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Ethyl 4-chloro-4,4-difluoroacetoacetate | CAS:2063-17-4
Ethyl 4-chloro-4,4-difluoroacetoacetate
  • 名称:4-氯-4,4-二氟乙酰乙酸乙酯 | Ethyl 4-chloro-4,4-difluoroacetoacetate
  • CAS号:2063-17-4
  • 别名:Ethyl 4-chloro-4,4-difluoro-3-oxobutyrate
  • 分子式:C6H7ClF2O3
  • 分子量:200.57
  • EINESC号:

产品描述

物理化学性质

沸点 103 ºC (93 Torr)**
闪点 63.0±15.1 ºC, 计算值*
密度 1.332±0.06 g/cm3 (20 º

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来源 SDS样本
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Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus.Adrien Daigeler et al.International journal of oncology, 32(6), 1205-1220 (2008-05-24) Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutrition patients.Abdoulaye Touré et al.Clinical nutrition (Edinburgh, Scotland), 31(4), 567-570 (2012-01-31) The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro.Kevin Marley et al.BMC veterinary research, 9, 15-15 (2013-01-22) Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin.Mette Møller Handrup et al.Pediatric blood & cancer, 60(8), 1292-1298 (2013-02-19) Biofilm formation in long-term central venous catheters in children with cancer: a randomized controlled open-labelled trial of taurolidine versus heparin.Mette Møller Handrup et al.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(10), 794-801 (2012-09-11) Taurolidine Acts on Bacterial Virulence Factors and Does Not Induce Resistance in Periodontitis-Associated Bacteria-An In-Vitro Study.Sabrina Radakovic et al.Antibiotics (Basel, Switzerland), 9(4) (2020-04-11) Prevention of Bloodstream Infections in Patients Undergoing Hemodialysis.Molly Fisher et al.Clinical journal of the American Society of Nephrology : CJASN, 15(1), 132-151 (2019-12-07) ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access.S Kolaček et al.Clinical nutrition (Edinburgh, Scotland), 37(6 Pt B), 2379-2391 (2018-07-30) [The protoskolicidal effect of 1% polyvinylpyrrolidone-iodine (PVP-1) and 2% taurolidine on abdominal hydatidosis].Baki Ekçı et al.Turkiye parazitolojii dergisi, 34(3), 152-155 (2010-10-19) Observational study of need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurolidine-citrate and heparin catheter locks in patients treated with hemodialysis.Laurie R Solomon et al.Seminars in dialysis, 25(2), 233-238 (2011-09-16) Gene expression analysis of cell death induction by taurolidine in different malignant cell lines.Ansgar M Chromik et al.BMC cancer, 10, 595-595 (2010-11-03) Unsuccessful application of taurolidine in the treatment of fungal peritonitis in peritoneal dialysis.M Gallieni et al.Clinical nephrology, 75(1), 70-73 (2010-12-24) Approaches to prolong the use of uncuffed hemodialysis catheters: results of a randomized trial.Vassilis Filiopoulos et al.American journal of nephrology, 33(3), 260-268 (2011-03-05) Scolicidal activity of taurolidine for the treatment of hydatid disease.I Aydin et al.Bratislavske lekarske listy, 113(11), 648-651 (2012-11-10) Amide compound synthesis by adenylation domain of bacillibactin synthetase.Tomoko Abe et al.The Journal of antibiotics, 70(4), 435-442 (2016-10-13) Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies.M J Dümichen et al.The Journal of hospital infection, 80(4), 304-309 (2012-02-22) Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma.Adrien Daigeler et al.Ultrasound in medicine & biology, 36(11), 1893-1906 (2010-09-28) Effects of TRAIL and taurolidine on apoptosis and proliferation in human rhabdomyosarcoma, leiomyosarcoma and epithelioid cell sarcoma.C Karlisch et al.International journal of oncology, 42(3), 945-956 (2013-01-23) The evolving role of taurolidine in cancer therapy.Peter M Neary et al.Annals of surgical oncology, 17(4), 1135-1143 (2009-12-30) In Vitro Assessment of the Antimicrobial Efficacy of Optimized Nitroglycerin-Citrate-Ethanol as a Nonantibiotic, Antimicrobial Catheter Lock Solution for Prevention of Central Line-Associated Bloodstream Infections.Ruth A Reitzel et al.Antimicrobial agents and chemotherapy, 60(9), 5175-5181 (2016-06-15) Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.Joanne