没有数据	没有数据

没有数据	没有数据

来源	SDS样本
Alfa-Aesar	浏览或下载
TCI	浏览或下载
Acros-Organics	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.Williams Porcal et al.Bioorganic & medicinal chemistry, 15(7), 2768-2781 (2007-02-09) Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.Ralf Heim et al.Journal of medicinal chemistry, 51(16), 5064-5074 (2008-08-05) Ketoconazole in bipolar patients with depressive symptoms: a case series and literature review.E S Brown et al.Bipolar disorders, 3(1), 23-29 (2001-03-21) Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.Flor Soriano-Agatón et al.Journal of natural products, 68(11), 1581-1587 (2005-11-29) Penetratin analogues acting as antifungal agents.Francisco M Garibotto et al.European journal of medicinal chemistry, 46(1), 370-377 (2010-11-26) Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.Aurelie Vivares et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Toxicogenomics directory of chemically exposed human hepatocytes.Marianna Grinberg et al.Archives of toxicology, 88(12), 2261-2287 (2014-11-17) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Francisco J Prado-Prado et al.Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27) Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.David E Moody et al.Journal of analytical toxicology, 39(5), 374-386 (2015-04-15) Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand.Naz M Aghatabay et al.European journal of medicinal chemistry, 42(2), 205-213 (2006-12-27) Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.Mohd Amir et al.European journal of medicinal chemistry, 43(10), 2056-2066 (2007-11-21) Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.Yasuhiro Horita et al.Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26) Synthesis and antifungal activity of (Z)-5-arylidenerhodanines.Maximiliano Sortino et al.Bioorganic & medicinal chemistry, 15(1), 484-494 (2006-10-20) 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.Alejandra Gerpe et al.Bioorganic & medicinal chemistry, 17(21), 7500-7509 (2009-10-09) Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.Qingzhong Hu et al.Journal of medicinal chemistry, 53(13), 5049-5053 (2010-06-17) Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.Ariel R Topletz et al.Molecular pharmacology, 87(3), 430-441 (2014-12-11) Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds.Naz M Aghatabay et al.European journal of medicinal chemistry, 44(11), 4681-4689 (2009-08-25) In vivo and in vitro evidence of the sex-dependent pharmacokinetics and disposition of G004, a potential hypoglycemic agent, in rats.Linlin Hu et al.European journal of drug metabolism and pharmacokinetics, 40(2), 187-202 (2014-04-04) Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives.Krasimira T Petrova et al.Carbohydrate research, 417, 66-71 (2015-10-04) Investigating the in vitro stereoselective metabolism of m-nisoldipine enantiomers: characterization of metabolites and cytochrome P450 isoforms involved.Yupeng Sun et al.Biomedical chromatography : BMC, 29(12), 1893-1900 (2015-05-23) Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.Lijun Zhu et al.The Journal of pharmacy and pharmacology, 66(11), 1534-1551 (2014-06-20) Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.Xiaomei Fan et al.Drug metabolism and disposition: the biological fate of chemicals, 42(12), 1982-1990 (2014-09-14) Bulky 1,4-benzoxazine derivatives with antifungal activity.Renata Fringuelli et al.Bioorganic & medicinal chemistry, 17(11), 3838-3846 (2009-05-13) Comparative effectiveness questions in oncology.Sham Mailankody et al.The New England journal of medicine, 370(16), 1478-1481 (2014-04-18) Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.James M Kraus et al.Journal of medicinal chemistry, 53(10), 3887-3898 (2010-05-01) Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones.Chandrasekaran Praveen et al.Bioorganic & medicinal chemistry letters, 21(13), 4072-4077 (2011-05-31) Bioactive polychlorinated bibenzyls from the liverwort Riccardia polyclada.Cecilia Labbé et al.Journal of natural products, 70(12), 2019-2021 (2007-11-21) Phenol-based millipede defence: antimicrobial activity of secretions from the Balkan endemic millipede Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida).Bojan Ilić et al.Die Naturwissenschaften, 106(7-8), 37-37 (2019-06-19) Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.David Cunningham et al.Human molecular genetics, 24(10), 2808-2825 (2015-02-06) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma.Poonam Sonawane et al.British journal of pharmacology, 171(23), 5330-5344 (2014-07-22) Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay.Tiong Chai Seah et al.International journal of toxicology, 34(5), 454-468 (2015-08-14) Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.Esther Castanys-Muñoz et al.Antimicrobial agents and chemotherapy, 52(10), 3573-3579 (2008-07-23) Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature.J Berwaerts et al.Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 13(3), 175-182 (1999-08-19) Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots.Delair Silveira Dos Santos et al.Acta pharmaceutica (Zagreb, Croatia), 64(4), 495-501 (2014-12-23) Drug-drug Interaction between Losartan and Paclitaxel in Human Liver Microsomes with Different CYP2C8 Genotypes.Yuji Mukai et al.Basic & clinical pharmacology & toxicology, 116(6), 493-498 (2014-11-27) Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells.Ghaith Bakdash et al.Vaccine, 32(47), 6294-6302 (2014-09-23) Ketoconazole in bipolar patients with depressive symptoms: a case series and literature review.E S Brown et al.Bipolar disorders, 3(1), 23-29 (2001-03-21) Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.Flor Soriano-Agatón et al.Journal of natural products, 68(11), 1581-1587 (2005-11-29) Penetratin analogues acting as antifungal agents.Francisco M Garibotto et al.European journal of medicinal chemistry, 46(1), 370-377 (2010-11-26) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Toxicogenomics directory of chemically exposed human hepatocytes.Marianna Grinberg et al.Archives of toxicology, 88(12), 2261-2287 (2014-11-17) Bulky 1,4-benzoxazine derivatives with antifungal activity.Renata Fringuelli et al.Bioorganic & medicinal chemistry, 17(11), 3838-3846 (2009-05-13) Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.Ralf Heim et al.Journal of medicinal chemistry, 51(16), 5064-5074 (2008-08-05) Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds.Naz M Aghatabay et al.European journal of medicinal chemistry, 44(11), 4681-4689 (2009-08-25) Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand.Naz M Aghatabay et al.European journal of medicinal chemistry, 42(2), 205-213 (2006-12-27) Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.Aurelie Vivares et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30) Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.Williams Porcal et al.Bioorganic & medicinal chemistry, 15(7), 2768-2781 (2007-02-09) Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.Francisco J Prado-Prado et al.Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27) Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.David E Moody et al.Journal of analytical toxicology, 39(5), 374-386 (2015-04-15) Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.Mohd Amir et al.European journal of medicinal chemistry, 43(10), 2056-2066 (2007-11-21) Ketoconazole-induced adrenal crisis in a patient with metastatic prostatic adenocarcinoma: case report and review of the literature.R G Sarver et al.Urology, 49(5), 781-785 (1997-05-01) Antimicrobial and P450 inhibitory properties of common functional foods.San Nguyen et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(2), 254-265 (2014-06-18) Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents.K Liaras et al.Bioorganic & medicinal chemistry, 19(24), 7349-7356 (2011-11-15) Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.Carolina B Moraes et al.SLAS discovery : advancing life sciences R & D, 24(3), 346-361 (2019-02-21) Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.Frederico L Gouveia et al.European journal of medicinal chemistry, 44(5), 2038-2043 (2008-11-26) Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.Claudia Kasserra et al.Journal of clinical pharmacology, 55(2), 168-178 (2014-08-28) Discovery of novel indazole-linked triazoles as antifungal agents.Joon Seok Park et al.Bioorganic & medicinal chemistry letters, 17(12), 3486-3490 (2007-04-17) Ketoconazole and Flutamide in the treatment of disseminated intravascular clotting from prostate cancer: a case report and review.S Chakrapee-Sirisuk et al.Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 84(10), 1495-1501 (2002-01-24) Comparative effectiveness questions in oncology.Sham Mailankody et al.The New England journal of medicine, 370(16), 1478-1481 (2014-04-18) Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.L L von Moltke et al.Clinical pharmacokinetics, 29 Suppl 1, 33-43 (1995-01-01) Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.Tomomi Taniguchi-Takizawa et al.Drug metabolism and pharmacokinetics, 30(1), 64-69 (2015-03-12) Antimicrobial and P450 inhibitory properties of common functional foods.San Nguyen et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(2), 254-265 (2014-06-18) Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).Sabbir Ahmed et al.Bioorganic & medicinal chemistry letters, 19(16), 4698-4701 (2009-07-18) Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects.Claudia Kasserra et al.Journal of clinical pharmacology, 55(2), 168-178 (2014-08-28) Ketoconazole-induced adrenal crisis in a patient with metastatic prostatic adenocarcinoma: case report and review of the literature.R G Sarver et al.Urology, 49(5), 781-785 (1997-05-01) Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents.K Liaras et al.Bioorganic & medicinal chemistry, 19(24), 7349-7356 (2011-11-15) Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.Qingzhong Hu et al.Journal of medicinal chemistry, 53(15), 5749-5758 (2010-08-06) N-Phenyl and N-phenylalkyl-maleimides acting against Candida spp.: time-to-kill, stability, interaction with maleamic acids.Maximiliano Sortino et al.Bioorganic & medicinal chemistry, 16(1), 560-568 (2007-10-27) Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model.Shuwei Ma et al.Life sciences, 114(2), 93-101 (2014-08-21) Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.Carolina B Moraes et al.SLAS discovery : advancing life sciences R & D, 24(3), 346-361 (2019-02-21) Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.Frederico L Gouveia et al.European journal of medicinal chemistry, 44(5), 2038-2043 (2008-11-26) Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents.Vasudeva Rao Avupati et al.Bioorganic & medicinal chemistry letters, 22(2), 1031-1035 (2011-12-28) Ketoconazole and Flutamide in the treatment of disseminated intravascular clotting from prostate cancer: a case report and review.S Chakrapee-Sirisuk et al.Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 84(10), 1495-1501 (2002-01-24) Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer.D M Peehl et al.Urology, 58(2 Suppl 1), 123-126 (2001-08-15) In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.Anne M Filppula et al.Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1202-1209 (2014-04-10) Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4.Emre M Isin et al.The Journal of biological chemistry, 282(9), 6863-6874 (2007-01-04) Discovery of novel indazole-linked triazoles as antifungal agents.Joon Seok Park et al.Bioorganic & medicinal chemistry letters, 17(12), 3486-3490 (2007-04-17) Synthesis and bioassay of pyrrolyl oxazolines and thiazolines.V Padmavathi et al.European journal of medicinal chemistry, 45(7), 3178-3183 (2010-05-07) Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.Claire M Martel et al.Antimicrobial agents and chemotherapy, 54(11), 4527-4533 (2010-08-25) New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.Williams Porcal et al.Bioorganic & medicinal chemistry, 16(14), 6995-7004 (2008-06-13) 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.Aik Jiang Lau et al.Pharmacological research, 100, 64-72 (2015-08-05) Evaluation of the Antifungal Activity of Mentha x piperita (Lamiaceae) of Pancalieri (Turin, Italy) Essential Oil and Its Synergistic Interaction with Azoles.Vivian Tullio et al.Molecules (Basel, Switzerland), 24(17) (2019-09-01) Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.Sang Hyun Cho et al.Antimicrobial agents and chemotherapy, 51(4), 1380-1385 (2007-01-11) Naftifine-analogues as anti-Trypanosoma cruzi agents.Alejandra Gerpe et al.European journal of medicinal chemistry, 45(6), 2154-2164 (2010-02-19) Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.Ramakrishna Nirogi et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 95-106 (2014-07-30) Synthesis and antifungal activities of novel 2-aminotetralin derivatives.Bin Yao et al.Journal of medicinal chemistry, 50(22), 5293-5300 (2007-09-29) Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro.David J Greenblatt et al.Xenobiotica; the fate of foreign compounds in biological systems, 40(10), 713-720 (2010-08-18) Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.Naomi L Kruhlak et al.Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01) Human hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation.Jan H Beumer et al.British journal of clinical pharmacology, 80(5), 1097-1108 (2015-07-17) Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.Simon Lucas et al.Journal of medicinal chemistry, 54(7), 2307-2319 (2011-03-10) Potential interactions between HIV drugs, ritonavir and efavirenz and anticancer drug, nilotinib--a study in primary cultures of human hepatocytes that is applicable to HIV patients with cancer.Venkateswaran C Pillai et al.Journal of clinical pharmacology, 54(11), 1272-1279 (2014-05-23) N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).Christina Zimmer et al.Bioorganic & medicinal chemistry letters, 21(1), 186-190 (2010-12-07) Response to "can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?": evaluation of CYP3A activity with microdoses of midazolam.N Hohmann et al.Clinical pharmacology and therapeutics, 95(5), 490-491 (2014-02-08) Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.Monika Sharma et al.Antimicrobial agents and chemotherapy, 53(8), 3256-3265 (2009-05-28) Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.Martin Kongsbak et al.PloS one, 9(5), e96695-e96695 (2014-05-06) Human pharmacokinetic profiling of the dipeptidyl peptidase-IV inhibitor teneligliptin using physiologically based pharmacokinetic modeling.Yoshinobu Nakamaru et al.Biopharmaceutics & drug disposition, 36(3), 148-162 (2014-12-03) Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.Sarah Tsao et al.Antimicrobial agents and chemotherapy, 53(4), 1344-1352 (2009-02-19) Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies.P Zoumpoulakis et al.Bioorganic & medicinal chemistry, 20(4), 1569-1583 (2012-01-24) Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity.Karen M VanderMolen et al.Journal of pharmaceutical and biomedical analysis, 98, 260-265 (2014-06-22) 1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies.Giuseppe La Regina et al.Journal of medicinal chemistry, 51(13), 3841-3855 (2008-06-06) Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs.Yong Zhao et al.Phytotherapy research : PTR, 29(6), 825-834 (2015-02-03) A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.John S Morrison et al.Journal of pharmaceutical sciences, 103(10), 3022-3032 (2014-07-30) Potentiation of interleukin 1 alpha mediated antitumor effects by ketoconazole.P G Braunschweiger et al.Cancer research, 50(15), 4709-4717 (1990-08-01) Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.Sarah Ulmschneider et al.Journal of medicinal chemistry, 48(5), 1563-1575 (2005-03-04) Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein.Huan-Qiu Li et al.European journal of medicinal chemistry, 43(3), 662-667 (2007-07-13) Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.Tarik El-Sayed Ali European journal of medicinal chemistry, 44(11), 4385-4392 (2009-07-10) Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.Gustav