
Triphenylpropargylphosphonium bromide | CAS:2091-46-5
Triphenylpropargylphosphonium bromide
- 名称:三苯基炔丙基溴化鏻 | Triphenylpropargylphosphonium bromide
- CAS号:2091-46-5
- 别名:NSC 219251; P 1379; Propargyltriphenylphosphonium bromide; Triphenyl-2-propynylphosphonium bromide
- 分子式:C21H18P.Br
- 分子量:381.25
- EINESC号:218-242-2
产品描述
物理化学性质
熔点 | 168-169 ºC* |
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SDS
来源 | SDS样本 |
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Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis.Ye Gong et al.Journal of neuroinflammation, 17(1), 198-198 (2020-06-27)
Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats.Wang J, Jiang Q, Wan L, et al. American Journal of Respiratory Cell and Molecular Biology (2012)
Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba.Gangping Hao et al.Plant physiology and biochemistry : PPB, 70, 21-32 (2013-06-19)
Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1.Nizamutdinova IT, Kim YM, Jin H, et al. International Immunopharmacology, 24, 650-657 (2012)
Synthesis and vasodilative activity of tanshinone IIA derivatives.Yue-Feng Bi et al.Bioorganic & medicinal chemistry letters, 20(16), 4892-4894 (2010-07-20)
Surfactant-coated graphitized multiwalled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids.Wan Cao et al.Electrophoresis, 36(7-8), 1055-1063 (2015-02-03)
TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells.Hyou-Ju Jin et al.PloS one, 8(1), e51720-e51720 (2013-01-24)
Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor.Seema Yadav et al.Cell stress & chaperones, 25(3), 427-440 (2020-03-08)
Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK/Nampt pathway.Hong-Sheng Zhang et al.Journal of cellular physiology, 229(9), 1193-1201 (2014-01-15)
Tanshinone derivatives: a patent review (January 2006 - September 2012).Xiao-Hong Tian et al.Expert opinion on therapeutic patents, 23(1), 19-29 (2012-10-26)
Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.Sadaf Naeem et al.Bioorganic & medicinal chemistry, 20(3), 1251-1258 (2012-01-21)
Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp.Haixue Dai et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(14), 1256-1262 (2012-10-09)
Novel microemulsion of tanshinone IIA, isolated from Salvia miltiorrhiza Bunge, exerts anticancer activity through inducing apoptosis in hepatoma cells.Hui Ma et al.The American journal of Chinese medicine, 41(1), 197-210 (2013-01-23)
Protective effects and active ingredients of Salvia miltiorrhiza Bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbumin-induced allergic asthma.Junming Luo et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 168-177 (2019-01-03)
Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926.Zhi-Wei Zhou et al.European journal of pharmacology, 697(1-3), 97-105 (2012-10-16)
The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats.Chao Wang et al.The Journal of steroid biochemistry and molecular biology, 145, 28-37 (2014-10-08)
Selective in-vitro Enzymes' Inhibitory Activities of Fingerprints Compounds of Salvia Species and Molecular Docking Simulations.Safak Ozhan Kocakaya et al.Iranian journal of pharmaceutical research : IJPR, 19(2), 187-198 (2020-11-24)
Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia via downregulation of PI3K/Akt pathway.Yanping Zhang et al.American journal of translational research, 11(5), 2995-3006 (2019-06-21)
Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1.Irina Tsoy Nizamutdinova et al.International immunopharmacology, 14(4), 650-657 (2012-10-23)
[Comparison of different preparation methods of tanshinoneporous silica solid dispersion].Yan-Rong Jiang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(19), 3271-3276 (2014-01-16)
Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer.Radha Munagala et al.Cancer letters, 356(2 Pt B), 536-546 (2014-10-12)
Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae.Weimin Peng et al.Genetics, 179(1), 277-289 (2008-05-22)
Tanshinone IIA Attenuates H₂O₂ -induced injury in human umbilical vein endothelial cells.Paul Chan et al.The American journal of Chinese medicine, 40(6), 1307-1319 (2012-12-12)
Nitrogen-containing compounds from Salvia miltiorrhiza.Ming-Jaw Don et al.Journal of natural products, 68(7), 1066-1070 (2005-07-26)
Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling.Tao Shang et al.VASA. Zeitschrift fur Gefasskrankheiten, 43(1), 39-46 (2014-01-17)
Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells.Li-Ling Lin et al.BMC genomics, 16, 41-41 (2015-02-06)
[Pharmacokinetic study on three main ingredients of refined coronary cataplasm].Rui Hou et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3641-3646 (2013-03-13)
[Preparation of panax notoginseng saponins-tanshinone H(A) composite method for pulmonary delivery with spray-drying method and its characterization].Hua-Mei Wang et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 559-563 (2013-05-30)
Activation of c-Jun N-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells.Sun-Mi Yun et al.Biological & pharmaceutical bulletin, 36(2), 208-214 (2013-02-02)
Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: in vitro and in vivo evaluation.Xiao Zhang et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 595-603 (2013-01-29)
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").M Jason Hatfield et al.Journal of natural products, 76(1), 36-44 (2013-01-05)
