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Leflunomide for inflammatory arthritis in end-stage renal disease on peritoneal dialysis: a pharmacokinetic and pharmacogenetic study.Paul A J Russo et al.The Annals of pharmacotherapy, 47(3), e15-e15 (2013-03-01) Alopecia areata during treatment of psoriasis with adalimumab and leflunomide: a case and review of the literature.R Navarro et al.Skin pharmacology and physiology, 25(2), 107-110 (2012-02-04) The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain.Andrea Zecca et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7475-7486 (2015-05-15) Leflunomide suppresses growth in human medullary thyroid cancer cells.Amal Alhefdhi et al.The Journal of surgical research, 185(1), 212-216 (2013-07-03) Leflunomide.Vandana Mehta et al.Indian journal of dermatology, venereology and leprology, 75(4), 422-424 (2009-07-09) Methotrexate in combination with other DMARDs is not superior to methotrexate alone for remission induction with moderate-to-high-dose glucocorticoid bridging in early rheumatoid arthritis after 16 weeks of treatment: the CareRA trial.P Verschueren et al.Annals of the rheumatic diseases, 74(1), 27-34 (2014-11-02) The efficacy and safety of leflunomide in patients with active rheumatoid arthritis.Ryszard Wiacek et al.Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 21(3), 337-342 (2012-12-12) [Anti-rheumatic drugs].Yasuo Suzuki Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 6, 185-189 (2012-11-20) Striking leflunomide efficacy against refractory cutaneous sarcoidosis.Gérôme Bohelay et al.Journal of the American Academy of Dermatology, 70(5), e111-e113 (2014-04-20) Leflunomide: friend or foe for systemic lupus erythematosus?Guo-Cui Wu et al.Rheumatology international, 33(2), 273-276 (2012-09-11) [Peripheral neuropathy caused by leflunomide. A case reported with a brief review].Aquiles Antonio-Valdiviezo et al.Revista medica del Instituto Mexicano del Seguro Social, 48(5), 567-570 (2011-01-06) Leflunomide in psoriatic arthritis: results from a large European prospective observational study.Frank Behrens et al.Arthritis care & research, 65(3), 464-470 (2012-10-09) Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids.Lie Dai et al.Clinical rheumatology, 30(6), 859-865 (2011-02-03) STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk.Stefan Kippenberger et al.PloS one, 10(7), e0131783-e0131783 (2015-07-03) Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials.Dominik Golicki et al.Polskie Archiwum Medycyny Wewnetrznej, 122(1-2), 22-32 (2012-02-23) Pulmonary aspergillosis in chronic leflunomide treatment.Perikles Tomos et al.Surgical infections, 13(4), 282-283 (2012-09-11) Efficacy and safety of leflunomide in DMARD-naive patients with early rheumatoid arthritis: comparison of a loading and a fixed-dose regimen.Maurizio Cutolo et al.Rheumatology (Oxford, England), 52(6), 1132-1140 (2013-02-13) Treatment of early rheumatoid arthritis in a multinational inception cohort of Latin American patients: the GLADAR experience.Mario H Cardiel et al.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 18(7), 327-335 (2012-10-11) Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13.Shanshan Gao et al.Journal of molecular and cellular cardiology, 85, 131-139 (2015-05-07) [The conversion of hypothyroidism into hyperthyroidism during leflunomide with povidone iodine treatment of rheumatoid arthritis].Marek Grzywa et al.Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 34(204), 348-350 (2013-07-26) New treatment strategies in large-vessel vasculitis.Sebastian Unizony et al.Current opinion in rheumatology, 25(1), 3-9 (2012-11-02) The efficacy and safety of leflunomide in patients with active rheumatoid arthritis.Ryszard Wiacek et al.Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 21(3), 337-342 (2012-12-12) BK virus in the kidney transplant patient.Sarat Kuppachi et al.The American journal of the medical sciences, 345(6), 482-488 (2013-05-24) Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation.Young H Jung et al.Pediatric transplantation, 17(2), E50-E54 (2012-12-06) Gingival pain: an unusual side effect of ziprasidone.Ashwati Raghunath BMJ case reports, 2013, doi:10-doi:10 (2013-01-04) Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults.Guoqiang Xie et al.PloS one, 7(9), e44330-e44330 (2012-09-08) Leflunomide use in renal transplantation.Nicolae Leca Current opinion in organ transplantation, 14(4), 370-374 (2009-06-11) Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients.Xin-Chuan Chen et al.Acta haematologica, 130(1), 52-56 (2013-02-23) Pharmacokinetics and bioequivalence evaluation of leflunomide tablets in Korean healthy volunteers.Y-J Lim et al.Drug research, 63(12), 633-638 (2013-07-26) Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis.Catherine O'Doherty et al.Pharmacogenomics, 13(12), 1427-1434 (2012-09-13) Conversion from tacrolimus/mycophenolic acid to tacrolimus/leflunomide to treat cutaneous warts in a series of four pediatric renal allograft recipients.Lieuko Nguyen et al.Transplantation, 94(5), 450-455 (2012-09-11) [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine].Tetsuji Sawada Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(10), 2929-2935 (2011-12-20) Defects in vesicle core induced by escherichia coli dihydroorotate dehydrogenase.Sheila G Couto et al.Biophysical journal, 94(5), 1746-1753 (2007-11-13) miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.Shicheng Su et al.Nature communications, 6, 8523-8523 (2015-10-06) Efficacy and tolerability of leflunomide in difficult-to-treat polymyalgia rheumatica and giant cell arteritis: a case series.T Adizie et al.International journal of clinical practice, 66(9), 906-909 (2012-08-18) Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis.Ahmed M Al-Abd et al.PloS one, 9(11), e111843-e111843 (2014-11-07) In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.X Xu et al.Journal of immunology (Baltimore, Md. : 1950), 159(1), 167-174 (1997-07-01) Non-biologic remission maintenance therapy in adult patients with ANCA-associated vasculitis: a systematic review and network meta-analysis.Glen S Hazlewood et al.Joint, bone, spine : revue du rhumatisme, 81(4), 337-341 (2014-01-07) Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.Sona Hubackova et al.Cell death & disease, 11(2), 110-110 (2020-02-09) [Anti-rheumatic drugs].Yasuo Suzuki Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 6, 185-189 (2012-11-20) Survivin is regulated by interleukin-4 in colon cancer stem cells.A B Di Stefano et al.Journal of cellular physiology, 225(2), 555-561 (2010-05-28) Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.T He et al.Oncogene, 33(27), 3538-3549 (2013-09-10) New lead structures in the isoxazole system: relationship between quantum chemical parameters and immunological activity.Marcin Maczyński et al.Acta poloniae pharmaceutica, 71(1), 71-83 (2014-05-02) Excessive periostin expression and Th2 response in patients with nasal polyps: association with asthma.Yi Wei et al.Journal of thoracic disease, 10(12), 6585-6597 (2019-02-13) Benefit/risk of leflunomide in rheumatoid arthritis.J M Kremer et al.Clinical and experimental rheumatology, 22(5 Suppl 35), S95-100 (2004-11-24) Leflunomide-induced DRESS syndrome with renal involvement and vasculitis.Benzeeta Pinto et al.Clinical rheumatology, 32(5), 689-693 (2012-12-29) Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.Michelle E Doscas et al.Neoplasia (New York, N.Y.), 16(10), 824-834 (2014-11-08) Efficacy and safety of leflunomide in treatment of steroid-dependent and steroid-resistant adult onset minimal change disease.Junhua Zhou et al.Clinical nephrology, 80(2), 121-129 (2013-03-06) Leflunomide inhibits the apoptosis of human embryonic lung fibroblasts infected by human cytomegalovirus.Ren Qi et al.European journal of medical research, 18, 3-3 (2013-02-02) Prevalence of BK polyomavirus infection and association with renal dysfunction in pediatric heart transplant recipients.Allison Ducharme-Smith et al.