密度	1.117±0.06 g/cm3 (20 º

没有数据	没有数据

来源	SDS样本
没有数据	没有数据

产品合成路线

更多

名称	CAS号

更多

文章

同行评议文献

Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.Ehsan A Ehsanipour et al.Cancer research, 73(10), 2998-3006 (2013-04-16) Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.Debora Soncini et al.Blood advances, 4(18), 4312-4326 (2020-09-12) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Sharon Gauci et al.Analytical chemistry, 81(11), 4493-4501 (2009-05-06) The K+-dependent asparaginase, NSE1, is crucial for plant growth and seed production in Lotus japonicus.Alfredo Credali et al.Plant & cell physiology, 54(1), 107-118 (2012-11-20) L-Asparaginase: discovery and development as a tumor-inhibitory agent.J D Broome Cancer treatment reports, 65 Suppl 4, 111-114 (1981-01-01) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).Daniela S Gerhard et al.Genome research, 14(10B), 2121-2127 (2004-10-19) Cerebral venous sinus thrombosis in pediatric cancer patients: long-term neurological outcomes.Christina S Ross et al.Journal of pediatric hematology/oncology, 35(4), 299-302 (2013-02-08) Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.Ajay Vora et al.The Lancet. Oncology, 14(3), 199-209 (2013-02-12) L-asparaginase with methotrexate and dexamethasone is an effective treatment combination in blastic plasmacytoid dendritic cell neoplasm.Bérengère Gruson et al.British journal of haematology, 163(4), 543-545 (2013-08-14) Mutations in subunit interface and B-cell epitopes improve antileukemic activities of Escherichia coli asparaginase-II: evaluation of immunogenicity in mice.Ranjit Kumar Mehta et al.The Journal of biological chemistry, 289(6), 3555-3570 (2013-12-04) Guinea pig serum and liver L-asparaginases. Comparison of serum and papain-digested liver L-asparaginases.H M Suld et al.The Journal of biological chemistry, 245(11), 2797-2801 (1970-06-10) Microchip CE-LIF method for the hydrolysis of L-glutamine by using L-asparaginase enzyme reactor based on gold nanoparticle.Juan Qiao et al.Electrophoresis, 34(3), 409-416 (2012-11-20) Fatal invasive aspergillosis of the larynx.Mark S Williams et al.European journal of haematology, 90(4), 354-354 (2012-12-12) Kinetic studies of L-asparaginase from Penicillium digitatum.Abhinav Shrivastava et al.Preparative biochemistry & biotechnology, 42(6), 574-581 (2012-10-04) Monitoring of anti-L-asparaginase antibody and L-asparaginase activity levels in a pediatric patient with acute lymphoblastic leukemia and hypersensitivity to native Escherichia coli L-asparaginase during desensitization courses.Yuta Kawahara et al.Journal of pediatric hematology/oncology, 36(2), e91-e93 (2013-05-22) A novel asparaginase-like protein is a sperm autoantigen in rats.Leigh Ann Bush et al.Molecular reproduction and development, 62(2), 233-247 (2002-05-02) Glutamine metabolism in the proliferation of GS-expression pituitary tumor cells.Jintao Hu et al.Endocrine connections (2020-02-19) Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter pylori infection.Emiko Rimbara et al.Microbiology and immunology, 57(10), 665-673 (2013-08-14) Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.Juliane Hitzel et al.Nature communications, 9(1), 2292-2292 (2018-06-14) Antineoplastic Drugs Pharmacology and Therapeutics for Dentistry, 530-562 (2017) Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol.Raheel A Raja et al.British journal of haematology, 165(1), 126-133 (2014-01-17) Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.Mi-Kyung Yun et al.Journal of molecular biology, 369(3), 794-811 (2007-04-25) [Antitumor activity of L-asparaginase from Erwinia carotovora from against different leukemic and solid tumours cell lines].O Iu Abakumova et al.Biomeditsinskaia khimiia, 59(5), 498-513 (2014-02-01) Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115.Noura El-Ahmady El-Naggar et al.BMC pharmacology & toxicology, 19(1), 51-51 (2018-08-25) What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation.Erica J Washington et al.Microbiology and molecular biology reviews : MMBR, 77(3), 527-539 (2013-09-06) Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.Martina Chiu et al.Pediatric blood & cancer, 60(11), 1915-1915 (2013-08-01) Efficient production