没有数据	没有数据

没有数据	没有数据

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Protective effects of melittin on tumor necrosis factor-α induced hepatic damage through suppression of apoptotic pathway and nuclear factor-kappa B activation.Ji-Hyun Park et al.Experimental biology and medicine (Maywood, N.J.), 239(12), 1705-1714 (2014-05-30) [Melittin: structure, properties, interaction with a membrane].A P Demchenko et al.Ukrainskii biokhimicheskii zhurnal (1978), 58(5), 92-103 (1986-09-01) Antimicrobial and Antifungal Activities of Terpene-Derived Palladium Complexes.Olga Zalevskaya et al.Antibiotics (Basel, Switzerland), 9(5) (2020-05-30) Design, synthesis and antimicrobial properties of non-hemolytic cationic alpha-cyclopeptoids.Daniela Comegna et al.Bioorganic & medicinal chemistry, 18(5), 2010-2018 (2010-02-16) Top-down sequencing of Apis dorsata apamin by MALDI-TOF MS and evidence of its inactivity against microorganisms.D Baracchi et al.Toxicon : official journal of the International Society on Toxinology, 71, 105-112 (2013-06-12) Melittin: a lytic peptide with anticancer properties.Goran Gajski et al.Environmental toxicology and pharmacology, 36(2), 697-705 (2013-07-31) Inclusion of lateral pressure/curvature stress effects in implicit membrane models.Huan Zhan et al.Biophysical journal, 104(3), 643-654 (2013-02-28) Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.Brandon Findlay et al.Antimicrobial agents and chemotherapy, 54(10), 4049-4058 (2010-08-11) The peptide components of bee venom.Gauldie J European Journal of Biochemistry, 61(2), 369-376 (1976) Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.Erika Kovacs et al.The Journal of biological chemistry, 285(3), 1799-1808 (2009-11-17) Sphingosylphosphorylcholine as a novel calmodulin inhibitor.Erika Kovacs et al.The Biochemical journal, 410(2), 427-437 (2007-11-06) New antiseptic peptides to protect against endotoxin-mediated shock.Thomas Gutsmann et al.Antimicrobial agents and chemotherapy, 54(9), 3817-3824 (2010-07-08) Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin.B Bechinger The Journal of membrane biology, 156(3), 197-211 (1997-04-01) Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens.Jörg Andrä et al.The Journal of biological chemistry, 282(20), 14719-14728 (2007-03-29) Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan.Moreno M and Giralt E Toxins, 17(4), 1126-1150 (2015) Melittin: a membrane-active peptide with diverse functions.H Raghuraman et al.Bioscience reports, 27(4-5), 189-223 (2006-12-02) Melittin-loaded immunoliposomes against viral surface proteins, a new approach to antiviral therapy.Alberto Falco et al.Antiviral research, 97(2), 218-221 (2012-12-25) Defined nanoscale chemistry influences delivery of peptido-toxins for cancer therapy.Santosh K Misra et al.PloS one, 10(6), e0125908-e0125908 (2015-06-02) Application of bee venom and its main constituent melittin for cancer treatment. Application of bee venom and its main constituent melittin for cancer treatment.Liu CC Cancer Chemotherapy and Pharmacology, 78(6), 1113-1130 (2016) Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression.Yun-Jeong Jeong et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3996-4002 (2012-08-29) Unraveling supported lipid bilayer formation kinetics: osmotic effects.Nicole Hain et al.Langmuir : the ACS journal of surfaces and colloids, 29(7), 2282-2288 (2013-01-15) Melittin-grafted HPMA-oligolysine based copolymers for gene delivery.Joan G Schellinger et al.Biomaterials, 34(9), 2318-2326 (2012-12-25) Absorption and folding of melittin onto lipid bilayer membranes via unbiased atomic detail microsecond molecular dynamics simulation.Charles H Chen et al.Biochimica et biophysica acta, 1838(9), 2243-2249 (2014-04-29) Preparation and functional characterization of human vascular endothelial growth factor-melittin fusion protein with analysis of the antitumor activity in vitro and in vivo.Dingding Wang et al.International journal of oncology, 47(3), 1160-1168 (2015-07-15) Role of the inflammasome in defense against venoms.Noah W Palm et al.Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1809-1814 (2013-01-09) Treatment. Bee venom destroyed HIV without damaging cells. AIDS policy & law, 28(5), 1-1 (2013-06-12) Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides.Mohamed F Mohamed et al.Antimicrobial agents and chemotherapy, 58(7), 4113-4122 (2014-05-07) Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line.Kieran F Geoghegan et al.Protein expression and purification, 87(1), 27-34 (2012-10-17) The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization.Gregory Wiedman et al.Biochimica et biophysica acta, 1828(5), 1357-1364 (2013-02-07) Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids.Stephanie Gross et al.Biological chemistry, 393(8), 817-827 (2012-09-05) Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.Noah W Palm et al.Immunity, 39(5), 976-985 (2013-11-12) Honey Bee Venom (Apis mellifera) Contains Anticoagulation Factors and Increases the Blood-clotting Time.Zolfagharian H Journal of pharmacopuncture, 18(4), 7-11 (2015) Conformational states of melittin at a bilayer interface.Magnus Andersson et al.Biophysical journal, 104(6), L12-L14 (2013-03-27) Anti-Inflammatory Applications of Melittin, a Major Component of Bee Venom: Detailed Mechanism of Action and Adverse Effects. Molecules (Basel), 21(5) (2016) Phospholipase-catalyzed hydrolysis in an artificial cell membrane in the presence of melittin.Jinyoung Lee et al.Journal of nanoscience and nanotechnology, 13(1), 144-148 (2013-05-08) Inhibitory effect of biosynthetic nanoscale peptide Melittin on hepatocellular carcinoma, driven by survivin promoter.Lili Qu et al.Journal of biomedical nanotechnology, 10(4), 695-706 (2014-04-17) The protective effects of melittin on Propionibacterium acnes-induced inflammatory responses in vitro and in vivo.Woo-Ram Lee et al.The Journal of investigative dermatology, 134(7), 1922-1930 (2014-02-06) Insights into Protein Structure and Dynamics by Ultraviolet and Visible Resonance Raman Spectroscopy.Ignacio López-Peña et al.Biochemistry, 54(31), 4770-4783 (2015-07-30) The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding.Melissa A Patterson et al.The Journal of biological chemistry, 290(48), 28944-28952 (2015-08-09) The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects on the Lyme disease spirochete.Lubke LL and Garon CF Clinical Infectious Diseases, suppl 1, S48-S51 (1997) Cytolytic nanoparticles attenuate HIV-1 infectivity.Joshua L Hood et al.Antiviral therapy, 18(1), 95-103 (2012-09-08) The actions of melittin on membranes.C E Dempsey Biochimica et biophysica acta, 1031(2), 143-161 (1990-05-07) Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides.Sunithi Gunasekera et al.Journal of medicinal chemistry, 51(24), 7697-7704 (2008-12-05) Synthesis of antibacterial pseudopeptides with less hemolytic activity from a cytotoxic peptide and their pH-dependent activity.Sung-Min Kim et al.Bioorganic & medicinal chemistry letters, 19(19), 5627-5631 (2009-08-26) How reliable are molecular dynamics simulations of membrane active antimicrobial peptides?Yukun Wang et al.Biochimica et biophysica acta, 1838(9), 2280-2288 (2014-04-22) Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin.J E Fletcher et al.Toxicon : official journal of the International Society on Toxinology, 31(6), 669-695 (1993-06-01) Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection.Woong Sik Jang et al.Antimicrobial agents and chemotherapy, 51(11), 4148-4156 (2007-09-12) Role of nanoparticle surface functionality in the disruption of model cell membranes.Babak Y