水溶性	slowly hydrolyzes
沸点	66-67 ºC (16 mmHg)
闪点	93 ºC
密度	1.322
折射率	1.481-1.483

危险品标志	T
危险类别码	R21/22;R23;R34
安全说明书	S24/25

来源	SDS样本
TCI	浏览或下载
Acros-Organics	浏览或下载

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Multimodal actions of the phytochemical sulforaphane suppress both AR and AR-V7 in 22Rv1 cells: Advocating a potent pharmaceutical combination against castration-resistant prostate cancer.Namrata Khurana et al.Oncology reports, 38(5), 2774-2786 (2017-09-14) Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells.Zhi-Jun Jiang et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(3), 863-879 (2018-07-23) Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers.Toshiyuki Matsunaga et al.Biological & pharmaceutical bulletin, 38(9), 1309-1319 (2015-09-04) Naringin in Combination with Isothiocyanates as Liposomal Formulations Potentiates the Anti-inflammatory Activity in Different Acute and Chronic Animal Models of Rheumatoid Arthritis.Sangeeta Mohanty et al.ACS omega, 5(43), 28319-28332 (2020-11-10) MicroRNA-365a-3p inhibits c-Rel-mediated NF-κB signaling and the progression of pancreatic cancer.Libo Yin et al.Cancer letters, 452, 203-212 (2019-03-27) Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3 inflammasome activation in a rat model of retinal ischemia/reperfusion injury.Yuerong Gong et al.International journal of immunopathology and pharmacology, 33, 2058738419861777-2058738419861777 (2019-07-04) The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.Matthew L Fisher et al.Molecular carcinogenesis, 55(12), 2024-2036 (2015-12-24) Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells.Tsutomu Takahashi et al.The Journal of toxicological sciences, 45(4), 237-243 (2020-04-03) Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.Vicente Orozco-Sevilla et al.Journal of vascular surgery, 58(5), 1360-1365 (2013-03-30) Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder.Huai-Ching Tai et al.Scientific reports, 6, 36110-36110 (2016-11-09) Nrf2 regulates PU.1 expression and activity in the alveolar macrophage.Bashar S Staitieh et al.American journal of physiology. Lung cellular and molecular physiology, 308(10), L1086-L1093 (2015-04-05) The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.Dagmar Faust et al.Archives of toxicology, 91(2), 967-982 (2016-02-10) Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway.Subhash Dwivedi et al.Molecular neurobiology, 53(8), 5310-5323 (2015-10-05) Alleviating the progression of acute myeloid leukemia (AML) by sulforaphane through controlling miR-155 levels.Mohsen Koolivand et al.Molecular biology reports, 45(6), 2491-2499 (2018-10-24) Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively.Antonela Matana et al.Biochemical pharmacology, 173, 113605-113605 (2019-08-20) Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.Chon-Kit Lio et al.Biochemical pharmacology, 173, 113639-113639 (2019-09-20) Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.Hae-Ryung Park et al.Toxicology and applied pharmacology, 281(1), 67-77 (2014-10-12) Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.Masayoshi Yamaguchi et al.International journal of oncology, 53(3), 1313-1322 (2018-06-30) Stimulation of suicidal erythrocyte death by sulforaphane.Kousi Alzoubi et al.Basic & clinical pharmacology & toxicology, 116(3), 229-235 (2014-08-20) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.Y Zhang et al.Proceedings of the National Academy of Sciences of the United States of America, 89(6), 2399-2403 (1992-03-15) Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction.Tao Shen et al.Vascular pharmacology, 109, 72-82 (2018-06-15) Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.Masaki Miyazawa et al.Molecular biology of the cell, 25(13), 2116-2127 (2014-05-09) Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.Lucas Sagrillo-Fagundes et al.PloS one, 14(1), e0202458-e0202458 (2019-01-11) Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.Yanying Liu et al.Journal of neurochemistry, 129(3), 539-547 (2014-01-05) Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3.Kyun Ha Kim et al.Evidence-based complementary and alternative medicine : eCAM, 2020, 8125758-8125758 (2020-04-08) Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.Chang Yu et al.International immunopharmacology, 45, 74-78 (2017-02-13) Generation and characterization of keap1a- and keap1b-knockout zebrafish.Vu Thanh Nguyen et al.Redox biology, 36, 101667-101667 (2020-08-23) Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis.Yuan Liang et al.Phytotherapy research : PTR, 33(1), 130-148 (2018-10-23) Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease.Siyoung