of L-asparaginase from Bacillus licheniformis with low-glutaminase activity: optimization, scale up and acrylamide degradation studies.Richi V Mahajan et al.Bioresource technology, 125, 11-16 (2012-09-29) [Asparaginase mediated acid adaptation of mycobacteria].Xiaolang Cai et al.Wei sheng wu xue bao = Acta microbiologica Sinica, 52(12), 1467-1476 (2013-03-06) Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia.Dan Douer et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(9), 905-911 (2014-02-12) No impact of high-dose cytarabine and asparaginase as early intensification with intermediate-risk paediatric acute lymphoblastic leukaemia: results of randomized trial TCCSG study L99-15.Motohiro Kato et al.British journal of haematology, 164(3), 376-383 (2013-10-30) Extranodal NK/T cell lymphoma, nasal type, presenting with meningeal infiltration in a Caucasian female.Catherine Hildyard et al.British journal of haematology, 163(5), 550-550 (2013-09-17) The DNA sequence and analysis of human chromosome 14.Roland Heilig et al.Nature, 421(6923), 601-607 (2003-01-01) Efficacy of a pegaspargase-based regimen in the treatment of newly-diagnosed extranodal natural killer/T-cell lymphoma.L Li et al.Neoplasma, 61(2), 225-232 (2013-12-05) Screening and characterization of extracelluar L-asparaginase producing Bacillus subtilis strain hswx88, isolated from Taptapani hotspring of Odisha, India.Biswaprakash Pradhan et al.Asian Pacific journal of tropical biomedicine, 3(12), 936-941 (2013-10-08) [Feasibility and safety of chemotherapy for acute lymphoblastic leukemia in adolescents and young adults: Interim analysis of JALSG ALL202-U].Eisei Kondo [Rinsho ketsueki] The Japanese journal of clinical hematology, 53(8), 747-752 (2012-09-15) Comparison of prognostic value of in vitro drug resistance and bone marrow residual disease on day 15 of therapy in childhood acute lymphoblastic leukemia.Jan Styczynski et al.Anticancer research, 32(12), 5495-5499 (2012-12-12) Conservative management of L-asparaginase-induced hypertriglyceridemia in an adult patient: a case report and review of the literature.Jonathan Seah et al.Onkologie, 35(10), 596-598 (2012-10-06) Changes in plasma angiotensin subtypes in Japanese eel acclimated to various salinities from deionized water to double-strength seawaterWong MKS, et al. General and Comparative Endocrinology, 178(2), 250-258 (2012) Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK SignalingMukherjee A, et al. Cellular and molecular gastroenterology and hepatology (2019) Complete sequencing and characterization of 21,243 full-length human cDNAs.Toshio Ota et al.Nature genetics, 36(1), 40-45 (2004-01-01) Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.W H Tong et al.Pediatric blood & cancer, 60(11), 1914-1914 (2013-07-03) Postinduction dexamethasone and individualized dosing of Escherichia Coli L-asparaginase each improve outcome of children and adolescents with newly diagnosed acute lymphoblastic leukemia: results from a randomized study--Dana-Farber Cancer Institute ALL Consortium Protocol 00-01.Lynda M Vrooman et al.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(9), 1202-1210 (2013-01-30) A review and assessment of drug-induced parotitis.Krista G Brooks et al.The Annals of pharmacotherapy, 46(12), 1688-1699 (2012-12-20) N-terminal domain of Pyrococcus furiosus l-asparaginase functions as a non-specific, stable, molecular chaperone.Rachana Tomar et al.The FEBS journal, 280(11), 2688-2699 (2013-04-05) Prevention and handling of acute allergic and infusion reactions in oncology.M Joerger Annals of oncology : official journal of the European Society for Medical Oncology, 23 Suppl 10, x313-x319 (2012-09-26) Acute megakaryoblastic leukemia with increased hematogones in children.Marieta Anton-Harisi et al.Journal of pediatric hematology/oncology, 34(8), e337-e340 (2012-09-18) The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.Gabriel J Wilson et al.American journal of physiology. Endocrinology and metabolism, 305(9), E1124-E1133 (2013-09-05) Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cellsHitzel J, et al. Nature Communications, 9(2292), 1-18 (2018) Clofarabine in combination with pegylated asparaginase in the frontline