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Mutational landscape of AML with normal cytogenetics: biological and clinical implications.Maria Paola Martelli et al.Blood reviews, 27(1), 13-22 (2012-12-25) Diphacinone-induced coagulopathy in the dog.A Schulman et al.Journal of the American Veterinary Medical Association, 188(4), 402-405 (1986-02-15) Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study.Paola Guglielmelli et al.Blood, 123(14), 2157-2160 (2014-01-25) The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.Patrick S Ward et al.The Journal of biological chemistry, 288(6), 3804-3815 (2012-12-25) IDH1 and IDH2 mutations in gliomas.Adam L Cohen et al.Current neurology and neuroscience reports, 13(5), 345-345 (2013-03-28) Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.Daniel H Wiseman et al.British journal of haematology, 166(1), 145-148 (2014-03-13) Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions.Jesse S Voss et al.Human pathology, 44(7), 1216-1222 (2013-02-09) Metabolic quirks yield tumour hope.Heidi Ledford Nature, 508(7495), 158-159 (2014-04-11) Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling.Guido Reifenberger et al.International journal of cancer, 135(8), 1822-1831 (2014-03-13) Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus.I H Steen et al.Archives of microbiology, 168(5), 412-420 (1997-11-05) IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma.Chunzhi Zhang et al.Neuro-oncology, 15(9), 1114-1126 (2013-07-24) Glioblastoma in the elderly.Marc C Chamberlain Cancer treatment and research, 163, 159-170 (2014-12-04) A novel COLD-PCR/FMCA assay enhances the detection of low-abundance IDH1 mutations in gliomas.Brendan Pang et al.Diagnostic molecular pathology : the American journal of surgical pathology, part B, 22(1), 28-34 (2013-02-02) cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome.Yazmin Odia et al.Journal of neuro-oncology, 115(2), 249-259 (2013-08-13) Hypolipidemic activity of indan-1,3-dione derivatives in rodents.A R Murthy et al.Journal of medicinal chemistry, 28(11), 1591-1596 (1985-11-01) Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.Maxime Janin et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(4), 297-305 (2013-12-18) Generation of a novel monoclonal antibody WMab-1 specific for IDH2-R172W mutation.Yukinari Kato et al.Biochemical and biophysical research communications, 433(4), 374-378 (2013-03-26) Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.S M Sarkaria et al.Leukemia, 28(12), 2403-2406 (2014-08-06) A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.Barbara Klink et al.PloS one, 8(3), e59773-e59773 (2013-03-26) Inhibition by diacylmethane derivatives of mutagenicity in Salmonella typhimurium and tRNA-binding of chemical carcinogens.C Y Wang et al.Mutation research, 262(3), 189-193 (1991-03-01) Purification of the isocitric enzyme (triphosphopyridine nucleotide-linked isocitric dehydrogenase-oxalosuccinic carboxylase).M DIXON et al.The Biochemical journal, 63(4), 548-552 (1956-08-01) [The role of the pathologist in the diagnosis and therapy planning of central nervous system tumors. Prognostic and predictive markers].Eszter Turányi et al.Magyar onkologia, 57(4), 215-221 (2013-12-20) Interlaboratory comparison of IDH mutation detection.Martin J van den Bent et al.Journal of neuro-oncology, 112(2), 173-178 (2013-01-30) IDH mutations are closely associated with mutations of DNMT3A, ASXL1 and SRSF2 in patients with myelodysplastic syndromes and are stable during disease evolution.Chien-Chin Lin et al.American journal of hematology, 89(2), 137-144 (2013-10-12) Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism.Ho-Jin Koh et al.The Journal of biological chemistry, 279(38), 39968-39974 (2004-07-16) Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia.Courtney D DiNardo et al.Blood, 121(24), 4917-4924 (2013-05-04) A suggested new nomenclature for the isomers of isocitric acid.H B VICKERY The Journal of biological chemistry, 237, 1739-1741 (1962-06-01) [Effect of S-oxidation on the anticoagulant effects of 4-hydroxycoumarins, 4-hydroxy-2-pyrones and 1,3-indanediones].K Rehse et al.Archiv der Pharmazie, 317(3), 262-267 (1984-03-01) IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival.Severina Leu et al.Neuro-oncology, 15(4), 469-479 (2013-02-15) Glioma biology and molecular markers.Adam L Cohen et al.Cancer treatment and research, 163, 15-30 (2014-12-04) Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.Mojca Brunskole et al.Bioorganic & medicinal chemistry, 16(11), 5881-5889 (2008-05-17) NADP(+)-specific isocitrate dehydrogenase from oleaginous yeast Yarrowia lipolytica CLIB122: biochemical characterization and coenzyme sites evaluation.Xue Li et al.Applied biochemistry and biotechnology, 171(2), 403-416 (2013-07-13) Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.Der-Cherng Liang et al.Blood, 121(15), 2988-2995 (2013-02-01) Whole-genome thermodynamic analysis reduces siRNA off-target effects.Xi Chen et al.PloS one, 8(3), e58326-e58326 (2013-03-14) Targeting IDH: the next big thing in AML.Mark Levis Blood, 122(16), 2770-2771 (2013-10-19) The preparation of isocitric dehydrogenase from mammalian heart.G SIEBERT et al.The Journal of biological chemistry, 226(2), 965-975 (1957-06-01) Isocitrate dehydrogenase mutations in leukemia.Anna Sophia McKenney et al.The Journal of clinical investigation, 123(9), 3672-3677 (2013-09-04) Interpreting new molecular genetics in myelodysplastic syndromes.Omar Abdel-Wahab et al.Hematology. American Society of Hematology. Education Program, 2012, 56-64 (2012-12-13) Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival.P Korkolopoulou et al.British journal of cancer, 108(10), 2142-2152 (2013-04-27) The evolving landscape in the therapy of acute myeloid leukemia.Grace L Peloquin et al.Protein & cell, 4(10), 735-746 (2013-08-29) Recent aspects of classification and epidemiology of epilepsy-associated tumors.Anna Japp et al.Epilepsia, 54 Suppl 9, 5-11 (2013-12-18) Personalized medicine for glioblastoma: current challenges and future opportunities.J-J Zhu et al.Current molecular medicine, 13(3), 358-367 (2013-01-22) The mobility of troponin C and troponin I in muscle.H C Li et al.Journal of molecular recognition : JMR, 10(4), 194-201 (1997-07-01) Synthesis and multi-spectroscopic study on DNA-binding, cleavage and biological properties of M(II) complexes based on NV Violet Dhayabaran et al.Luminescence : the journal of biological and chemical luminescence, 32(7), 1339-1348 (2017-05-19) An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Dan Rohle et al.Science (New York, N.Y.), 340(6132), 626-630 (2013-04-06) Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China.Chuan-Bao Zhang et al.Journal of cancer research and clinical oncology, 140(1), 45-51 (2013-10-24) Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.Jiang-Han Wang et al.Proceedings of the National Academy of Sciences of the United States of America, 110(42), 17017-17022 (2013-10-02) Subgrouping of gliomas on the basis of genetic profiles.Yuichi Hirose et al.Brain tumor pathology, 30(4), 203-208 (2013-04-23) Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones.Majid M Heravi et al.Molecular diversity, 13(3), 385-387 (2009-03-03) The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation.Remco J Molenaar et al.Biochimica et biophysica acta, 1846(2), 326-341 (2014-06-01) Distinct IDH1/IDH2 mutation profiles in purely insular versus paralimbic WHO Grade II gliomas.Catherine Gozé et al.Journal of neurosurgery, 118(4), 866-872 (2013-01-22) Benzylidine indane-1,3-diones: As novel urease inhibitors; synthesis, in vitro, and in silico studies.Bilquees Bano et al.Bioorganic chemistry, 81, 658-671 (2018-09-27) Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism.Christopher Ceccarelli et al.The Journal of biological chemistry, 277(45), 43454-43462 (2002-09-19) Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age.Daniela Lötsch et al.Neuro-oncology, 15(4), 423-432 (2013-02-09) A green method for the electroorganic synthesis of new 1,3-Indandione derivatives.Abdolmajid Bayandori Moghaddam et al.Chemical & pharmaceutical bulletin, 54(10), 1391-1396 (2006-10-04) Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.Janice L Hyatt et al.Journal of medicinal chemistry, 50(8), 1876-1885 (2007-03-24) Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.Anuhar Chaturvedi et al.Blood, 122(16), 2877-2887 (2013-08-21) A population-based study of high-grade gliomas and mutated isocitrate dehydrogenase 1.Rikke H Dahlrot et al.International journal of clinical and experimental pathology, 6(1), 31-40 (2012-12-14) Mitochondria Export Sulfur Species Required for Cytosolic tRNA Thiolation.Alok Pandey et al.Cell chemical biology, 25(6), 738-748 (2018-05-01) IDH1 mutation is associated with improved overall survival in patients with glioblastoma: a meta-analysis.Hong-Bin Cheng et al.