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Vitamin K2(35) | CAS:2124-57-4 (27670-94-6)
Vitamin K2(35)
  • 名称:维生素 K2(35); 甲萘醌-7 | Vitamin K2(35)
  • CAS号:2124-57-4 (27670-94-6)
  • 别名:Menlaquinone 7; Vitamin MK 7; MK-7; (all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
  • 分子式:C46H64O2
  • 分子量:649.00
  • EINESC号:

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物理化学性质

熔点 54 ºC
密度 0.961

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Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.John R Hornick et al.Journal of experimental & clinical cancer research : CR, 31, 41-41 (2012-05-04) Novel and Selective Fluorescent σ2 -Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells.Mauro Niso et al.Chembiochem : a European journal of chemical biology, 16(7), 1078-1083 (2015-03-11) Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.Carmen Abate et al.Journal of medicinal chemistry, 54(16), 5858-5867 (2011-07-13) Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent and σ receptors binding properties.Carmen Abate et al.Journal of medicinal chemistry, 57(8), 3314-3323 (2014-04-05) Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).Francesco Berardi et al.Journal of medicinal chemistry, 52(23), 7817-7828 (2009-10-22) 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity.Carmen Abate et al.ChemMedChem, 6(1), 73-80 (2010-11-12) Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.Maria Laura Pati et al.BMC cancer, 17(1), 51-51 (2017-01-15) Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.Nicola Antonio Colabufo et al.Naunyn-Schmiedeberg's archives of pharmacology, 370(2), 106-113 (2004-08-24) 2-Aminopyridine derivatives as potential σ(2) receptor antagonists.Carmen Abate et al.ChemMedChem, 7(10), 1847-1857 (2012-08-15) Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity.Mauro Niso et al.ChemMedChem, 8(12), 2026-2035 (2013-10-10) Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer.Carmen Abate et al.ChemMedChem, 5(2), 268-273 (2010-01-16) Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.Maria Laura Pati et al.Pharmacological research, 117, 67-74 (2016-12-23)
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