treatment of childhood acute lymphoblastic leukaemia: a feasibility report from the CoALL 08-09 trial.Gabriele Escherich et al.British journal of haematology, 163(2), 240-247 (2013-08-14) The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.Jason R Cantor et al.Biochemistry, 48(46), 11026-11031 (2009-10-21) Mitoxantrone as a substitute for daunorubicin during induction in newly diagnosed lymphoblastic leukemia and lymphoma.Robert S Nickel et al.Pediatric blood & cancer, 61(5), 810-814 (2013-12-21) Optimizing asparaginase therapy for acute lymphoblastic leukemia.Carmelo Rizzari et al.Current opinion in oncology, 25 Suppl 1, S1-S9 (2013-02-13) L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence.Amy L Kullas et al.Cell host & microbe, 12(6), 791-798 (2012-12-19) Current issues in dietary acrylamide: formation, mitigation and risk assessment.Franco Pedreschi et al.Journal of the science of food and agriculture, 94(1), 9-20 (2013-08-14) Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth.Hongbo Lu et al.Annals of hematology, 93(3), 485-492 (2013-10-25) [Recombinant intracellular Rhodospirillum rubrum L-asparaginase with low L-glutaminase activity and antiproliferative effect].M V Pokrovskaia et al.Biomeditsinskaia khimiia, 59(2), 192-208 (2013-06-26) Resveratrol induces cell cycle arrest and apoptosis in malignant NK cells via JAK2/STAT3 pathway inhibition.Ly Quoc Trung et al.PloS one, 8(1), e55183-e55183 (2013-02-02) [A clinical study of drug-related toxicities of CCLG-ALL 08 protocol for childhood acute lymphoblastic leukemia].Bo Chen et al.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 15(9), 737-742 (2013-09-17) [Successful treatment with high-dose methotrexate/cytarabine regimen in a patient in SMILE regimen-resistant extranodal natural killer/T-cell lymphoma].Masuho Saburi et al.[Rinsho ketsueki] The Japanese journal of clinical hematology, 55(1), 120-124 (2014-02-05) Identification of CRASH, a gene deregulated in gynecological tumors.Vesna Evtimova et al.International journal of oncology, 24(1), 33-41 (2003-12-05) Chemotherapy induces enhanced procoagulant activity through phosphatidylserine exposure in acute lymphoblastic leukemia.Xiushuai Dong et al.Thrombosis research, 132(5), 614-620 (2013-10-01) Antineoplastic drugs Drugs During Pregnancy and Lactation, 373-399 (2015) The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia.E Truelove et al.Leukemia, 27(3), 553-559 (2012-10-27) Hydrolysis of amides by extracts from Mycobacteria.Y S HALPERN et al.The Biochemical journal, 65(4), 716-720 (1957-04-01) Crystalline L-asparaginase from escherichia coli B.P P Ho et al.Science (New York, N.Y.), 165(3892), 510-512 (1969-08-01) Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115El-Naggar NEA, et al. BMC Pharmacology & Toxicology, 19(1), 1-15 (2018) Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia.Jassada Buaboonnam et al.Pediatric blood & cancer, 60(7), 1161-1164 (2013-01-22) No evidence of increased asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.Wing H Tong et al.Pediatric blood & cancer, 60(2), 258-261 (2012-09-11) Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia.Toni Grönroos et al.Scientific reports, 10(1), 2043-2043 (2020-02-08) Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.Julian Nomme et al.Biochemistry, 51(34), 6816-6826 (2012-08-07) TK1656, a thermostable l-asparaginase from Thermococcus kodakaraensis, exhibiting highest ever reported enzyme activity.Shahid Mahmood Chohan et al.Journal of bioscience and bioengineering, 116(4), 438-443 (2013-05-08) Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.Wenzong Li et al.ACS chemical biology, 7(11), 1840-1847 (2012-08-16) Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.Lise Willems et al.Blood, 122(20), 3521-3532 (2013-09-10) Incidence and outcome of pancreatitis in children and young adults with acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003.Sujith Samarasinghe et al.British journal of haematology, 162(5), 710-713 (2013-06-12) [Physicochemical properties and antiproliferative activity of recombinant Yersinia pseudotuberculosis L-asparaginase].V S Pokrovskiĭ et al.Prikladnaia biokhimiia i mikrobiologiia, 49(1), 24-28 (2013-05-15)

备注