H Bradshaw et al.Journal of pediatric gastroenterology and nutrition, 47(2), 179-186 (2008-07-31) [Tunnelled internal jugular vein catheters with taurolidine lock: an acceptable challenge to arterio-venous fistula in 70 years old haemodialyzed patients: a prospective pilot study].Bernard Branger et al.Nephrologie & therapeutique, 7(4), 237-241 (2011-05-24) Antibacterial effect of N-acetylcysteine and taurolidine on planktonic and biofilm forms of Enterococcus faecalis.Ayca Tuba Ulusoy et al.Dental traumatology : official publication of International Association for Dental Traumatology, 32(3), 212-218 (2015-10-31) Taurolidine/Citrate Lock Therapy for Primary Prevention of Catheter-Related Infections in Cancer Patients: Results of a Prospective, Randomized, Phase IV Trial (ATAPAC).Raffaele Longo et al.Oncology, 93(2), 99-105 (2017-05-04) The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity.Matthias J E Arlt et al.International journal of cancer, 131(5), E804-E812 (2011-11-29) Taurolidine lock - experience from the West of Scotland.Paul S Cullis et al.Clinical nutrition (Edinburgh, Scotland), 30(3), 399-400 (2011-01-25) Efficacy of taurolidine against periodontopathic species--an in vitro study.Sigrun Eick et al.Clinical oral investigations, 16(3), 735-744 (2011-05-25) Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines.Ansgar M Chromik et al.Journal of experimental & clinical cancer research : CR, 29, 21-21 (2010-03-09) Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies. An update.Suzanne Kats et al.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 39(4), 451-458 (2010-07-29) Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections.Brian Jurewitsch et al.Clinical nutrition (Edinburgh, Scotland), 24(3), 462-465 (2005-05-18) Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.Eduardo López-Briz et al.The Cochrane database of systematic reviews, 7, CD008462-CD008462 (2018-07-31) Treatment of long-term catheter-related bloodstream infections with a taurolidine block: a single cancer center experience.Georg-Martin Haag et al.The journal of vascular access, 12(3), 244-247 (2011-02-01) [Adjuvant therapy of peritonitis with taurolidine. Modulation of mediator liberation].K H Staubach Langenbecks Archiv fur Chirurgie, 382(4 Suppl 1), S26-S30 (1997-01-01) Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro.Christian Luckert et al.Journal of pediatric hematology/oncology, 36(4), e219-e223 (2014-04-26) Combination chemical genetics.Joseph Lehár et al.Nature chemical biology, 4(11), 674-681 (2008-10-22) Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock.Hui-Ping Chu et al.Journal of pediatric gastroenterology and nutrition, 55(4), 403-407 (2012-05-19) Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines.Birgit Hotz et al.International journal of colorectal disease, 29(11), 1339-1348 (2014-09-03) Toxicity of antiseptics against chondrocytes: what is best for the cartilage in septic joint surgery?Eric Röhner et al.International orthopaedics, 35(11), 1719-1723 (2011-01-18) A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis.Laurie R Solomon et al.American journal of kidney diseases : the official journal of the National Kidney Foundation, 55(6), 1060-1068 (2010-03-09) The concept of foam as a drug carrier for intraperitoneal chemotherapy, feasibility, cytotoxicity and characteristics.Justyna Schubert et al.Scientific reports, 10(1), 10341-10341 (2020-06-27) Taurolidine--a new drug with anti-tumor and anti-angiogenic effects.Christoph A Jacobi et al.Anti-cancer drugs, 16(9), 917-921 (2005-09-16) TRAIL and taurolidine enhance the anticancer activity of doxorubicin, trabectedin and mafosfamide in HT1080 human fibrosarcoma cells.K Harati et al.Anticancer research, 32(7), 2967-2984 (2012-07-04) Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer.Feifei Li et al.Oncology reports, 40(6), 3743-3751 (2018-10-03) Antibacterial effect of taurolidine (2%) on established dental plaque biofilm.Nicole Birgit Arweiler et al.Clinical oral investigations, 16(2), 499-504 (2011-03-02)
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