熔点	200-202 ºC (benzene hexane
密度	1.083±0.06 g/cm3 (20 º

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Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems.Omar S A Al-Khazrajy et al.Journal of hazardous materials, 317, 198-209 (2016-06-09) The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum.D Dobrev et al.British journal of pharmacology, 127(2), 576-582 (1999-06-29) [The choked heart].F Furrer et al.Praxis, 101(14), 919-922 (2012-07-06) Micro-suspension coating method: a new approach in formulation and development of controlled porosity osmotic pump systems.K Adibkia et al.Drug research, 64(4), 203-207 (2013-09-13) Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.Selina M Garcia et al.PloS one, 15(7), e0236288-e0236288 (2020-07-24) [Topical diltiazem preparations for the treatment of anal fissures].V Schaus Journal de pharmacie de Belgique, (4)(4), 14-17 (2014-01-24) Partial lateral internal sphincterotomy versus combined botulinum toxin A injection and topical diltiazem in the treatment of chronic anal fissure: a randomized clinical trial.Hossein Gandomkar et al.Diseases of the colon and rectum, 58(2), 228-234 (2015-01-15) Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.Takeshi Ogura et al.Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05) The influence of the API properties on the ODTs manufacturing from co-processed excipient systems.Anna Krupa et al.AAPS PharmSciTech, 13(4), 1120-1129 (2012-09-04) Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.Jonathan R Dalzell et al.The American journal of cardiology, 111(3), 454-454 (2013-01-16) [Diltiazem hydrochloride: synthetic and pharmacological studies and development].K Abe et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01) Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass graftingAhonen J, et al. Anesthesiology, 85(6), 1246-1252 (1996) [Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].Jarosław D Kasprzak et al.Kardiologia polska, 70(10), 1081-1094 (2012-10-20) A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney disease.Mahboob Rahman et al.Hypertension (Dallas, Tex. : 1979), 61(1), 82-88 (2012-11-23) The use of diltiazem hydrochloride in cardiovascular disorders.B J McAuley et al.Pharmacotherapy, 2(3), 121-133 (1982-05-01) Diltiazem causes open channel block of recombinant 5-HT3 receptors.M J Gunthorpe et al.The Journal of physiology, 519 Pt 3, 713-722 (1999-08-24) Formulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M.Faaiza Qazi et al.Pakistan journal of pharmaceutical sciences, 26(4), 653-663 (2013-07-03) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) pH-dependent block of the L-type Ca2+ channel current by diltiazem in human mesenteric arterial myocytes.S V Smirnov et al.European journal of pharmacology, 360(1), 81-90 (1998-12-09) Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT.Bruce A Berkowitz et al.Investigative ophthalmology & visual science, 60(5), 1566-1570 (2019-04-18) ECG of the month. Multiple episodes of collapse in a cat.Yamir Reina Doreste et al.Journal of the American Veterinary Medical Association, 242(7), 926-928 (2013-03-23) Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.Takaya Kurokawa et al.Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17) Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate.T Jindal et al.Annals of the Royal College of Surgeons of England, 95(5), 361-364 (2013-07-11) Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats.Fu Qiang et al.Biopharmaceutics & drug disposition, 33(8), 446-454 (2012-08-29) Coronary artery spasm due to thyrotoxicosis.Krystina Common et al.The New Zealand medical journal, 126(1368), 75-78 (2013-02-07) The role of fillers and sodium metabisulfite on drug release from aged polyox tablets.Saeed Shojaee et al.Drug development and industrial pharmacy, 40(11), 1451-1458 (2013-08-22) A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.Kotaro Ogawa et al.Xenobiotica; the fate of foreign compounds in biological systems, 43(5), 468-478 (2012-11-17) Protective effect of diltiazem, a L-type calcium channel antagonist, on lysophosphatidylcholine-enhanced hydroxyl radical generation by MPP(+) in rat striatum.Toshio Obata et al.Clinical biochemistry, 46(1-2), 164-166 (2012-09-25) Differences in the acute pulmonary vascular effects of oxygen with nitric oxide and diltiazem: implications for the long-term treatment of pulmonary arterial hypertension.Ronald W Day Congenital heart disease, 8(1), 71-77 (2012-08-16) Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.M Muz et al.Environmental technology, 35(9-12), 1055-1063 (2014-04-08) Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivoBerkowitz BA, et al. Investigative Ophthalmology & Visual Science, 56(5), 3132-3139 (2015) High-resolution mass spectrometry elucidates metabonate (false metabolite) formation from alkylamine drugs during in vitro metabolite profiling.Joanna E Barbara et al.Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1966-1975 (2012-07-17) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.Michael Levine et al.Annals of emergency medicine, 62(3), 252-258 (2013-05-07) [Topical diltiazem preparations for the treatment of anal fissures].V Schaus Journal de pharmacie de Belgique, (4)(4), 14-17 (2014-01-24) Diltiazem causes open channel block of recombinant 5-HT3 receptors.M J Gunthorpe et al.The Journal of physiology, 519 Pt 3, 713-722 (1999-08-24) Formulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M.Faaiza Qazi et al.Pakistan journal of pharmaceutical sciences, 26(4), 653-663 (2013-07-03) The role of fillers and sodium metabisulfite on drug release from aged polyox tablets.Saeed Shojaee et al.Drug development and industrial pharmacy, 40(11), 1451-1458 (2013-08-22) Protective effect of diltiazem, a L-type calcium channel antagonist, on lysophosphatidylcholine-enhanced hydroxyl radical generation by MPP(+) in rat striatum.Toshio Obata et al.Clinical biochemistry, 46(1-2), 164-166 (2012-09-25) Chemical genetics reveals a complex functional ground state of neural stem cells.Phedias Diamandis et al.Nature chemical biology, 3(5), 268-273 (2007-04-10) Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.Takeshi Ogura et al.Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05) [Diltiazem hydrochloride: synthetic and pharmacological studies and development].K Abe et al.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01) The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum.D Dobrev et al.British journal of pharmacology, 127(2), 576-582 (1999-06-29) A predictive ligand-based Bayesian model for human drug-induced liver injury.Sean Ekins et al.Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17) Micro-suspension coating method: a new approach in formulation and development of controlled porosity osmotic pump systems.K Adibkia et al.Drug research, 64(4), 203-207 (2013-09-13) Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.Selina M Garcia et al.PloS one, 15(7), e0236288-e0236288 (2020-07-24) Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.Jonathan R Dalzell et al.The American journal of cardiology, 111(3), 454-454 (2013-01-16) The influence of the API properties on the ODTs manufacturing from co-processed excipient systems.Anna Krupa et al.AAPS PharmSciTech, 13(4), 1120-1129 (2012-09-04) Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems.Omar S A Al-Khazrajy et al.Journal of hazardous materials, 317, 198-209 (2016-06-09) Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass graftingAhonen J, et al. Anesthesiology, 85(6), 1246-1252 (1996) [Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].Jarosław D Kasprzak et al.Kardiologia polska, 70(10), 1081-1094 (2012-10-20) [The choked heart].F Furrer et al.Praxis, 101(14), 919-922 (2012-07-06) Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate.T Jindal et al.Annals of the Royal College of Surgeons of England, 95(5), 361-364 (2013-07-11) Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.Takaya Kurokawa et al.Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17) Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats.Fu Qiang et al.Biopharmaceutics & drug disposition, 33(8), 446-454 (2012-08-29) Partial lateral internal sphincterotomy versus combined botulinum toxin A injection and topical diltiazem in the treatment of chronic anal fissure: a randomized clinical trial.Hossein Gandomkar et al.Diseases of the colon and rectum, 58(2), 228-234 (2015-01-15) The use of diltiazem hydrochloride in cardiovascular disorders.B J McAuley et al.Pharmacotherapy, 2(3), 121-133 (1982-05-01) A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney disease.Mahboob Rahman et al.Hypertension (Dallas, Tex. : 1979), 61(1), 82-88 (2012-11-23) Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.Michael Levine et al.Annals of emergency medicine, 62(3), 252-258 (2013-05-07) Differences in the acute pulmonary vascular effects of oxygen with nitric oxide and diltiazem: implications for the long-term treatment of pulmonary arterial hypertension.Ronald W Day Congenital heart disease, 8(1), 71-77 (2012-08-16) Removal of endocrine disrupting compounds in a lab-scale anaerobic/aerobic sequencing batch reactor unit.M Muz et al.Environmental technology, 35(9-12), 1055-1063 (2014-04-08) Coronary artery spasm due to thyrotoxicosis.Krystina Common et al.The New Zealand medical journal, 126(1368), 75-78 (2013-02-07) Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivoBerkowitz BA, et al. Investigative Ophthalmology & Visual Science, 56(5), 3132-3139 (2015) Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT.Bruce A Berkowitz et al.Investigative ophthalmology & visual science, 60(5), 1566-1570 (2019-04-18) Effects of CYP3A5 and CYP2D6 genetic polymorphism on the pharmacokinetics of diltiazem and its metabolites in Chinese subjects.T Zheng et al.Die Pharmazie, 68(4), 257-260 (2013-05-25) Non-ionic contrast media induces oxidative stress and apoptosis through Ca²⁺ influx in human neutrophils.Mustafa Kayan et al.The Journal of membrane biology, 245(12), 833-840 (2012-08-21) Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms.Matthew Prideaux et al.PloS one, 10(5), e0125731-e0125731 (2015-05-06)

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