Lee et al.Molecular nutrition & food research, 62(12), e1800240-e1800240 (2018-05-02) Co -delivery of Sulforaphane and Curcumin with PEGylated Iron Oxide-Gold Core Shell Nanoparticles for Delivery to Breast Cancer Cell Line.Hossein Danafar et al.Iranian journal of pharmaceutical research : IJPR, 17(2), 480-494 (2018-06-09) U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.Tomas Smutny et al.Archives of toxicology, 88(12), 2243-2259 (2014-05-14) Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.Chisato Inoue et al.Nagoya journal of medical science, 82(2), 261-280 (2020-06-26) HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.Chunyu Cao et al.International journal of cancer, 143(6), 1388-1401 (2018-04-11) Modulation of Myb-induced NF-kB -STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors.Miao Tian et al.Journal of cellular physiology, 234(11), 21126-21134 (2019-05-01) Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy.Avani R Vyas et al.Cancer research, 73(19), 5985-5995 (2013-08-08) Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction.Chia-Ming Liu et al.Journal of the Formosan Medical Association = Taiwan yi zhi, 116(1), 41-48 (2016-02-18) Overexpression of Regucalcin Suppresses the Growth of Human Osteosarcoma Cells in Vitro: Repressive Effect of Extracellular Regucalcin.Masayoshi Yamaguchi et al.Cancer investigation, 38(1), 37-51 (2019-12-24) A bacterial metabolite induces Nrf2-mediated anti-oxidative responses in gingival epithelial cells by activating the MAPK signaling pathway.Mai Yokoji-Takeuchi et al.Archives of oral biology, 110, 104602-104602 (2019-11-18) Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.Elizabeth J Pereira et al.Science signaling, 13(627) (2020-04-16) Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.Shanmugam Thangapandiyan et al.Environmental science and pollution research international, 26(12), 12247-12263 (2019-03-06) Development of an oxidative stress in vitro assay in zebrafish (Danio rerio) cell lines.Sebastian Lungu-Mitea et al.Scientific reports, 8(1), 12380-12380 (2018-08-19) Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver.Clémence M Canivet et al.Biochimica et biophysica acta. Molecular basis of disease, 1866(5), 165705-165705 (2020-02-01) Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2.Chengcao Sun et al.Journal of applied physiology (Bethesda, Md. : 1985), 118(2), 224-237 (2015-01-17) Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.Mahesh Appari et al.International journal of oncology, 45(4), 1391-1400 (2014-07-16) The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer.Shasha Tao et al.Molecular carcinogenesis, 57(2), 182-192 (2017-10-05) Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo.Nadia P Castro et al.Cancer prevention research (Philadelphia, Pa.), 12(3), 147-158 (2019-01-27) Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia.Sisi Qin et al.Pharmacological research, 133, 218-235 (2018-02-03) Sulforaphane improves syncytiotrophoblast mitochondrial function after in vitro hypoxic and superoxide injury.A Langston-Cox et al.Placenta, 96, 44-54 (2020-06-21) Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo.Fang Liu et al.OncoTargets and therapy, 13, 4957-4969 (2020-06-26) The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.Melina Mitsiogianni et al.Antioxidants (Basel, Switzerland), 8(4) (2019-04-21) Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis.Dengfeng Li et al.Cancer letters, 424, 97-108 (2018-03-28) Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells.Steven J T Jackson et al.Journal of medicinal food, 19(1), 47-53 (2015-12-02) AOP1, a New Live Cell Assay for the Direct and Quantitative Measure of Intracellular Antioxidant Effects.Camille Gironde et al.Antioxidants (Basel, Switzerland), 9(6) (2020-06-05) Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.Yangfan P Liu et al.The Journal of clinical investigation, 124(5), 2059-2070 (2014-04-03) Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.Bharath K Mani et al.American journal of physiology. Endocrinology and metabolism, 319(2), E330-E337 (2020-06-17) Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation.Zhe Sha et al.The Journal of cell biology, 217(5), 1757-1776 (2018-03-15) Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.Hua Liu et al.Proceedings of the National Academy of Sciences of the United States of America, 110(47), 19065-19070 (2013-11-06) Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.Li Yang et al.Carcinogenesis, 34(11), 2587-2592 (2013-07-12) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells.Ju-Ying Tsai et al.Toxicology