熔点	126-127 ºC**
密度	1.405±0.06 g/cm3 (20 º

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来源	SDS样本
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[Mechanisms of anti-atherogenic effect of probucol and the prospects of its clinical use].V Z Lankin et al.Kardiologiia, 31(6), 87-90 (1991-06-01) New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.Eleni Ladopoulou et al.Journal of medicinal chemistry, 56(8), 3330-3338 (2013-04-16) Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses.S V Stovbun et al.Bulletin of experimental biology and medicine, 153(4), 455-458 (2012-09-15) Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro.Dirleise Colle et al.Mitochondrion, 13(2), 125-133 (2013-01-22) [Discrimination between the effects of hypolipidemic and antiatherogenic drugs: probucol pharmacokinetics (review of the literature)].V N Titov et al.Klinicheskaia laboratornaia diagnostika, (8)(8), 3-9 (2000-10-14) Epithelial-to-mesenchymal transdifferentiation of renal tubular epithelial cell mediated by oxidative stress and intervention effect of probucol in diabetic nephropathy rats.Shao-Bin Duan et al.Renal failure, 34(10), 1244-1251 (2012-09-27) Nano-pulverization of poorly water soluble compounds with low melting points by a rotation/revolution pulverizer.K Yuminoki et al.Die Pharmazie, 67(8), 681-686 (2012-09-11) Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.Ling Guo et al.Arteriosclerosis, thrombosis, and vascular biology, 34(5), 966-975 (2014-03-08) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) [Combined laser therapy of the reactivated form of cytomegalovirus infection of the urogenital tract in the women of reproductive age].Iu N Perlamutrov et al.Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (3)(3), 45-51 (2013-07-04) Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth.Sheila A Doggrell Expert opinion on investigational drugs, 12(11), 1855-1859 (2003-10-31) Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque stability in vivo.Jian-Fei Li et al.Experimental and molecular pathology, 96(2), 250-256 (2014-03-07) Statistical considerations when using a composite endpoint for comparing treatment groups.Guadalupe Gómez et al.Statistics in medicine, 32(5), 719-738 (2012-08-03) Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids.Ankita V Shah et al.Pharmaceutical research, 29(10), 2817-2832 (2012-03-01) [Effects of three different treatments on atherosclerosis and adipose in rats].Xiao-hong Lan et al.Zhonghua yi xue za zhi, 92(23), 1635-1640 (2012-09-05) Design of more potent squalene synthase inhibitors with multiple activities.Angeliki P Kourounakis et al.Bioorganic & medicinal chemistry, 18(21), 7402-7412 (2010-10-05) [Probucol].Makoto Ayaori et al.Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 7, 470-475 (2007-09-08) Inhibition of suicidal erythrocyte death by probucol.Nazneen Shaik et al.Journal of cardiovascular pharmacology, 61(2), 120-126 (2012-10-31) ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.Wijtske Annema et al.Journal of lipid research, 53(5), 929-940 (2012-03-03) Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.Hyun Sook Kwon et al.Bioorganic & medicinal chemistry letters, 18(1), 194-198 (2007-11-14) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.David Tanous et al.Redox report : communications in free radical research, 13(2), 48-59 (2008-03-15) Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.Ki Hun Park et al.Bioorganic & medicinal chemistry letters, 16(21), 5580-5583 (2006-08-22) Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies.Jean-Claude Tardif et al.Current opinion in lipidology, 14(6), 615-620 (2003-11-19) A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons.Zhuoyang Fan et al.International journal of pharmaceutics, 445(1-2), 141-147 (2013-02-12) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding.Ryusuke Takechi et al.Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22) [Probucol treatment of hyperlipidemia].J Koizumi Nihon rinsho. Japanese journal of clinical medicine, 52(12), 3279-3284 (1994-12-01) A case of lipoprotein glomerulopathy successfully treated with probucol.M Amenomori et al.Nephron, 67(1), 109-113 (1994-01-01) Development of a novel model of hypertriglyceridemic acute pancreatitis in hamsters: protective effects of probucol.Guoyong Hu et al.Pancreas, 41(6), 845-848 (2012-07-12) Probucol ameliorates the development of nonalcoholic steatohepatitis in rats fed high-fat diets.Rong Wu et al.Digestive diseases and sciences, 58(1), 163-171 (2012-08-11) [Mechanisms of anti-atherogenic action of probucol].T Ohya et al.Nihon rinsho. Japanese journal of clinical medicine, 57(12), 2831-2836 (2000-01-19) Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells.Elham Fanaee-Danesh et al.Biochimica et biophysica acta. Molecular basis of disease, 1865(9), 2224-2245 (2019-05-06) Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids.Ankita V Shah et al.Pharmaceutical research, 29(10), 2817-2832 (2012-03-01) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.Hyun Sook Kwon et al.Bioorganic & medicinal chemistry letters, 18(1), 194-198 (2007-11-14) Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?Eduardo Luiz Moreira et al.Toxicological sciences : an official journal of the Society of Toxicology, 130(2), 373-382 (2012-08-21) ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.Wijtske Annema et al.Journal of lipid research, 53(5), 929-940 (2012-03-03) Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.Ki Hun Park et al.Bioorganic & medicinal chemistry letters, 16(21), 5580-5583 (2006-08-22) Probucol prevents blood-brain barrier dysfunction in wild-type mice induced by saturated fat or cholesterol feeding.Ryusuke Takechi et al.Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22) [Discrimination between the effects of hypolipidemic and antiatherogenic drugs: probucol pharmacokinetics (review of the literature)].V N Titov et al.Klinicheskaia laboratornaia diagnostika, (8)(8), 3-9 (2000-10-14) [Probucol treatment of hyperlipidemia].J Koizumi Nihon rinsho. Japanese journal of clinical medicine, 52(12), 3279-3284 (1994-12-01) Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds.David Tanous et al.Redox report : communications in free radical research, 13(2), 48-59 (2008-03-15) [Effects of three different treatments on atherosclerosis and adipose in rats].Xiao-hong Lan et al.Zhonghua yi xue za zhi, 92(23), 1635-1640 (2012-09-05) Statistical considerations when using a composite endpoint for comparing treatment groups.Guadalupe Gómez et al.Statistics in medicine, 32(5), 719-738 (2012-08-03) Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Denis Fourches et al.Chemical research in toxicology, 23(1), 171-183 (2009-12-18) [Mechanisms of anti-atherogenic effect of probucol and the prospects of its clinical use].V Z Lankin et al.Kardiologiia, 31(6), 87-90 (1991-06-01) Design of more potent squalene synthase inhibitors with multiple activities.Angeliki P Kourounakis et al.Bioorganic & medicinal chemistry, 18(21), 7402-7412 (2010-10-05) Nano-pulverization of poorly water soluble compounds with low melting points by a rotation/revolution pulverizer.K Yuminoki et al.Die Pharmazie, 67(8), 681-686 (2012-09-11) Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque stability in vivo.Jian-Fei Li et al.Experimental and molecular pathology, 96(2), 250-256 (2014-03-07) Epithelial-to-mesenchymal transdifferentiation of renal tubular epithelial cell mediated by oxidative stress and intervention effect of probucol in diabetic nephropathy rats.Shao-Bin Duan et al.Renal failure, 34(10), 1244-1251 (2012-09-27) A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons.Zhuoyang Fan et al.International journal of pharmaceutics, 445(1-2), 141-147 (2013-02-12) A case of lipoprotein glomerulopathy successfully treated with probucol.M Amenomori et al.Nephron, 67(1), 109-113 (1994-01-01) Succinobucol versus probucol: higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro.Dirleise Colle et al.Mitochondrion, 13(2), 125-133 (2013-01-22) [Probucol].Makoto Ayaori et al.Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 7, 470-475 (2007-09-08) Inhibition of suicidal erythrocyte death by probucol.Nazneen Shaik et al.Journal of cardiovascular pharmacology, 61(2), 120-126 (2012-10-31) Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies.Jean-Claude Tardif et al.Current opinion in lipidology, 14(6), 615-620 (2003-11-19) Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth.Sheila A Doggrell Expert opinion on investigational drugs, 12(11), 1855-1859 (2003-10-31) Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.Ling Guo et al.Arteriosclerosis, thrombosis, and vascular biology, 34(5), 966-975 (2014-03-08) Developing structure-activity relationships for the prediction of hepatotoxicity.Nigel Greene et al.Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18) Effects of physicochemical forms of phenazepam and Panavir on their action at ultra-low doses.S V Stovbun et al.Bulletin of experimental biology and medicine, 153(4), 455-458 (2012-09-15) New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.Eleni Ladopoulou et al.Journal of medicinal chemistry, 56(8), 3330-3338 (2013-04-16) [Combined laser therapy of the reactivated form of cytomegalovirus infection of the urogenital tract in the women of reproductive age].Iu N Perlamutrov et al.Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (3)(3), 45-51 (2013-07-04) Probucol.K D Pfuetze et al.Current atherosclerosis reports, 2(1), 47-57 (2000-12-21) The ABCA1 blocking agent probucol decreases capacitation in ejaculated dog spermatozoa.Sabine Schäfer-Somi et al.Acta veterinaria Scandinavica, 62(1), 2-2 (2020-01-08) Does methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?Eduardo Luiz Moreira et al.Toxicological sciences : an official journal of the Society of Toxicology, 130(2), 373-382 (2012-08-21)

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