沸点	310 ºC
密度	1.065
折射率	1.451

危险品标志	T
危险类别码	R45;R46
安全说明书	S53;S23;S36/37/39;S45

来源	SDS样本
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Ethyl pyruvate.Mitchell P Fink Current opinion in anaesthesiology, 21(2), 160-167 (2008-04-30) Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment.Yimin Yuan et al.British journal of pharmacology, 166(2), 749-763 (2011-12-07) Effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation during early sepsis treatment.Ismael Francisco Mota Siqueira Guarda et al.Clinics (Sao Paulo, Brazil), 70(7), 508-514 (2015-07-30) Reperfusion strategies in the management of extremity vascular injury with ischaemia.T J Percival et al.The British journal of surgery, 99 Suppl 1, 66-74 (2012-03-28) HMGB1 in renal ischemic injury.May M Rabadi et al.American journal of physiology. Renal physiology, 303(6), F873-F885 (2012-07-05) Ethyl pyruvate improves healing of colonic anastomosis in a rat model of peritonitis.Ender Onur et al.Surgical innovation, 19(4), 394-398 (2012-02-03) Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.Min Jung Lee et al.Molecular pain, 8, 40-40 (2012-05-30) Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.Runkuan Yang et al.Critical care (London, England), 16(1), R9-R9 (2012-01-18) HMGB1: a potential therapeutic target for myocardial ischemia and reperfusion injury.Xiaorong Hu et al.International journal of cardiology, 155(3), 489-489 (2012-01-14) A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.In Hye Lee et al.Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3374-3379 (2008-02-26) Highly Enantioselective Henry (Nitroaldol) Reaction of Aldehydes and ?-Ketoesters Catalyzed by N,N'-Dioxide-Copper (I) Complexes.Qin B, et al. The Journal of Organic Chemistry, 72(24), 9323-9328 (2007) Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?Florian Wagner et al.Critical care (London, England), 16(1), 112-112 (2012-02-22) Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer.Zhen Wang et al.Oncogenesis, 9(9), 82-82 (2020-09-19) HMGB1 was a pivotal synergistic effecor for CpG oligonucleotide to enhance the progression of human lung cancer cells.Chunhong Wang et al.Cancer biology & therapy, 13(9), 727-736 (2012-05-24) Ethyl Pyruvate Emerges as a Safe and Fast Acting Agent against Trypanosoma brucei by Targeting Pyruvate Kinase Activity.Netsanet Worku et al.PloS one, 10(9), e0137353-e0137353 (2015-09-05) Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress.Li-Fu Li et al.Experimental biology and medicine (Maywood, N.J.), 237(6), 720-727 (2012-06-21) HMGB1 translocation is involved in the transformation of autophagy complexes and promotes chemoresistance in leukaemia.Qian Kong et al.International journal of oncology, 47(1), 161-170 (2015-05-09) Protection by ethyl pyruvate against gamma radiation induced damage in bovine serum albumin.Deepti Sharma et al.International journal of biological macromolecules, 150, 1053-1060 (2019-11-19) Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axis.M-L Li et al.International journal of immunopathology and pharmacology, 25(4), 955-965 (2013-01-10) Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.Xuemei Li et al.Expert opinion on investigational drugs, 18(8), 1047-1060 (2009-06-27) Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.Divya Gupta et al.Investigative ophthalmology & visual science, 53(10), 6589-6599 (2012-08-25) HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells.Katherine H Parker et al.Cancer research, 74(20), 5723-5733 (2014-08-29) Activation of the high-mobility group box 1 protein-receptor for advanced glycation end-products signaling pathway in rats during neurogenesis after intracerebral hemorrhage.Chunyan Lei et al.Stroke, 46(2), 500-506 (2014-12-30) Ethyl pyruvate treatment mitigates oxidative stress damage in cultured trabecular meshwork cells.Amin Famili et al.Molecular vision, 19, 1304-1309 (2013-06-28) [Ethyl pyruvate inhibited HMGB1 expression induced by LPS in macrophages].Xiao-xing Tian et al.Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 27(12), 1304-1307 (2011-12-14) Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms.Joo-Hyun Shin et al.Neurochemistry international, 61(1), 89-99 (2012-04-24) Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis.Zheng-Gang Luan et al.The Journal of surgical research, 181(1), 76-84 (2012-06-22) Ethyl pyruvate: a novel treatment for sepsis.Mitchell P Fink Current drug targets, 8(4), 515-518 (2007-04-14) Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution.Mitchell P Fink Current opinion in clinical nutrition and metabolic care, 5(2), 167-174 (2002-02-15) Ethyl pyruvate: a novel treatment for sepsis.Mitchell P Fink Novartis Foundation symposium, 280, 147-156 (2007-03-27) Ethyl pyruvate protects against Salmonella intestinal infection in mice through down-regulation of pro-inflammatory factors and inhibition of TLR4/MAPK pathway.Na Dong et al.International immunopharmacology, 71, 155-163 (2019-03-23) Decontamination of green onions and baby spinach by vaporized ethyl pyruvate.M Zeki Durak et al.Journal of food protection, 75(6), 1012-1022 (2012-06-14) Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate.Michael C Reade et al.Critical care (London, England), 9(6), 556-560 (2005-12-17) Exploring glyoxalase 1 expression in prostate cancer tissues: targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties.Martin Baunacke et al.The Prostate, 74(1), 48-60 (2013-10-10) Ethyl pyruvate significantly inhibits tumour necrosis factor-α, interleukin-1β and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury.Z-G Luan et al.Clinical and experimental immunology, 172(3), 417-426 (2013-04-23) Improvement of hypoxia-ischemia-induced white matter injury in immature rat brain by ethyl pyruvate.Yingyan Wang et al.Neurochemical research, 38(4), 742-752 (2013-03-09) Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis.Zheng-Gang Luan et al.Pancreas, 41(5), 729-737 (2012-06-16) Ethyl pyruvate: a novel treatment for sepsis and shock.M P Fink Minerva anestesiologica, 70(5), 365-371 (2004-06-08) Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate.E D Vasilyeva et al.Experimental oncology, 34(1), 66-68 (2012-03-29) Ethyl pyruvate: a novel anti-inflammatory agent.Mitchell P Fink Critical care medicine, 31(1 Suppl), S51-S56 (2003-01-25) Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats.Lin Sun et al.Journal of neurotrauma, 36(3), 421-435 (2018-06-23) Ethyl Pyruvate Attenuates CaCl2-Induced Tubular Epithelial Cell Injury by Inhibiting Autophagy and Inflammatory Responses.Jiawen Zhao et al.Kidney & blood pressure research, 43(5), 1585-1595 (2018-10-24) The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.Kenneth K Kao et al.Biochemical pharmacology, 80(2), 151-159 (2010-03-17) Ethyl pyruvate protects against lipopolysaccharide-induced white matter injury in the developing rat brain.Yingyan Wang et al.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(3), 181-188 (2013-01-03) Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation.Alessandra di Penta et al.PloS one, 8(2), e54722-e54722 (2013-02-23) Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo.Jing Zhang et al.Oncology reports, 27(5), 1511-1519 (2012-01-17) Effects of high-mobility group box1 on cerebral angiogenesis and neurogenesis after intracerebral hemorrhage.C Lei et al.Neuroscience, 229, 12-19 (2012-11-10) Ethyl pyruvate: a novel anti-inflammatory agent.M P Fink Journal of internal medicine, 261(4), 349-362 (2007-03-30) Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats.H Akkoc et al.Acta gastro-enterologica Belgica, 75(3), 336-341 (2012-10-23) A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury.Suha Turkmen et al.Fertility and sterility, 98(3), 626-631 (2012-06-22) Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Vitali Alexeev et al.Molecular cancer therapeutics, 13(12), 2968-2977 (2014-11-16) 98% Enantioselectivity in the asymmetric synthesis of a useful chiral building block by heterogeneous method: Enantioselective hydrogenation of ethyl-benzoylformate over cinchona modified Pt/Al2 O3 catalysts in the acetic acid.Sutyinszki M, et al. Catalysis Communications, 3(3), 125-127 (2002) Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation.Emel Kiyak Caglayan et al.European journal of obstetrics, gynecology, and reproductive biology, 182, 154-159 (2014-10-08)

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