熔点	218-220 ºC

没有数据	没有数据

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon.V Gil et al.American journal of physiology. Gastrointestinal and liver physiology, 303(3), G412-G423 (2012-05-29) Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles.Yu-Cheng Hsieh et al.Circulation. Arrhythmia and electrophysiology, 6(2), 410-418 (2013-02-20) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss.Stephen Paul Zachary et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9701-9706 (2015-07-03) Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice.Franciele Donato et al.Journal of medicinal food, 18(7), 818-823 (2015-02-04) Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease.Yuan Wang et al.Molecular neurobiology, 51(1), 424-436 (2014-05-21) Intrinsic Ca2+-dependent theta oscillations in apical dendrites of hippocampal CA1 pyramidal cells in vitro.Allan Kjeldsen Hansen et al.Journal of neurophysiology, 112(3), 631-643 (2014-09-25) Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior.Hironori Kamii et al.The European journal of neuroscience, 41(9), 1126-1138 (2015-02-26) Effects of morphine withdrawal on the membrane properties of medium spiny neurons in the nucleus accumbens shell.Xiaobo Wu et al.Brain research bulletin, 90, 92-99 (2012-10-17) Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats.Le Gui et al.American journal of physiology. Regulatory, integrative and comparative physiology, 303(3), R301-R310 (2012-06-01) Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.Marta Baranowska-Kuczko et al.Pharmacological research, 66(3), 251-259 (2012-05-26) Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries.Fui C Yap et al.PloS one, 9(8), e104686-e104686 (2014-08-12) Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.Shigeo Hayashi et al.Bioorganic & medicinal chemistry, 18(21), 7675-7699 (2010-09-30) Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients.Yuhong Liu et al.Journal of the American Heart Association, 4(8), e002062-e002062 (2015-08-26) Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons.Sarah Y Branch et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11) Nitric oxide as intracellular modulator: internal production of NO increases neuronal excitability via modulation of several ionic conductances.Liana Artinian et al.The European journal of neuroscience, 36(10), 3333-3343 (2012-08-24) Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats.Le Gui et al.American journal of physiology. Regulatory, integrative and comparative physiology, 303(3), R301-R310 (2012-06-01) Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.Marta Baranowska-Kuczko et al.Pharmacological research, 66(3), 251-259 (2012-05-26) Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.Shigeo Hayashi et al.Bioorganic & medicinal chemistry, 18(21), 7675-7699 (2010-09-30) Ovariectomy-induced reductions in endothelial SK3 channel activity and endothelium-dependent vasorelaxation in murine mesenteric arteries.Fui C Yap et al.PloS one, 9(8), e104686-e104686 (2014-08-12) Apamin binding proteins and oligosaccharyltransferases.P N Strong et al.Toxicon : official journal of the International Society on Toxinology, 34(5), 507-509 (1996-05-01) Pregnancy Increases Relaxation in Human Omental Arteries to the CGRP Family of Peptides.Yuanlin Dong et al.Biology of reproduction, 93(6), 134-134 (2015-10-30) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.Huaqing Liu et al.Journal of medicinal chemistry, 51(22), 7094-7098 (2008-11-06) The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone.Alice E McGovern et al.British journal of pharmacology, 171(15), 3633-3650 (2014-04-26) Estrogen regulates the expression of small-conductance Ca-activated K+ channels in colonic smooth muscle cells.Yu-Rong Tang et al.Digestion, 91(3), 187-196 (2015-03-21) Ginsenoside Re enhances small-conductance Ca(2+)-activated K(+) current in human coronary artery endothelial cells.Suporn Sukrittanon et al.Life sciences, 115(1-2), 15-21 (2014-09-23) Opposing actions of TRPV4 channel activation in the lung vasculature.Sun-Kui Ke et al.Respiratory physiology & neurobiology, 219, 43-50 (2015-08-19) Cilostazol induces vasodilation through the activation of Ca(2+)-activated K(+) channels in aortic smooth muscle.Hongliang Li et al.Vascular pharmacology, 70, 15-22 (2015-03-10) Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels.Ramesh C Mishra et al.Journal of cardiovascular pharmacology, 66(1), 118-127 (2015-03-31) Bis-quinolinium cyclophanes: highly potent and selective non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.Ana Conejo-García et al.Current medicinal chemistry, 15(13), 1305-1315 (2008-06-10) Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease.Eun Sook Chung et al.Journal of immunology (Baltimore, Md. : 1950), 195(10), 4853-4860 (2015-10-11) Menthol inhibits detrusor contractility independently of TRPM8 activation.Antonio Celso Saragossa Ramos-Filho et al.PloS one, 9(11), e111616-e111616 (2014-11-07) A Comparison of the Ability of Leu8-and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin ReceptorsPierce ML, et al. Molecular Pharmacology, 95(4), 376-385 (2019) Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers.Robert G Gentles et al.Bioorganic & medicinal chemistry letters, 18(20), 5694-5697 (2008-10-01) Expression of small-conductance calcium-activated potassium channels (SK3) in skeletal muscle: regulation by muscle activity.Morgana Favero et al.The