密度	1.621±0.06 g/cm3 (20 º

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Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.Miryam Andrea Hortua Triana et al.Molecular and biochemical parasitology, 184(2), 71-81 (2012-05-15) Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.Danny T Huang et al.Biochemistry, 45(27), 8275-8283 (2006-07-06) Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.Jonathan P Combe et al.The Journal of biological chemistry, 281(26), 17977-17988 (2006-04-21) Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.Pengfei Zhang et al.Biochemistry, 48(4), 766-778 (2009-01-09) Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.Al-Walid A Mohsen et al.Biochemistry, 43(21), 6498-6510 (2004-05-26) Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.Rebecca L Fagan et al.Biochemistry, 48(30), 7169-7178 (2009-06-18) Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.Rebecca L Fagan et al.Biochemistry, 45(50), 14926-14932 (2006-12-13) Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.Michelle L Zaharik et al.Microbiology (Reading, England), 153(Pt 8), 2472-2482 (2007-07-31) [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway].Kiyoshi Kita et al.Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(12 Suppl), 1676-1683 (2009-09-01) The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria.Laura Martorano et al.Disease models & mechanisms, 12(3) (2019-03-06) Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension.Sheila G Couto et al.Biochemical and biophysical research communications, 414(3), 487-492 (2011-10-12) Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.Mihwa Lee et al.Journal of molecular biology, 348(3), 523-533 (2005-04-14) In Vitro Human Dihydroorotate Dehydrogenase Inhibitory, Anti-inflammatory and Cytotoxic Activities of Alkaloids from the Seeds of Nigella glandulifera.Jun-Bo Gao et al.Planta medica, 84(14), 1013-1021 (2018-04-06) Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase.Claudia A McDonald et al.Biochemistry, 50(14), 2714-2716 (2011-03-16) Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.O Björnberg et al.Archives of biochemistry and biophysics, 391(2), 286-294 (2001-07-05) 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.Mark A Anderson et al.Biochemistry, 45(23), 7132-7139 (2006-06-07) Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.Ling Li et al.Molecular cell, 80(3), 525-540 (2020-10-18) Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.Z Minic et al.The Journal of biological chemistry, 276(26), 23777-23784 (2001-04-18) Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.Majbritt Hansen et al.Protein science : a publication of the Protein Society, 13(4), 1031-1042 (2004-03-27) Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.Idalia Sariego et al.Parasitology international, 55(1), 11-16 (2005-09-21) Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.Joe Rainger et al.Human molecular genetics, 21(18), 3969-3983 (2012-06-14) Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.Daniel Ken Inaoka et al.Biochemistry, 47(41), 10881-10891 (2008-09-24) Mechanism of the dihydroorotase reaction.Tamiko N Porter et al.Biochemistry, 43(51), 16285-16292 (2004-12-22) SEC-TID: A Label-Free Method for Small-Molecule Target Identification.Michael Salcius et al.Journal of biomolecular screening, 19(6), 917-927 (2014-02-21) Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors.D B Jordan et al.Archives of biochemistry and biophysics, 378(1), 84-92 (2000-06-28) Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.Juliana Cheleski et al.Analytical biochemistry, 399(1), 13-22 (2009-11-26) Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression.E A Neidhardt et al.Journal of molecular microbiology and biotechnology, 1(1), 183-188 (2000-08-15) The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.Björn Walse et al.Biochemistry, 47(34), 8929-8936 (2008-08-05) Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.E Takashima et al.Parasitology international, 50(4), 273-278 (2001-11-24)

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