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1H-Indole-4-methanamine | CAS:3468-18-6
1H-Indole-4-methanamine
  • 名称:1H-吲哚-4-甲胺 | 1H-Indole-4-methanamine
  • CAS号:3468-18-6
  • 别名:4-(Aminomethyl)indole; NSC 131886
  • 分子式:C9H10N2
  • 分子量:146.19
  • EINESC号:

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物理化学性质

熔点 132 ºC
密度 1.199

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Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension.Italo Biaggioni et al.BMC neurology, 17(1), 90-90 (2017-05-13) [New perspectives on molecular and genic therapies in Down syndrome].Jean Maurice Delabar Medecine sciences : M/S, 26(4), 371-376 (2010-04-24) Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats.Mar Coll et al.Hepatology (Baltimore, Md.), 56(5), 1849-1860 (2012-05-23) L-threo-3,4-dihydroxyphenylserine (L-DOPS) co-administered with entacapone improves freezing of gait in Parkinson's disease.Kei Fukada et al.Medical hypotheses, 80(2), 209-212 (2012-12-26) Motor and non-motor outcomes of continuous apomorphine infusion in 125 Parkinson's disease patients.Robbert W K Borgemeester et al.Parkinsonism & related disorders, 23, 17-22 (2015-12-29) The effect of ultrasonic irradiation on the morphology of NiO/Co3O4 nanocomposite and its application to the simultaneous electrochemical determination of droxidopa and carbidopa.Reyhaneh Torkzadeh-Mahani et al.Ultrasonics sonochemistry, 56, 183-192 (2019-05-19) Depletion of Neural Crest-Derived Cells Leads to Reduction in Plasma Noradrenaline and Alters B Lymphopoiesis.Naoki Tsunokuma et al.Journal of immunology (Baltimore, Md. : 1950), 198(1), 156-169 (2016-11-23) L-threo-dihydroxyphenylserine corrects neurochemical abnormalities in a Menkes disease mouse model.Anthony Donsante et al.Annals of neurology, 73(2), 259-265 (2012-12-12) Diastereoselective synthesis of L: -threo-3,4-dihydroxyphenylserine by low-specific L: -threonine aldolase mutants.Hui-Jeong Gwon et al.Biotechnology letters, 32(1), 143-149 (2009-09-18) Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa.Italo Biaggioni et al.Hypertension (Dallas, Tex. : 1979), 65(1), 101-107 (2014-10-29) Alpha2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment.Sudhirkumar U Yanpallewar et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(3), 1096-1109 (2010-01-22) Optimal production of L-threo-2,3-dihydroxyphenylserine (L-threo-DOPS) on a large scale by diastereoselectivity-enhanced variant of L-threonine aldolase expressed in Escherichia coli.Hui-Jeong Gwon et al.Preparative biochemistry & biotechnology, 42(2), 143-154 (2012-03-08) L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug.David S Goldstein Cardiovascular drug reviews, 24(3-4), 189-203 (2007-01-12) L-DOPS and the treatment of neurogenic orthostatic hypotensionVichayanrat E, et al. Future Neurology, 8(4), 381-397 (2013) Is there room for non-dopaminergic treatment in Parkinson disease?Abraham Lieberman et al.Journal of neural transmission (Vienna, Austria : 1996), 120(2), 347-348 (2012-12-18) The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease.Sergey Kalinin et al.Neurobiology of aging, 33(8), 1651-1663 (2011-06-28) Midodrine hydrochloride and L-threo-3,4-dihydroxy-phenylserine preserve cerebral blood flow in hemodialysis patients with orthostatic hypotension.Kiichiro Fujisaki et al.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 11(1), 49-55 (2007-02-21) [Acute poisoning of droxidopa: report of a case].Shuichi Hagiwara Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 26(3), 244-245 (2013-11-15) L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience.Christopher J Mathias Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 18 Suppl 1, 25-29 (2008-04-23) Synthesis of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) with thermostabilized low-specific L-threonine aldolase from Streptomyces coelicolor A3(2).Sang-Ho Balk et al.Journal of microbiology and biotechnology, 17(5), 721-727 (2007-12-07) Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial.Horacio Kaufmann et al.Neurology, 83(4), 328-335 (2014-06-20) Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline.Yusuke Saito et al.The Tohoku journal of experimental medicine, 226(1), 75-83 (2011-12-28) Enhanced synthesis of L-threo-3,4-dihydroxyphenylserine by high-density whole-cell biocatalyst of recombinant L-threonine aldolase from Streptomyces avelmitilis.Sang-Ho Baik et al.Biotechnology letters, 31(3), 443-448 (2008-11-29) Hemodynamic effects of L-threo-3,4-dihydroxyphenylserine (Droxidopa) in hypotensive individuals with spinal cord injury.Jill M Wecht et al.Archives of physical medicine and rehabilitation, 94(10), 2006-2012 (2013-04-23) Neurogenic orthostatic hypotension: new prospects in treatment. Introduction.Horacio Kaufmann Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 18 Suppl 1, 1-1 (2008-04-23) Application of the BCS biowaiver approach to assessing bioequivalence of orally disintegrating tablets with immediate release formulations.Asami Ono et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 64, 37-43 (2014-08-26) Prospects for droxidopa in neurogenic orthostatic hypotension.Amanda J Ross et al.Hypertension (Dallas, Tex. : 1979), 65(1), 34-35 (2014-10-29) Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony.Kafui Dzirasa et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(18), 6387-6397 (2010-05-07) Effects of carbidopa and entacapone on the metabolic fate of the norepinephrine prodrug L-DOPS.David S Goldstein et al.Journal of clinical pharmacology, 51(1), 66-74 (2010-03-12) Dopamine dysregulation syndrome including mania related to coadministration of droxidopa.Shinnosuke Saito et al.Journal of clinical psychopharmacology, 32(3), 428-429 (2012-05-09) Contamination of the norepinephrine prodrug droxidopa by dihydroxyphenylacetaldehyde.Courtney Holmes et al.Clinical chemistry, 56(5), 832-838 (2010-03-09) L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience.Horacio Kaufmann Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 18 Suppl 1, 19-24 (2008-04-23) DBH deficiency in an elderly patient: efficacy and safety of chronic droxidopa.Fabien Despas et al.Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 20(3), 205-207 (2010-01-12) Comment on "Midodrine hydrochloride and L-threo-3,4-dihydroxy-phenylserine preserve cerebral blood flow in hemodialysis patients with orthostatic hypotension" by Fujisaki et al.Vijay Sharma et al.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 11(5), 407-408 (2007-09-12) [Pharmacological hypotheses and therapeutic strategies for gait disorders in Parkinson's disease].D Devos et al.Revue neurologique, 166(2), 168-177 (2009-10-09) Is there room for new non-dopaminergic treatments in Parkinson's disease?Manuela Pilleri et al.Journal of neural transmission (Vienna, Austria : 1996), 120(2), 349-352 (2012-12-12)
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