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Anticancer agent shikonin is an incompetent inducer of cancer drug resistance.Hao Wu et al.PloS one, 8(1), e52706-e52706 (2013-01-10) Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine.Hui-Ming Chen et al.Cancer immunology, immunotherapy : CII, 61(11), 1989-2002 (2012-04-25) Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway.Liushun Jia et al.Artificial cells, nanomedicine, and biotechnology, 47(1), 2662-2669 (2019-07-02) Inhibitory effect of Shikonin on Candida albicans growth.Hao Miao et al.Biological & pharmaceutical bulletin, 35(11), 1956-1963 (2012-11-06) Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy.I Andújar et al.Current medicinal chemistry, 20(23), 2892-2898 (2013-05-09) [Rationality for dynamic detection of shikonin of Arnerbia euchroma in industrial process].Ying-jie Wei et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(7), 1129-1133 (2011-11-10) [Tissue cultures of Lithospermum erythrorhizon and biosynthesis of shikonin derivatives].H X Fan et al.Yao xue xue bao = Acta pharmaceutica Sinica, 23(9), 716-720 (1988-01-01) PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma.Sean P Martin et al.Journal of experimental & clinical cancer research : CR, 39(1), 99-99 (2020-06-04) The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway.Bo Zhang et al.Oxidative medicine and cellular longevity, 2012, 781516-781516 (2012-11-03) Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.Alexander J Lakhter et al.Oncotarget, 5(24), 12694-12703 (2015-01-15) Shikonin induces mitochondria-mediated apoptosis and attenuates epithelial-mesenchymal transition in cisplatin-resistant human ovarian cancer cells.Kristina Shilnikova et al.Oncology letters, 15(4), 5417-5424 (2018-03-23) Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia.Sungmi Song et al.Cell death & disease, 11(2), 109-109 (2020-02-09) Quinones derived from plant secondary metabolites as anti-cancer agents.Jin-Jian Lu et al.Anti-cancer agents in medicinal chemistry, 13(3), 456-463 (2012-08-31) Ionization of shikonin derivatives using negative-ion electrospray mass spectrometry: [M-H]- versus [M + e]•-.Yufeng Zhang et al.Journal of mass spectrometry : JMS, 47(5), 581-585 (2012-05-12) Cellular pharmacology studies of shikonin derivatives.Xin Chen et al.Phytotherapy research : PTR, 16(3), 199-209 (2002-08-08) Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway.Yongwei Wang et al.Biochemical pharmacology, 88(3), 322-333 (2014-02-14) Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology.Konstantinos N Kontogiannopoulos et al.International journal of pharmaceutics, 422(1-2), 381-389 (2011-10-08) Compounds from Arnebia euchroma and their related anti-HCV and antibacterial activities.Hong-Mei Li et al.Planta medica, 78(1), 39-45 (2011-10-11) Shikonin and its derivatives: a patent review.Rubing Wang et al.Expert opinion on therapeutic patents, 22(9), 977-997 (2012-07-28) Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.Ke Gong et al.Free radical biology & medicine, 51(12), 2259-2271 (2011-10-21) Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES.Hui-Ming Chen et al.Journal of biomedical science, 19, 42-42 (2012-04-13) The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing.Shu-Yi Yin et al.Evidence-based complementary and alternative medicine : eCAM, 2013, 262796-262796 (2013-07-19) Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.Ji Young Kim et al.Bioorganic & medicinal chemistry, 20(5), 1740-1748 (2012-02-04) Glutathione-S-transferase enhances proliferation-migration and protects against shikonin-induced cell death in breast cancer cells.Shiping He et al.The Kaohsiung journal of medical sciences, 27(11), 477-484 (2011-10-19) PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.Wenjuan Li et al.Molecular carcinogenesis, 53(5), 403-412 (2012-12-21) Novel multiple apoptotic mechanism of shikonin in human glioma cells.Ching-Hsein Chen et al.Annals of surgical oncology, 19(9), 3097-3106 (2012-03-27) Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.Xian Ding et al.Journal of medical microbiology, 60(Pt 12), 1827-1834 (2011-08-20) [Compare the composition and content of Arnebiae radix and the stem residues].Jian Zhou et al.Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(3), 361-366 (2012-08-11) In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.Seetharaman Rajasekar et al.Journal of ethnopharmacology, 144(2), 335-345 (2012-09-22) Shikonin ameliorates cerulein-induced acute pancreatitis in mice.Jie Xiong et al.Journal of ethnopharmacology, 145(2), 573-580 (2012-12-04) The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells.Jin-Lan Piao et al.Chemico-biological interactions, 205(2), 119-127 (2013-07-03) Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway.Heyong Wang et al.Toxicology, 308, 104-112 (2013-04-09) Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response.Kanwal Ahmed et al.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 28(1), 1-8 (2012-01-13) [Growth and accumulation of shikonin compounds of two kinds of cells in suspension culture of Arnebia euchroma].Sheng Wang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(8), 1138-1144 (2013-08-16) Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.Hao He et al.Bioorganic & medicinal chemistry letters, 22(4), 1582-1586 (2012-01-28) Shikonin attenuates lipopolysaccharide-induced acute lung injury in mice.Guang-Zhen Bai et al.The Journal of surgical research, 182(2), 303-311 (2012-11-20) [Antitumor effect research progress of shikonin and its derivatives].Meng-Yuan Zhu et al.Yao xue xue bao = Acta pharmaceutica Sinica, 47(5), 588-593 (2012-07-20) The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing.Linxin Liu et al.PloS one, 10(11), e0143438-e0143438 (2015-11-26) Optimization of shikonin homogenate extraction from Arnebia euchroma using response surface methodology.Tingting Liu et al.Molecules (Basel, Switzerland), 18(1), 466-481 (2013-01-04)

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