
(1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol | CAS:2964-48-9
(1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol
- 名称:(1S,2S)-2-氨基-1-(4-硝基苯基)丙烷-1,3-二醇 | (1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol
- CAS号:2964-48-9
- 别名:
- 分子式:C9H12N2O4
- 分子量:212.20
- EINESC号:221-001-4
产品描述
物理化学性质
熔点 | 160-166 ºC |
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比旋光度 | 31 º (c=1 in 6 M HCl) |
安全数据
安全说明书 | S22;S24/25 |
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产品合成路线
名称 | CAS号 |
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Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regenerationShi D, et al. ACS Nano, 10(1), 1292-1299 (2016)
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Erythropoietin-producing hepatocellular A7 triggering ovulation indicates a potential beneficial role for polycystic ovary syndrome.Shang Li et al.EBioMedicine, 36, 539-552 (2018-10-08)
Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome.Gengxiang Wu et al.Molecular and cellular endocrinology, 506, 110760-110760 (2020-02-20)
Naturally existing isoforms of miR-222 have distinct functions.Feng Yu et al.Nucleic acids research, 45(19), 11371-11385 (2017-10-06)
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Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.Erin D Giles et al.Breast cancer research : BCR, 20(1), 50-50 (2018-06-15)
Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage.Yuping Wu et al.Reproductive biology and endocrinology : RB&E, 16(1), 85-85 (2018-09-05)
Mutation -388 C>G of NR5A1 gene affects litter size and promoter activity in sheep.Yinxia Li et al.Animal reproduction science, 196, 19-27 (2018-07-19)
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Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.Lan Xu et al.Journal of molecular endocrinology (2019-03-27)
Proof of principle: Physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep.Kevin Yu et al.PloS one, 14(6), e0217211-e0217211 (2019-06-07)
Impaired development of female mouse offspring maternally exposed to simazine.Seeun Park et al.Environmental toxicology and pharmacology, 38(3), 845-851 (2014-12-03)
SNAIL Mediates TGF-β1-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells.Hui Li et al.Endocrinology, 159(4), 1644-1657 (2018-02-21)
Hyaluronic Acid Hydrogel Functionalized with Self-Assembled Micelles of Amphiphilic PEGylated Kartogenin for the Treatment of Osteoarthritis.Mi-Lan Kang et al.Tissue engineering. Part A, 23(13-14), 630-639 (2017-03-25)
FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells.Hanyong Jin et al.PloS one, 11(7), e0159112-e0159112 (2016-07-16)
The casein kinase 2α promotes the occurrence polycystic ovary syndrome.Chuan-Jin Yu et al.Biochemical and biophysical research communications (2020-02-23)
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Insulin Reduces Reaction of Follicular Granulosa Cells to FSH Stimulation in Women With Obesity-Related Infertility During IVF.Pei Xu et al.The Journal of clinical endocrinology and metabolism, 104(7), 2547-2560 (2018-11-27)
Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate IGF1 secretion by adult ovarian granulosa cell tumor spheroids and thereby increase proliferation of non-cancer ovarian granulosa cells.Justyna Gogola et al.Toxicology in vitro : an international journal published in association with BIBRA, 65, 104769-104769 (2020-01-11)
Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-like Symptoms.Po-Han Lin et al.Biomolecules, 9(8) (2019-08-03)
Early-Onset Complete Ovarian Failure and Lack of Puberty in a Woman With Mutated Estrogen Receptor β (ESR2).Mariarosaria Lang-Muritano et al.The Journal of clinical endocrinology and metabolism, 103(10), 3748-3756 (2018-08-17)
CD24: a marker of granulosa cell subpopulation and a mediator of ovulation.Jun-Peng Dong et al.Cell death & disease, 10(11), 791-791 (2019-10-19)
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.Yulin Li et al.Journal of cellular physiology, 234(5), 7435-7447 (2018-12-24)
Kartogenin induces cartilage-like tissue formation in tendon-bone junction.Jianying Zhang et al.Bone research, 2 (2014-11-25)
Tyrosine nitrations impaired intracellular trafficking of FSHR to the cell surface and FSH-induced Akt-FoxO3a signaling in human granulosa cells.Ge Zhou et al.Aging, 11(10), 3094-3116 (2019-05-18)
Kartogenin induces cartilage-like tissue formation in tendon-bone junctionZhang J and Wang J H C Bone research, 2(1), 1-10 (2014)