Moghadam et al.Langmuir : the ACS journal of surfaces and colloids, 28(47), 16318-16326 (2012-08-28) Structural and Dynamic Insights into S100B Protein Activity Inhibition by Melittin for the Treatment of EpilepsyVerma N International Journal of Computer Applications, 55-60 (2013) Selective cytotoxicity Assay in anticancer drug of Melittin Isolated from Bee Venom (Apis cerana indica) to several human cell lines: HeLa, WiDr and Vero.Plasay M Journal of Chemical and Pharmaceutical Sciences , 9:4, 2674-2676 (2016) Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae.Bin Chen et al.Journal of natural products, 69(1), 23-28 (2006-01-31) Acyl transfer from membrane lipids to peptides is a generic process.Robert H Dods et al.Journal of molecular biology, 425(22), 4379-4387 (2013-07-23) Peptide-induced bilayer thinning structure of unilamellar vesicles and the related binding behavior as revealed by X-ray scattering.Chun-Jen Su et al.Biochimica et biophysica acta, 1828(2), 528-534 (2012-11-06) The mediation of the central histaminergic system in the pressor effect of intracerebroventricularly injected melittin, a phospholipase A2 activator, in normotensive rats.Burcin Altinbas et al.Prostaglandins, leukotrienes, and essential fatty acids, 87(4-5), 153-158 (2012-09-22) Vesicle deposition and subsequent membrane-melittin interactions on different substrates: a QCM-D experiment.Nai-Yan Lu et al.Biochimica et biophysica acta, 1828(8), 1918-1925 (2013-04-24) Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes.Y Dombrowski et al.Allergy, 67(11), 1400-1407 (2012-09-15) Design and synthesis of novel antibacterial peptide-resin conjugates.Won-Mi Cho et al.Bioorganic & medicinal chemistry letters, 17(21), 5772-5776 (2007-09-11) A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides.Belén López-García et al.BMC microbiology, 10, 289-289 (2010-11-17) A novel melittin-MhIL-2 fusion protein inhibits the growth of human ovarian cancer SKOV3 cells in vitro and in vivo tumor growth.Mingjun Liu et al.Cancer immunology, immunotherapy : CII, 62(5), 889-895 (2013-02-28) The biochemical effect of Ser166 phosphorylation on Euplotes octocarinatus centrin.Ya-Qin Zhao et al.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 18(1), 123-136 (2012-11-28) Metal complexes as a promising source for new antibiotics.Angelo Frei et al.Chemical science, 11(10), 2627-2639 (2020-03-25) Construction and expression of sTRAIL-melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli.Hongyan Liu et al.Applied microbiology and biotechnology, 97(7), 2877-2884 (2012-11-15) Effect of melittin on ion transport across cell membranes.S Yang et al.Zhongguo yao li xue bao = Acta pharmacologica Sinica, 18(1), 3-5 (1997-01-01) Melittin derived peptides for nanoparticle based siRNA transfection.Kirk K Hou et al.Biomaterials, 34(12), 3110-3119 (2013-02-06) Activation of tetrodotoxin-resistant sodium channel NaV1.9 in rat primary sensory neurons contributes to melittin-induced pain behavior.Yao-Qing Yu et al.Neuromolecular medicine, 15(1), 209-217 (2012-12-25) Melittin-A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells.Michal Ceremuga et al.Biomolecules, 10(2) (2020-02-12) Cationic methacrylate polymers as topical antimicrobial agents against Staphylococcus aureus nasal colonization.Laura M Thoma et al.Biomacromolecules, 15(8), 2933-2943 (2014-07-11) Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K.Kent R Thurber et al.Journal of magnetic resonance (San Diego, Calif. : 1997), 226, 100-106 (2012-12-15) Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice.Famke Aeffner et al.PloS one, 7(10), e46660-e46660 (2012-10-12) Depolarization, bacterial membrane composition, and the antimicrobial action of ceragenins.Raquel F Epand et al.Antimicrobial agents and chemotherapy, 54(9), 3708-3713 (2010-06-30)

备注