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(6), 3555-3559 (2013-08-02) Partial purification and characterization of the isocitric dehydrogenase from Trypanosoma cruzi.M AGOSIN et al.Biochimica et biophysica acta, 21(1), 117-126 (1956-07-01) IDH1-associated primary glioblastoma in young adults displays differential patterns of tumour and vascular morphology.Sergey Popov et al.PloS one, 8(2), e56328-e56328 (2013-03-02) A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1).Rikke H Dahlrot et al.Journal of neuro-oncology, 114(3), 309-317 (2013-07-03) Dynamic aspects of the incorporation of proteins into biological membranes.L I Horváth et al.Journal of molecular recognition : JMR, 10(4), 188-193 (1997-07-01) How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia?Jay P Patel et al.Hematology. American Society of Hematology. Education Program, 2012, 28-34 (2012-12-13) (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.Julie-Aurore Losman et al.Science (New York, N.Y.), 339(6127), 1621-1625 (2013-02-09) A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions.Feng Shi et al.Molecular diversity, 15(2), 497-505 (2010-09-04) Isocitrate dehydrogenase-1 is mutated in inflammatory bowel disease-associated intestinal adenocarcinoma with low-grade tubuloglandular histology but not in sporadic intestinal adenocarcinoma.Douglas J Hartman et al.The American journal of surgical pathology, 38(8), 1147-1156 (2014-07-17) [Effect of glyphosate on the energy exchange in carp organs].A A Zhidenko et al.Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(3), 22-30 (2013-08-14) [Reaction products of indandione with ethyl alpha-cyano-beta-acrylates].M V Diurno et al.Bollettino della Societa italiana di biologia sperimentale, 60(1), 79-84 (1984-01-30) Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-ToxVaibhav Shinde et al.Archives of toxicology, 91(2), 839-864 (2016-05-18) Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations.Darcy A Kerr et al.The American journal of surgical pathology, 37(6), 787-795 (2013-04-20) Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism.Mohammad Zulkifli et al.Nature communications, 11(1), 4866-4866 (2020-09-27) Secondary glioblastomas with IDH1/2 mutations have longer glioma history from preceding lower-grade gliomas.Makoto Ohno et al.Brain tumor pathology, 30(4), 224-232 (2013-03-16) Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation.Yui Mano et al.Journal of neurosurgery. Pediatrics, 11(5), 518-525 (2013-02-26) Silencing of mitochondrial NADP(+)-dependent isocitrate dehydrogenase gene enhances glioma radiosensitivity.Sung Youl Kim et al.Biochemical and biophysical research communications, 433(2), 260-265 (2013-03-19) [Pyrosequencing and its application in clinical diagnosis and therapy].Mei-hua Ye et al.Zhonghua bing li xue za zhi = Chinese journal of pathology, 42(2), 138-142 (2013-05-29) Cancer. Silencing a metabolic oncogene.Jiyeon Kim et al.Science (New York, N.Y.), 340(6132), 558-559 (2013-05-04) Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.Waraporn Chan-On et al.Nature genetics, 45(12), 1474-1478 (2013-11-05) Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia.Liran I Shlush et al.Nature, 506(7488), 328-333 (2014-02-14) Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.Alan R Rendina et al.Biochemistry, 52(26), 4563-4577 (2013-06-05) Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.Supriya K Saha et al.Nature, 513(7516), 110-114 (2014-07-22) IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme.Rasime Kalkan et al.Gene, 554(1), 81-86 (2014-12-03) Expression of molecular markers in low-grade chondrosarcomas and cartilaginous tumors with uncertain differentiation.I V Boulytcheva et al.Klinicheskaia laboratornaia diagnostika, (10)(10), 61-63 (2014-03-20) Novel Bioactive Co(II), Cu(II), Ni(II) and Zn(II) Complexes with Schiff Base Ligand Derived from Histidine and 1,3-Indandione: Synthesis, Structural Elucidation, Biological Investigation and Docking Analysis.V Violet Dhayabaran et al.Journal of fluorescence, 27(1), 135-150 (2016-10-04) Low-grade glioma.Priya Kumthekar et al.Cancer treatment and research, 163, 75-87 (2014-12-04) Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence.M L Camacho et al.FEMS microbiology letters, 134(1), 85-90 (1995-12-01) Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry.Matthew