Ahlin et al.Journal of medicinal chemistry, 51(19), 5932-5942 (2008-09-16) Multilocus sequence typing of Candida africana from patients with vulvovaginal candidiasis in New Delhi, India.Cheshta Sharma et al.Mycoses, 57(9), 544-552 (2014-04-05) Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.Roslyn Thelingwani et al.Expert opinion on drug metabolism & toxicology, 10(10), 1313-1324 (2014-09-16) Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.V Padmavathi et al.European journal of medicinal chemistry, 44(5), 2106-2112 (2008-11-28) A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas.Y L N Murthy et al.Bioorganic & medicinal chemistry letters, 21(24), 7522-7525 (2011-11-11) Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential.Dennis J Pelletier et al.Journal of chemical information and modeling, 47(3), 1196-1205 (2007-04-13) Corticotropin-dependent Cushing's syndrome in older people: presentation of five cases and therapeutical use of ketoconazole.J J Berwaerts et al.Journal of the American Geriatrics Society, 46(7), 880-884 (1998-07-22) Fosamprenavir plus ritonavir increases plasma ketoconazole and ritonavir exposure, while amprenavir exposure remains unchanged.Mary B Wire et al.Antimicrobial agents and chemotherapy, 51(8), 2982-2984 (2007-05-23) Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy.Albrecht Serfling et al.Antimicrobial agents and chemotherapy, 51(10), 3672-3676 (2007-07-11) New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy.Mónica S Olivella et al.Bioorganic & medicinal chemistry letters, 20(16), 4808-4811 (2010-07-14) Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women.Animesh N Sharma et al.American journal of physiology. Regulatory, integrative and comparative physiology, 306(9), R627-R635 (2014-02-28) Identifying off-target effects and hidden phenotypes of drugs in human cells.Marnie L MacDonald et al.Nature chemical biology, 2(6), 329-337 (2006-05-09) A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.Shaoji Cheng et al.Antimicrobial agents and chemotherapy, 51(5), 1855-1858 (2007-02-28) Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.Mariano A E Pinto-Bazurco Mendieta et al.Journal of medicinal chemistry, 51(16), 5009-5018 (2008-08-05) Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.Christoph Ruckenstuhl et al.Antimicrobial agents and chemotherapy, 51(1), 275-284 (2006-10-18) Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth.Patrick Vandeputte et al.Antimicrobial agents and chemotherapy, 53(7), 3034-3041 (2009-04-22) CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.Aline Guerra M Fraga et al.European journal of medicinal chemistry, 46(1), 349-355 (2010-12-15) Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid.Wen Gu et al.European journal of medicinal chemistry, 45(10), 4692-4696 (2010-08-13) Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs.James McNulty et al.Bioorganic & medicinal chemistry letters, 20(7), 2335-2339 (2010-03-02) Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation.Le P Ngo et al.Cell reports, 26(6), 1668-1678 (2019-02-07) Increased systemic exposure of fimasartan, an angiotensin II receptor antagonist, by ketoconazole and rifampicin.Jung Won Kim et al.Journal of clinical pharmacology, 53(1), 75-81 (2013-02-13) Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR.Hao Li et al.The Journal of biological chemistry, 288(19), 13655-13668 (2013-03-26) Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.Rafael Luis Kessler et al.PloS one, 8(1), e55497-e55497 (2013-02-06) In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum.Mónica Azor et al.Antimicrobial agents and chemotherapy, 52(6), 2228-2231 (2008-04-09) In vitro activity of thimerosal against ocular pathogenic fungi.Yan Xu et al.Antimicrobial agents and chemotherapy, 54(1), 536-539 (2009-10-21) Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.V Mistretta et al.Acta clinica Belgica, 69(1), 53-61 (2014-03-19) The taiwaniaquinoids: a review.George Majetich et al.Journal of natural products, 73(2), 284-298 (2010-01-28) Inhibitory effect of ketoconazole on the pharmacokinetics of a multireceptor tyrosine kinase inhibitor BMS-690514 in healthy participants: assessing the mechanism of the interaction with physiologically-based pharmacokinetic simulations.Zheng Yang et al.Journal of clinical pharmacology, 53(2), 217-227 (2013-02-26) CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48.Niels Bjerre Holm et al.The AAPS journal, 17(5), 1237-1245 (2015-05-24) Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.Marieke Voets et al.Journal of medicinal chemistry, 48(21), 6632-6642 (2005-10-14) Ketoconazole in the prevention of acute respiratory distress syndrome.A DeVries et al.Pharmacotherapy, 18(3), 581-587 (1998-06-10) Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation.K Liaras et al.Bioorganic & medicinal chemistry, 19(10), 3135-3140 (2011-04-29) 4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.Zhu-Ping Xiao et al.Bioorganic & medicinal chemistry, 19(13), 3884-3891 (2011-06-15) High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections.Lixin Zhang et al.Proceedings of the National Academy of Sciences of the United States of America, 104(11), 4606-4611 (2007-03-16) Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells.Jinhee Kim et al.Biochimie, 105, 36-44 (2014-06-15) Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth.Patrick Vandeputte et al.Antimicrobial agents and chemotherapy, 51(3), 982-990 (2006-12-13) Cardiac contractility in Antarctic teleost is modulated by nitrite through xanthine oxidase and cytochrome p-450 nitrite reductase.Filippo Garofalo et al.Nitric oxide : biology and chemistry, 49, 1-7 (2015-06-06) Synthesis and antimicrobial evaluation of new benzofuran derivatives.Xizhen Jiang et al.European journal of medicinal chemistry, 46(8), 3526-3530 (2011-05-17) Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles.Ezhumalai Yamuna et al.European journal of medicinal chemistry, 47(1), 228-238 (2011-11-29) The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs.Laura L Gray et al.Veterinary dermatology, 24(1), 118-125 (2013-01-22) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Quantitative assessment of intestinal first-pass metabolism of oral drugs using portal-vein cannulated rats.Yoshiki Matsuda et al.Pharmaceutical research, 32(2), 604-616 (2014-08-29) Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor.Aneta Novotna et al.PloS one, 9(7), e101832-e101832 (2014-07-08) Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: a new class of antimicrobial agents.Rondla Rohini et al.European journal of medicinal chemistry, 44(8), 3330-3339 (2009-04-18) Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.Arturo Luna-Tapia et al.Antimicrobial agents and chemotherapy, 59(4), 2410-2420 (2015-02-11) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones.Ahmed S Aboraia et al.European journal of medicinal chemistry, 45(10), 4427-4434 (2010-07-27) Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis.Fillipe de Oliveira Pereira et al.Pharmaceutical biology, 53(2), 228-234 (2014-11-22) Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.Qingzhong Hu et al.Bioorganic & medicinal chemistry, 16(16), 7715-7727 (2008-08-05) Ketoconazole enantiomer for the treatment of diabetes mellitus.Richard Arakaki et al.Expert opinion on investigational drugs, 19(2), 185-194 (2010-01-06) A nanogram dose of the CYP3A probe substrate midazolam to evaluate drug interactions.B Halama et al.Clinical pharmacology and therapeutics, 93(6), 564-571 (2013-03-21) Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).Tina Korosec et al.Bioorganic & medicinal chemistry, 16(1), 209-221 (2007-10-30) Synthesis, characterization and biocidal activity of new organotin complexes of 2-(3-oxocyclohex-1-enyl)benzoic acid.Flaviana T Vieira et al.European journal of medicinal chemistry, 45(3), 883-889 (2009-12-05) Potent in vitro antifungal activities of naturally occurring acetylenic acids.Xing-Cong Li et al.Antimicrobial agents and chemotherapy, 52(7), 2442-2448 (2008-05-07) Peel bond strength of resilient liner modified by the addition of antimicrobial agents to denture base acrylic resin.Cristiane S Alcântara et al.Journal of applied oral science : revista FOB, 20(6), 607-612 (2013-01-19) High sensitive multiresidue analysis of pharmaceuticals and antifungals in surface water using U-HPLC-Q-Exactive Orbitrap HRMS. Application to the Danube river basin on the Romanian territory.Carmen Lidia Chitescu et al.The Science of the total environment, 532, 501-511 (2015-06-24) Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials.Zhu-Ping Xiao et al.Bioorganic & medicinal chemistry, 19(5), 1571-1579 (2011-02-19) Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.Chunquan Sheng et al.Journal of medicinal chemistry, 49(8), 2512-2525 (2006-04-14) Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.Katsunori Sasahara et al.Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1267-1276 (2015-06-10) Cytochrome P450 3A4 and 2D6-mediated metabolism of leisure and medicinal teas.Teresa W Tam et al.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 294-301 (2014-09-17) Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization.Ajay Saxena et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 76, 173-180 (2015-05-12) Multicenter, double-blind, parallel group study investigating the non-inferiority of efficacy and safety of a 2% miconazole nitrate shampoo in comparison with a 2% ketoconazole shampoo in the treatment of seborrhoeic dermatitis of the scalp.Stanislaw A Buechner The Journal of dermatological treatment, 25(3), 226-231 (2013-04-06) Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.Xiaoru Wang et al.Journal of natural products, 73(5), 942-948 (2010-05-11) Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation.Zhihong Xu et al.Bioorganic & medicinal chemistry letters, 21(13), 4005-4007 (2011-05-27) In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods.Eidi Alvarado-Ramírez et al.Antimicrobial agents and chemotherapy, 51(7), 2420-2423 (2007-04-18) Are 1,4- and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?Alberto Massarotti et al.ChemMedChem, 9(11), 2497-2508 (2014-08-01) 3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents.B Suresh Kuarm et al.Bioorganic & medicinal chemistry letters, 21(1), 524-527 (2010-12-08) Penetratin and derivatives acting as antifungal agents.Marcelo F Masman et al.European journal of medicinal chemistry, 44(1), 212-228 (2008-04-24) Identifying and targeting cancer-specific metabolism with network-based drug target prediction.Maria Pires Pacheco et al.EBioMedicine, 43, 98-106 (2019-05-28) Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.Nidhi Puri et al.European journal of medicinal chemistry, 45(11), 4813-4826 (2010-08-27) Co-administration of ritonavir and primaquine decreases plasma concentration of primaquine: single- and multiple-dose study in the rats.Melva Louisa et al.Acta medica Indonesiana, 44(4), 273-279 (2013-01-15) New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.Ilse M Zolle et al.Journal of medicinal chemistry, 51(7), 2244-2253 (2008-03-20) Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues.Nilkanth G Aher et al.Bioorganic & medicinal chemistry letters, 19(3), 759-763 (2008-12-27) Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.Caroline P Owen et al.Bioorganic & medicinal chemistry letters, 20(17), 5345-5348 (2010-08-03) In vitro inhibition of CYP2C9-mediated warfarin 7-hydroxylation by iguratimod: possible mechanism of iguratimod-warfarin interaction.Satoshi Yamaori et al.Biological & pharmaceutical bulletin, 38(3), 441-447 (2015-03-12) Inhibition of cytochrome P450 by ethambutol in human liver microsomes.Sang Yoon Lee et al.Toxicology letters, 229(1), 33-40 (2014-06-10) Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents.Rahul V Patel et al.European journal of medicinal chemistry, 46(9), 4354-4365 (2011-07-29) Gender determines ACTH recovery from hypercortisolemia in healthy older humans.Animesh Sharma et al.Metabolism: clinical and experimental, 62(12), 1819-1829 (2013-10-01) Susceptibility of clinically important dermatophytes against statins and different statin-antifungal combinations.Ildikó Nyilasi et al.Medical mycology, 52(2), 140-148 (2013-09-06) A multi-targeted liquid chromatography-mass spectrometry screening procedure for the detection in human urine of drugs non-prohibited in sport commonly used by the athletes.Monica Mazzarino et al.Journal of pharmaceutical and biomedical analysis, 117, 47-60 (2015-09-08) Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans.Niina Tani et al.European journal of medicinal chemistry, 47(1), 270-277 (2011-11-22) Metabolism of the polycyclic musk galaxolide and its interference with endogenous and xenobiotic metabolizing enzymes in the European sea bass (Dicentrarchus labrax).Denise Fernandes et al.Environmental pollution (Barking, Essex : 1987), 174, 214-221 (2013-01-01) African histoplasmosis: report of two patients treated with amphotericin B and ketoconazole.F C Akpuaka et al.Mycoses, 41(9-10), 363-364 (1999-01-23) Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.Keith W Ward et al.Drug metabolism and disposition: the biological fate of chemicals, 32(2), 172-177 (2004-01-28) Molecular characteristics for solid-state limited solubility.Carola M Wassvik et al.Journal of medicinal chemistry, 51(10), 3035-3039 (2008-04-10) Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.Cui Li et al.Journal of natural products, 74(7), 1658-1662 (2011-07-05) Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.Emmanoel Vilaça Costa et al.Journal of natural products, 73(6), 1180-1183 (2010-05-19) Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.Chaitali Ghosh et al.Epilepsia, 56(3), 439-449 (2015-02-07) In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o.Leonard Blum et al.Scientific reports, 10(1), 7534-7534 (2020-05-07) Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.Ralf Heim et al.Journal of medicinal chemistry, 51(16), 5064-5074 (2008-08-05) Phase II trial assessing granulocyte-macrophage-colony stimulating factor, ketoconazole plus mitoxantrone in metastatic castration-resistant prostate cancer progressing after docetaxel treatments.Robert J Amato et al.Cancer investigation, 31(3), 177-182 (2013-02-14) Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies.A B Ke et al.Clinical pharmacology and therapeutics, 95(5), 473-476 (2014-04-22) Steroidal saponins from Smilax medica and their antifungal activity.Marc Sautour et al.Journal of natural products, 68(10), 1489-1493 (2005-10-29) Cytochrome p450-mediated metabolic activation of diosbulbin B.Dongju Lin et al.Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16) Antihormonal potential of selected D-homo and D-seco estratriene derivatives.Suzana S Jovanović-Šanta et al.Steroids, 97, 45-53 (2014-09-11) Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents.Ping Liu et al.Bioorganic & medicinal chemistry letters, 18(11), 3261-3265 (2008-05-10) In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids.Loai Basheer et al.Food chemistry, 237, 895-903 (2017-08-03) Investigation of minor species Candida africana, Candida stellatoidea and Candida dubliniensis in the Candida albicans complex among Yaoundé (Cameroon) HIV-infected patients.Thierry K Ngouana et al.Mycoses, 58(1), 33-39 (2014-10-08) The effect of Cree traditional medicinal teas on the activity of human cytochrome P450-mediated metabolism.Teresa W Tam et al.Journal of ethnopharmacology, 155(1), 841-846 (2014-06-28) Synthesis and antimicrobial activities of 7-O-modified genistein derivatives.Li-Na Zhang et al.European journal of medicinal chemistry, 43(7), 1543-1551 (2007-11-06) Phase I study of cabazitaxel plus cisplatin in patients with advanced solid tumors: study to evaluate the impact of cytochrome P450 3A inhibitors (aprepitant, ketoconazole) or inducers (rifampin) on the pharmacokinetics of cabazitaxel.John Sarantopoulos et al.Cancer chemotherapy and pharmacology, 74(6), 1113-1124 (2014-10-14) Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)).Eoin C Power et al.Bioorganic & medicinal chemistry letters, 16(4), 887-890 (2005-12-20) Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4.James McNulty et al.Bioorganic & medicinal chemistry letters, 19(19), 5607-5612 (2009-08-29) Ketoconazole: a review of a workhorse antifungal molecule with a focus on new foam and gel formulations.Noah Scheinfeld Drugs of today (Barcelona, Spain : 1998), 44(5), 369-380 (2008-06-13) Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety.Yusuf Ozkay et al.European journal of medicinal chemistry, 45(8), 3293-3298 (2010-05-11) Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols.Xiaoyun Chai et al.Bioorganic & medicinal chemistry letters, 19(6), 1811-1814 (2009-02-24) Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.Sarah Ulmschneider et al.Journal of medicinal chemistry, 48(6), 1796-1805 (2005-03-18) The treatment of advanced prostate cancer with ketoconazole: safety issues.R A Bok et al.Drug safety, 20(5), 451-458 (1999-05-29) Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major.José Ignacio Manzano et al.Antimicrobial agents and chemotherapy, 55(3), 1045-1052 (2011-01-05) FDA-approved drug labeling for the study of drug-induced liver injury.Minjun Chen et al.Drug discovery today, 16(15-16), 697-703 (2011-06-01) Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays.Sook Wah Yee et al.Journal of medicinal chemistry, 48(23), 7123-7131 (2005-11-11) New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines.A B A el-Gazzar et al.European journal of medicinal chemistry, 44(4), 1427-1436 (2008-11-04) Enamines as novel antibacterials and their structure-activity relationships.Zhu-Ping Xiao et al.European journal of medicinal chemistry, 43(9), 1828-1836 (2008-01-15) The truth about the lower plasma concentration of the (-)-isomer after racemic doxazosin administration in rats: Stereoselective inhibition of the (-)-isomer by the (+)-isomer at CYP3A.Dezhi Kong et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 238-245 (2015-06-29) In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.Simon Lucas et al.Journal of medicinal chemistry, 51(24), 8077-8087 (2008-12-04) Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.Azumi Iida et al.Drug metabolism and disposition: the biological fate of chemicals, 43(7), 958-968 (2015-04-15) Enhanced activation of human NK cells by drug-exposed hepatocytes.Frank Fasbender et al.Archives of toxicology, 94(2), 439-448 (2020-02-16) Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.Ming Li et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1070-1078 (2015-04-29) Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles.V Padmavathi et al.European journal of medicinal chemistry, 43(5), 917-924 (2007-08-19) Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17.Mariano A E Pinto-Bazurco Mendieta et al.Bioorganic & medicinal chemistry letters, 18(1), 267-273 (2007-11-21) Heme reversibly damps PERIOD2 rhythms in mouse suprachiasmatic nucleus explants.C J Guenthner et al.Neuroscience, 164(2), 832-841 (2009-08-25) Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen.W Edward Martucci et al.Bioorganic & medicinal chemistry letters, 19(2), 418-423 (2008-12-09) Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.P C Leal et al.Bioorganic & medicinal chemistry letters, 19(6), 1793-1796 (2009-02-24) Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide.Neslihan Ozbek et al.Bioorganic & medicinal chemistry, 15(15), 5105-5109 (2007-06-05) Effect of antimicrobial agents incorporated into resilient denture relines on the Candida albicans biofilm.M G Bueno et al.Oral diseases, 21(1), 57-65 (2013-11-14) Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.Kathleen W Mosure et al.Journal of pharmaceutical sciences, 104(9), 2813-2823 (2015-01-30) Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.A Padmaja et al.European journal of medicinal chemistry, 44(11), 4557-4566 (2009-07-28) In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents.Nikolaos G Almyroudis et al.Antimicrobial agents and chemotherapy, 51(7), 2587-2590 (2007-04-25) Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis.Kristina Haslinger et al.Chembiochem : a European journal of chemical biology, 15(18), 2719-2728 (2014-11-02) Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives.Maurício S dos Santos et al.Bioorganic & medicinal chemistry letters, 21(24), 7451-7454 (2011-11-08) Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys.Ikuo Yamamiya et al.The Journal of pharmacy and pharmacology, 66(12), 1686-1697 (2014-08-15) Biotransformation of isoflavone using enzymatic reactions.Changhyun Roh Molecules (Basel, Switzerland), 18(3), 3028-3040 (2013-03-08) Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines.Rondla Rohini et al.European journal of medicinal chemistry, 45(3), 1200-1205 (2009-12-17) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Jing Yuan et al.Nature chemical biology, 5(10), 765-771 (2009-09-08) The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity.Liping Li et al.Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1227-1234 (2014-04-30) The effect of prior androgen synthesis inhibition on outcomes of subsequent therapy with docetaxel in patients with metastatic castrate-resistant prostate cancer: results from a retrospective analysis of a randomized phase 3 clinical trial (CALGB 90401) (Alliance).Rahul Aggarwal et al.Cancer, 119(20), 3636-3643 (2013-08-06) Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.Masato Ohbuchi et al.Antimicrobial agents and chemotherapy, 57(3), 1332-1338 (2013-01-01) An improved and versatile immunosuppression protocol for the development of tumor xenograft in mice.Mehul Jivrajani et al.Anticancer research, 34(12), 7177-7183 (2014-12-17) Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles.V Padmavathi et al.European journal of medicinal chemistry, 46(4), 1367-1373 (2011-02-24) In vitro antifungal susceptibilities of five species of sporothrix.Rita Marimon et al.Antimicrobial agents and chemotherapy, 52(2), 732-734 (2007-11-28) Kerion mimicking erosive pustular dermatosis in elderly patients.Charles Chia et al.Cutis, 91(2), 73-77 (2013-03-22) Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.Roger Lille-Langøy et al.Toxicology and applied pharmacology, 284(1), 54-64 (2015-02-15) Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.Caroline Camaré et al.British journal of pharmacology, 172(1), 106-118 (2014-09-02) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.Venkatesh D Handratta et al.Journal of medicinal chemistry, 48(8), 2972-2984 (2005-04-15) Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole.M Y Roth et al.The Journal of clinical endocrinology and metabolism, 98(3), 1198-1206 (2013-01-26) Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.Ahmed S Aboraia et al.Bioorganic & medicinal chemistry, 18(14), 4939-4946 (2010-07-03) Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors.Antoinette R Tan et al.Cancer chemotherapy and pharmacology, 71(6), 1635-1643 (2013-05-03) Phenotyping of CYP450 in human liver microsomes using the cocktail approach.Dany Spaggiari et al.Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05) Cytochrome P17 inhibition with ketoconazole as treatment for advanced granulosa cell ovarian tumor.Jesus Garcia-Donas et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(10), e165-e166 (2013-01-30) Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex.Naz M Aghatabay et al.European journal of medicinal chemistry, 42(8), 1069-1075 (2007-03-14) Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.Yiming Jiang et al.Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 107-115 (2014-10-17) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).Zhichao Liu et al.PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24) The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application.Jacek Wójcikowski et al.Biochemical pharmacology, 90(2), 188-195 (2014-05-21) Ketoconazole as a secondary hormonal intervention in advanced prostate cancer.Christine Liebertz et al.Clinical journal of oncology nursing, 10(3), 361-366 (2006-06-23) Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua.Shunyan Mo et al.Journal of natural products, 72(5), 894-899 (2009-04-18) In vitro metabolism and drug-drug interaction potential of UTL-5g, a novel chemo- and radioprotective agent.Jianmei Wu et al.Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2058-2067 (2014-09-25) Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models.Neil Mathias et al.The AAPS journal, 17(4), 988-998 (2015-05-03) Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model.Shinji Yamazaki et al.Drug metabolism and disposition: the biological fate of chemicals, 43(10), 1417-1429 (2015-07-17) Potent CYP3A4 inhibitory constituents of Piper cubeba.Tepy Usia et al.Journal of natural products, 68(1), 64-68 (2005-02-01) Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.Nelilma C Romeiro et al.Bioorganic & medicinal chemistry, 17(2), 641-652 (2008-12-27) Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles.V Padmavathi et al.European journal of medicinal chemistry, 45(9), 4246-4251 (2010-07-16) Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.Andrew G Warrilow et al.Antimicrobial agents and chemotherapy, 57(3), 1352-1360 (2013-01-01) New small-size peptides possessing antifungal activity.Francisco M Garibotto et al.Bioorganic & medicinal chemistry, 18(1), 158-167 (2009-12-05) Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.Roman Řemínek et al.Electrophoresis, 36(11-12), 1349-1357 (2014-11-11) Interaction between ketoconazole and human serum albumin on epoxy modified magnetic nanoparticles for drug delivery.Esra Maltas et al.Journal of nanoscience and nanotechnology, 13(10), 6522-6528 (2013-11-20) In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.Williams Porcal et al.Journal of medicinal chemistry, 50(24), 6004-6015 (2007-10-27) Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds.Naz Mohammed Aghatabay et al.European journal of medicinal chemistry, 44(1), 365-372 (2008-04-18) OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.Makoto Matsumoto et al.PLoS medicine, 3(11), e466-e466 (2006-11-30) Ketoconazole associated hepatotoxicity: a systematic review and meta- analysis.Jiang Ying Yan et al.Biomedical and environmental sciences : BES, 26(7), 605-610 (2013-07-31) Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds.M Sortino et al.Bioorganic & medicinal chemistry, 19(9), 2823-2834 (2011-04-13) Effect of increased blood levels of β-endorphin on perception of breathlessness.Donald A Mahler et al.Chest, 143(5), 1378-1385 (2013-05-30) Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents.Wendy W J van de Sande et al.Antimicrobial agents and chemotherapy, 54(6), 2738-2740 (2010-03-31) In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.Xiangrong Zhang et al.PloS one, 9(4), e94962-e94962 (2014-04-17) Metabolic study of Angelica dahurica extracts using a reusable liver microsomal nanobioreactor by liquid chromatography-mass spectrometry.Hai-Li Shi et al.Biomedical chromatography : BMC, 29(10), 1514-1521 (2015-03-11) Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Caroline P Owen et al.Bioorganic & medicinal chemistry letters, 16(15), 4011-4015 (2006-06-06) CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells.Katrin Kittler et al.Archives of toxicology, 88(8), 1519-1526 (2014-02-08) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).Chirag H Patel et al.Bioorganic & medicinal chemistry letters, 16(18), 4752-4756 (2006-07-28) Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria.Chung-Ren Su et al.Journal of natural products, 70(12), 1930-1933 (2007-11-13) Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.Carsten Jagusch et al.Bioorganic & medicinal chemistry, 16(4), 1992-2010 (2007-12-07) Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers.Catherine Dutreix et al.Cancer chemotherapy and pharmacology, 72(6), 1223-1234 (2013-10-03) Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes.Yoshiki Murakami et al.Drug development and industrial pharmacy, 40(8), 1065-1071 (2013-06-21) Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics.Thierry Wendling et al.Journal of pharmacokinetics and pharmacodynamics, 42(6), 639-657 (2015-08-02) Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.Xiaoyu Niu et al.Archives of toxicology, 89(1), 107-119 (2014-04-29) Screening of herbal constituents for aromatase inhibitory activity.S Paoletta et al.Bioorganic & medicinal chemistry, 16(18), 8466-8470 (2008-09-10) Foetithiophenes C-F, thiophene derivatives from the roots of Ferula foetida.Mahsa Chitsazian-Yazdi et al.Pharmaceutical biology, 53(5), 710-714 (2014-11-29) Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells.Camille C Savary et al.Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1235-1240 (2014-05-17) Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).Shotaro Uehara et al.Drug metabolism and disposition: the biological fate of chemicals, 43(5), 735-742 (2015-03-05) Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).James McNulty et al.Bioorganic & medicinal chemistry letters, 22(1), 718-722 (2011-11-15) Stereoselective oxidation metabolism of 20(S)-protopanaxatriol in human liver microsomes and in rats.Wenyan Wang et al.Xenobiotica; the fate of foreign compounds in biological systems, 45(5), 385-395 (2014-11-29) Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.Andrea Escalante et al.Journal of natural products, 71(10), 1720-1725 (2008-09-26) Regioselective synthesis and antimicrobial activities of some novel aryloxyacetic acid derivatives.Bakr F Abdel-Wahab et al.European journal of medicinal chemistry, 50, 55-62 (2012-03-01) Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins.Kyra J Barnes et al.European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24) Long-term safety of ketoconazole foam, 2% in the treatment of seborrheic dermatitis: results of a phase IV, open-label study.Zoë D Draelos et al.Journal of drugs in dermatology : JDD, 12(1), e1-e6 (2013-02-05) Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles.André P Liesen et al.European journal of medicinal chemistry, 45(9), 3685-3691 (2010-06-15) Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives.Wei Zhang et al.European journal of medicinal chemistry, 46(9), 3639-3650 (2011-06-07) Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.Simon Lucas et al.Journal of medicinal chemistry, 51(19), 6138-6149 (2008-09-04) Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.M F Guzzo et al.Journal of neuroendocrinology, 27(7), 616-623 (2015-03-27) An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives.Bijoy P Mathew et al.European journal of medicinal chemistry, 45(4), 1502-1507 (2010-02-02) Synthesis and antimultidrug resistance evaluation of icariin and its derivatives.Dong-Fang Liu et al.Bioorganic & medicinal chemistry letters, 19(15), 4237-4240 (2009-06-16) BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.N Creusot et al.Environmental science and pollution research international, 22(21), 16393-16404 (2014-12-05) Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense.Virginie Treyvaud Amiguet et al.Journal of natural products, 69(7), 1005-1009 (2006-07-29) The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.Neeraj Chauhan et al.Antimicrobial agents and chemotherapy, 51(10), 3747-3751 (2007-08-01) New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.Sandrine Marchais-Oberwinkler et al.Journal of medicinal chemistry, 54(2), 534-547 (2010-12-30) Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo.L L von Moltke et al.The Journal of pharmacology and experimental therapeutics, 268(3), 1278-1283 (1994-03-01) Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.Guolin Shen et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 90-96 (2014-06-10) Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.Ruqaiyyah Siddiqui et al.Antimicrobial agents and chemotherapy, 51(12), 4471-4473 (2007-09-19) Bioactive oligostilbenoids from the stem bark of Hopea exalata.Hui Ming Ge et al.Journal of natural products, 69(12), 1800-1802 (2006-12-28) A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.Steven G Potkin et al.Journal of clinical psychopharmacology, 33(1), 3-10 (2013-01-02) Enantioselective N-demethylation and hydroxylation