没有数据	没有数据

没有数据	没有数据

来源	SDS样本
Apollo	浏览或下载
Matrix	浏览或下载

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine.Glyn R Hemsworth et al.The Journal of biological chemistry, 286(18), 16470-16481 (2011-04-02) Substrate specificity of vaccinia virus thymidylate kinase.Dimitri Topalis et al.The FEBS journal, 272(24), 6254-6265 (2005-12-13) 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.Stefania Ferrari et al.Journal of medicinal chemistry, 56(22), 9356-9360 (2013-10-24) A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.Aaron Mason et al.Chemical communications (Cambridge, England), (16)(16), 1781-1783 (2006-04-13) Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.Golo Kronenberg et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(28), 7219-7230 (2008-07-11) Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.Orsolya Barabás et al.Nucleic acids research, 41(22), 10542-10555 (2013-08-29) Simultaneous determination of genomic DNA methylation and uracil misincorporation.Abalo Chango et al.Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 18(2), 81-84 (2009-02-11) Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695.Xiaoli Zhang et al.Protein and peptide letters, 19(11), 1225-1230 (2012-04-20) The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR.Adam Jarmuła et al.Bioorganic & medicinal chemistry, 15(6), 2346-2358 (2007-02-06) An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.Eric M Koehn et al.Nature, 458(7240), 919-923 (2009-04-17) The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.Zachary Newby et al.Biochemistry, 45(24), 7415-7428 (2006-06-14) Novel positron emission tomography tracer distinguishes normal from cancerous cells.Muhammad Saeed et al.The Journal of biological chemistry, 286(39), 33872-33878 (2011-08-13) Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase.Adam Jarmuła et al.Journal of computer-aided molecular design, 27(1), 45-66 (2012-12-15) Synthesis and anticancer activities of amphiphilic 5-fluoro-2'-deoxyuridylic acid prodrugs.Peter S Ludwig et al.European journal of medicinal chemistry, 40(5), 494-504 (2005-05-17) Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.Rogerio R Sotelo-Mundo et al.Journal of biochemical and molecular toxicology, 20(2), 88-92 (2006-04-15) Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase.Przemysław Ziemkowski et al.Biochemical and biophysical research communications, 362(1), 37-43 (2007-08-19) Biochemistry: Anchors away.Maria Paola Costi et al.Nature, 458(7240), 840-841 (2009-04-17) YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.Bernard Weiss Journal of bacteriology, 189(5), 2186-2189 (2006-12-26) Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.Ryan S Funk et al.The Journal of pharmacology and experimental therapeutics, 347(1), 154-163 (2013-07-28) Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.Sergey P Laptenok et al.Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8924-8929 (2013-05-15) QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.Natalia Kanaan et al.The journal of physical chemistry. A, 113(10), 2176-2182 (2009-02-03) Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.Jonathan E Ulmer et al.Journal of bacteriology, 190(6), 2056-2064 (2008-01-15) Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretionHolen E, et al. Nutrition, 21(10), 1003-1009 (2005) Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS.Delphine Carli et al.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 2937-2944 (2009-07-22) Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.Jennifer A Fischer et al.Cancer research, 66(17), 8829-8837 (2006-09-05) Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.BeiBei Luo et al.Protein science : a publication of the Protein Society, 20(1), 87-94 (2010-11-11) Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones.Stéphane Skouloubris et al.Open biology, 5(6), 150015-150015 (2015-06-05) Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.Kristen E Mengwasser et al.Molecular cell, 73(5), 885-899 (2019-01-29) Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase.Ramiro Téllez-Sanz et al.Biochimie, 89(8), 972-980 (2007-04-27) [Uracil in DNA--friend or foe?].Ryszard Oliński et al.Postepy biochemii, 55(1), 25-35 (2009-06-12) Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.Kuifeng Wang et al.Protein science : a publication of the Protein Society, 20(8), 1398-1410 (2011-06-03) Functional identity of the active sites of crustacean and viral thymidylate synthases.Aldo A Arvizu-Flores et al.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 150(3), 406-413 (2009-06-30) Interaction of nucleotide excision repair proteins with DNA containing bulky lesion and apurinic/apyrimidinic site.L V Skosareva et al.Biochemistry. Biokhimiia, 77(5), 524-531 (2012-07-21)

备注