and applied pharmacology, 362, 116-124 (2018-10-27) Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells.Hyuk-Sang Jeong et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 884-892 (2015-04-07) Regulation of hepatic P-gp expression and activity by genistein in rats.M Semeniuk et al.Archives of toxicology, 94(5), 1625-1635 (2020-03-19) Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention.Yongping Bao et al.PloS one, 9(12), e114764-e114764 (2014-12-23) Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway.Tianjie Qi et al.International journal of molecular medicine, 37(1), 182-188 (2015-11-05) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.Shivendra V Singh et al.The Journal of biological chemistry, 280(20), 19911-19924 (2005-03-15) Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response.Tian Wang et al.Free radical biology & medicine, 152, 525-539 (2019-11-25) Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes.Baolong Li et al.Food & function, 6(6), 1984-1991 (2015-05-27) Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes.Nouf Abdulkareem Omer Alkharashi et al.Environmental toxicology and pharmacology, 55, 223-239 (2017-09-25) Differential effects of sulforaphane in regulation of angiogenesis in a co-culture model of endothelial cells and pericytes.Yichong Wang et al.Oncology reports, 37(5), 2905-2912 (2017-04-14) Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.Xingguo Zhu et al.Experimental biology and medicine (Maywood, N.J.), 244(2), 171-182 (2019-01-25) Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice.Bin Li et al.Experimental neurology, 250, 239-249 (2013-10-15) Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro.Naoki Mine et al.Molecular cancer therapeutics, 13(9), 2215-2225 (2014-07-24) Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells.Tze Khee Chan et al.Journal of immunology (Baltimore, Md. : 1950), 199(1), 39-47 (2017-05-21) Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Tatsuro Iso et al.Molecular and cellular biology, 36(24), 3100-3112 (2016-10-05) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage.Huaping Li et al.Photochemistry and photobiology, 92(6), 808-815 (2016-08-16) Microencapsulation of sulforaphane from broccoli seed extracts by gelatin/gum arabic and gelatin/pectin complexes.Jesús S García-Saldaña et al.Food chemistry, 201, 94-100 (2016-02-13) Cadmium and α-lipoic acid activate similar de novo synthesis and recycling pathways for glutathione balance.Jose Macias-Barragan et al.Environmental toxicology and pharmacology, 52, 38-46 (2017-04-04) Li-Ying Peng et al.The American journal of Chinese medicine, 47(5), 1113-1131 (2019-07-30)Pulmonary fibrosis (PF) is characterized by myofibroblast activation, which can be triggered by oxidative stress. In this study, we investigated the antifibrotic effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on PF and examined the underlying molecular mechanism.... A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling.Lei Du et al.Acta pharmacologica Sinica, 41(3), 358-372 (2019-10-28) Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine.Martha E Floy et al.Stem cell research, 45, 101831-101831 (2020-05-24) Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.Masayoshi Yamaguchi et al.International journal of oncology, 48(5), 1955-1964 (2016-03-05) NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.Pengfei Liu et al.PLoS biology, 18(2), e3000620-e3000620 (2020-02-14) WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells.Maribel Escoll et al.Antioxidants (Basel, Switzerland), 9(9) (2020-08-23) Sulforaphane improves 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manner.Lian Xue et al.Toxicology research, 7(2), 258-270 (2018-08-10) Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer.Libo Yin et al.Molecular therapy oncolytics, 14, 74-81 (2019-05-03) Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis.Áislan de Carvalho Vivarini et al.Frontiers in immunology, 8, 1127-1127 (2017-09-30) Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.Andreas Bitter et al.Archives of toxicology, 89(11), 2089-2103 (2014-09-04) In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.Anssi Lipponen et al.International journal of molecular sciences, 20(21) (2019-11-02) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced 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(2020-01-29) Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.Jelena Todoric et al.Cancer cell, 32(6), 824-839 (2017-11-21) HO-1 mediates the anti-inflammatory actions of Sulforaphane in monocytes stimulated with a mycoplasmal lipopeptide.Luo Haodang