply of calories from glucose.Marc Gilbert et al.Diabetes, 52(2), 277-282 (2003-01-24) ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools.F Benoist et al.Arteriosclerosis, thrombosis, and vascular biology, 16(10), 1229-1235 (1996-10-01) Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.Patrizia Romani et al.Nature cell biology, 21(3), 338-347 (2019-02-06) Lactate metabolism and cytosolic NADH reducing equivalents in ovine adipocytes.Y T Yang et al.The International journal of biochemistry, 14(4), 335-340 (1982-01-01) Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis.Alexandre Sepriano et al.Annals of the rheumatic diseases, 79(6), 760-770 (2020-02-09) TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status.Natalya V Guseva et al.Cancer biology & therapy, 12(1), 80-85 (2011-04-29) Fatty acids are required for epidermal permeability barrier function.M Mao-Qiang et al.The Journal of clinical investigation, 92(2), 791-798 (1993-08-01) Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.Subarna Sinha et al.Nature communications, 8, 15580-15580 (2017-06-01) Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition.Shihao Xu et al.Journal of virology, 89(12), 6406-6417 (2015-04-10) Fanconi anemia mesenchymal stromal cells-derived glycerophospholipids skew hematopoietic stem cell differentiation through toll-like receptor signalingAmarachintha S, et al. Stem Cells, 33(11), 3382-3396 (2015) Influence of glucagon or 5-(tetradecyloxy)-2-furoic acid on binding to mitochondria and phosphorylation of ATP-citrate lyase.A M Janski et al.Bioscience reports, 2(2), 117-122 (1982-02-01) Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells.Sharon M Rymut et al.American journal of physiology. Lung cellular and molecular physiology, 316(6), L1081-L1093 (2019-03-21) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.Weibo Zhou et al.Cancer research, 63(21), 7330-7337 (2003-11-13) Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family.A Schmidt et al.Molecular and cellular endocrinology, 155(1-2), 51-60 (1999-12-02) Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.Weibo Zhou et al.Cancer research, 67(7), 2964-2971 (2007-04-06) AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.Albert Herms et al.Nature communications, 6, 7176-7176 (2015-05-28) JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation.Keigo Ikeda et al.BMC immunology, 18(1), 41-41 (2017-08-24) Metabolic vulnerability of cisplatin-resistant cancers.Florine Obrist et al.The EMBO journal, 37(14) (2018-06-08) RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis.Lei Wu et al.Cancer immunology research, 8(5), 710-721 (2020-03-04) PKA/AMPK signaling in relation to adiponectin's antiproliferative effect on multiple myeloma cells.E A Medina et al.Leukemia, 28(10), 2080-2089 (2014-03-22) Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis.Na Xie et al.American journal of physiology. Lung cellular and molecular physiology, 313(5), L834-L844 (2017-08-12) Inhibition of fatty acid synthesis induces apoptosis of human pancreatic cancer cellsNishi K, et al. Anticancer Research, 36(9), 4655-4660 (2016) Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid.D L Halvorson et al.Lipids, 19(11), 851-856 (1984-11-01) Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.Valentina Sica et al.Cell reports, 27(3), 820-834 (2019-04-18) Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.Maria Casas et al.The Journal of cell biology, 219(10) (2020-09-16) Amphiphile-induced heart muscle-cell (myocyte) injury: effects of intracellular fatty acid overload.D R Janero et al.Journal of cellular physiology, 137(1), 1-13 (1988-10-01) Effect of centrally administered C75, a fatty acid synthase inhibitor, on gastric emptying and gastrointestinal transit in mice.Lai-Fu Li et al.European journal of pharmacology, 595(1-3), 90-94 (2008-08-19) Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.Kristen E N Scott et al.PloS one, 7(1), e29761-e29761 (2012-01-13) Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrenceGarcia MR, et al. Cell Metabolism, 26(6), 842-855 (2017) AMP kinase promotes glioblastoma bioenergetics and tumour growth.Rishi Raj Chhipa et al.Nature cell biology, 20(7), 823-835 (2018-06-20) Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma.Fang-Fang Zhu et al.Pharmacological reports : PR, 72(4), 1011-1020 (2020-02-13) Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.Renate Wagner et al.Oncotarget, 8(7), 11600-11613 (2017-01-14) Serum Lipidomics Analysis of Classical Swine Fever Virus Infection in Piglets and Emerging Role of Free Fatty Acids in Virus Replication in vitro.Shengming Ma et al.Frontiers in cellular and infection microbiology, 9, 410-410 (2019-12-19) Modulation of lipolysis and glycolysis pathways in cancer stem cells changed multipotentiality and differentiation capacity toward endothelial lineagePouyafar A, et al. Cell & Bioscience, 9(1), 30-30 (2019) Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.Andreas Bitter et al.Archives of toxicology, 89(11), 2089-2103 (2014-09-04) CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.Lixia Gao et al.Journal of experimental & clinical cancer research : CR, 39(1), 73-73 (2020-04-30) Inhibitors of Fatty Acid Synthesis Induce PPAR α -Regulated Fatty Acid β -Oxidative Genes: Synergistic Roles of L-FABP and Glucose.Huan Huang et al.PPAR research, 2013, 865604-865604 (2013-03-28) Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication.P T Lange et al.mBio, 9(4) (2018-07-19) Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia.J N Li et al.Experimental cell research, 261(1), 159-165 (2000-11-18) Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis.Laura R Parisi et al.Cell chemical biology, 24(12), 1445-1454 (2017-10-17) Age-related decrease in sensitivity to glucagon and dibutyryl cyclic AMP inhibition of fatty acid synthesis in hepatocytes isolated from obese female Zucker rats.S A McCune et al.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 16(2), 79-84 (1984-02-01) Effects of a novel dual lipid synthesis inhibitor and its potential utility in treating dyslipidemia and metabolic syndromeCramer CT, et al. Journal of Lipid Research, 45(7), 1289-1301 (2004) Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.Ilenia Pacella et al.Proceedings of the National Academy of Sciences of the United States of America, 115(28), E6546-E6555 (2018-06-27) Expression, purification, and characterization of human acetyl-CoA carboxylase 2.Ki Won Kim et al.Protein expression and purification, 53(1), 16-23 (2007-01-16) Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.Miguel López et al.Diabetes, 55(5), 1327-1336 (2006-04-29) Palmitate attenuates osteoblast differentiation of fetal rat calvarial cells.Lee-Chuan C Yeh et al.Biochemical and biophysical research communications, 450(1), 777-781 (2014-06-24)
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