熔点	122-123 ºC**
密度	1.94±0.1 g/cm3 (20 ºC

没有数据	没有数据

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Urapidil, a dual-acting antihypertensive agent: Current usage considerations.Jan Buch Advances in therapy, 27(7), 426-443 (2010-07-24) Effects of α1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats.Hiroko Yanai-Inamura et al.European journal of pharmacology, 679(1-3), 127-131 (2012-02-09) Quantification of urapidil, α-1-adrenoreceptor antagonist, in plasma by LC-MS/MS: validation and application to pharmacokinetic studies.Ramakrishna Nirogi et al.Biomedical chromatography : BMC, 25(12), 1319-1326 (2011-02-11) [Use of injectable urapidil in pregnancy-induced hypertension and preeclampsia].G Carles et al.Journal de gynecologie, obstetrique et biologie de la reproduction, 41(7), 645-649 (2012-06-26) MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart diseaseHe L and Huang C Biomedicine and Pharmacotherapy, 91(1), 1178-1183 (2017) Dexmedetomidine sedation for carotid endarterectomy.Magdalena Sidorowicz et al.Anestezjologia intensywna terapia, 41(2), 78-83 (2009-08-25) [Phaeochromocytoma revealed by a cardiogenic shock treated by extracorporeal life support].C Contargyris et al.Annales francaises d'anesthesie et de reanimation, 31(12), 965-968 (2012-11-21) Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi.Sakineh Pirahmadi et al.Malaria journal, 18(1), 146-146 (2019-04-25) Preparation of pH-dependent modified-release pellets of urapidil to improve its bioavailability.Haibing He et al.Pharmaceutical development and technology, 16(3), 212-218 (2010-02-16) Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy.Kenji Ohgaki et al.Scandinavian journal of urology and nephrology, 44(6), 420-424 (2010-07-08) Effects of vasoactive substances on the neurovascular structures and microcirculation in the developing callus 10 and 15 days after bone injury.Zsolt Vendégh et al.Clinical hemorheology and microcirculation, 50(4), 279-291 (2012-01-14) Decrease in blood pressure after intravenous administration of urapidil during recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke.Jean-Marc Bugnicourt et al.Clinical therapeutics, 30(9), 1675-1680 (2008-10-09) Amyloid-β peptides activate α1-adrenergic cardiovascular receptors.Nadine Haase et al.Hypertension (Dallas, Tex. : 1979), 62(5), 966-972 (2013-09-05) Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport.Kohji Takara et al.PloS one, 7(2), e30697-e30697 (2012-02-23) [Experience with ebrantil used in patients with resistant arterial hypertension in chronic kidney disease].R I Semenova et al.Terapevticheskii arkhiv, 84(8), 72-74 (2012-09-22) Pharmacokinetics of diluted (U20) insulin aspart compared with standard (U100) in children aged 3-6 years with type 1 diabetes during closed-loop insulin delivery: a randomised clinical trial.Yue Ruan et al.Diabetologia, 58(4), 687-690 (2014-12-30) Ultrafiltration isolation, hypoglycemic activity analysis and structural characterization of polysaccharides from Brasenia schreberi.Simin Feng et al.International journal of biological macromolecules, 135, 141-151 (2019-05-28) The effect of different surface treatments on the shear bond strength of luting cements to titanium.Filipe de Oliveira Abi-Rached et al.The Journal of prosthetic dentistry, 108(6), 370-376 (2012-12-12) Identification of 13 novel human modification guide RNAs.Patrice Vitali et al.Nucleic acids research, 31(22), 6543-6551 (2003-11-07) Silica-based nano-coating on zirconia surfaces using reactive magnetron sputtering: effect on chemical adhesion of resin cements.José Renato Queiroz et al.The journal of adhesive dentistry, 15(2), 151-159 (2013-03-28) Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46.Yasuko Mori et al.Journal of virology, 77(8), 4992-4999 (2003-03-29) Pressable feldspathic inlays in premolars: effect of cementation strategy and mechanical cycling on the adhesive bond between dentin and restoration.Sabrina Alves Feitosa et al.The journal of adhesive dentistry, 16(2), 147-154 (2013-09-13) [Influence of light irradiation mode on microhardness of dual cured resin cements].Xiao-dong Xu et al.Shanghai kou qiang yi xue = Shanghai journal of stomatology, 22(5), 514-517 (2013-11-16) Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.U A Nuber et al.European journal of cell biology, 71(1), 1-13 (1996-09-01) Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo.Hiroshi Tsuneki et al.Diabetes research and clinical practice, 129, 62-72 (2017-05-17) Degree of conversion of resin cement with varying methacrylate compositions used to cement fiber dowels: A Raman spectroscopy study.Abdulelah M BinMahfooz et al.The Journal of prosthetic dentistry, 119(6), 1014-1020 (2017-11-21) Synthesis of a quinazoline derivative: a new α₁-adrenoceptor ligand for conjugation to quantum dots to study α₁-adrenoceptors in living cells.Guoheng Zhou et al.Bioorganic & medicinal chemistry letters, 21(19), 5905-5909 (2011-08-31) Preparation for surgery of phaeochromocytoma by blockade of alpha-adrenergic receptors with urapidil: what dose?P Gosse et al.Journal of human hypertension, 23(9), 605-609 (2009-02-20) [Efficacy of sublingual nifedipine and intravenous urapidil for treatment of acute postoperative hypertension].Zhi Wang et al.Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 31(2), 317-319 (2011-03-01) Measuring of IgG2c isotype instead of IgG2a in immunized C57BL/6 mice with Plasmodium vivax TRAP as a subunit vaccine candidate in order to correct interpretation of Th1 versus Th2 immune response.Saeed Nazeri et al.Experimental parasitology, 216, 107944-107944 (2020-07-04) [Features of urapidil in treatment of resistant hypertension].L O Minushkina Kardiologiia, 52(8), 77-82 (2012-10-27) Interaction of urapidil with brain serotonin-1A receptors increases the blood pressure reduction due to peripheral alpha-adrenoceptor inhibition.K H Sanders et al.Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 6(2), S65-S68 (1988-12-01) Expression of alpha1-adrenoceptors on thymic cells and their role in fine tuning of thymopoiesis.V Pesić et al.Journal of neuroimmunology, 214(1-2), 55-66 (2009-08-04) Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice.Saeed Nazeri et al.Medical microbiology and immunology, 207(5-6), 271-286 (2018-06-28) Evidence for the interaction of urapidil with 5-HT1A receptors in the brain leading to a decrease in blood pressure.N Kolassa et al.The American journal of cardiology, 63(6), 36C-39C (1989-02-02) A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in chronic fatigue syndrome/myalgic encephalomyelitisJohnston S, et al. BMC Medical Genetics, 17(1), 79-79 (2016) Prevention of hypertensive crises in rats induced by acute and chronic norepinephrine excess.D Weismann et al.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 42(11), 803-808 (2010-07-29) Capillary electrophoresis with end-column electrochemiluminescence for ultrasensitive determination of urapidil hydrochloride in rat plasma and its application to pharmacokinetics study.Shuangjiao Sun et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 146-150 (2015-11-10) Immunological evaluation of two novel engineered Plasmodium vivax circumsporozoite proteins formulated with different human-compatible vaccine adjuvants in C57BL/6 mice.Samaneh H Shabani et al.Medical microbiology and immunology, 208(6), 731-745 (2019-04-27) Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.Chandramohan Chitraju et al.Cell reports, 33(5), 108348-108348 (2020-11-05) Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study.Laura Kranaster et al.European archives of psychiatry and clinical neuroscience, 261(8), 575-582 (2011-03-15) Urapidil, a multiple-action alpha-blocking drug.B N Prichard et al.The American journal of cardiology, 64(7), 11D-15D (1989-08-15) Therapeutic effect of urapidil on myocardial perfusion in patients with ST-elevation acute coronary syndrome.Dao-kuo Yao et al.European journal of internal medicine, 20(2), 152-157 (2009-03-31) [Hypertensive emergency].Uwe Kuhlmann et al.MMW Fortschritte der Medizin, 150(51-52), 47-48 (2009-01-20) Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets.Fumiaki Nagashima et al.Biomolecules & therapeutics, 26(4), 399-408 (2017-12-11) Age-associated plasticity of α1-adrenoceptor-mediated tuning of T-cell development.G Leposavić et al.Experimental gerontology, 45(12), 918-935 (2010-08-31) [Hypertensive crisis in cardiology: place of urapidil].Zh D Kobalava et al.Kardiologiia, 52(1), 86-90 (2012-02-07) Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT).Alain Vuylsteke et al.Critical care (London, England), 15(6), R271-R271 (2011-11-18) Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21 Adjuvants Induces Strong and Persistent Functional Antibodies and T Cell Responses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS) of Plasmodium falciparum in BALB/c Mice.Sakineh Pirahmadi et al.Infection and immunity, 87(6) (2019-04-03) [Hypertensive crisis: pathogenesis, clinic, treatment].A L Vertkin et al.Kardiologiia, 53(6), 66-70 (2013-08-21) Synthesis, alpha-adrenoceptors affinity and alpha 1-adrenoceptor antagonistic properties of some 1,4-substituted piperazine derivatives.H Marona et al.Die Pharmazie, 66(10), 733-739 (2011-10-27)

备注