et al.Chemico-biological interactions, 306, 10-18 (2019-04-10) SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.G W Watson et al.Oncogenesis, 3, e131-e131 (2014-12-09) The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.Catalina Carrasco-Pozo et al.International journal of molecular sciences, 20(21) (2019-11-02) The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.Constance Lay Lay Saw et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 303-311 (2014-08-12) Chemopreventive glucosinolate accumulation in various broccoli and collard tissues: Microfluidic-based targeted transcriptomics for by-product valorization.Young-Sang Lee et al.PloS one, 12(9), e0185112-e0185112 (2017-09-26) Influence of Sulforaphane Metabolites on Activities of Human Drug-Metabolizing Cytochrome P450 and Determination of Sulforaphane in Human Liver Cells.Alena Vanduchova et al.Journal of medicinal food, 19(12), 1141-1146 (2016-10-26) Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo.Sara Eslava-Alcon et al.International journal of molecular sciences, 21(15) (2020-07-30) Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.Chengcao Sun et al.Journal of applied physiology (Bethesda, Md. : 1985), 120(4), 377-390 (2015-10-24) A cell-based assay system for activators of the environmental cell stress response.Jennifer A Harbottle et al.Analytical biochemistry, 592, 113583-113583 (2020-01-17) Diallyl trisulfide induces apoptosis and mitotic arrest in AGS human gastric carcinoma cells through reactive oxygen species-mediated activation of AMP-activated protein kinase.Yung Hyun Choi Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 63-71 (2017-07-29) Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis.Rohit Upadhyay et al.JCI insight, 5(14) (2020-06-17) Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles.Daniela Perroni Frias et al.Scientific reports, 10(1), 3704-3704 (2020-03-01) SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.Zhen Jin et al.Experimental cell research, 387(1), 111744-111744 (2019-11-25) Multimodal actions of the phytochemical sulforaphane suppress both AR and AR-V7 in 22Rv1 cells: Advocating a potent pharmaceutical combination against castration-resistant prostate cancer.Namrata Khurana et al.Oncology reports, 38(5), 2774-2786 (2017-09-14) Galectin-1 Restores Immune Tolerance to Liver Transplantation Through Activation of Hepatic Stellate Cells.Zhi-Jun Jiang et al.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(3), 863-879 (2018-07-23) Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers.Toshiyuki Matsunaga et al.Biological & pharmaceutical bulletin, 38(9), 1309-1319 (2015-09-04) Naringin in Combination with Isothiocyanates as Liposomal Formulations Potentiates the Anti-inflammatory Activity in Different Acute and Chronic Animal Models of Rheumatoid Arthritis.Sangeeta Mohanty et al.ACS omega, 5(43), 28319-28332 (2020-11-10) MicroRNA-365a-3p inhibits c-Rel-mediated NF-κB signaling and the progression of pancreatic cancer.Libo Yin et al.Cancer letters, 452, 203-212 (2019-03-27) Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3 inflammasome activation in a rat model of retinal ischemia/reperfusion injury.Yuerong Gong et al.International journal of immunopathology and pharmacology, 33, 2058738419861777-2058738419861777 (2019-07-04) The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.Matthew L Fisher et al.Molecular carcinogenesis, 55(12), 2024-2036 (2015-12-24) Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells.Tsutomu Takahashi et al.The Journal of toxicological sciences, 45(4), 237-243 (2020-04-03) Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery.Vicente Orozco-Sevilla et al.Journal of vascular surgery, 58(5), 1360-1365 (2013-03-30) Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder.Huai-Ching Tai et al.Scientific reports, 6, 36110-36110 (2016-11-09) Nrf2 regulates PU.1 expression and activity in the alveolar macrophage.Bashar S Staitieh et al.American journal of physiology. Lung cellular and molecular physiology, 308(10), L1086-L1093 (2015-04-05) The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.Dagmar Faust et al.Archives of toxicology, 91(2), 967-982 (2016-02-10) Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway.Subhash Dwivedi et al.Molecular neurobiology, 53(8), 5310-5323 (2015-10-05) Alleviating the progression of acute myeloid leukemia (AML) by sulforaphane through controlling miR-155 levels.Mohsen Koolivand et al.Molecular biology reports, 45(6), 2491-2499 (2018-10-24) Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively.Antonela Matana et al.Biochemical pharmacology, 173, 113605-113605 (2019-08-20) Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1.Chon-Kit Lio et al.Biochemical pharmacology, 173, 113639-113639 (2019-09-20) Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.Hae-Ryung Park et al.Toxicology and applied pharmacology, 281(1), 67-77 (2014-10-12) Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro.Masayoshi Yamaguchi et al.International journal of oncology, 53(3), 1313-1322 (2018-06-30) Stimulation of suicidal erythrocyte death by sulforaphane.Kousi Alzoubi et al.Basic & clinical pharmacology & toxicology, 116(3), 229-235 (2014-08-20) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.Y Zhang et al.Proceedings of the National Academy of Sciences of the United States of America, 89(6), 2399-2403 (1992-03-15) Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction.Tao Shen et al.Vascular pharmacology, 109, 72-82 (2018-06-15) Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.Masaki Miyazawa et al.Molecular biology of the cell, 25(13), 2116-2127 (2014-05-09) Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.Lucas Sagrillo-Fagundes et al.PloS one, 14(1), e0202458-e0202458 (2019-01-11) Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease.Yanying Liu et al.Journal of neurochemistry, 129(3), 539-547 (2014-01-05) Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3.Kyun Ha Kim et al.Evidence-based complementary and alternative medicine : eCAM, 2020, 8125758-8125758 (2020-04-08) Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.Chang Yu et al.International immunopharmacology, 45, 74-78 (2017-02-13) Generation and characterization of keap1a- and keap1b-knockout zebrafish.Vu Thanh Nguyen et al.Redox biology, 36, 101667-101667 (2020-08-23) Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis.Yuan Liang et al.Phytotherapy research : PTR, 33(1), 130-148 (2018-10-23) Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease.Siyoung Lee et al.Molecular nutrition & food research, 62(12), e1800240-e1800240 (2018-05-02) Co -delivery of Sulforaphane and Curcumin with PEGylated Iron Oxide-Gold Core Shell Nanoparticles for Delivery to Breast Cancer Cell Line.Hossein Danafar et al.Iranian journal of pharmaceutical research : IJPR, 17(2), 480-494 (2018-06-09) Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.Seema Negi et al.Toxicology in vitro : an international journal published in association with BIBRA, 52, 222-234 (2018-06-23) Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway.Hyun Hwangbo et al.Biomolecules & therapeutics, 28(5), 443-455 (2020-08-29) Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases.Maria Chiara Cristiano et al.Pharmaceutics, 12(1) (2019-12-22) Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass.Bao Nguyen et al.The Journal of thoracic and cardiovascular surgery, 148(2), 690-697 (2014-02-14) Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish.Akihito Yamashita et al.Journal of pharmacological and toxicological methods, 96, 34-45 (2018-12-31) Rapha Myr®, a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation.Barbara Tomasello et al.International journal of molecular sciences, 21(15) (2020-07-31) Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.Wensong Zhang et al.Renal failure, 38(7), 1099-1106 (2016-06-15) Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis.Seyed Mojtaba Ghiasi et al.Molecular and cellular endocrinology, 478, 106-114 (2018-08-20) Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.Wu Bi et al.Food & function, 9(5), 2809-2819 (2018-04-26) Sulforaphane effects on postinfarction cardiac remodeling in rats: modulation of redox-sensitive prosurvival and proapoptotic proteins.Rafael Oliveira Fernandes et al.The Journal of nutritional biochemistry, 34, 106-117 (2016-06-12) The combination of β-caryophyllene, baicalin and catechin synergistically suppresses the proliferation and promotes the death of RAW267.4 macrophages in vitro.Masayoshi Yamaguchi et al.International journal of molecular medicine, 38(6), 1940-1946 (2016-11-15) Cigarette Smoke-Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells.Dimitra Kerdidani et al.Journal of immunology (Baltimore, Md. : 1950), 201(5), 1558-1569 (2018-07-25) Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function.Yonggang Wang et al.American journal of physiology. Endocrinology and metabolism, 307(1), E14-E23 (2014-05-08) Protective Effect of Glyceollins in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.Hyelin Seo et al.Journal of medicinal food, 20(11), 1055-1062 (2017-09-29) The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.Melina Mitsiogianni et al.Antioxidants (Basel, Switzerland), 