Journal of physiology, 586(19), 4763-4774 (2008-08-16) Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.Christine Wandall-Frostholm et al.PloS one, 9(5), e97687-e97687 (2014-05-27) AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.Swapnil K Sonkusare et al.Science signaling, 7(333), ra66-ra66 (2014-07-10) The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells.Y M AlSuleimani et al.British journal of pharmacology, 172(12), 3043-3057 (2015-02-06) Stimulation of electroporation-induced inward currents in glioblastoma cell lines by the heat shock protein inhibitor AUY922.Nai-Jung Chiang et al.Clinical and experimental pharmacology & physiology, 41(10), 830-837 (2014-06-10) [Apamin--a highly specific and effective blockader of calcium-dependent potassium conductance].L V Baĭdan et al.Neirofiziologiia = Neurophysiology, 20(6), 833-846 (1988-01-01) Topography of native SK channels revealed by force nanoscopy in living neurons.Jamie L Maciaszek et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11435-11440 (2012-08-17) Apamin, a neurotoxin specific for one class of Ca2+-dependent K+ channels.M Lazdunski Cell calcium, 4(5-6), 421-428 (1983-12-01) L-Type Ca(2+) Channels and SK Channels in Mouse Embryonic Stem Cells and Their Contribution to Cell Proliferation.Josefina M Vegara-Meseguer et al.The Journal of membrane biology, 248(4), 671-682 (2015-02-11) Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.Amaury Graulich et al.Journal of medicinal chemistry, 49(24), 7208-7214 (2006-11-28) Antioxidant and vasorelaxant activities induced by northeastern Brazilian fermented grape skinsAlbuquerque J, et al. BMC Complementary and Alternative Medicine, 17(1), 376-376 (2017) Electrophysiological characterization and computational models of HVC neurons in the zebra finchDaou A, et al. Journal of Neurophysiology, 110(5), 1227-1245 (2013) Evidence that nitric oxide is a non-adrenergic non-cholinergic inhibitory neurotransmitter in the circular muscle of the mouse distal colon: a study on the mechanism of nitric oxide-induced relaxation.Kazuhiro Nishiyama et al.Pharmacology, 94(3-4), 99-108 (2014-09-18) Reduced hyperpolarization of endothelial cells following high dietary Na+: effects of enalapril and tempol.Alexander Bondarenko et al.Clinical and experimental pharmacology & physiology, 39(7), 608-613 (2012-05-01) Pharmacological characteristics of the inhibitory effects of docosahexaenoic acid on vascular contractions studied in rat mesenteric artery.Kyosuke Sato et al.Pharmacology, 93(5-6), 229-243 (2014-07-12) Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.Robert G Gentles et al.Bioorganic & medicinal chemistry letters, 18(19), 5316-5319 (2008-09-09) Effects of Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) on contractile activity of circular smooth muscle of the rat distal colon.Yoshihiko Kito et al.American journal of physiology. Gastrointestinal and liver physiology, 303(9), G1059-G1066 (2012-08-25) KCa3.1 modulates neuroblast migration along the rostral migratory stream (RMS) in vivo.Kathryn L Turner et al.Cerebral cortex (New York, N.Y. : 1991), 24(9), 2388-2400 (2013-04-16) Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats.José M La Fuente et al.European journal of pharmacology, 735, 68-76 (2014-04-22) Type 2 diabetes: increased expression and contribution of IKCa channels to vasodilation in small mesenteric arteries of ZDF rats.Christian Schach et al.American journal of physiology. Heart and circulatory physiology, 307(8), H1093-H1102 (2014-08-17) The effect of apamin, a small conductance calcium activated potassium (SK) channel blocker, on a mouse model of neurofibromatosis 1.Angy J Kallarackal et al.Behavioural brain research, 237, 71-75 (2012-09-18) Na/Ca(2+) exchanger 1 transgenic mice display increased relaxation in the distal colon.Kazuhiro Nishiyama et al.Pharmacology, 94(5-6), 230-238 (2014-11-28) Involvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension test.Morgana Moretti et al.European journal of pharmacology, 687(1-3), 21-27 (2012-05-12) SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions.Serge A Y Afeli et al.American journal of physiology. Renal physiology, 303(4), F559-F568 (2012-05-18) Apamin modulates electrophysiological characteristics of the pulmonary vein and the Sinoatrial Node.Wei-Ta Chen et al.European journal of clinical investigation, 43(9), 957-963 (2013-07-10) Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5.Paul F Kramer et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(10), 2418-2424 (2015-04-02) Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells.David H F Vandael et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(46), 16345-16359 (2012-11-16) A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.P S Wong et al.Pharmacological research, 90, 25-35 (2014-09-27) SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells.Gen Ohtsuki et al.Neuron, 75(1), 108-120 (2012-07-17) KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.Serge Simonet et al.British journal of pharmacology, 167(4), 854-867 (2012-06-01) The contribution of K(+) channels to human thoracic duct contractility.Niklas Telinius et al.American journal of physiology. Heart and circulatory physiology, 307(1), H33-H43 (2014-04-30) Spontaneous transient hyperpolarizations in the rabbit small intestine.Yoshihiko Kito et al.The Journal of physiology, 592(21), 4733-4745 (2014-09-14) The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels.Sébastien Dilly et al.Biochemical pharmacology, 85(4), 560-569 (2012-12-29) CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking.Courtney L Williams et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10402-10414 (2014-08-01) Mechanisms underlying desynchronization of cholinergic-evoked thalamic network activity.Juan Diego Pita-Almenar et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(43), 14463-14474 (2014-10-24) Ventricular tachyarrhythmias in rats with acute myocardial infarction involves activation of small-conductance Ca2+-activated K+ channels.Le Gui et al.American journal of physiology. Heart and circulatory physiology, 304(1), H118-H130 (2012-10-23) Apamin.E Habermann Pharmacology & therapeutics, 25(2), 255-270 (1984-01-01) The apamin-sensitive Ca2+-dependent K+ channel molecular properties, differentiation and endogenous ligands in mammalian brain.M Lazdunski et al.Biochemical Society symposium, 50, 31-42 (1985-01-01) KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.Audrey E Padula et al.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(8), 1928-1939 (2015-02-11) Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves.Kumiko Nakamura et al.European journal of pharmacology, 694(1-3), 98-103 (2012-09-12) Intrinsic neuronal properties represent song and error in zebra finch vocal learning.Arij Daou et al.Nature communications, 11(1), 952-952 (2020-02-23) Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons.Hiroshi Todaka et al.The European journal of neuroscience, 37(3), 339-350 (2012-11-10) Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors.Marsha L Pierce et al.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125, 109832-109832 (2020-02-06) Apamin inhibits hepatic fibrosis through suppression of transforming growth factor β1-induced hepatocyte epithelial-mesenchymal transition.Woo-Ram Lee et al.Biochemical and biophysical research communications, 450(1), 195-201 (2014-06-01) Apamin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppressions of activated Akt and Erk signaling pathway.Jung-Yeon Kim et al.Vascular pharmacology, 70, 8-14 (2015-03-05) Imatinib mesylate (Gleevec) induces human corpus cavernosum relaxation by inhibiting receptor tyrosine kinases (RTKs): identification of new RTK targets.Serap Gur et al.Urology, 82(3), 745-745 (2013-07-17) β-Resorcylidene aminoguanidine (RAG) dilates coronary arteries in an endothelium-independent manner.Piotr A Kazmierczak et al.Pharmacological reports : PR, 67(3), 631-635 (2015-05-03) Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature.Jessica MacIntyre et al.European journal of pharmacology, 735, 105-114 (2014-04-23) Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.Andrew R Rau et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9730-9740 (2015-07-03) Top-down sequencing of Apis dorsata apamin by MALDI-TOF MS and evidence of its inactivity against microorganisms.D Baracchi et al.Toxicon : official journal of the International Society on Toxinology, 71, 105-112 (2013-06-12) Expression and contributions of TRPM7 and KCa2.3/SK3 channels to the increased migration and invasion of microglia in anti-inflammatory activation states.Tamjeed Siddiqui et al.PloS one, 9(8), e106087-e106087 (2014-08-26) A1-adenosine acute withdrawal response and cholecystokinin-8 induced contractures are regulated by Ca(2+)- and ATP-activated K(+) channels.Maria Grazia Cascio et al.Pharmacological research, 95-96, 82-91 (2015-04-04) Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles.Po-Cheng Chang et al.Journal of the American Heart Association, 2(1), e004713-e004713 (2013-03-26) Apamin from bee venom. Effects of the neurotoxin on subcellular particles of neural culturesSpoerri E, et al. Febs Letters, 53(2), 143-147 (1975) Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia.Amalia M Dolga et al.Glia, 60(12), 2050-2064 (2012-09-25) Apamin attenuated cerulein-induced acute pancreatitis by inhibition of JNK pathway in mice.Gi-Sang Bae et al.Digestive diseases and sciences, 58(10), 2908-2917 (2013-08-07) Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.James M Dell'Orco et al.The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(32), 11292-11307 (2015-08-14) Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy.Clint Gray et al.PloS one, 8(1), e53505-e53505 (2013-01-12) Apamin, a centrally acting neurotoxic peptide: binding and actions.E Habermann et al.Advances in cytopharmacology, 3, 387-394 (1979-01-01) NO-donating oximes relax corpora cavernosa through mechanisms other than those involved in arterial relaxation.Bart Pauwels et al.The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21) Functional expression of SK channels in murine detrusor PDGFR+ cells.Haeyeong Lee et al.The Journal of physiology, 591(2), 503-513 (2012-11-14) Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine.Amaury Graulich et al.Journal of medicinal chemistry, 48(15), 4972-4982 (2005-07-22) Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery.Y M Al Suleimani et al.European journal of pharmacology, 765, 107-114 (2015-08-25) SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle.Rupal P Soder et al.American journal of physiology. Regulatory, integrative and comparative physiology, 304(2), R155-R163 (2012-11-24) SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts.Ramesh C Mishra et al.Cardiovascular research, 97(2), 339-348 (2012-11-03)

备注