J Schniederjan et al.The American journal of surgical pathology, 37(5), 763-771 (2013-04-17) Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.Mamiko Sakata-Yanagimoto et al.Nature genetics, 46(2), 171-175 (2014-01-15) Cytotoxicity and mode of action of substituted indan-1, 3-diones in murine and human tissue cultured cells.I H Hall et al.Anticancer research, 14(5A), 2053-2058 (1994-09-01) Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.Ashkan Emadi et al.Experimental hematology, 42(4), 247-251 (2013-12-18) Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases.Rithvik Vinekar et al.BMC bioinformatics, 13 Suppl 17, S2-S2 (2013-01-11) WT1 expression increases with malignancy and indicates unfavourable outcome in astrocytoma.Julian Rauscher et al.Journal of clinical pathology, 67(7), 556-561 (2014-03-13) Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.Ovidiu C Andronesi et al.The Journal of clinical investigation, 123(9), 3659-3663 (2013-09-04) Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivo.Xiang Hu et al.Cancer letters, 346(1), 114-121 (2013-12-26) Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis.Halise Inci Gul et al.Anti-cancer agents in medicinal chemistry, 18(12), 1770-1778 (2018-05-26) Impact of genetic targets on primary brain tumor therapy: what's ready for prime time?O Zalatimo et al.Advances in experimental medicine and biology, 779, 267-289 (2013-01-05) Mutations and prognosis in primary myelofibrosis.A M Vannucchi et al.Leukemia, 27(9), 1861-1869 (2013-04-27) Protein tyrosine nitration in pea roots during development and senescence.Juan C Begara-Morales et al.Journal of experimental botany, 64(4), 1121-1134 (2013-01-31) [Effect of anticoagulants of the 4-hydroxycoumarin derivative group on aminotransferase activity in vitro and in vivo].E Marchut et al.Folia medica Cracoviensia, 22(3-4), 331-339 (1980-01-01) A vaccine targeting mutant IDH1 induces antitumour immunity.Theresa Schumacher et al.Nature, 512(7514), 324-327 (2014-07-22) Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation.Wolfgang Wick et al.Neurology, 81(17), 1515-1522 (2013-09-27) Ovarian cellular fibroma harbouring an isocitrate dehydrogenase 1 (1DH1) mutation in a patient with Ollier disease: evidence for a causal relationship.Sarah L Kenny et al.Histopathology, 62(4), 667-670 (2013-01-26) Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice.Seontae Kim et al.Biochimica et biophysica acta, 1842(2), 135-143 (2013-11-19) Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.Wen-Liang Li et al.Gene, 546(2), 263-270 (2014-06-03) Metabolomic comparison between cells over-expressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism.He Wen et al.Journal of neurochemistry, 132(2), 183-193 (2014-09-25) Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases.Lynn J Poole Perry et al.American journal of ophthalmology, 155(3), 593-608 (2012-12-12) Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds.André S de Oliveira et al.PloS one, 14(9), e0223017-e0223017 (2019-09-27) Inhibition by diacylmethane derivatives of mutagenicity and nucleic acid binding of 2-aminofluorene derivatives.C Y Wang et al.Journal of the National Cancer Institute, 81(22), 1743-1747 (1989-11-15) Outcome and molecular characteristics of adolescent and young adult patients with newly diagnosed primary glioblastoma: a study of the Society of Austrian Neurooncology (SANO).Annette Leibetseder et al.Neuro-oncology, 15(1), 112-121 (2012-12-12) Epigenetics: reversible tags.Jessica Wright Nature, 498(7455), S10-S11 (2013-06-28) Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012.Takashi Komori et al.Brain tumor pathology, 30(4), 253-261 (2013-10-09) Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs.Linda Mulligan et al.Clinical neuropathology, 33(4), 292-298 (2014-07-06) Immunohistochemical expression of IDH1 in gliomas: a tissue microarray-based approach.Varuna Sipayya et al.Journal of cancer research and therapeutics, 8(4), 598-601 (2013-01-31) BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Martje Tönjes et al.Nature medicine, 19(7), 901-908 (2013-06-25) Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial.Mariam G Aslanyan et al.Annals of hematology, 93(8), 1401-1412 (2014-07-06) Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors.Frank G Schaap et al.Advances in anatomic pathology, 20(1), 32-38 (2012-12-13)

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