8(4) (2019-04-21) Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis.Dengfeng Li et al.Cancer letters, 424, 97-108 (2018-03-28) Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells.Steven J T Jackson et al.Journal of medicinal food, 19(1), 47-53 (2015-12-02) AOP1, a New Live Cell Assay for the Direct and Quantitative Measure of Intracellular Antioxidant Effects.Camille Gironde et al.Antioxidants (Basel, Switzerland), 9(6) (2020-06-05) Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.Yangfan P Liu et al.The Journal of clinical investigation, 124(5), 2059-2070 (2014-04-03) Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.Bharath K Mani et al.American journal of physiology. Endocrinology and metabolism, 319(2), E330-E337 (2020-06-17) Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation.Zhe Sha et al.The Journal of cell biology, 217(5), 1757-1776 (2018-03-15) Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention.Hua Liu et al.Proceedings of the National Academy of Sciences of the United States of America, 110(47), 19065-19070 (2013-11-06) Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.Li Yang et al.Carcinogenesis, 34(11), 2587-2592 (2013-07-12) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells.Ju-Ying Tsai et al.Toxicology and applied pharmacology, 362, 116-124 (2018-10-27) Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells.Hyuk-Sang Jeong et al.Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 884-892 (2015-04-07) Regulation of hepatic P-gp expression and activity by genistein in rats.M Semeniuk et al.Archives of toxicology, 94(5), 1625-1635 (2020-03-19) Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention.Yongping Bao et al.PloS one, 9(12), e114764-e114764 (2014-12-23) Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway.Tianjie Qi et al.International journal of molecular medicine, 37(1), 182-188 (2015-11-05) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.Shivendra V Singh et al.The Journal of biological chemistry, 280(20), 19911-19924 (2005-03-15) Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response.Tian Wang et al.Free radical biology & medicine, 152, 525-539 (2019-11-25) Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes.Baolong Li et al.Food & function, 6(6), 1984-1991 (2015-05-27) Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes.Nouf Abdulkareem Omer Alkharashi et al.Environmental toxicology and pharmacology, 55, 223-239 (2017-09-25) Differential effects of sulforaphane in regulation of angiogenesis in a co-culture model of endothelial cells and pericytes.Yichong Wang et al.Oncology reports, 37(5), 2905-2912 (2017-04-14) Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease.Xingguo Zhu et al.Experimental biology and medicine (Maywood, N.J.), 244(2), 171-182 (2019-01-25) Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice.Bin Li et al.Experimental neurology, 250, 239-249 (2013-10-15) Activation of Nrf2 pathways correlates with resistance of NSCLC cell lines to CBP501 in vitro.Naoki Mine et al.Molecular cancer therapeutics, 13(9), 2215-2225 (2014-07-24) Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells.Tze Khee Chan et al.Journal of immunology (Baltimore, Md. : 1950), 199(1), 39-47 (2017-05-21) Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Tatsuro Iso et al.Molecular and cellular biology, 36(24), 3100-3112 (2016-10-05) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage.Huaping Li et al.Photochemistry and photobiology, 92(6), 808-815 (2016-08-16) Microencapsulation of sulforaphane from broccoli seed extracts by gelatin/gum arabic and gelatin/pectin complexes.Jesús S García-Saldaña et al.Food chemistry, 201, 94-100 (2016-02-13) Cadmium and α-lipoic acid activate similar de novo synthesis and recycling pathways for glutathione balance.Jose Macias-Barragan et al.Environmental toxicology and pharmacology, 52, 38-46 (2017-04-04) Li-Ying Peng et al.The American journal of Chinese medicine, 47(5), 1113-1131 (2019-07-30)Pulmonary fibrosis (PF) is characterized by myofibroblast activation, which can be triggered by oxidative stress. In this study, we investigated the antifibrotic effect of the ethyl acetate extract of Salvia miltiorrhiza (EASM) on PF and examined the underlying molecular mechanism.... A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling.Lei Du et al.Acta pharmacologica Sinica, 41(3), 358-372 (2019-10-28) Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine.Martha E Floy et al.Stem cell research, 45, 101831-101831 (2020-05-24) Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.Masayoshi Yamaguchi et al.International journal of oncology, 48(5), 1955-1964 (2016-03-05) NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.Pengfei Liu et al.PLoS biology, 18(2), e3000620-e3000620 (2020-02-14) WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells.Maribel Escoll et al.Antioxidants (Basel, Switzerland), 9(9) (2020-08-23) Sulforaphane improves endothelial function and reduces placental oxidative stress in vitro.Annie G Cox et al.Pregnancy hypertension, 16, 1-10 (2019-05-06) Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway.Jin-Jun Wu et al.Phytomedicine : international journal of phytotherapy and phytopharmacology, 44, 87-97 (2017-12-27) Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β.Jae-Sook Song et al.Toxicology and applied pharmacology, 307, 138-149 (2016-08-12) Melanocyte-protective effect of afzelin is mediated by the Nrf2-ARE signalling pathway via GSK-3β inactivation.Eunsun Jung et al.Experimental dermatology, 26(9), 764-770 (2016-12-20) Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner.Lian Xue et al.Toxicology research, 7(2), 258-270 (2018-08-10) Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer.Libo Yin et al.Molecular therapy oncolytics, 14, 74-81 (2019-05-03) Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis.Áislan de Carvalho Vivarini et al.Frontiers in immunology, 8, 1127-1127 (2017-09-30) Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.Andreas Bitter et al.Archives of toxicology, 89(11), 2089-2103 (2014-09-04) In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.Anssi Lipponen et al.International journal of molecular sciences, 20(21) (2019-11-02) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.Richard Zhou et al.Biochimica et biophysica acta, 1840(1), 209-218 (2013-09-26) Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells.Jia-Wei Zhou et al.Oncology letters, 18(3), 2639-2647 (2019-08-28) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment.Alireza Ziaei et al.Investigative ophthalmology & visual science, 54(10), 6724-6734 (2013-09-14) Activation of Nrf2 protects against triptolide-induced hepatotoxicity.Jia Li et al.PloS one, 9(7), e100685-e100685 (2014-07-06) Screening of traditional Chinese medicines with therapeutic potential on chronic obstructive pulmonary disease through inhibiting oxidative stress and inflammatory response.Ming-Xing Zhou et al.BMC complementary and alternative medicine, 16, 360-360 (2016-09-15) Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress.Beate Hegge et al.BMC cancer, 18(1), 496-496 (2018-05-03) Estrogen down regulates COMT transcription via promoter DNA methylation in human breast cancer cells.Qian Wu et al.Toxicology and applied pharmacology, 367, 12-22 (2019-01-27) Application of Centrifugal Partition Chromatography for Bioactivity-Guided Purification of Antioxidant-Response-Element-Inducing Constituents from Atractylodis Rhizoma Alba.Myeong Il Kim et al.Molecules (Basel, Switzerland), 23(9) (2018-09-12) Nuclear factor erythroid-2 related factor 2 inhibits human disc nucleus pulpous cells apoptosis induced by excessive hydrogen peroxide.Hao Lin et al.Revista da Associacao Medica Brasileira (1992), 66(7), 986-991 (2020-08-28) Keap calm, and carry on covalently.Anthony J Wilson et al.Journal of medicinal chemistry, 56(19), 7463-7476 (2013-07-11) HPLC Separation of Sulforaphane Enantiomers in Broccoli and Its Sprouts by Transformation into Diastereoisomers Using Derivatization with (S)-Leucine.Makiko Okada et al.Journal of agricultural and food chemistry, 65(1), 244-250 (2016-12-19) The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).Nada Alhazmi et al.Biochimica et biophysica acta. Molecular cell research, 1867(8), 118707-118707 (2020-04-04) Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway.Guk Heui Jo et al.International journal of oncology, 45(4), 1497-1506 (2014-07-06) Sulforaphane Rescues Ethanol-Suppressed Angiogenesis through Oxidative and Endoplasmic Reticulum Stress in Chick Embryos.Guang Wang et al.Journal of agricultural and food chemistry, 66(36), 9522-9533 (2018-08-21) Overexpression of long non-coding RNA TUG1 alleviates TNF-α-induced inflammatory injury in interstitial cells of Cajal.K Zhao et al.European review for medical and pharmacological sciences, 23(1), 312-320 (2019-01-19) Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.Sicong Tian et al.Molecular nutrition & food research, 63(20), e1900183-e1900183 (2019-07-22) Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.Angela Gibbs et al.Proceedings of the National Academy of Sciences of the United States of America, 106(39), 16663-16668 (2009-10-07) Reconstructing Biosynthetic Pathway of the Plant-Derived Cancer