询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交
中文版 English
请输入产品名称、CAS式、分子式
1,2-Dihydro-2-methyl-3H-indazol-3-one | CAS:1848-40-4
1,2-Dihydro-2-methyl-3H-indazol-3-one
  • 名称:1,2-二氢-2-甲基-3H-吲唑-3-酮 | 1,2-Dihydro-2-methyl-3H-indazol-3-one
  • CAS号:1848-40-4
  • 别名:
  • 分子式:C8H8N2O
  • 分子量:148.16
  • EINESC号:

产品描述

物理化学性质

熔点 202 ºC**
沸点 260.7±23.0 ºC (760 Tor
闪点 111.5±22.6 ºC, 计算值*
密度 1.213±0.06 g/cm3 (20 º

安全数据

没有数据没有数据

SDS

来源 SDS样本
没有数据没有数据
产品合成路线
更多

名称 CAS号
更多
文章
同行评议文献
Heliolactone, a non-sesquiterpene lactone germination stimulant for root parasitic weeds from sunflower.Kotomi Ueno et al.Phytochemistry, 108, 122-128 (2014-12-03) Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition.Rebecca A Whipple et al.Breast cancer research : BCR, 15(5), R83-R83 (2013-09-14) [Chemical constituents of Dolomiaea souliei].Hu Wei et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(9), 1249-1253 (2012-07-19) Costunolide stimulates the function of osteoblastic MC3T3-E1 cells.Young Soon Lee et al.International immunopharmacology, 11(6), 712-718 (2011-02-08) In vitro benchmarking of NF-κB inhibitors.Alexandria P Harrold et al.European journal of pharmacology, 873, 172981-172981 (2020-02-06) A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.Cristina Avonto et al.Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13) Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.Lixia Pei et al.Journal of mass spectrometry : JMS, 47(8), 962-968 (2012-08-18) DaHuangWan targets EGF signaling to inhibit the proliferation of hepatoma cells.Ha Si et al.PloS one, 15(4), e0231466-e0231466 (2020-04-17) Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.Qi Zhang et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(26), 2809-2814 (2011-08-30) Costunolide inhibits osteoclast differentiation by suppressing c-Fos transcriptional activity.Yoon-Hee Cheon et al.Phytotherapy research : PTR, 28(4), 586-592 (2013-07-09) Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.Bo-Kyung Lee et al.Journal of ethnopharmacology, 213, 256-261 (2017-11-22) New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines.Yurika Kitai et al.Journal of agricultural and food chemistry, 63(50), 10856-10861 (2015-11-19) Costunolide: A novel anti Costunolide: A novel anti-cancer sesquiterpene lactone cancer sesquiterpene lactone cancer sesquiterpene lactoneRasul A, et al. Bangladesh Journal of Pharmacology, 7, 6-13 (2012) Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.Fahim Ahmad et al.Journal of neurochemistry, 143(6), 671-683 (2017-08-24) Heliolactone, a non-sesquiterpene lactone germination stimulant for root parasitic weeds from sunflower.Kotomi Ueno et al.Phytochemistry, 108, 122-128 (2014-12-03) Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species.Yeong-In Yang et al.Gynecologic oncology, 123(3), 588-596 (2011-09-29) [Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots].Ting Zhang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(9), 1232-1236 (2012-07-19) Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats.M T Tinoco et al.Fitoterapia, 80(2), 130-133 (2009-01-27) Simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.Baolian Wang et al.Biomedical chromatography : BMC, 29(9), 1393-1398 (2015-02-14) Genepolide, a sesterpene gamma-lactone with a novel carbon skeleton from mountain wormwood (Artemisia umbelliformis).Giovanni Appendino et al.Journal of natural products, 72(3), 340-344 (2008-12-05) Should home-based HIV testing and counseling services be offered periodically in programs of ARV treatment as prevention? A case study in Likoma (Malawi).Stéphane Helleringer et al.AIDS and behavior, 17(6), 2100-2108 (2012-11-28) Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells.Zhanpeng Yan et al.BMC complementary and alternative medicine, 19(1), 151-151 (2019-06-28) Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae).Cândida Aparecida Leite Kassuya et al.Journal of ethnopharmacology, 124(3), 369-376 (2009-06-16) Saussurea lappa Clarke-Derived Costunolide Prevents TNF α -Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF- κ B Activity.Youn Kyung Choi et al.Evidence-based complementary and alternative medicine : eCAM, 2013, 936257-936257 (2013-09-03) Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.Jui-Ling