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Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.Michael C Montana et al.Anesthesiology, 115(6), 1239-1250 (2011-11-01) A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.Kalina Szteyn et al.Pain, 156(11), 2364-2372 (2015-07-15) Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.Simona M Ceccarelli et al.Bioorganic & medicinal chemistry letters, 17(5), 1302-1306 (2006-12-27) mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.Michael D B Swedberg et al.The Journal of pharmacology and experimental therapeutics, 349(1), 155-164 (2014-01-30) A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.Allison Doyle Brackley et al.Scientific reports, 7(1), 1842-1842 (2017-05-14) Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study.J C Pecknold et al.Journal of clinical psychopharmacology, 2(2), 129-133 (1982-04-01) Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.Andrew Anighoro et al.Bioorganic & medicinal chemistry, 23(13), 3040-3058 (2015-05-28) The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.Michael C Montana et al.The Journal of pharmacology and experimental therapeutics, 330(3), 834-843 (2009-06-12) Aquaporin 4-Mediated Glutamate-Induced Astrocyte Swelling Is Partially Mediated through Metabotropic Glutamate Receptor 5 Activation.Zhongfang Shi et al.Frontiers in cellular neuroscience, 11, 116-116 (2017-05-16) A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.E Berry-Kravis et al.Journal of medical genetics, 46(4), 266-271 (2009-01-08) In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat.W N Wu et al.Journal of pharmaceutical sciences, 84(2), 185-189 (1995-02-01) A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.Daniella Rylander et al.Neurobiology of disease, 39(3), 352-361 (2010-05-11) Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.Lara W Crock et al.Molecular pain, 8, 20-20 (2012-03-28) Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.Argel Aguilar-Valles et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(31), 11125-11132 (2015-08-08) The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice.M F Vinueza Veloz et al.Genes, brain, and behavior, 11(3), 325-331 (2012-01-20) Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.Sajesh P Thomas et al.Chemical communications (Cambridge, England), 48(85), 10559-10561 (2012-09-25) The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.Laura F Cavallone et al.Pain, 161(1), 135-146 (2019-10-01) Phenyl ureas of creatinine as mGluR5 antagonists. 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