In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.M Fronza et al.Bioorganic & medicinal chemistry, 19(16), 4876-4881 (2011-07-22)
Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization.Wen-Quan Wang et al.Journal of hematology & oncology, 5, 69-69 (2012-11-10)
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.Wayne Y W Lee et al.Journal of natural products, 73(5), 854-859 (2010-05-12)
Ultrasound-assisted ionic liquid-based homogeneous liquid-liquid microextraction high-performance liquid chromatography for determination of tanshinones in Salvia miltiorrhiza Bge. root.Zhibing Wang et al.Journal of pharmaceutical and biomedical analysis, 104, 97-104 (2014-12-17)
Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways.Caiyu Lin et al.Journal of cellular biochemistry, 114(9), 2061-2070 (2013-04-05)
Cardiovascular actions and therapeutic potential of tanshinone IIA.Si Gao et al.Atherosclerosis, 220(1), 3-10 (2011-07-22)
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.Qiqiang Tang et al.Brain research, 1488, 81-91 (2012-10-16)
Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.Shixiang Wang et al.Environmental toxicology and pharmacology, 36(2), 403-410 (2013-06-15)
Tanshinone II-A: new perspectives for old remedies.Suowen Xu et al.Expert opinion on therapeutic patents, 23(2), 149-153 (2012-12-13)
Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots.Dongfeng Yang et al.PloS one, 7(11), e46797-e46797 (2012-12-05)
Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.Nguyen Tien Dat et al.Journal of natural products, 70(7), 1093-1097 (2007-06-23)
Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.Alan K S Wan et al.Journal of natural products, 71(11), 1825-1828 (2008-10-16)
Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells.Tung-Wu Chang et al.Anticancer research, 34(10), 5473-5480 (2014-10-03)
Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins.Wenli Zhang et al.Biomaterials, 34(1), 306-319 (2012-10-17)
Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer.Li-Hong Zhou et al.Asian Pacific journal of cancer prevention : APJCP, 13(9), 4453-4458 (2012-11-22)
Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.Qing Cai et al.Chinese journal of integrative medicine, 18(11), 837-845 (2012-10-23)
Conical coils counter-current chromatography for preparative isolation and purification of tanshinones from Salvia miltiorrhiza Bunge.Junling Liang et al.Journal of chromatography. A, 1288, 35-39 (2013-04-02)
PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes.Peter Tzu-Yu Chien et al.British journal of pharmacology, 171(19), 4504-4519 (2014-06-07)
Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts.Shuai Mao et al.Experimental cell research, 323(1), 189-197 (2014-02-15)
The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia.Xin Liu et al.Biomaterials, 34(28), 6893-6905 (2013-06-19)
Hydrogen peroxide-mediated oxidative stress and collagen synthesis in cardiac fibroblasts: blockade by tanshinone IIA.Ping Wang et al.Journal of ethnopharmacology, 145(1), 152-161 (2012-11-21)
Hydrophobic ionic liquid modified thermoresponsive molecularly imprinted monolith for the selective recognition and separation of tanshinones.Weiyang Tang et al.Journal of separation science, 41(17), 3372-3381 (2018-07-15)
Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/p27-associated pathway.Ying Luo et al.PloS one, 8(2), e56774-e56774 (2013-02-26)
The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.Pei-Ling Chi et al.British journal of pharmacology, 171(12), 2993-3009 (2014-03-19)
Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy.Lorenzo Di Cesare Mannelli et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 105, 1042-1049 (2018-07-20)
Tanshinone IIA improves endoplasmic reticulum stress-induced insulin resistance through AMP-activated protein kinase.Seung-Lark Hwang et al.Biochemical and biophysical research communications, 430(4), 1246-1252 (2012-12-26)
Tanshinone IIA inhibits the dihydrotestosterone-induced secretion of lipids and activation of sterol regulatory element binding protein-1 in HaCaT cells.Dong-Yan Song et al.Experimental and therapeutic medicine, 4(2), 339-343 (2012-11-10)
Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells.Kedong Zhang et al.American journal of physiology. Cell physiology, 306(1), C59-C65 (2013-10-25)
Synthesis of novel chemical probes for the study of tanshinone binding proteins.Jin-Soo Lee et al.Bioorganic & medicinal chemistry letters, 16(18), 4733-4737 (2006-07-29)
[Study on effective constituents extracted from fibrous roots of Salvia miltiorrhiza with degrading multi-enzymes from taishan Ganoderma lucidum].Yan-Ling Li et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 678-682 (2013-06-04)
Small molecule regulators of autophagy identified by an image-based high-throughput screen.Lihong Zhang et al.Proceedings of the National Academy of Sciences of the United States of America, 104(48), 19023-19028 (2007-11-21)
Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake.Yusong Zhang et al.Biochemical pharmacology, 84(11), 1492-1500 (2012-10-02)
Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia.Xin Liu et al.Biomaterials, 34(3), 817-830 (2012-11-01)
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Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer's risk.
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271 +A13(1).
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