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Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.Satoko Nagao et al.Endocrine journal, 66(2), 157-164 (2018-12-07)
Highly biosafe biomimetic stem cell membrane-disguised nanovehicles for cartilage regeneration.Xingyu Zhang et al.Journal of materials chemistry. B, 8(38), 8884-8893 (2020-10-08)
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.Guangfeng Zhao et al.Scientific reports, 5, 7647-7647 (2015-01-07)
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Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency.Yuan Ni et al.The Journal of endocrinology (2019-07-26)
Mouse GDF9 decreases KITL gene expression in human granulosa cells.Astrud R Tuck et al.Endocrine, 48(2), 686-695 (2014-07-06)
Sequence variants of KHDRBS1 as high penetrance susceptibility risks for primary ovarian insufficiency by mis-regulating mRNA alternative splicing.Binbin Wang et al.Human reproduction (Oxford, England), 32(10), 2138-2146 (2017-09-25)
Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS.Xin Huang et al.Reproductive biology and endocrinology : RB&E, 16(1), 73-73 (2018-08-05)
Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors.Justyna Gogola et al.Chemosphere, 217, 100-110 (2018-11-11)
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Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants.Ye Liu et al.Science China. Life sciences, 62(2), 257-267 (2018-09-30)
Upregulation of the lncRNA SRLR in polycystic ovary syndrome regulates cell apoptosis and IL-6 expression.Lisha Li et al.Cell biochemistry and function, 38(7), 880-885 (2020-01-31)
Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study.Xin Tao et al.Biochemical and biophysical research communications, 494(3-4), 615-620 (2017-10-11)
Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†.Patricia G Tremblay et al.Biology of reproduction, 96(4), 855-865 (2017-04-07)
miR-15a-5p levels correlate with poor ovarian response in human follicular fluid.Kaiyue Zhang et al.Reproduction (Cambridge, England), 154(4), 483-496 (2017-07-22)
Preparation and characterization of the collagen/cellulose nanocrystals/USPIO scaffolds loaded kartogenin for cartilage regeneration.Wei Yang et al.Materials science & engineering. C, Materials for biological applications, 99, 1362-1373 (2019-03-21)
Vigilin interacts with ER-β to protect against palmitic acid-induced granulosa cells apoptosis via inhibiting calcineurin-mediated Drp1 signaling pathway.Hong-Qing Liao et al.Steroids, 163, 108699-108699 (2020-07-21)
Tyrosine Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of Granulosa Cell Tumors of the Ovary.Stacey Jamieson et al.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 25(7), 1224-1231 (2015-06-13)
Effects of Nanoparticle Properties on Kartogenin Delivery and Interactions with Mesenchymal Stem Cells.Bethany Almeida et al.Annals of biomedical engineering, 48(7), 2090-2102 (2019-12-07)
Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin.Xingquan Xu et al.Arthritis research & therapy, 17, 20-20 (2015-02-03)
Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis.Lile Jiang et al.Aging, 12(10), 9041-9065 (2020-05-16)
MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1.Xiaolan Huang et al.Pathology, research and practice, 215(5), 918-923 (2019-02-06)
MiR-423-5p may regulate ovarian response to ovulation induction via CSF1.Shi Xie et al.Reproductive biology and endocrinology : RB&E, 18(1), 26-26 (2020-04-09)
Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome.Mingming Wang et al.Endocrinology, 159(1), 297-309 (2017-10-14)
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MicroRNA-181a promotes follicular granulosa cell apoptosis via sphingosine-1-phosphate receptor 1 expression downregulation†.Chunxue Zhang et al.Biology of reproduction, 101(5), 975-985 (2019-07-31)
Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment.Guanlan Fan et al.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 128, 256-266 (2019-04-09)
Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity.Xiaoting Ma et al.Endocrinology, 158(9), 2944-2954 (2017-07-02)
Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.Jun Zhao et al.EBioMedicine, 36, 526-538 (2018-10-09)
Flavonoid glycosides isolated from Epimedium brevicornum and their estrogen biosynthesis-promoting effects.Fu Li et al.Scientific reports, 7(1), 7760-7760 (2017-08-12)
Synergistic Effects of Kartogenin and Transforming Growth Factor-β3 on Chondrogenesis of Human Umbilical Cord Mesenchymal Stem Cells In Vitro.Yanhong Zhao et al.Orthopaedic surgery, 12(3), 938-945 (2020-05-29)
Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models.Michal Silber et al.The Journal of endocrinology, 244(2), 297-308 (2019-10-30)
Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells.Anwar Abdurahman et al.International journal of molecular sciences, 20(11) (2019-06-07)
Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration.Dongquan Shi et al.ACS nano, 10(1), 1292-1299 (2016-01-13)
Loss of hsa_circ_0118530 inhibits human granulosa-like tumor cell line KGN cell injury by sponging miR-136.Chanwei Jia et al.Gene, 744, 144591-144591 (2020-03-30)
11-Ketotestosterone Is a Major Androgen Produced in Human Gonads.Yoshitaka Imamichi et al.The Journal of clinical endocrinology and metabolism, 101(10), 3582-3591 (2016-07-19)
Dual functional construct containing kartogenin releasing microtissues and curcumin for cartilage regeneration.Negin Asgari et al.Stem cell research & therapy, 11(1), 289-289 (2020-07-18)
MicroRNA‑320a inhibition decreases insulin‑induced KGN cell proliferation and apoptosis by targeting PCGF1.Lei Yang et al.Molecular medicine reports, 16(4), 5706-5712 (2017-08-30)
Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis.Qiuwan Zhang et al.Molecular therapy. Nucleic acids, 16, 407-418 (2019-04-26)
FOXL2 402C>G Mutation Can Be Identified in the Circulating Tumor DNA of Patients with Adult-Type Granulosa Cell Tumor.Anniina Färkkilä et al.The Journal of molecular diagnostics : JMD, 19(1), 126-136 (2016-11-05)
Androgen upregulates NR4A1 via the TFAP2A and ETS signaling networks.Jie Song et al.The international journal of biochemistry & cell biology, 113, 1-7 (2019-05-31)
MiR-3940-5p promotes granulosa cell proliferation through targeting KCNA5 in polycystic ovarian syndrome.Ling Gao et al.Biochemical and biophysical research communications, 524(4), 791-797 (2020-02-06)
miR-424 suppresses proliferation and promotes apoptosis of human ovarian granulosa cells by targeting Apelin and APJ expression.Jing Du et al.American journal of translational research, 12(7), 3660-3673 (2020-08-11)
Advanced glycation end products interfere in luteinizing hormone and follicle stimulating hormone signaling in human granulosa KGN cells.Eleni A Kandaraki et al.Experimental biology and medicine (Maywood, N.J.), 243(1), 29-33 (2017-09-16)
Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells.Yifan Wang et al.Oxidative medicine and cellular longevity, 2018, 1368142-1368142 (2018-08-18)
Kartogenin, transforming growth factor-β1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells.Chun Liu et al.Cell biology international, 39(9), 1026-1035 (2015-04-11)
Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis.M G Yefimova et al.Human reproduction (Oxford, England), 35(6), 1346-1362 (2020-06-13)
EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells.Hanyong Jin et al.Biochemical and biophysical research communications, 482(4), 877-882 (2016-11-29)
Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells.Alix Barbe et al.International journal of molecular sciences, 20(17) (2019-08-31)
Vitamin D attenuates the effect of advanced glycation end products on anti-Mullerian hormone signaling.Zaher Merhi Molecular and cellular endocrinology, 479, 87-92 (2018-09-27)
Absence of the long noncoding RNA H19 results in aberrant ovarian STAR and progesterone production.Yong Chen et al.Molecular and cellular endocrinology, 490, 15-20 (2019-03-30)
LncRNA-LET inhibits cell viability, migration and EMT while induces apoptosis by up-regulation of TIMP2 in human granulosa-like tumor cell line KGN.Qingfang Han et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 100, 250-256 (2018-02-13)
MicroRNA-181a promotes follicular granulosa cell apoptosis via sphingosine-1-phosphate receptor 1 expression downregulation†.Chunxue Zhang et al.Biology of reproduction, 101(5), 975-985 (2019-07-31)
Vitamin D attenuates the effect of advanced glycation end products on anti-Mullerian hormone signaling.Zaher Merhi Molecular and cellular endocrinology, 479, 87-92 (2018-09-27)
Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells.Amandine Palandri et al.Human molecular genetics, 24(9), 2615-2626 (2015-01-30)
EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells.Hanyong Jin et al.Biochemical and biophysical research communications, 482(4), 877-882 (2016-11-29)
Down-regulation of long non-coding RNA MALAT1 inhibits granulosa cell proliferation in endometriosis by up-regulating P21 via activation of the ERK/MAPK pathway.Ying Li et al.Molecular human reproduction, 25(1), 17-29 (2018-10-30)
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