密度	1.545±0.06 g/cm3 (20 º

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Combining cytotoxic and targeted therapies for lung cancer.Matjaz Zwitter Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(10), 1498-1499 (2010-09-28) [Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1].Zhong Guo et al.Sheng li xue bao : [Acta physiologica Sinica], 63(2), 164-170 (2011-04-21) A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies.Hongxia Lin et al.Journal of pharmaceutical and biomedical analysis, 66, 371-375 (2012-04-10) Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.Hope M Amm et al.Molecular cancer research : MCR, 9(4), 403-417 (2011-03-02) Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms.Connor Hall et al.Clinical genitourinary cancer, 11(1), 10-19 (2012-10-23) Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels.Asli Kisim et al.Journal of cancer research and clinical oncology, 138(7), 1155-1163 (2012-03-14) Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells.Archana Thakur et al.PloS one, 7(11), e47520-e47520 (2012-11-28) The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs.Aneel Paulus et al.British journal of haematology, 165(1), 78-88 (2014-01-29) Neutropenia as a potential pharmacodynamic marker for docetaxel-based chemotherapy in men with metastatic castration-resistant prostate cancer.Gregory R Pond et al.Clinical genitourinary cancer, 10(4), 239-245 (2012-09-25) [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone].Wei Cheng et al.Zhongguo shi yan xue ye xue za zhi, 20(2), 229-234 (2012-05-01) Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression.Foong Ying Wong et al.PloS one, 7(12), e50786-e50786 (2012-12-12) The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.Seon-Hyeong Lee et al.Cancers, 12(6) (2020-06-03) Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer.G Sonpavde et al.Annals of oncology : official journal of the European Society for Medical Oncology, 23(7), 1803-1808 (2011-11-25) AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model.Natalie McGregor et al.Journal of cellular biochemistry, 110(5), 1187-1194 (2010-07-01) Morphological-metric, ultrastructural and immunohistochemical effects of gossypol on cultured granulosa cells and oocytes of ewes using MOEPF.Carolina Rodriguez Jimenez et al.Animal reproduction science, 201, 22-31 (2018-12-21) Re: Gregory R. Pond, Andrew J. Armstrong, Brian A. Wood, et al. Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Eur Urol 2012;61:363-9.Yijun Shen et al.European urology, 61(2), e3-e3 (2011-08-10) Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects.Atsushi Imai et al.Cancer research, 72(3), 716-725 (2011-12-14) Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer.Gregory R Pond et al.European urology, 61(2), 363-369 (2011-07-01) Radiographic progression by Prostate Cancer Working Group (PCWG)-2 criteria as an intermediate endpoint for drug development in metastatic castration-resistant prostate cancer.Guru Sonpavde et al.BJU international, 114(6b), E25-E31 (2013-12-05) Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.Rebecca Suk Heist et al.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(10), 1637-1643 (2010-09-03) Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats.Qing Chang et al.Chinese medical journal, 124(11), 1678-1682 (2011-07-12) Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol).Selim Uzunoglu et al.Toxicology mechanisms and methods, 20(8), 482-486 (2010-09-17) AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer.Luigi Moretti et al.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(5), 680-687 (2010-04-01) Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer.Neal Ready et al.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(4), 781-785 (2011-02-04) Inhibition of pepsinogen activation by gossypol.T D Tanksley et al.The Journal of biological chemistry, 245(23), 6456-6461 (1970-12-10) [Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism].Wen-Qing Wang et al.Zhongguo shi yan xue ye xue za zhi, 17(6), 1459-1463 (2009-12-25) Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin.R C Wong et al.The Journal of biological chemistry, 247(5), 1625-1631 (1972-03-10) Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.Aisha Masood et al.British journal of haematology, 157(1), 59-66 (2011-12-17) Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia.Christian Billard Molecular cancer research : MCR, 10(6), 673-676 (2012-04-03) Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.Wenbin Hu et al.The Journal of biological chemistry, 287(1), 68-80 (2011-11-05)

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