of sibutramine in human liver microsomes and recombinant cytochrome p-450 isoforms.Dhananjay D Shinde et al.Journal of toxicology and environmental health. Part A, 77(22-24), 1419-1430 (2014-10-25) A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities.Mutlu Dilsiz Aytemir et al.European journal of medicinal chemistry, 45(9), 4089-4095 (2010-07-02) Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation.Tassilo Kruis et al.The Journal of clinical endocrinology and metabolism, 95(3), 1137-1142 (2010-01-28) Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.Qing-Zhong Zheng et al.European journal of medicinal chemistry, 45(7), 3207-3212 (2010-04-13) A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.Claire M Martel et al.Antimicrobial agents and chemotherapy, 54(9), 3578-3583 (2010-06-16) Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.Songhee Han et al.Archives of biochemistry and biophysics, 575, 1-7 (2015-04-08) Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.Marieke Voets et al.Journal of medicinal chemistry, 49(7), 2222-2231 (2006-03-31) Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis.Delphine Renard et al.Bioorganic & medicinal chemistry, 17(23), 8123-8137 (2009-10-17) Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.James McNulty et al.Bioorganic & medicinal chemistry letters, 19(12), 3233-3237 (2009-05-12) High-throughput fluorescence assay of cytochrome P450 3A4.Qian Cheng et al.Methods in molecular biology (Clifton, N.J.), 987, 157-162 (2013-03-12) Pharmacokinetic interaction of intravenous fentanyl with ketoconazole.Victoria C Ziesenitz et al.Journal of clinical pharmacology, 55(6), 708-717 (2015-02-05) Ketoconazole modulates the infectivity of Ichthyophonus sp. (Mesomycetozoa) in vivo in experimentally injected European sea bass.Francisco Hontoria et al.Diseases of aquatic organisms, 105(3), 225-235 (2013-09-04) Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.V A Eagling et al.British journal of clinical pharmacology, 45(2), 107-114 (1998-03-10) Oral ketoconazole in cutaneous fungal infections.C C Rheney et al.The Annals of pharmacotherapy, 32(6), 709-711 (1998-06-26) Synthesis and anticandidal activity of new triazolothiadiazine derivatives.Mehlika Dilek Altıntop et al.European journal of medicinal chemistry, 46(11), 5562-5566 (2011-10-01) Cytochrome P450 isoenzymes in rat and human liver microsomes associate with the metabolism of total coumarins in Fructus Cnidii.Xiao Hu et al.European journal of drug metabolism and pharmacokinetics, 40(4), 373-377 (2014-07-06) Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.K-H Shin et al.Clinical pharmacology and therapeutics, 94(5), 601-609 (2013-06-21) Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.Dorota Łażewska et al.European journal of medicinal chemistry, 83, 534-546 (2014-07-06) In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.Lingmei Sun et al.Antimicrobial agents and chemotherapy, 53(4), 1586-1591 (2009-01-28) Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.Ulrike E Hille et al.European journal of medicinal chemistry, 44(7), 2765-2775 (2009-02-13) Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS(n) combined with specific inhibitors.Yunfeng Bi et al.Biomedical chromatography : BMC, 29(7), 1027-1034 (2014-11-27) Interaction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition.Sk Milan Ahmmed et al.Indian journal of pharmacology, 47(5), 530-534 (2015-11-26) Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp.Kamolchanok Tianpanich et al.Journal of natural products, 74(1), 79-81 (2010-12-23) Evaluation of drug-drug interactions for oncology therapies: in vitro-in vivo extrapolation model-based risk assessment.Nigel J Waters British journal of clinical pharmacology, 79(6), 946-958 (2014-12-03) Electrochemical behavior of the antifungal agents itraconazole, posaconazole and ketoconazole at a glassy carbon electrode.H Knoth et al.Die Pharmazie, 70(6), 374-378 (2015-07-21) Design of endoperoxides with anti-Candida activity.Thomas D Avery et al.Bioorganic & medicinal chemistry, 15(1), 36-42 (2006-11-03) Differential pulse polarographic investigation of the antifungal drugs itraconazole, ketoconazole, fluconazole and voriconazole using a dropping mercury electrode.H Knoth et al.Die Pharmazie, 67(12), 987-990 (2013-01-26) Madurella mycetomatis is highly susceptible to ravuconazole.Sarah Abdalla Ahmed et al.PLoS neglected tropical diseases, 8(6), e2942-e2942 (2014-06-20) Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.Angela Stefanachi et al.Journal of medicinal chemistry, 54(6), 1613-1625 (2011-02-24) An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model.X Jin et al.European journal of drug metabolism and pharmacokinetics, 39(2), 139-146 (2013-06-26) Effect of co-administration of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics, safety and tolerability of navitoclax, a first-in-class oral Bcl-2 family inhibitor, in cancer patients.Ahmed Hamed Salem et al.Anticancer research, 34(4), 2001-2006 (2014-04-03) Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.Lei Shi et al.European journal of medicinal chemistry, 42(4), 558-564 (2006-12-30) A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata.Patrick Vandeputte et al.Antimicrobial agents and chemotherapy, 52(10), 3701-3709 (2008-08-13) Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys.Mikiko Tsukimoto et al.Biopharmaceutics & drug disposition, 36(1), 15-33 (2014-09-30) Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.Shichong Yu et al.European journal of medicinal chemistry, 45(10), 4435-4445 (2010-08-03) Thermodynamic scaling of molecular dynamics in supercooled liquid state of pharmaceuticals: Itraconazole and ketoconazole.M Tarnacka et al.The Journal of chemical physics, 142(22), 224507-224507 (2015-06-15) In vitro metabolism of the lignan (-)-grandisin, an anticancer drug candidate, by human liver microsomes.Thiago Barth et al.Drug testing and analysis, 7(9), 780-786 (2015-01-17) Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes.Salvador Alonso et al.Oncotarget, 6(17), 14905-14912 (2015-04-29) Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.Andrew G S Warrilow et al.Antimicrobial agents and chemotherapy, 53(3), 1157-1164 (2008-12-17) Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives.Afshin Fassihi et al.European journal of medicinal chemistry, 44(5), 2145-2157 (2008-12-06) Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole.Jean-Benoît Corcuff et al.European journal of endocrinology, 172(4), 473-481 (2015-01-28) Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug.Mariappan Babu et al.European journal of medicinal chemistry, 47(1), 608-614 (2011-12-03) [Inhibition of steroidogenesis by ketoconazole. Therapeutic uses].P Miossec et al.Annales d'endocrinologie, 58(6), 494-502 (1997-01-01) Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.Silvia Gobbi et al.Journal of medicinal chemistry, 53(14), 5347-5351 (2010-06-24) Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.Anja Krick et al.Journal of natural products, 70(3), 353-360 (2007-02-13) Effects of cytochrome P450 inhibitors on peroxidase activity.Marketa Martinkova et al.Neuro endocrinology letters, 33 Suppl 3, 33-40 (2013-01-29) Why Small Differences Matter: Elucidation of the Mechanisms Underlying the Transformation of 2OH- and 3OH-Carbamazepine in Contact with Sand Filter Material.Elena Brezina et al.Environmental science & technology, 49(17), 10449-10456 (2015-08-25) Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.Yasuhiro Tezuka et al.Journal of natural products, 74(1), 102-105 (2010-12-09) Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals.Chun Pang et al.Journal of Zhejiang University. Science. B, 16(7), 602-610 (2015-07-15) Inhibition of SN-38 glucuronidation by gefitinib and its metabolite.Wei Li et al.Cancer chemotherapy and pharmacology, 75(6), 1253-1260 (2015-04-29) In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions.Carlos M Meléndez Gómez et al.Bioorganic & medicinal chemistry, 16(17), 7908-7920 (2008-08-30) Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.Sonal Girish et al.Parasites & vectors, 8, 332-332 (2015-06-18) CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.Vinay R Sonawane et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 131, 177-194 (2019-02-19) Neuropharmacokinetics of two investigational compounds in rats: divergent temporal profiles in the brain and cerebrospinal fluid.Cuyue Tang et al.Biochemical pharmacology, 91(4), 543-551 (2014-08-06) Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.Vladímir V Kouznetsov et al.Bioorganic & medicinal chemistry, 16(2), 794-809 (2007-11-06) Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel.Avivit Peer et al.The Prostate, 74(4), 433-440 (2013-12-18) Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives.Fernanda Mahle et al.European journal of medicinal chemistry, 45(11), 4761-4768 (2010-08-17) A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.Motoi Tobita et al.Bioorganic & medicinal chemistry letters, 15(11), 2886-2890 (2005-05-25) Support vector machines classification of hERG liabilities based on atom types.Lei Jia et al.Bioorganic & medicinal chemistry, 16(11), 6252-6260 (2008-05-02) Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).Jenny M Pedersen et al.Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07) The Japanese toxicogenomics project: application of toxicogenomics.Takeki Uehara et al.Molecular nutrition & food research, 54(2), 218-227 (2009-12-31) Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 35(3), 493-500 (2006-12-30) A new ketoconazole topical gel formulation in seborrhoeic dermatitis: an updated review of the mechanism.Jan Faergemann et al.Expert opinion on pharmacotherapy, 8(9), 1365-1371 (2007-06-15) Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.Zhu-Ping Xiao et al.European journal of medicinal chemistry, 46(10), 4904-4914 (2011-08-23) Regioselective synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4-disubstituted 1,2,3-bistriazoles as anti-infective agents.M Damodiran et al.Bioorganic & medicinal chemistry letters, 19(13), 3611-3614 (2009-05-19) A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.Faraz Kazmi et al.Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18) Effect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate.Lu Han et al.Xenobiotica; the fate of foreign compounds in biological systems, 49(8), 975-980 (2018-09-15) Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs.Kouatli Omar et al.Bioorganic & medicinal chemistry, 18(1), 426-432 (2009-11-17) Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).Yagmur Muftuoglu et al.Bioorganic & medicinal chemistry letters, 20(10), 3050-3064 (2010-04-24) NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds.Joerg Konter et al.Bioorganic & medicinal chemistry, 16(17), 8294-8300 (2008-08-20) Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.Alexander Pontius et al.Journal of natural products, 71(11), 1793-1799 (2008-10-23) Imidazolium salts with antifungal potential against multidrug-resistant dermatophytes.D F Dalla Lana et al.Journal of applied microbiology, 119(2), 377-388 (2015-06-06) Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network.Albi Celaj et al.Cell systems, 10(1), 25-38 (2019-11-02) Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.Ramesh Boinpally et al.Clinical therapeutics, 36(11), 1638-1649 (2014-09-23) Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.Susanna Tse et al.Drug metabolism and disposition: the biological fate of chemicals, 42(12), 2023-2032 (2014-09-14) Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.Yuki Ogawa et al.European journal of pediatrics, 174(4), 509-518 (2014-09-25) Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.Erwin Lamping et al.Antimicrobial agents and chemotherapy, 53(2), 354-369 (2008-11-19) The role of ketoconazole in seborrheic dermatitis.Marcel Borgers et al.Cutis, 80(4), 359-363 (2007-11-28) Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.Piyanuch Wonganan et al.Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1191-1201 (2014-04-26) Phytochemical and antifungal activities of Uvaria. chamae leaves and roots, Spondias mombin leaves and bark and Combretum racemosum leaves.O M T B Okwuosa et al.African journal of medicine and medical sciences, 41 Suppl, 99-103 (2013-05-18) Considerations for using ketoconazole in solid organ transplant recipients receiving cyclosporine immunosuppression.S A Chapman et al.Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization (NATCO), 6(3), 148-154 (1996-09-01) Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.Shohei Takai et al.Journal of applied toxicology : JAT, 36(1), 35-47 (2015-04-23) Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.J E Parker et al.Antimicrobial agents and chemotherapy, 52(10), 3597-3603 (2008-08-13) Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.J William Higgins et al.Drug metabolism and disposition: the biological fate of chemicals, 42(11), 1780-1784 (2014-08-12) Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts.Manuel Cuenca-Estrella et al.Antimicrobial agents and chemotherapy, 52(3), 1062-1065 (2008-01-16) Personalized Mapping of Drug Metabolism by the Human Gut Microbiome.Bahar Javdan et al.Cell, 181(7), 1661-1679 (2020-06-12) Can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?C Oo et al.Clinical pharmacology and therapeutics, 95(5), 489-489 (2014-02-13) Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.Satyanarayana R Pondugula et al.Toxicology letters, 232(3), 580-589 (2014-12-30) A novel biocompatible bicephalous dianionic surfactant from oleic acid for solid lipid nanoparticles.Rahul S Kalhapure et al.Colloids and surfaces. B, Biointerfaces, 105, 215-222 (2013-02-05) Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6.Peng Fu et al.Journal of natural products, 74(8), 1751-1756 (2011-07-21) Activation of the pleiotropic drug resistance pathway can promote mitochondrial DNA retention by fusion-defective mitochondria in Saccharomyces cerevisiae.Nebibe Mutlu et al.G3 (Bethesda, Md.), 4(7), 1247-1258 (2014-05-09) Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles.Bakr F Abdel-Wahab et al.European journal of medicinal chemistry, 46(5), 1505-1511 (2011-03-01) Synthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase.Takahiro Katoh et al.Bioorganic & medicinal chemistry, 15(7), 2736-2748 (2007-02-09) Novel endoperoxides: synthesis and activity against Candida species.Peter Macreadie et al.Bioorganic & medicinal chemistry letters, 16(4), 920-922 (2005-11-22) Results of gamma knife surgery for Cushing's disease.Jason P Sheehan et al.Journal of neurosurgery, 119(6), 1486-1492 (2013-08-13) Effects of ketoconazole on the pharmacokinetics of ponatinib in healthy subjects.Narayana I Narasimhan et al.Journal of clinical pharmacology, 53(9), 974-981 (2013-06-27) Ketoconazole foam--connetics: connetics ketoconazole foam. Drugs in R&D, 4(5), 323-325 (2003-09-04) Inhibiton of cytochrome P450 isoenzymes and P-gp activity by multiple extracts of Huang-Lian-Jie-Du decoction.Ying Wang et al.Journal of ethnopharmacology, 156, 175-181 (2014-09-16) Oxidation of nonionic detergents by cytochrome P450 enzymes.N A Hosea et al.Archives of biochemistry and biophysics, 353(2), 365-373 (1998-06-02) Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms.C J Seneviratne et al.Antimicrobial agents and chemotherapy, 52(9), 3259-3266 (2008-07-16) Multiple hyperpigmented macules on the torso of a dark-skinned man.Joseph R Kallini et al.JAAPA : official journal of the American Academy of Physician Assistants, 26(10), 13-15 (2013-11-10) Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.Kunal Roy et al.European journal of medicinal chemistry, 44(7), 2913-2922 (2009-01-09) Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy.Alexandra Maier-Salamon et al.International journal of oncology, 45(2), 877-886 (2014-06-04) A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery.Yutao Jiang et al.Journal of chromatography. A, 1411, 63-68 (2015-08-11) Rational modification of a candidate cancer drug for use against Chagas disease.James M Kraus et al.Journal of medicinal chemistry, 52(6), 1639-1647 (2009-02-26)

备注