Chemopreventive-Precursor Glucoraphanin in Escherichia coli.Han Yang et al.ACS synthetic biology, 7(1), 121-131 (2017-11-19) EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages.Da-Min Gu et al.Biochemical and biophysical research communications, 457(3), 391-397 (2015-01-15) The efficacy and safety of sulforaphane as an adjuvant in the treatment of bipolar depressive disorder: Study protocol for a randomized, double-blinded, placebo-controlled, parallel-group clinical trial.Congchong Wu et al.Medicine, 99(26), e20981-e20981 (2020-06-27) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo.Rose K Davidson et al.Arthritis and rheumatism, 65(12), 3130-3140 (2013-08-29) Transfusion of Old RBCs Induces Neuroinflammation and Cognitive Impairment.Hongying Tan et al.Critical care medicine, 43(8), e276-e286 (2015-04-11) Roles of aldo-keto reductases 1B10 and 1C3 and ATP-binding cassette transporter in docetaxel tolerance.Toshiyuki Matsunaga et al.Free radical research, 50(12), 1296-1308 (2016-09-16) CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies.Sara Castro-Sánchez et al.Redox biology, 22, 101118-101118 (2019-02-16) Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta.T Matsui et al.Nutrition, metabolism, and cardiovascular diseases : NMCD, 26(9), 797-807 (2016-05-24) Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.Fahad Al-Rashed et al.Scientific reports, 8(1), 6271-6271 (2018-04-21) Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma.Osama A Elkashty et al.British journal of cancer, 123(9), 1395-1403 (2020-08-11) How Glucosinolates Affect Generalist Lepidopteran Larvae: Growth, Development and Glucosinolate Metabolism.Verena Jeschke et al.Frontiers in plant science, 8, 1995-1995 (2017-12-07) Potentials and pitfalls of transient in vitro reporter bioassays: interference by vector geometry and cytotoxicity in recombinant zebrafish cell lines.Sebastian Lungu-Mitea et al.Archives of toxicology, 94(8), 2769-2784 (2020-05-25) Sulforaphane reduces YAP/∆Np63α signaling to reduce cancer stem cell survival and tumor formation.Matthew L Fisher et al.Oncotarget, 8(43), 73407-73418 (2017-11-02) The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells.Marshall Ellison et al.Cell communication and signaling : CCS, 18(1), 15-15 (2020-01-29) Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.Jelena Todoric et al.Cancer cell, 32(6), 824-839 (2017-11-21) HO-1 mediates the anti-inflammatory actions of Sulforaphane in monocytes stimulated with a mycoplasmal lipopeptide.Luo Haodang et al.Chemico-biological interactions, 306, 10-18 (2019-04-10) SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.G W Watson et al.Oncogenesis, 3, e131-e131 (2014-12-09) The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.Catalina Carrasco-Pozo et al.International journal of molecular sciences, 20(21) (2019-11-02) The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.Constance Lay Lay Saw et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 303-311 (2014-08-12) A cell-based assay system for activators of the environmental cell stress response.Jennifer A Harbottle et al.Analytical biochemistry, 592, 113583-113583 (2020-01-17) Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.Chengcao Sun et al.Journal of applied physiology (Bethesda, Md. : 1985), 120(4), 377-390 (2015-10-24) Chemopreventive glucosinolate accumulation in various broccoli and collard tissues: Microfluidic-based targeted transcriptomics for by-product valorization.Young-Sang Lee et al.PloS one, 12(9), e0185112-e0185112 (2017-09-26) Influence of Sulforaphane Metabolites on Activities of Human Drug-Metabolizing Cytochrome P450 and Determination of Sulforaphane in Human Liver Cells.Alena Vanduchova et al.Journal of medicinal food, 19(12), 1141-1146 (2016-10-26) Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo.Sara Eslava-Alcon et al.International journal of molecular sciences, 21(15) (2020-07-30) Diallyl trisulfide induces apoptosis and mitotic arrest in AGS human gastric carcinoma cells through reactive oxygen species-mediated activation of AMP-activated protein kinase.Yung Hyun Choi Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, 63-71 (2017-07-29) Free light chains injure proximal tubule cells through the STAT1/HMGB1/TLR axis.Rohit Upadhyay et al.JCI insight, 5(14) (2020-06-17) Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles.Daniela Perroni Frias et al.Scientific reports, 10(1), 3704-3704 (2020-03-01) SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation.Zhen Jin et al.Experimental cell research, 387(1), 111744-111744 (2019-11-25)

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