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Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis.Reka Chakravarthy et al.Biology of the cell, 105(9), 414-429 (2013-06-06) Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model.Zhanrong Li et al.International journal of nanomedicine, 7, 2389-2398 (2012-06-05) Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes.Gi Soo Youn et al.Toxicology and applied pharmacology, 280(1), 42-52 (2014-07-30) Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.Wei Fang et al.Molecules (Basel, Switzerland), 17(9), 11113-11123 (2012-09-19) Encyclopedia of Cancer, 568-568 (2008) Strong inhibition of celastrol towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction.Yong-Sheng Zhang et al.Molecules (Basel, Switzerland), 17(6), 6832-6839 (2012-06-07) Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1Zhang Y, et al. Molecular Metabolism, 6(1), 138-147 (2017) Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.Hong Zhu et al.PloS one, 7(12), e52333-e52333 (2013-01-04) Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.Hua Yu et al.International immunopharmacology, 13(4), 499-506 (2012-06-06) Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo.Lin Zheng et al.International journal of cancer, 135(7), 1721-1732 (2014-03-13) Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.Mirela Matokanovic et al.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 50(1), 149-158 (2013-04-16) Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.Eva-Lotta von Rüden et al.ACS chemical neuroscience, 10(3), 1434-1444 (2018-11-07) Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model.Zhanrong Li et al.International journal of nanomedicine, 7, 2389-2398 (2012-06-05) The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.Yanyu Wang et al.Molecular biology of the cell, 23(17), 3290-3298 (2012-07-20) Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.Eva-Lotta von Rüden et al.ACS chemical neuroscience, 10(3), 1434-1444 (2018-11-07) Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.Shivaprasad H Venkatesha et al.Bioorganic & medicinal chemistry, 20(17), 5229-5234 (2012-08-03) Tripterine emerges as a potential anti-scarring agent in NIH/3T3 cells by repressing ANRIL.Lei Jiang et al.General physiology and biophysics, 39(4), 355-362 (2020-09-10) [Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid].Shao-Ying Hu et al.Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(20), 3052-3055 (2013-01-15) [Effects of tripterine on NF-kappaB and eotaxin in nasal mucosa of allergic rhinitis rat].Ying Li et al.Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 26(20), 943-945 (2013-01-01) Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.Xiaolong Yu et al.Oncology reports, 34(3), 1129-1136 (2015-07-15) Celastrol: Molecular targets of Thunder God Vine.Antero Salminen et al.Biochemical and biophysical research communications, 394(3), 439-442 (2010-03-17) Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.Sujuan Chen et al.Journal of neurochemistry, 128(2), 256-266 (2013-10-12) Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.Guo-qing Li et al.International immunopharmacology, 14(4), 422-431 (2012-09-08) Protective effect of celastrol in rat cerebral ischemia model: down-regulating p-JNK, p-c-Jun and NF-κB.Yanhua Li et al.Brain research, 1464, 8-13 (2012-05-12) Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling.Yongsheng Hu et al.Biochimica et biophysica acta, 1830(3), 2779-2789 (2012-11-13) Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers.Yan Chen et al.International journal of nanomedicine, 7, 3023-3032 (2012-07-13) Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-kappaB pathway in TMPRSS2/ERG fusion gene expressing prostate cancerShao L, et al. PLoS ONE, 8(3), e58391-e58391 (2013) Mini-review: Foldosome regulation of androgen receptor action in prostate cancer.Laia Querol Cano et al.Molecular and cellular endocrinology, 369(1-2), 52-62 (2013-02-12) Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s.Meirong Zang et al.Oncogenesis, 9(3), 31-31 (2020-03-07) Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.Zi Liu et al.Carcinogenesis, 35(4), 905-914 (2013-12-03) Preparation of tripterine nanostructured lipid carriers and their absorption in rat intestine.Lei Zhou et al.Die Pharmazie, 67(4), 304-310 (2012-05-11) Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis.Alexander J Baker-Williams et al.Cell reports, 28(7), 1894-1906 (2019-08-15) Celastrol protects kidney against ischemia-reperfusion-induced injury in rats.Changbin Chu et al.The Journal of surgical research, 186(1), 398-407 (2013-08-29) Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a.Anjun Zuo et al.Biological chemistry (2019-03-27) Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells.Sang-Wook Kang et al.Journal of cellular biochemistry, 114(2), 398-408 (2012-09-06) [Expression, purification of proteasome subunit PSMB1 and application in screening of possible proteasome inhibitors].Cuiying Fan et al.Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 28(2), 233-242 (2012-06-07) Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cellsXiong Y, et al. Biomedicine and Pharmacotherapy, 105, 798-804 (2018) Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine.Yan Chen et al.International journal of nanomedicine, 7, 4581-4591 (2012-09-04) The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation.Can Aztekin et al.Development (Cambridge, England), 147(3) (2020-01-29) The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.Erin M O'Leary et al.Molecular genetics and metabolism, 107(1-2), 173-185 (2012-08-18) Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk.Siddaraju M Nanjundaiah et al.The Journal of biological chemistry, 287(26), 22216-22226 (2012-05-03) Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.Radhamani Kannaiyan et al.Cancer letters, 303(1), 9-20 (2010-12-21) Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats.Jun Zhang et al.Journal of ethnopharmacology, 144(1), 195-200 (2012-09-18) Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.A C Allison et al.Progress in neuro-psychopharmacology & biological psychiatry, 25(7), 1341-1357 (2001-08-22) Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells.Shuai Huang et al.Biochemical and biophysical research communications, 423(3), 467-472 (2012-06-12) Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells.Wenzong Lu et al.Life sciences, 91(7-8), 279-283 (2012-08-11) ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network.L Feng et al.Cell death & disease, 4, e715-e715 (2013-07-13) Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response.Tatiana V Cohen et al.Neuromuscular disorders : NMD, 22(7), 648-658 (2012-05-09) Genome-wide functional screening identifies CDC37 as a crucial HSP90-cofactor for KIT oncogenic expression in gastrointestinal stromal tumors.A Mariño-Enríquez et al.Oncogene, 33(14), 1872-1876 (2013-04-16) Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.Taesik Gwag et al.Archives of biochemistry and biophysics, 537(1), 21-30 (2013-07-03) Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway.Ji Hae Kim et al.Cellular signalling, 25(4), 805-813 (2012-12-26) Encyclopedia of Cancer, 568-568 (2008) Celastrol and attenuation of tumor growth in systemic malignancies: a clinical perspective.Shailendra Kapoor Journal of cellular physiology, 229(2), 258-258 (2013-06-15) Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.Chunzhang Yang et al.Proceedings of the National Academy of Sciences of the United States of America, 111(1), 249-254 (2013-12-20) Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.Shivaprasad H Venkatesha et al.Bioorganic & medicinal chemistry, 20(17), 5229-5234 (2012-08-03) Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis.Reka Chakravarthy et al.Biology of the cell, 105(9), 414-429 (2013-06-06)

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