Hsu et al.The Journal of urology, 185(5), 1967-1974 (2011-03-23) N,N-dimethylacrylamide-A new sensitizer in the FreeStyle Libre glucose sensor.Martin Mowitz et al.Contact dermatitis, 81(1), 27-31 (2019-02-19) Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne.Chang-Seob Seo et al.Molecular medicine reports, 12(5), 7789-7795 (2015-09-24) Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experimentsLee BK, et al. Journal of Ethnopharmacology, 213, 256-261 (2018) Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.Hwayong Park et al.Journal of ethnopharmacology, 156, 182-189 (2014-09-15) Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors.Nadine Mahfouz et al.PloS one, 12(6), e0179202-e0179202 (2017-06-09) Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4Eunchong Park et al.International immunopharmacology, 40, 508-516 (2016-10-19) Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells.Chia-Yuan Liu et al.Radiation oncology (London, England), 6, 56-56 (2011-06-01) Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.Nobuhiro Ikezawa et al.The Journal of biological chemistry, 286(24), 21601-21611 (2011-04-26) Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.Charles A Berdan et al.Cell chemical biology, 26(7), 1027-1035 (2019-05-14) Longzhibu disease and its therapeutic effects by traditional Tibetan medicine: Ershi-wei Chenxiang pills.Ya Hou et al.Journal of ethnopharmacology, 249, 112426-112426 (2019-11-28) Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation.Jung-Hye Choi et al.Biological & pharmaceutical bulletin, 32(10), 1803-1808 (2009-10-06) Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.Mao-Xu Ge et al.British journal of pharmacology, 177(2), 372-387 (2019-10-18) Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction.Azhar Rasul et al.Molecules (Basel, Switzerland), 18(2), 1418-1433 (2013-01-26) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.Qing Liu et al.PloS one, 6(8), e23255-e23255 (2011-08-23) Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia.Nirmala Arul Rayan et al.Frontiers in bioscience (Elite edition), 3, 1079-1091 (2011-05-31) Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.Min Hu et al.Gene, 678, 261-269 (2018-08-14) Asteraceae species as potential environmental factors of allergy.Marta Denisow-Pietrzyk et al.Environmental science and pollution research international, 26(7), 6290-6300 (2019-01-23) Antileukemic Properties of Sesquiterpene Lactones: A Systematic Review.Elaine da Silva Castro et al.Anti-cancer agents in medicinal chemistry, 18(3), 323-334 (2017-09-20) Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production.Arman Beyraghdar Kashkooli et al.Metabolic engineering, 54, 12-23 (2019-03-02) Regulatory effects of costunolide on dopamine metabolism-associated genes inhibit dopamine-induced apoptosis in human dopaminergic SH-SY5Y cells.Ahrom Ham et al.Neuroscience letters, 507(2), 101-105 (2011-11-02) Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm.J Eliza et al.Chemico-biological interactions, 188(3), 467-472 (2010-08-17) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium).Aldana M Ramirez et al.PloS one, 8(5), e65030-e65030 (2013-06-07) Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.Nadine Kretschmer et al.Planta medica, 78(16), 1749-1756 (2012-10-11) Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress.Zhen Wang et al.Cell biology international, 40(3), 289-297 (2015-11-27) A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.Cristina Avonto et al.Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13) New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines.Yurika Kitai et al.Journal of agricultural and food chemistry, 63(50), 10856-10861 (2015-11-19) Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.Bo-Kyung Lee et al.Journal of ethnopharmacology, 213, 256-261 (2017-11-22) Costunolide: A novel anti Costunolide: A novel anti-cancer sesquiterpene lactone cancer sesquiterpene lactone cancer sesquiterpene lactoneRasul A, et al. Bangladesh Journal of Pharmacology, 7, 6-13 (2012)
备注

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.

Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).

名称 CAS号

相关产品

相关资讯

热门标签
询 单
请 填 写 相 关 信 息
产品信息
产品名称
别名
CAS号
结构式 上传
联系方式
公司
联系人
电话
邮箱
内容
提交