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 34(2), 222-226 (2014-12-30) Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011?Ora Singer et al.Current opinion in rheumatology, 23(3), 288-292 (2011-03-08) Recurrent pneumothorax associated with pulmonary nodules after leflunomide therapy in rheumatoid arthritis: a case report and review of the literature.Sun-Hee Kim et al.Rheumatology international, 31(7), 919-922 (2009-10-29) LC-MS/MS Method for Determination of Teriflunomide, Over a 40,000-Fold Dynamic Range Using Overlapping Calibrators.Geoffrey S Rule et al.Therapeutic drug monitoring, 37(4), 472-478 (2014-12-20) Leflunomide in dermatology.Alan S Boyd Journal of the American Academy of Dermatology, 66(4), 673-679 (2011-10-04) Leflunomide: dermatologic perspective.Virendra N Sehgal et al.The Journal of dermatological treatment, 24(2), 89-95 (2011-08-02) Leflunomide biodegradable microspheres intended for intra-articular administration: Development, anti-inflammatory activity and histopathological studies.Doaa Ahmed El-Setouhy et al.International journal of pharmaceutics, 495(2), 664-670 (2015-09-24) Regulation of B cell function by the immunosuppressive agent leflunomide.K F Siemasko et al.Transplantation, 61(4), 635-642 (1996-02-27) Etanercept normalises left ventricular mass in patients with rheumatoid arthritis.Claire Immediato Daïen et al.Annals of the rheumatic diseases, 72(6), 881-887 (2012-08-09) Leflunomide in dialysis patients with rheumatoid arthritis--a pharmacokinetic study.Raoul Bergner et al.Clinical rheumatology, 32(2), 267-270 (2012-11-28) Combination regimen of leflunomide plus methylprednisolone in a female patient with reactive arthritis and concomitant IgA nephropathy.Yi-zhi Chen et al.Chinese medical journal, 123(3), 375-378 (2010-03-03) Leflunomide: psoriasis, lupus. Prescrire international, 22(139), 154-154 (2013-07-20) Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.X Xu et al.Biochemical pharmacology, 52(4), 527-534 (1996-08-23) Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.Shymaa E Bilasy et al.Pharmacological reports : PR, 67(1), 102-114 (2015-01-07) Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.Frank Behrens et al.Current opinion in rheumatology, 23(3), 282-287 (2011-03-24) Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.Zhu Chen et al.International immunopharmacology, 15(3), 474-477 (2013-02-19) An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.Jonathan W Astin et al.Molecular cancer therapeutics, 13(10), 2450-2462 (2014-07-24) Successful treatment of recalcitrant eczematous dermatitis with leflunomide.Alan S Boyd Journal of the American Academy of Dermatology, 69(3), e148-e149 (2013-08-21) Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury.Shigeko Inokuma Expert opinion on drug safety, 10(4), 603-611 (2011-03-18) Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of Tregs and stem cells.Babak Baban et al.American journal of physiology. Regulatory, integrative and comparative physiology, 303(11), R1136-R1146 (2012-10-27) SND-117, a sinomenine bivalent alleviates type II collagen-induced arthritis in mice.Yu-Ren Zhou et al.International immunopharmacology, 26(2), 423-431 (2015-04-19) Leflunomide in renal transplantation.W James Chon et al.Expert review of clinical immunology, 7(3), 273-281 (2011-05-21) De novo identification of toxicants that cause irreparable damage to parasitic nematode intestinal cells.Douglas P Jasmer et al.PLoS neglected tropical diseases, 14(5), e0007942-e0007942 (2020-05-27) Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.Erdogan Ozturk et al.The Journal of surgical research, 187(2), 610-615 (2014-02-04) Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide.T R Brazelton et al.Current opinion in immunology, 8(5), 710-720 (1996-10-01) Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use.Susanna M Proudman et al.Annals of the rheumatic diseases, 74(1), 89-95 (2013-10-02) RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.Cristina Santoriello et al.Nature cell biology, 22(4), 372-379 (2020-04-02) Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing.Nicola Alcorn et al.Drug safety, 32(12), 1123-1134 (2009-11-18) A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.Qiong Luo et al.Journal of immunology (Baltimore, Md. : 1950), 191(10), 4969-4978 (2013-10-15) Leflunomide in systemic onset Juvenile idiopathic arthritis.Afsana Jahan et al.Indian pediatrics, 49(9), 750-752 (2012-10-02) Leflunomide: a drug with a potential beyond rheumatology.Sven Teschner et al.Immunotherapy, 2(5), 637-650 (2010-09-30) The SMILE study -- safety of methotrexate in combination with leflunomide in rheumatoid arthritis.Paul Bird et al.The Journal of rheumatology, 40(3), 228-235 (2013-01-17)

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